AICAR (Acadesine): Mechanism of Action

AICAR (Acadesine) MOA:Targeting ACC/AMPK Pathway for Metabolic Diseases

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AICAR (Acadesine) is a cell-permeable AMP-mimetic AMPK activator. It affects AMPK/mTOR and AMPK/PGC-1α signaling by phosphorylating AMPK and downstream targets, to promote autophagy and mitochondrial biogenesis, and inhibit apoptosis, lipid accumulation, and tumor proliferation.

Primary Applications and Mechanism of Action