Clinical Trials

Tenofovir is evaluated across multiple clinical trials ranging from early to late phases, focusing on human immunodeficiency virus (HIV) infection, HIV prevention, chronic hepatitis B, SARS-CoV-2, and HIV-tuberculosis co-infections. Sponsored by diverse governmental, academic, and pharmaceutical organizations—including the National Institute of Allergy and Infectious Diseases, Johns Hopkins University, and Merck Sharp & Dohme—these studies encompass completed, active, and non-recruiting protocols. Through several clinical trials, such as the PROMISE maternal-infant study, researchers continue to evaluate combination therapies and long-term safety profiles.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07708727 RECRUITING
HIV-1-infection
Gilead Sciences
 2026-07-29 PHASE2; PHASE3
NCT03304717 WITHDRAWN
Aicardi Goutières Syndrome
Children's Hospital of Philadelphia
 2025-12 PHASE1; PHASE2
NCT07792096 NOT_YET_RECRUITING
HIV Infection
University College, London
 2026-11 PHASE3
NCT06707922 ENROLLING_BY_INVITATION
Chronic Hepatitis B
Xiamen Amoytop Biotech Co., Ltd.
 2022-03-18
NCT04375800 RECRUITING
Human Immunodeficiency Virus (HIV) Infection
Merck Sharp & Dohme LLC
 2021-02-03 PHASE2
NCT07797231 NOT_YET_RECRUITING
Chronic Hepatitis B
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2026-09 PHASE3
NCT07631897 NOT_YET_RECRUITING
HIV; Art Therapy; TB - Tuberculosis
Shanghai Public Health Clinical Center
 2026-06 PHASE4
NCT07055451 ACTIVE_NOT_RECRUITING
HIV-1-infection
Gilead Sciences
 2025-08-12 PHASE1
NCT06497465 RECRUITING
Tuberculosis; HIV
Johns Hopkins University
 2025-09-18 PHASE3
NCT06203132 RECRUITING
HIV-1-infection
ANRS, Emerging Infectious Diseases
 2025-01-27 PHASE3
NCT05195450 RECRUITING
Non-cirrhotic, Chronic Hepatitis B
Institute of Liver and Biliary Sciences, India
 2022-02-23
NCT03933384 RECRUITING
Hepatitis B; Viral Hepatitis
Taichung Veterans General Hospital
 2019-08-19 PHASE4
NCT07133776 NOT_YET_RECRUITING
Epstein-Barr Virus (EBV) Infection; PD-1 Inhibitor; Tenofovir; Chidamide; Lenalidomide
The Affiliated Hospital of Xuzhou Medical University
 2025-09-01 PHASE1; PHASE2
NCT06891066 ACTIVE_NOT_RECRUITING
Human Immunodeficiency Virus Type 1 (HIV-1) Infection
Merck Sharp & Dohme LLC
 2025-04-14 PHASE2
NCT07645287 RECRUITING
HIV-1-infection
Gilead Sciences
 2026-06-15 PHASE2
NCT07476339 RECRUITING
HIV -1 Infection; HIV (Human Immunodeficiency Virus); HIV; HIV 1 Infection
CAN Community Health
 2026-06-17 PHASE4
NCT07202546 RECRUITING
HIV Infections
ViiV Healthcare
 2026-02-11 PHASE2
NCT05957913 ENROLLING_BY_INVITATION
Multiple Sclerosis
Massachusetts General Hospital
 2023-06-05 PHASE2
NCT02656511 ACTIVE_NOT_RECRUITING
HIV
University of California, San Francisco
 2015-12 PHASE4
NCT06963710 ACTIVE_NOT_RECRUITING
Chronic Hepatitis B Infection
Aligos Therapeutics
 2025-07-15 PHASE2
NCT07349758 RECRUITING
Healthy Volunteer; HIV Prevention
Johns Hopkins University
 2026-01-06 PHASE1
NCT06221657 NOT_YET_RECRUITING
Patients With Malignant Blood Disease Requiring Hepatitis B Antiviral Medication
Yonsei University
 2024-02-01 PHASE4
NCT07584122 RECRUITING
HIV Infections
Oswaldo Cruz Foundation
 2025-09-01
NCT02932150 ACTIVE_NOT_RECRUITING
Chronic Hepatitis B
Gilead Sciences
 2016-11 PHASE2
NCT06101329 ACTIVE_NOT_RECRUITING
Pre-Exposure Prophylaxis of HIV Infection
Gilead Sciences
 2023-11-17 PHASE2
NCT07678268 RECRUITING
HIV Infection; Antiretroviral Therapy; Lentivirus Infections
Instituto Mexicano del Seguro Social
