Adenosine Clinical Trials

Size	Price	Qty
50mg	USD 147
1g	USD 370

Clinical Trials

Adenosine has been evaluated in numerous clinical trials spanning Early Phase 1 through Phase 4 across diverse indications, including supraventricular tachycardia, coronary artery disease, ischemia-reperfusion injury, mild persistent asthma, and solid tumors such as pancreatic ductal adenocarcinoma and ovarian cancer. Sponsored by academic institutions, medical centers, and pharmaceutical leaders—such as Pfizer, Chiesi Farmaceutici, and Radboud University Medical Center—these studies feature recruitment statuses ranging from active or completed to terminated or not yet recruiting. Key investigative focus areas encompass anti-arrhythmic administration protocols and combination immunotherapeutic strategies targeting adenosine pathways.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04666454	RECRUITING	Takotsubo Syndrome	Vastra Gotaland Region	2020-12-14	PHASE4
NCT07249034	NOT_YET_RECRUITING	Epilepsy; Drug-resistant Focal Epilepsy; Healthy Controls	Hospices Civils de Lyon	2026-08-07
NCT06921720	RECRUITING	Phosphate Diabetes; X-linked Hypophosphatemia	Hospices Civils de Lyon	2025-05-16
NCT05309655	ACTIVE_NOT_RECRUITING	Breast Cancer; Triple Negative Breast Cancer; Cardiovascular Complications	Duke University	2022-09-02
NCT05272709	RECRUITING	Advanced Solid Tumors	Cancer Research UK	2022-01-19	PHASE1; PHASE2
NCT07296354	NOT_YET_RECRUITING	Neuropathic Pain	Egyptian International Pharmaceutical Industries Co	2026-01-10	PHASE4
NCT05217498	NOT_YET_RECRUITING	Spinal Cord Injuries; Myelopathy	Randy Trumbower, PT, PhD	2027-09-01	PHASE1; PHASE2
NCT07426237	NOT_YET_RECRUITING	Myocardial Protection	Hospital Nossa Senhora da Conceicao	2026-03-30	PHASE4
NCT06993038	RECRUITING	Supraventricular Tachycardia (SVT)	Anne E. Zepeski	2025-08-01	PHASE4
NCT00412594	RECRUITING	Hairy Cell Leukemia; Recurrent Hairy Cell Leukemia	M.D. Anderson Cancer Center	2004-06-10	PHASE2
NCT06048484	RECRUITING	Pancreatic Ductal Adenocarcinoma	Gulam Manji	2024-05-10	PHASE2
NCT04600115	RECRUITING	MRI Scans	University of Utah	2017-03-03	EARLY_PHASE1
NCT06763172	RECRUITING	Healthy; Caffeine; Adenosine; Dopamine D2/3 Receptor Availability	Hsiao-Ying Wey	2023-05-17	PHASE4
NCT06578234	RECRUITING	Chronic Coronary Syndrome; Coronary Artery Disease; Ischemic Heart Disease	Region Skane	2024-10-23	PHASE4
NCT05915442	RECRUITING	Oligometastatic Prostate Cancer	Catherine Spina	2023-07-01	PHASE2
NCT05024097	RECRUITING	Rectal Cancer	Weill Medical College of Cornell University	2022-03-31	PHASE2
NCT05501054	ACTIVE_NOT_RECRUITING	Renal Cell Carcinoma	M.D. Anderson Cancer Center	2023-02-09	PHASE1; PHASE2
NCT02205762	ACTIVE_NOT_RECRUITING	Langerhans Cell Histiocytosis	North American Consortium for Histiocytosis	2016-11-02	PHASE2; PHASE3
NCT04969315	RECRUITING	Renal Cell Cancer; Castrate Resistant Prostate Cancer; Non Small Cell Lung Cancer; Head and Neck Squamous Cell Carcinoma; Colorectal Cancer (CRC); Endometrial Cancer; Ovarian Cancer	Portage Biotech	2023-06-23	PHASE1; PHASE2
NCT07536802	RECRUITING	ST-Segment Elevation Myocardial Infarction (STEMI); No-Reflow Phenomenon; Coronary Slow Flow; Acute Myocardial Infarction	National Institute of Cardiovascular Diseases, Pakistan	2025-06-01	PHASE4
NCT05017649	UNKNOWN	Hypercholesterolemia	Assistance Publique Hopitaux De Marseille	2021-09-20
NCT06650605	COMPLETED	Glioma Glioblastoma Multiforme	Theragnostics Ltd	2024-07-04	PHASE1
