CAS No. 1448347-49-6
Batch:
Purity:99.93
Chemical Structure
Check the
AG-120 (Ivosidenib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxopyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 1448347-49-6 | |
| Molecular Formula |
C28H22ClF3N6O3 |
|
| Molecular Weight (MW) | 582.96 | |
| SMILES | C1CC(=O)N(C1C(=O)N(C2=CC(=CN=C2)F)C(C3=CC=CC=C3Cl)C(=O)NC4CC(C4)(F)F)C5=NC=CC(=C5)C#N | |
| InChIKey | WIJZXSAJMHAVGX-DHLKQENFSA-N |
AG-120 (Ivosidenib) is an orally bioavailable, small-molecule inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). By selectively inhibiting mutant IDH1, AG-120 blocks the reduction of alpha-ketoglutarate to the oncometabolite D-2-hydroxyglutarate (2-HG). This reduction in cellular 2-HG levels promotes demethylation of histones and DNA, reversing malignant epigenetic reprogramming and inducing cellular differentiation to suppress tumor growth. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(171.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(171.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(171.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(171.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(171.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- AG-120 (Ivosidenib) Mechanism of Action: IDH1 Inhibition in Leukemic Blast Cells Research
- AG-120 (Ivosidenib) Clinical Trials
- AG-120 (Ivosidenib): Selectivity & Specificity
- AG-120 (Ivosidenib) Working Concentration | Cell Culture | Treatment
- AG-120 (Ivosidenib) Solubility in DMSO
- AG-120 (Ivosidenib) Stock Solution
- AG-120 (Ivosidenib) Storage
- AG-120 (Ivosidenib) Stability
- AG-120 (Ivosidenib) Combination Database
- AG-120 (Ivosidenib) Molecular Weight
- AG-120 (Ivosidenib) SMILES
- AG-120 (Ivosidenib) Chemical Structure (2D and 3D)
- AG-120 (Ivosidenib) IC50 for Cell-based and Cell-free Assays
- AG-120 (Ivosidenib) Sigma (AMBH303C4A12)? Try a better option.
- AG-120 (Ivosidenib) APExBIO (B7805)? Try a better option.
- AG-120 (Ivosidenib) MedChemExpress (HY-18767)? Try a better option.
- AG-120 (Ivosidenib) Cayman (19894)? Try a better option.
- AG-120 (Ivosidenib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.