 2025-07-10 PHASE4
NCT06485154 RECRUITING
HIV Prevention
University of Witwatersrand, South Africa
 2024-06-01 PHASE4
NCT06560684 COMPLETED
Tenofovir
National Institute of Allergy and Infectious Diseases (NIAID)
 2024-10-29 PHASE2
NCT06513312 ACTIVE_NOT_RECRUITING
Pre-Exposure Prophylaxis of HIV Infection
Gilead Sciences
 2024-10-07 PHASE2
NCT06250504 RECRUITING
HIV Infections
Africa Health Research Institute
 2024-02-27 PHASE3
NCT06630286 ACTIVE_NOT_RECRUITING
HIV-1-infection
Gilead Sciences
 2024-10-09 PHASE3
NCT05979311 ACTIVE_NOT_RECRUITING
HIV; HIV Infections
ViiV Healthcare
 2024-02-21 PHASE3
NCT06613685 TERMINATED
HIV-1-infection
Gilead Sciences
 2024-10-21 PHASE2; PHASE3
NCT06907056 RECRUITING
HIV Infection
José Antonio Mata Marín
 2023-11-09 PHASE4
NCT06356662 RECRUITING
Parkinson Disease
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
 2024-01-23 PHASE1
NCT06133686 NOT_YET_RECRUITING
HIV
MRC/UVRI and LSHTM Uganda Research Unit
 2024-04-01 PHASE3
NCT05793268 ACTIVE_NOT_RECRUITING
Chronic Hepatitis b
E-DA Hospital
 2022-12-20
NCT07006246 ACTIVE_NOT_RECRUITING
HIV Infection
Professor Francois Venter
 2023-05-19 PHASE4
NCT06602622 RECRUITING
HIV; HIV Associate Weight Loss; HIV-1 Infection; Integrase Inhibitors, HIV; HIV PROTEASE INHIB; Weight Change; Weight Loss
Instituto Mexicano del Seguro Social
 2024-08-14 PHASE4
NCT04640129 UNKNOWN
Liver Fibrosis
Third Affiliated Hospital, Sun Yat-Sen University
 2021-01-01 PHASE4
NCT06273943 NOT_YET_RECRUITING
Prevention
ANRS, Emerging Infectious Diseases
 2024-04-01 PHASE3
NCT05898841 COMPLETED
HIV Infections; Fatty Liver Disease
Fundacion SEIMC-GESIDA
 2023-05-26 PHASE4
NCT05333679 COMPLETED
Risk Reduction
University of California, San Francisco
 2022-03-02
NCT06816043 COMPLETED
Healthy
Merck Sharp & Dohme LLC
 2025-02-21 PHASE1
NCT05326971 UNKNOWN
HIV Infections; Weight Gain
Jussi Sutinen
 2023-01-19 PHASE4
NCT06295328 RECRUITING
Chronic Hepatitis b
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2022-04-13 PHASE1; PHASE2
NCT06274398 COMPLETED
Safety Issues
Eastern Virginia Medical School
 2024-01-16 PHASE1
NCT06221605 COMPLETED
Chronic Hepatitis B
Wecare Probiotics Co., Ltd.
 2024-03-30
NCT05463783 UNKNOWN
HIV Infections; Obesity
East Carolina University
 2023-03-14 PHASE4
NCT05467553 UNKNOWN
Hepatitis D
National Taiwan University Hospital
 2023-02-24 PHASE2
NCT04022967 UNKNOWN
HIV-1-infection
ANRS, Emerging Infectious Diseases
 2020-09-21 PHASE3
NCT04496882 ACTIVE_NOT_RECRUITING
Chronic Hepatitis b; Hepatitis B Reactivation
National Taiwan University Hospital
 2020-09-09 PHASE4
NCT05721300 UNKNOWN
Hepatocellular Carcinoma; Chronic Hepatitis B
Zhongshan Hospital (Xiamen), Fudan University
 2023-02-10
NCT04619082 ACTIVE_NOT_RECRUITING
Hepatitis B Reactivation
Chiayi Christian Hospital
 2021-07-01 PHASE4
NCT06087913 COMPLETED
Safety Issues
Eastern Virginia Medical School
 2023-11-08 PHASE1
NCT05663892 ACTIVE_NOT_RECRUITING
Hiv; Transgenderism
Maple Leaf Research
 2022-11-23 PHASE4
NCT03356834 COMPLETED
Chronic Hepatitis B
Humanity and Health Research Centre
 2017-12-01 PHASE4
NCT05630755 ACTIVE_NOT_RECRUITING
HIV-1 Infection
Merck Sharp & Dohme LLC
 2023-02-17 PHASE3
NCT03058835 COMPLETED
PrEP Adherence Monitoring
Rutgers, The State University of New Jersey
 2016-09 PHASE4
NCT06592300 COMPLETED
Chronic Hepatitis B in Adults and Paediatric Patients
Humanis Saglık Anonim Sirketi
 2024-07-06 PHASE1
NCT06743438 ACTIVE_NOT_RECRUITING
Hepatitis B, Chronic
Jiangsu Hansoh Pharmaceutical Co., Ltd.