NCT05325502	ACTIVE_NOT_RECRUITING	Caffeine	Yu-Shiuan Lin	2022-05-05
NCT04822649	RECRUITING	Heart Failure With Preserved Ejection Fraction (HFpEF)	Korea University Anam Hospital	2021-04-15
NCT07554170	COMPLETED	Supraventricular Tachycardia; Supraventricular Tachycardias; Supraventricular Arrhythmia; SVT; PSVT	Hormozgan University of Medical Sciences	2024-05-21	PHASE4
NCT04588441	WITHDRAWN	Acute Respiratory Distress	University of Florida	2023-12	PHASE2
NCT04892875	WITHDRAWN	Head and Neck Cancer; Squamous Cell Carcinoma of Head and Neck; Oral Cavity Squamous Cell Carcinoma; Oral Cavity Cancer; Oropharynx Cancer; Oropharynx Squamous Cell Carcinoma; Larynx Cancer; Pharynx Cancer; Hypopharynx Cancer; Hypopharynx Squamous Cell Carcinoma	Jennifer Choe	2023-12-31	PHASE1
NCT07456423	COMPLETED	Supraventricular Tachycardia (SVT); Atrioventricular Nodal Re Entrant Tachycardia	Haseki Training and Research Hospital	2024-07-01	PHASE4
NCT03537586	ACTIVE_NOT_RECRUITING	Coronary Microvascular Disease; Ischemic Heart Disease; Myocardial Ischemia	NYU Langone Health	2018-06-29
NCT06145490	COMPLETED	Panic Disorder; Healthy	Uppsala University	2024-10-29
NCT06717685	RECRUITING	Supraventricular Tachycardia (SVtach)	Rashid Latif Medical College	2024-10-28	PHASE3
NCT05022290	UNKNOWN	Supraventricular Tachycardia	Khon Kaen University	2020-10-01
NCT06167512	Not yet recruiting	Multi-organ Failure After Severe Trauma	Assistance Publique - Hôpitaux de Paris	2024-04-01	--
NCT05713019	UNKNOWN	Cough	Imperial College London	2023-02-28
NCT05091749	ACTIVE_NOT_RECRUITING	Chronic Coronary Syndromes	Assistance Publique Hopitaux De Marseille	2021-11-09
NCT06269874	Not yet recruiting	Microvascular Coronary Artery Disease	Johannes Gutenberg University Mainz	2024-03-02	Not Applicable
NCT03661827	COMPLETED	Heart Failure; Coronary Artery Disease; Cardiac MRI	University of Leicester	2019-02-05
NCT04640844	UNKNOWN	Chronic Coronary Artery Disease	Assistance Publique Hopitaux De Marseille	2021-01-25
NCT03848325	COMPLETED	HIV-1-infection; Sleep Deprivation; Inflammation	University of Pittsburgh	2020-11-09
NCT03722849	COMPLETED	Cough	Stuart Mazzone	2019-03-01
NCT03557385	COMPLETED	Percutaneous Coronary Intervention	Duke University	2019-01-17	PHASE4
NCT05100589	COMPLETED	Cognitive Change; Mood	University of Central Florida	2021-10-06
NCT03330405	TERMINATED	Avelumab in Combination With Talazoparib Will be Investigated in Patients With Locally Advanced (Primary or Recurrent) or Metastatic Solid Tumors	Pfizer	2017-10-19	PHASE1; PHASE2
NCT04401657	UNKNOWN	Coronary Artery Stenosis	Asan Medical Center	2020-05-08
NCT03642132	TERMINATED	Ovarian Cancer	Pfizer	2018-07-19	PHASE3
NCT04577443	COMPLETED	Headache, Migraine	Danish Headache Center	2020-11-01
NCT03765632	COMPLETED	Severe Combined Immunodeficiency Due to ADA Deficiency	Great Ormond Street Hospital for Children NHS Foundation Trust	2018-01-03	PHASE1; PHASE2
NCT04961931	UNKNOWN	Chronic Kidney Disease stage3	Medical University of Lodz	2019-01-01
NCT04140539	WITHDRAWN	Severe Combined Immunodeficiency Due to ADA Deficiency	University of California, Los Angeles	2019-10-15	PHASE2; PHASE3
NCT03072589	UNKNOWN	Lung Transplant	Christine Lau, MD	2017-11-30	PHASE1
NCT03972683	WITHDRAWN	Vasoconstriction; Vasodilation	Colorado State University	2019-04-16	EARLY_PHASE1
NCT03738943	COMPLETED	Receptor Blockade	Colorado State University	2019-02-07	EARLY_PHASE1
