SB203580 (Adezmapimod) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

Product Name: SB203580 (Adezmapimod)
Catalog Number: S1076
CAS Number: 152121-47-6
IUPAC Name: 4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine

Relevant identified uses and uses advised against

Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

Company : Selleck Chemicals
TollFree : +1 877 796-6397
Tel : +1 832 582-8158
Fax : +1 832 582-8590

Emergency telephone number

Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

GHS classification in accordance with the OSHA Hazard Communication Standard (29 CFR 1910.1200)
Acute toxicity (Oral) : Category 4

Pictogram: GHS07

Signal Word : Warning

Hazard Statements :
H302 Harmful if swallowed.

Precautionary statements :
Prevention:
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.

Response:
P301 + P312 + P330 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. Rinse mouth.

Disposal:
P501 Dispose of contents/ container to an approved waste disposal plant.

Other hazards
None known.

3. COMPOSITION/INFORMATION ON INGREDIENTS

Substance / Mixture : Substance

Components
Chemical name: 4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine
CAS-No.: 152121-47-6
Concentration (% w/w): >= 90 - <= 100
Trade secret: Actual concentration is withheld as a trade secret.

4. FIRST AID MEASURES

General advice : Show this safety data sheet to the doctor in attendance.
If inhaled : After inhalation: fresh air.
In case of skin contact : In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact : After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed : After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Most important symptoms and effects, both acute and delayed : The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11.
Protection of first-aiders : For personal protection see section 8.
Notes to physician : N/A

5. FIREFIGHTING MEASURES

Suitable extinguishing media : Water, Foam, Carbon dioxide (CO2), Dry powder.
Unsuitable extinguishing media : For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting : Combustible. Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products : Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides, Hydrogen fluoride.
Specific extinguishing methods : N/A
Further information : Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters : In the event of fire, wear self-contained breathing apparatus.

6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures :
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
Advice for emergency responders: For personal protection see section 8.

Environmental precautions : Do not let product enter drains.

Methods and materials for containment and cleaning up : Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

7. HANDLING AND STORAGE

Precautions for safe handling : For precautions see section 2.2.
Further information on storage conditions : Tightly closed. Dry.
Storage class : 13, Non Combustible powder
Recommended storage temperature : -4 °F / -20 °C

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Ingredients with workplace control parameters : Contains no substances with occupational exposure limit values.
Engineering measures : N/A

Personal protective equipment :
Respiratory protection : Required when dusts are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type : Filter type P2. The entrepreneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Hand protection :
Material: Nitrile rubber
Break through time: 480 min
Glove thickness: 0.11 mm
Protective index: Full contact
Manufacturer: KCL 741 Dermatril-L

Material: Nitrile rubber
Break through time: 480 min
Glove thickness: 0.11 mm
Protective index: Splash contact
Manufacturer: KCL 741 Dermatril-L
Remarks: Handle with impervious gloves.

Eye protection : Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses.
Skin and body protection : Protective clothing.
Hygiene measures : Change contaminated clothing. Preventive skin protection recommended. Wash hands after working with substance.

9. PHYSICAL AND CHEMICAL PROPERTIES

Appearance : powder
Color : light yellow
Odor : N/A
Odor Threshold : N/A
pH : N/A
Melting point : 291 - 295 °F / 144 - 146 °C
Boiling point : 1140.01 °F / 615.56 °C (1,013.3 hPa)
Flash point : Not applicable
Evaporation rate : N/A
Flammability (powder, gas) : The product is not flammable.
Burning rate : N/A
Upper explosion limit / Upper flammability limit : N/A
Lower explosion limit / Lower flammability limit : N/A
Vapor pressure : N/A
Relative vapour density : N/A
Relative density : N/A
Density : N/A
Water solubility : N/A
Partition coefficient: n-octanol/water : N/A
Autoignition temperature : N/A
Decomposition temperature : N/A
Viscosity, dynamic : N/A
Viscosity, kinematic : N/A
Flow time : N/A
Explosive properties : N/A
Oxidizing properties : none
Molecular weight : 377.43 g/mol
Particle size : N/A

10. STABILITY AND REACTIVITY

Reactivity : The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability : The product is chemically stable under standard ambient conditions (room temperature).
Possibility of hazardous reactions : N/A
Conditions to avoid : No information available
Incompatible materials : Oxidizing agents, Strong oxidizing agents.
Hazardous decomposition products : In the event of fire: see section 5.

11. TOXICOLOGICAL INFORMATION

11.1 Information on toxicological effects
Acute toxicity :
Oral: N/A
Inhalation: N/A
Dermal: N/A

Skin corrosion/irritation : N/A
Serious eye damage/eye irritation : Remarks: N/A
Respiratory or skin sensitization : N/A
Germ cell mutagenicity : N/A

Carcinogenicity :
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA's list of regulated carcinogens.

Reproductive toxicity : N/A
Specific target organ toxicity - single exposure : N/A
Specific target organ toxicity - repeated exposure : N/A
Aspiration hazard : N/A

11.2 Additional Information
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

12. ECOLOGICAL INFORMATION

Ecotoxicity : N/A
Persistence and degradability : N/A
Bioaccumulative potential : N/A
Mobility in soil : N/A
Other adverse effects : N/A

13. DISPOSAL CONSIDERATIONS

Disposal methods
Waste from residues : Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

14. TRANSPORT INFORMATION

International Regulations
IATA-DGR : Not regulated as a dangerous good
IMDG-Code : Not regulated as a dangerous good
Transport in bulk according to IMO instruments : Not applicable for product as supplied.

National Regulations
49 CFR Road : Not regulated as a dangerous good
Poison Inhalation Hazard : No

Special precautions for user
Remarks : Not classified as dangerous in the meaning of transport regulations.

15. REGULATORY INFORMATION

CERCLA Reportable Quantity
This material does not contain any components with a CERCLA RQ.

SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.

SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
This material does not contain any components with a section 302 EHS TPQ.

SARA 311/312 Hazards : Acute Health Hazard

SARA 313 : This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.

US State Regulations
Massachusetts Right To Know
No components are subject to the Massachusetts Right to Know Act.

Maine Chemicals of High Concern
Product does not contain any listed chemicals

Vermont Chemicals of High Concern
Product does not contain any listed chemicals

Washington Chemicals of High Concern
Product does not contain any listed chemicals

The components of this product are reported in the following inventories:
TSCA : Product contains substance(s) not listed on TSCA inventory.

TSCA list
No substances are subject to a Significant New Use Rule.
No substances are subject to TSCA 12(b) export notification requirements.

16. OTHER INFORMATION

Revision Date: 2026/07/07
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.