 2022-03-10 PHASE4
NCT05244057 COMPLETED
Chronic Hepatitis B
Shanghai HEP Pharmaceutical Co., Ltd.
 2022-08-23 PHASE2
NCT05410496 ACTIVE_NOT_RECRUITING
Safety Issues; Chronic Hepatitis B; Transplant Recipient
Taichung Veterans General Hospital
 2021-06-22 PHASE4
NCT06356194 COMPLETED
Healthy Volunteer Study
Atea Pharmaceuticals, Inc.
 2024-04-15 PHASE1
NCT04994509 ACTIVE_NOT_RECRUITING
Pre-Exposure Prophylaxis of HIV Infection
Gilead Sciences
 2021-08-30 PHASE3
NCT06278389 COMPLETED
Healthy Adult Participants
Jiangsu Aidea Pharmaceutical Group Co., Ltd.
 2024-01-24 PHASE1
NCT05797714 ACTIVE_NOT_RECRUITING
HBV Infection; Chronic Hepatitis b
Ruijin Hospital
 2022-06-08
NCT05602506 COMPLETED
HIV Infections
Fundacion Clinic per a la Recerca Biomédica
 2022-11-15 PHASE4
NCT05122754 UNKNOWN
HIV-1-infection
Shanghai Public Health Clinical Center
 2021-12-08 PHASE4
NCT04891770 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2021-08-14 PHASE2
NCT05177926 UNKNOWN
Hepatitis B, Chronic; Mother to Child Transmission
Nanfang Hospital, Southern Medical University
 2021-04-04 PHASE4
NCT05405751 COMPLETED
HIV Infections
Fundacion SEIMC-GESIDA
 2022-07-04 PHASE4
NCT02650271 COMPLETED
Hepatocellular Carcinoma
Guangxi Medical University
 2021-02-02 PHASE3
NCT03464266 COMPLETED
Bone Demineralization; Hypoestrogenism; Subclinical Kidney Injury; Bone Microarchitecture
University of Washington
 2018-05-15 PHASE4
NCT05458765 COMPLETED
Acceptability of Health Care; Adherence, Medication
Eastern Virginia Medical School
 2022-06-21 PHASE2
NCT05275023 COMPLETED
Hepatitis B, Chronic
Janssen Research & Development, LLC
 2022-06-30 PHASE2
NCT04997564 UNKNOWN
Chronic Hepatitis C; Chronic Hepatitis B
Peking University First Hospital
 2021-08 PHASE4
NCT06177574 COMPLETED
HIV Infections
Carmen Hidalgo Tenorio
 2020-10-27 PHASE4
NCT04535544 COMPLETED
Hepatitis D, Chronic
Janssen Research & Development, LLC
 2020-09-17 PHASE2
NCT04593680 ACTIVE_NOT_RECRUITING
Drug Interaction
Thai Red Cross AIDS Research Centre
 2022-01-24
NCT04201808 UNKNOWN
Hepatitis B, Chronic
New Discovery LLC
 2021-05-01 PHASE4
NCT04114890 COMPLETED
Hepatitis B; Tenofovir; Pregnancy
University of Oxford
 2021-01-08 PHASE2
NCT06773754 ACTIVE_NOT_RECRUITING
Virally Suppressed People With HIV
National Taiwan University Hospital
 2022-06-14
NCT04429152 UNKNOWN
HIV-1-infection
Professor Francois Venter
 2021-02-09 PHASE3
NCT05313477 COMPLETED
Parathyroid Hormone; Tenofovir Disoproxil Fumarate; Chronic Hepatitis B Virus; Vitamin D
Mahidol University
 2022-05-01 PHASE4
NCT04442737 COMPLETED
HIV-1
Janssen Scientific Affairs, LLC
 2020-07-01 PHASE4
NCT05123599 COMPLETED
Hepatitis B, Chronic
Janssen Research & Development, LLC
 2021-12-06 PHASE1