NCT04699110	COMPLETED	Acute Coronary Syndrome; No-Reflow Phenomenon; Normotensive	National Institute of Cardiovascular Diseases, Pakistan	2021-01-01	PHASE4
NCT02509546	COMPLETED	Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia	City of Hope Medical Center	2015-09-02	PHASE1; PHASE2
NCT05247385	COMPLETED	Coronary Artery Disease	University of Sao Paulo	2017-03-20	PHASE4
NCT04392362	COMPLETED	Supra-ventricular Tachycardia	University of Pretoria	2018-04-01	PHASE3
NCT04203368	COMPLETED	Supraventricular Tachycardia	Ain Shams University	2020-02-01
NCT04312477	UNKNOWN	Diarrhea-predominant Irritable Boewl Syndrome	Xiyuan Hospital of China Academy of Chinese Medical Sciences	2019-04-01	EARLY_PHASE1
NCT03235700	UNKNOWN	Heart Failure With Reduced Ejection Fraction; Coronary Artery Disease	Sejong General Hospital	2017-03-01
NCT03774290	COMPLETED	Asthma	Palobiofarma SL	2018-06-01	PHASE2
NCT03039205	COMPLETED	Platelet Aggregation; Adenosine; Coronary Artery Disease; Kidney Dysfunction; Antiplatelet Therapy	University of Sao Paulo	2017-11-07	PHASE2
NCT01672346	UNKNOWN	Paroxysmal Atrial Fibrillation	Texas Cardiac Arrhythmia Research Foundation	2013-05	PHASE3
NCT04057547	UNKNOWN	Ulcerative Colitis	Xiyuan Hospital of China Academy of Chinese Medical Sciences	2019-04-01	EARLY_PHASE1
NCT04051541	COMPLETED	Supraventricular Tachycardia	HealthPartners Institute	2019-05-06
NCT03138681	UNKNOWN	Major Depressive Disorder	Zhujiang Hospital	2017-05-03	PHASE2
NCT03249272	TERMINATED	Hypertrophic Cardiomyopathy; Non-ischemic Dilated Cardiomyopathy; Microvascular Ischaemia of Myocardium	Duke University	2017-09-05	PHASE4
NCT01852071	COMPLETED	ADA-SCID	University of California, Los Angeles	2013-08-02	PHASE1; PHASE2
NCT03461705	TERMINATED	Coronary; Ischemic	Columbia University	2017-10-20
NCT02681913	UNKNOWN	Pathological Processes; Cardiomyopathies	Amphia Hospital	2016-02	PHASE2
NCT03111420	COMPLETED	Risk Factor, Cardiovascular; Platelet Dysfunction Due to Drugs	Aggredyne, Inc.	2017-01-09
NCT03098979	COMPLETED	Heart Failure	Bayer	2017-05-10	PHASE2
NCT02580851	COMPLETED	Stable Coronary Artery Disease; Cardiac Magnetic Resonance Imaging; Coronary Angiography; Myocardial Revascularization; Outcomes and Prognosis; Quality of Life	University of Ulm	2011-12
NCT03119818	COMPLETED	End-Stage Renal Disease (ESRD)	Hospices Civils de Lyon	2017-06-14
NCT01477983	COMPLETED	Atrial Fibrillation	Kyoto University, Graduate School of Medicine	2011-11	PHASE4
NCT03344679	COMPLETED	Breast Surgery	Menoufia University	2015-02-01
NCT01481168	COMPLETED	Syncope	Newcastle-upon-Tyne Hospitals NHS Trust	2012-04-12
NCT00580905	TERMINATED	Inflammation	Vanderbilt University	2007-06	PHASE1
NCT01690884	COMPLETED	Coronary Artery Disease	Vanderbilt University	2012-08	PHASE1
NCT00179010	TERMINATED	Ischemia	Vanderbilt University Medical Center	2003-10	PHASE1
NCT02885740	UNKNOWN	Atrial Fibrillation	Central Hospital, Nancy, France	2010-03
NCT02284048	UNKNOWN	Microvascular Angina	Second Xiangya Hospital of Central South University	2014-11	PHASE4
NCT02527616	COMPLETED	Coronary Artery Disease	Diasolve Ltd	2016-05
NCT00714103	COMPLETED	Leukemia; Chronic Lymphocytic Leukemia	M.D. Anderson Cancer Center	2008-06	PHASE1
NCT01939912	COMPLETED	Heart Failure; Peripheral Chemoreceptor Hypersensitivity	Noblewell	2013-08
NCT01680081	TERMINATED	Coronary Artery Disease	Yonsei University	2012-01-30	PHASE4
