CAS No. 955365-80-7
Batch:
Purity:99.99
Chemical Structure
Check the
Adavosertib (AZD1775, MK-1775)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one | |
|---|---|---|
| CAS Number | 955365-80-7 | |
| Molecular Formula |
C27H32N8O2 |
|
| Molecular Weight (MW) | 500.6 | |
| SMILES | CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O | |
| InChIKey | BKWJAKQVGHWELA-UHFFFAOYSA-N |
Adavosertib (AZD1775, MK-1775) is a potent and selective Wee1 kinase inhibitor with an IC50 of 5.2 nM. It inhibits Wee1-mediated phosphorylation of CDK1 at Tyr15, thereby abrogating the G2 DNA damage checkpoint and promoting cell cycle progression into premature mitosis. Consequently, adavosertib induces apoptosis and sensitizes p53-deficient tumor cells to DNA-damaging agents.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Adavosertib (AZD1775, MK-1775) Mechanism of Action: WEE1 Inhibition in Ovarian Cancer Cell Research
- Adavosertib (AZD1775, MK-1775) Clinical Trials
- Adavosertib (AZD1775, MK-1775): Selectivity & Specificity
- Adavosertib (AZD1775, MK-1775) Working Concentration | Cell Culture | Treatment
- Adavosertib (AZD1775, MK-1775) Solubility in DMSO
- Adavosertib (AZD1775, MK-1775) Stock Solution
- Adavosertib (AZD1775, MK-1775) Storage
- Adavosertib (AZD1775, MK-1775) Stability
- Adavosertib (AZD1775, MK-1775) Combination Database
- Adavosertib (AZD1775, MK-1775) Molecular Weight
- Adavosertib (AZD1775, MK-1775) SMILES
- Adavosertib (AZD1775, MK-1775) Chemical Structure (2D and 3D)
- Adavosertib (AZD1775, MK-1775) IC50 for Cell-based and Cell-free Assays
- Adavosertib (AZD1775, MK-1775) Sigma (BL3H1F1C7CA8)? Try a better option.
- Adavosertib (AZD1775, MK-1775) MedChemExpress (HY-10993)? Try a better option.
- Adavosertib (AZD1775, MK-1775) Tocris (7589)? Try a better option.
- Adavosertib (AZD1775, MK-1775) CST (69589)? Try a better option.
- Adavosertib (AZD1775, MK-1775) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.