NCT04890626 COMPLETED
SARS-CoV-2 Infection
Instituto de Investigación Hospital Universitario La Paz
 2020-04-04 PHASE3
NCT04249037 TERMINATED
HIV/AIDS
University of Colorado, Denver
 2020-12-15 PHASE4
NCT03711253 UNKNOWN
Acute HIV Infection
University of Southern California
 2019-10-14 PHASE4
NCT05243602 COMPLETED
HIV-1-infection
University of Nairobi
 2022-02-01 PHASE4
NCT03084250 UNKNOWN
Hepatitis B
Shanghai Nanhui Nanhua Hospital
 2017-03-10 PHASE4
NCT05423106 TERMINATED
Healthy; Hepatitis B, Chronic
Janssen Research & Development, LLC
 2022-07-04 PHASE1
NCT04597424 COMPLETED
Unsafe Sex; Risk-Taking
ANRS, Emerging Infectious Diseases
 2021-01-19 PHASE3
NCT04903847 UNKNOWN
Hiv; HIV Infections; HIV Lipodystrophy; Osteoporosis; Renal Insufficiency; Weight Gain; Obesity
Thomas Benfield
 2021-02-02 PHASE4
NCT04870671 COMPLETED
HIV/AIDS; Adherence, Medication; Drug Use
Eastern Virginia Medical School
 2021-03-25 EARLY_PHASE1
NCT04824131 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2020-11-04 PHASE2
NCT04850950 UNKNOWN
Chronic Hepatitis B; Mother-to-Child Transmission; Safety; Efficacy; Hepatitis B Virus; Tenofovir Alafenamide Fumarate
The First Affiliated Hospital of Zhengzhou University
 2021-04-26 PHASE4
NCT04583267 UNKNOWN
HIV Infections
Yonsei University
 2018-08-28
NCT03797014 COMPLETED
HIV-1-infection; Hepatitis B
University of Maryland, Baltimore
 2019-04-30 PHASE4
NCT02437110 COMPLETED
Amyotrophic Lateral Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS)
 2019-04-01 PHASE1
NCT03510468 COMPLETED
Healthy Volunteers
National Institutes of Health Clinical Center (CC)
 2018-06-12 PHASE1
NCT04543565 UNKNOWN
Chronic Hepatitis b
Xi'an Xintong Pharmaceutical Research Co.,Ltd.
 2020-09 PHASE3
NCT04847440 TERMINATED
Hepatitis B, Chronic; Hepatitis D
Antios Therapeutics, Inc
 2021-03-30 PHASE2
NCT04539119 UNKNOWN
B-cell Lymphoma; HBV
Ruijin Hospital
 2020-07-03 PHASE3
NCT04298697 COMPLETED
Human Immunodeficiency Virus
Emory University
 2020-02-28 PHASE4
NCT04391608 UNKNOWN
Renal Insufficiency; Tenofovir
Mahidol University
 2019-11-09 PHASE4
NCT04898699 COMPLETED
HIV
Columbia University
 2021-11-24 EARLY_PHASE1
NCT04542070 COMPLETED
HIV Infections
ViiV Healthcare
 2020-11-09 PHASE3
NCT04032860 UNKNOWN
HCC; HBV Coinfection
West China Hospital
 2017-07-01 PHASE4
NCT04040075 TERMINATED
HIV-1-infection
Southampton Healthcare, Inc.
 2019-07-01 PHASE4
NCT05453448 COMPLETED
Antiviral Drugs
Xiangya Hospital of Central South University
 2022-05-01
NCT05238844 TERMINATED
Chronic Hepatitis b
Antios Therapeutics, Inc
 2022-04-11 PHASE2
NCT07002268 COMPLETED
Healthy
Henan Genuine Biotech Co., Ltd.
 2022-03-14 PHASE1
NCT04303598 UNKNOWN
HIV-infection/Aids
Henan Genuine Biotech Co., Ltd.