NCT03327168	COMPLETED	Obesity	Turku University Hospital	2015-11-01
NCT02574975	UNKNOWN	Asthma	Zhujiang Hospital	2015-04	PHASE4
NCT02462941	COMPLETED	Sinus Bradycardia; Atrioventricular Block	Columbia University	2015-07	PHASE1
NCT02279511	COMPLETED	Alzheimer's Disease	Sara Varea	2014-12	PHASE2
NCT02121288	WITHDRAWN	Peripheral Artery Disease; Vascular Disease; Arterial Occlusion Disease; Intermittent Claudication; Ankle Brachial Index (0.9 or Less)	AstraZeneca	2014-12	PHASE4
NCT02040233	COMPLETED	Heart Failure	Bayer	2014-01-28	PHASE2
NCT02255006	UNKNOWN	Healthy	Kyunghee University Medical Center	2014-05
NCT01939587	COMPLETED	Asthma	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	2013-12	PHASE2
NCT01495481	COMPLETED	Supraventricular Tachycardia	University of Pittsburgh	2012-01
NCT02238392	COMPLETED	Paroxysmal Atrial Fibrillation	Johannes Gutenberg University Mainz	2012-01
NCT01034306	COMPLETED	Rheumatoid Arthritis	Can-Fite BioPharma	2010-10	PHASE2
NCT02161081	COMPLETED	Myocardial Ischemia	Samsung Medical Center	2012-01
NCT01837108	COMPLETED	Pharmacodynamics	Radboud University Medical Center	2013-04	PHASE4
NCT01996735	COMPLETED	Healthy	Radboud University Medical Center	2013-04	PHASE4
NCT01610921	COMPLETED	Asthma	University Medical Center Groningen	2012-02
NCT01809743	COMPLETED	Coronary Artery Disease	Lokien van Nunen	2013-01	PHASE3
NCT02357212	COMPLETED	Acute Coronary Syndrome	University of Florida	2009-04
NCT01058980	COMPLETED	Paroxysmal Atrial Fibrillation; Pulmonary Vein Isolation; Dormant Pulmonary Vein Conduction	Montreal Heart Institute	2009-12	PHASE4
NCT01295593	UNKNOWN	Chronic Lymphocytic Leukemia	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	2010-12	PHASE1; PHASE2
NCT01161121	COMPLETED	Coronary Artery Disease	St. Louis University	2010-07	PHASE1
NCT02764892	COMPLETED	Parkinson's Disease	Vernalis (R&D) Ltd	2012-08	PHASE1
NCT01642966	COMPLETED	Acute Coronary Syndrome	University of Patras	2012-09	PHASE4
NCT00781404	COMPLETED	Acute Myocardial Infarction	David Garcia-Dorado	2008-10	PHASE3
NCT01313572	TERMINATED	Coronary Artery Disease	Forest Laboratories	2011-08	PHASE3
NCT00990327	TERMINATED	Coronary Artery Disease	Forest Laboratories	2009-11	PHASE3
NCT01370265	COMPLETED	Coronary Artery Disease	Mayo Clinic	2011-02
NCT00923962	COMPLETED	Type 2 Diabetes Mellitus	University Hospital, Gentofte, Copenhagen	2009-06
NCT01234870	COMPLETED	Heart Disease, Ischemic; Atherosclerosis, Coronary	Northwestern University	2010-06	PHASE2; PHASE3
NCT01331902	UNKNOWN	Coronary Artery Disease; Myocardial Ischemia	Seoul National University Hospital	2011-03	PHASE4
NCT00733993	COMPLETED	Cocaine Dependence	Virginia Commonwealth University	2008-04	PHASE1; PHASE2
NCT00590070	COMPLETED	Myocardial Infarction	Catholic University of the Sacred Heart	2008-01	PHASE2; PHASE3
NCT01162824	UNKNOWN	Endothelial Dysfunction; Atherosclerosis; Inflammation; Myocardial Ischemia	St George's Healthcare NHS Trust	2011-01
NCT01226602	COMPLETED	Blood Flow Speed; Coronary Flow Velocity	AstraZeneca	2010-12	PHASE1
NCT01123525	COMPLETED	Angina Pectoris	University Hospital of North Norway	2010-04	PHASE1; PHASE2
NCT03231371	COMPLETED	Orthotopic Heart Transplant	Bryan Goldstein	2008-11	PHASE3
NCT01148147	COMPLETED	Coronary Angioplasty	Azienda Ospedaliero Universitaria Maggiore della Carita	2009-11	PHASE3
NCT00859833	COMPLETED	Obesity; Endothelial Dysfunction; Decreased Vascular Flow	University of Utah	2009-02
