Alisertib (MLN8237) is a potent and highly selective Aurora A kinase inhibitor. It affects DNA damage, PI3K/AKT, and cGAS/STING signaling pathways, by blocking AURKA phosphorylation and inducing G2/M cell cycle arrest, thereby inhibiting tumor cell proliferation and promoting apoptosis and senescence.
Alisertib (MLN8237) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Alisertib (MLN8237) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.