 2020-04-01 PHASE3
NCT03988387 COMPLETED
HIV
Columbia University
 2019-10-31
NCT04311944 UNKNOWN
HIV-1-infection
Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic
 2020-09-01
NCT03547908 COMPLETED
HIV-1/HBV Co-Infection
Gilead Sciences
 2018-05-30 PHASE3
NCT03357822 UNKNOWN
Chronic Hepatitis B
Tongji Hospital
 2018-01-25 PHASE4
NCT04998838 UNKNOWN
Hepatitis B
Myanmar Liver Foundation
 2018-07-01
NCT05137548 COMPLETED
Drug Interaction
Antios Therapeutics, Inc
 2021-10-27 PHASE1
NCT03717129 COMPLETED
Healthy Volunteers
Johns Hopkins University
 2019-04-15 PHASE4
NCT04501224 UNKNOWN
Chronic Hepatitis b; Cirrhosis Due to Hepatitis B
Third Affiliated Hospital, Sun Yat-Sen University
 2020-08-03
NCT03919565 UNKNOWN
Hepatitis B; Liver Fibrosis
Third Affiliated Hospital, Sun Yat-Sen University
 2019-02-01
NCT03920605 UNKNOWN
Hepatitis B; Liver Fibrosis
Third Affiliated Hospital, Sun Yat-Sen University
 2019-02-01
NCT04329442 WITHDRAWN
HIV/AIDS
University of Chicago
 2020-04-01
NCT04392700 UNKNOWN
Hepatocellular Carcinoma Recurrent
Sun Yat-sen University
 2019-07-25 PHASE3
NCT05355467 COMPLETED
Chronic Hepatitis B Infection
Mylan (Taiwan) Ltd
 2019-08-21 PHASE4
NCT04129554 COMPLETED
Hepatitis B, Chronic
Janssen Sciences Ireland UC
 2019-11-06 PHASE2
NCT04661397 COMPLETED
Healthy
Janssen Research & Development, LLC
 2021-01-05 PHASE1
NCT04385719 COMPLETED
Ebola; HIV/AIDS
Makerere University
 2021-05-05 PHASE2
NCT03251144 COMPLETED
HIV/AIDS; Antiviral Toxicity; Antiviral Drug Adverse Reaction; Mitochondrial Alteration
University of California, Los Angeles
 2019-04-01 PHASE1; PHASE2
NCT03563742 TERMINATED
Human Immunodeficiency Virus Infections
Janssen Research & Development, LLC
 2018-09-24 PHASE3
NCT04202536 UNKNOWN
Hepatitis B; Besifovir Dipivoxil Maleate; Tenofovir Disoproxil Fumarate
IlDong Pharmaceutical Co Ltd
 2019-05-29 PHASE4
NCT02555943 COMPLETED
Chronic Hepatitis C Infection; HBV Coinfection; Hepatitis B Reactivation
Humanity and Health Research Centre
 2015-02 PHASE2; PHASE3
NCT04016233 COMPLETED
HIV/AIDS; HIV Prevention
Johns Hopkins University
 2020-01-10 PHASE1
NCT04685512 COMPLETED
Covid19
University Hospital, Caen
 2020-11-18 PHASE2; PHASE3
NCT03986697 WITHDRAWN
Coronary Artery Disease; Hiv
University of Liverpool
 2020-02-04 PHASE4
NCT03241641 COMPLETED
Chronic Hepatitis b
Young-Suk Lim
 2017-10-26 PHASE4
NCT01369212 COMPLETED
Hepatitis B
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2012-11 PHASE3
NCT04047420 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2019-12-11 PHASE1
NCT02815566 COMPLETED
Osteoporosis; HIV; Menopause
University Health Network, Toronto
 2017-09-12 PHASE4
NCT04334928 COMPLETED
Coronavirus Infection
Plan Nacional sobre el Sida (PNS)
 2020-04-15 PHASE3
NCT04507607 UNKNOWN
Chronic Hepatitis B; Mother-to-child Block; Antiviral Treatment
Third Affiliated Hospital, Sun Yat-Sen University
 2020-08-01 EARLY_PHASE1
NCT02859558 COMPLETED
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2017-01-24 PHASE2
NCT04157699 UNKNOWN
Chronic Hepatitis b
Qilu Pharmaceutical Co., Ltd.
 2019-07-26 PHASE2
NCT04157257 UNKNOWN
Chronic Hepatitis b
Qilu Pharmaceutical Co., Ltd.