NCT00744341	TERMINATED	Acute Decompensated Heart Failure; Renal Dysfunction	Solvay Pharmaceuticals	2009-02	PHASE2
NCT00851175	COMPLETED	Atherosclerosis; Cardiovascular Disease	Radboud University Medical Center	2009-03	PHASE4
NCT00881686	COMPLETED	Heart Defects, Congenital; Cardiac Surgical Procedures; Myocardial Reperfusion Injury; Adenosine	Xijing Hospital	2008-06	PHASE1; PHASE2
NCT00612521	TERMINATED	Coronary Artery Stenosis; Coronary Artery Disease	Ottawa Heart Institute Research Corporation	2007-08	PHASE3
NCT01343745	COMPLETED	Mild Persistent Asthma	Chiesi Farmaceutici S.p.A.	2008-02	PHASE2
NCT00531193	COMPLETED	Healthy	Biogen	2007-09	PHASE1
NCT00349921	COMPLETED	Pain	Wake Forest University Health Sciences	2004-08	PHASE2
NCT02318043	COMPLETED	Asthma	Guangzhou Institute of Respiratory Disease	2007-01
NCT00133042	COMPLETED	Asthma	University of Florida	2004-12	PHASE4
NCT00380198	TERMINATED	Coronary Artery Disease	Forest Laboratories	2006-07	PHASE3
NCT00944294	COMPLETED	Coronary Artery Disease	Pfizer	2004-02	PHASE3
NCT00483067	COMPLETED	Leukemia	M.D. Anderson Cancer Center	1998-03	PHASE2
NCT00053027	COMPLETED	Lymphoma	Alliance for Clinical Trials in Oncology	2003-02	PHASE2
NCT00003746	COMPLETED	Leukemia	Swiss Cancer Institute	1998-09	PHASE3
NCT00400855	COMPLETED	Asthma	GlaxoSmithKline	2005-01	PHASE2
NCT00208312	COMPLETED	Coronary Artery Disease	Gilead Sciences	2004-04	PHASE3
NCT00712764	COMPLETED	Ocular Physiology; Microcirculation	Medical University of Vienna	2005-01
NCT00159315	COMPLETED	Asthma; COPD; Smoking	Imperial College London	2002-10
NCT00014248	COMPLETED	Cachexia; Unspecified Adult Solid Tumor, Protocol Specific	Dartmouth-Hitchcock Medical Center	2000-10	PHASE1
NCT00006337	COMPLETED	Parkinson's Disease	National Institute of Neurological Disorders and Stroke (NINDS)	2000-10	PHASE2
NCT00253929	COMPLETED	Blood Flow in Healthy Volunteers	Radboud University Medical Center	2005-11
NCT00845689	UNKNOWN	Liver Tumors	Ludwig-Maximilians - University of Munich		PHASE1; PHASE2
NCT00004762	COMPLETED	Cholangitis, Sclerosing	National Center for Research Resources (NCRR)	1994-12	PHASE2
NCT00200629	TERMINATED	Coronary Artery Disease	Midwest Heart Foundation	2005-06	PHASE4
NCT01280071	UNKNOWN	Venoarteriolar Reflex	Tel-Aviv Sourasky Medical Center
NCT00960817	UNKNOWN	Coronary Angiography	Hillel Yaffe Medical Center		EARLY_PHASE1
NCT00298636	COMPLETED	Perioperative Pain	Xsira Pharmaceuticals	2005-10	PHASE2
NCT00184886	COMPLETED	Methotrexate; Vasodilation	Radboud University Medical Center	2003-11
NCT00184847	SUSPENDED	Ischemia-Reperfusion Injury	Radboud University Medical Center	2005-03
NCT00565188	COMPLETED	Cancer; Palliative Care; Survival; Quality of Life	Maastricht University Medical Center	2002-03	PHASE3

(data from https://clinicaltrials.gov, updated on 2024-12-02)

Check the Adenosine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Adenosine binds to cell-surface purinergic adenosine receptors, suppressing adenylyl cyclase-mediated cyclic AMP production and altering downstream second messenger signaling to diminish cellular metabolic stress and modulate vascular tone. This targeted receptor activation induces cytoprotective, anti-inflammatory, and dromotropic effects, mitigating tissue damage in ischemia-reperfusion injury and slowing conduction through the atrioventricular node in supraventricular tachycardia.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).