Adavosertib (AZD1775, MK-1775): Selectivity & Specificity
Adavosertib (AZD1775, MK-1775) is a potent inhibitor of Wee1 kinase (5.2 nmol/L), CYP3A (14 μM), and pCDK1 (240 nmol/L). Adavosertib (AZD1775, MK-1775) exhibits the greatest inhibitory potency toward Wee1 kinase (IC50 = 5.2 nM).