 2019-07-26 PHASE2
NCT04405271 TERMINATED
Healthcare Workers; COVID-19; SARS-CoV 2
Hospital Italiano de Buenos Aires
 2020-07-31 PHASE3
NCT04424264 COMPLETED
HIV-1-infection; Tuberculosis
Professor Francois Venter
 2019-12-05 PHASE1
NCT03048422 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2018-01-19 PHASE3
NCT03988452 UNKNOWN
Human Immunodeficiency Virus
Makerere University
 2019-07-30 PHASE3
NCT03596697 COMPLETED
Hepatitis B; Infectious Disease; Liver Diseases
Hepion Pharmaceuticals, Inc.
 2019-07-09 PHASE1
NCT03512964 COMPLETED
Human Immunodeficiency Virus
Johns Hopkins University
 2016-11-29
NCT03798119 UNKNOWN
Hepatitis B; Fibrosis and Cirrhosis of Liver
Kaohsiung Medical University Chung-Ho Memorial Hospital
 2019-02-25 PHASE4
NCT03120936 COMPLETED
Transgender Persons; Pre-Exposure Prophylaxis
Public Health Foundation Enterprises, Inc.
 2017-08-08 PHASE4
NCT03332095 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2018-07-02 PHASE1; PHASE2
NCT05286346 COMPLETED
Chronic Hepatitis b
Samjin Pharmaceutical Co., Ltd.
 2018-10-12 PHASE4
NCT03532425 TERMINATED
HIV-1-infection
University of Alberta
 2018-10-29 PHASE4
NCT03549312 UNKNOWN
HIV-1-infection; Hepatitis C, Chronic; Methadone Dependence; Opioid Dependence; Bone Diseases, Metabolic; HIV/AIDS; Co-infection; Buprenorphine Dependence; HCV Coinfection
Saskatchewan Health Authority - Regina Area
 2018-02-01 PHASE4
NCT02774837 UNKNOWN
Chronic Hepatitis B
Seng Gee Lim
 2016-04 PHASE4
NCT03719053 COMPLETED
Medication Adherence; HIV Prevention
Johns Hopkins University
 2018-10-25 PHASE1
NCT04132674 UNKNOWN
Human Immunodeficiency Virus I Infection; Drug Use
Vancouver Infectious Diseases Centre
 2018-11-26 PHASE4
NCT02957864 UNKNOWN
Renal Insufficiency,Chronic; Hiv; Therapeutic Agent Toxicity
Erasmus Medical Center
 2016-10 PHASE4
NCT03693508 COMPLETED
HIV Infections; Severe Immunosuppression
Fundacion SEIMC-GESIDA
 2018-04-13 PHASE4
NCT03360682 COMPLETED
HIV-1-infection; Solid Organ Transplant
Fundacion Clinic per a la Recerca Biomédica
 2018-04-13 PHASE4
NCT02720094 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2016-12-19 PHASE2; PHASE3
NCT03405194 WITHDRAWN
HIV/AIDS
Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic
 2018-05-01
NCT03771638 COMPLETED
Adherence, Medication; Risk Behavior; Pre-Exposure Prophylaxis; HIV Prevention
Public Health Foundation Enterprises, Inc.
 2019-02-01 PHASE4
NCT04059198 TERMINATED
Hepatitis B; HBV; Hepatitis B, Chronic
F-star Therapeutics, Inc.
 2019-10-10 PHASE2
NCT02937779 UNKNOWN
Hepatitis B Chronic Infection; Pregnancy
ANRS, Emerging Infectious Diseases
 2017-10-04 PHASE4
NCT02751996 COMPLETED
Hepatitis B; Hepatitis, Viral
F-star Therapeutics, Inc.
