CAS No. 2627-69-2
Batch:
Purity:99.97
Chemical Structure
Check the
AICAR (Acadesine)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide | |
|---|---|---|
| CAS Number | 2627-69-2 | |
| Molecular Formula |
C9H14N4O5 |
|
| Molecular Weight (MW) | 258.23 | |
| SMILES | C1=NC(=C(N1C2C(C(C(O2)CO)O)O)N)C(=O)N | |
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
AICAR (Acadesine) is an AMP-activated protein kinase (AMPK) activator. Intracellular conversion of AICAR leads to the accumulation of ZMP, an AMP derivative that mimics AMP to directly stimulate AMPK and AMPK kinase activity. Activation of the AMPK signaling pathway regulates cellular energy homeostasis, inhibits protein and lipid synthesis, and induces mitophagy as well as apoptosis in leukemic cells. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(197.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | Insoluble |
| DMSO |
52 mg/mL
(201.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 52 mg/mL |
| Ethanol | Insoluble |
| DMSO |
52 mg/mL
(201.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 26 mg/mL |
| Ethanol | Insoluble |
| DMSO |
52 mg/mL
(201.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 23 mg/mL (超声加热五分钟) |
| Ethanol | Insoluble |
| DMSO |
52 mg/mL
(201.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 52 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- AICAR (Acadesine) Mechanism of Action: ACC Inhibition in Adipocytes Research
- AICAR (Acadesine) Clinical Trials
- AICAR (Acadesine) Working Concentration | Cell Culture | Treatment
- AICAR (Acadesine) Solubility in DMSO
- AICAR (Acadesine) Stock Solution
- AICAR (Acadesine) Storage
- AICAR (Acadesine) Stability
- AICAR (Acadesine) Combination Database
- AICAR (Acadesine) Molecular Weight
- AICAR (Acadesine) SMILES
- AICAR (Acadesine) Chemical Structure (2D and 3D)
- AICAR (Acadesine) IC50 for Cell-based and Cell-free Assays
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- AICAR (Acadesine) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.