CAS No. 320345-99-1

Batch: Purity:99.56
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Aclidinium Bromide Chemical Structure
Chemical Structure
Check the Aclidinium Bromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 320345-99-1
Molecular Formula

C26H30NO4S2.Br
Molecular Weight (MW) 564.55
SMILES C1C[N+]2(CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5.[Br-]

Ordering Information

Biological Activity

Aclidinium bromide is a long-acting muscarinic acetylcholine receptor antagonist that inhibits human M1 (Ki 0.1 nM), M2 (Ki 0.14 nM), M3 (Ki 0.14 nM), M4 (Ki 0.21 nM), and M5 (Ki 0.16 nM). By blocking muscarinic receptors, particularly M3 in airway smooth muscle, it inhibits acetylcholine-mediated signaling to prevent bronchoconstriction and promote sustained bronchodilation.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (125.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.