 2016-05 PHASE2
NCT02792088 COMPLETED
Chronic Hepatitis B
IlDong Pharmaceutical Co Ltd
 2015-07 PHASE3
NCT03214302 UNKNOWN
Chronic Hepatitis B
Beijing Ditan Hospital
 2017-01-01
NCT01491295 UNKNOWN
Chronic Hepatitis B
Taipei Veterans General Hospital, Taiwan
 2012-09 PHASE4
NCT02285114 COMPLETED
HIV-1
Gilead Sciences
 2015-01-20 PHASE2; PHASE3
NCT00973219 COMPLETED
Chronic Hepatitis B
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2009-09
NCT02287857 UNKNOWN
Chronic Hepatitis B
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
 2014-09
NCT03670355 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2019-01-02 PHASE1
NCT03917420 COMPLETED
HIV/AIDS
University of North Carolina, Chapel Hill
 2019-03-26 PHASE1
NCT02322099 TERMINATED
Bone Demineralization
University College Dublin
 2016-05 PHASE4
NCT02081469 COMPLETED
Hepatitis B, Chronic; Tumor
Chang Gung Memorial Hospital
 2014-03-17 PHASE4
NCT02987530 COMPLETED
HIV-1 Infection
ANRS, Emerging Infectious Diseases
 2017-04-11 PHASE3
NCT03126370 COMPLETED
Hepatitis C; HIV Coinfection
University of Colorado, Denver
 2018-01-08 PHASE4
NCT03220152 UNKNOWN
HIV, Prevention
Oswaldo Cruz Foundation
 2017-07-10 PHASE4
NCT02584140 COMPLETED
HIV Prevention
University of California, Los Angeles
 2016-05 PHASE4
NCT02150993 COMPLETED
HIV-2 Infection
ANRS, Emerging Infectious Diseases
 2016-01-26 PHASE2; PHASE3
NCT02750540 COMPLETED
HIV Prevention
Johns Hopkins University
 2016-10 PHASE1
NCT03327155 COMPLETED
HIV Prevention
Kirby Institute
 2017-11-16 PHASE3
NCT03067285 COMPLETED
HIV Infections
Fundacion SEIMC-GESIDA
 2017-09-08 PHASE4
NCT03836729 COMPLETED
HIV Infections
ViiV Healthcare
 2019-02-11 PHASE1
NCT03180619 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2017-06-29 PHASE2
NCT03595709 COMPLETED
HIV Infections
Yu-Jay Corp.
 2018-12-06 PHASE3
NCT02967939 COMPLETED
Hepatitis B， Chronic
Dong-A ST Co., Ltd.
 2017-03-28 PHASE3
NCT03227861 COMPLETED
HIV-1
Janssen Scientific Affairs, LLC
 2017-07-31 PHASE3
NCT02463019 UNKNOWN
Chronic Hepatitis B; Antiviral Treatment
E-DA Hospital
 2015-01 PHASE4
NCT03258710 COMPLETED
Hepatitis B, Chronic
GlaxoSmithKline
 2017-10-02 PHASE4
NCT03110380 COMPLETED
HIV-1-infection
Gilead Sciences
 2017-06-12 PHASE3
NCT02308319 UNKNOWN
Carcinoma, Hepatocellular
Samsung Medical Center
 2015-01 PHASE4
NCT02973646 UNKNOWN
Chronic Hepatitis b
Third Affiliated Hospital, Sun Yat-Sen University
 2016-01 PHASE4
NCT02273765 COMPLETED
HIV-1 Infection; Tuberculosis
ANRS, Emerging Infectious Diseases
 2015-09-11 PHASE3
NCT03405935 COMPLETED
HIV-1 Infection
Gilead Sciences
 2018-03-01 PHASE3
NCT02652793 COMPLETED
Human Immunodeficiency Virus
Judit Pich
 2015-11
NCT02966964 UNKNOWN
Hepatitis; Virus, Chronic, Type B
Uijeongbu St. Mary Hospital
 2015-04 PHASE2
NCT01522625 COMPLETED
Chronic Hepatitis B
E-DA Hospital
 2012-01 PHASE4
NCT02616029 COMPLETED
HIV-1 Infection
Gilead Sciences
 2015-12-17 PHASE3
NCT02979613 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2016-12-29 PHASE3
NCT03270969 COMPLETED
HIV Prevention
University of Nebraska
 2018-01-05 PHASE1
NCT03387462 COMPLETED
Adherence, Medication; Risk Behavior; Pre-Exposure Prophylaxis; HIV Prevention
Public Health Foundation Enterprises, Inc.
 2018-02-28 PHASE4
NCT02652260 COMPLETED
HIV-1; Central Nervous System
Merck Sharp & Dohme LLC
 2016-03-04 PHASE2
NCT02195518 COMPLETED
Hepatitis B, Chronic
GlaxoSmithKline
 2015-03-18 PHASE4
NCT03662568 COMPLETED
Chronic Hepatitis B
Sunshine Lake Pharma Co., Ltd.
 2018-06-26 PHASE1
NCT02998320 COMPLETED
HIV Risk
Groupe d'Etude sur le Risque d'Exposition des Soignants aux Agents Infectieux
 2017-03-10 PHASE3
NCT03060785 COMPLETED
HIV Prevention
Johns Hopkins University
 2016-03-08 PHASE1
NCT04050371 COMPLETED
HIV Prevention; Transgender Health
University of California, San Francisco
 2017-08-03 PHASE4
NCT01125696 COMPLETED
HIV; Hepatitis B
Centers for Disease Control and Prevention
 2012-05 PHASE2
NCT02831764 COMPLETED
Infection, Human Immunodeficiency Virus; HIV Infections
ViiV Healthcare
 2016-07-18 PHASE3
NCT02369965 COMPLETED
HIV Infections; AIDS
Frontier Biotechnologies Inc.
 2014-02-19 PHASE3
NCT03109730 COMPLETED
Chronic Hepatitis B
Assembly Biosciences
 2017-06-15 PHASE1; PHASE2
NCT01639092 COMPLETED
Chronic Viral Hepatitis B Without Delta-agent
Asan Medical Center
 2012-09-28 PHASE4
NCT03493568 TERMINATED
HIV-1-infection
IRCCS San Raffaele
 2017-02-06 PHASE3
NCT01435018 COMPLETED
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2013-10-01 PHASE3
NCT02862548 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2016-09-16 PHASE2
NCT03284164 COMPLETED
Renal Impairment
ContraVir Pharmaceuticals, Inc.
 2017-09-28 PHASE1
NCT03186482 COMPLETED
HIV
St. Stephens Clinical Research
 2017-06-01 PHASE1
NCT01088659 COMPLETED
Hepatitis D, Chronic
Hoffmann-La Roche
 2010-02-16 PHASE3
NCT02652624 COMPLETED
HIV-1 Infection
Gilead Sciences
 2016-02-19 PHASE3
NCT02499874 COMPLETED
HIV
St Stephens Aids Trust
 2015-08 PHASE1
NCT01639066 COMPLETED
Chronic Viral Hepatitis B Without Delta-agent
Asan Medical Center
 2012-09-25 PHASE4
NCT02707601 COMPLETED
HIV-1 Infection; HCV Infection
Gilead Sciences
 2016-04-01 PHASE3
NCT07558967 COMPLETED
Healthy
Haisco Pharmaceutical Group Co., Ltd.
 2017-06-20 PHASE1
NCT01528865 WITHDRAWN
Lymphoma
University of Michigan Rogel Cancer Center
 2015-12 PHASE1; PHASE2
NCT00932971 COMPLETED
Hepatitis D
HepNet Study House, German Liverfoundation
 2009-06 PHASE2
NCT01727271 WITHDRAWN
Hepatitis B
Merck Sharp & Dohme LLC
 2013-08 PHASE4
NCT02470650 WITHDRAWN
Patient Compliance; Antiretroviral Therapy Intolerance
Juan A. Arnaiz
 2015-06 PHASE4
NCT02957994 UNKNOWN
Hepatitis B
Asian Pacific Liver Center at Coalition of Inclusive Medicine
 2016-12-22 PHASE4
NCT02605954 COMPLETED
HIV-1 Infection
Gilead Sciences
 2015-11-18 PHASE3
NCT02510963 UNKNOWN
Hepatitis B, Chronic
First Affiliated Hospital Xi'an Jiaotong University
 2015-11
NCT02603107 COMPLETED
HIV-1 Infection
Gilead Sciences
 2015-11-20 PHASE3
NCT02607956 COMPLETED
HIV-1 Infection
Gilead Sciences
 2015-11-11 PHASE3
NCT02607930 COMPLETED
HIV-1 Infection
Gilead Sciences
 2015-11-13 PHASE3
NCT02529059 COMPLETED
HIV
St Stephens Aids Trust
 2015-11 PHASE4
NCT02836236 COMPLETED
HBV; Chronic HBV Infection
Gilead Sciences
 2015-06-19 PHASE3
NCT02403674 COMPLETED
Human Immunodeficiency Virus (HIV)
Merck Sharp & Dohme LLC
 2015-06-05 PHASE3
NCT03070405 UNKNOWN
Healthy Volunteers
Inje University
 2016-10 PHASE1
NCT03309566 COMPLETED
Healthy
Laboratorio Elea Phoenix S.A.
 2016-09-04 PHASE4
NCT00524173 TERMINATED
Hepatitis B
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2007-08-29 PHASE2
NCT02269917 COMPLETED
Human Immunodeficiency Virus Type 1
Janssen R&D Ireland
 2015-03 PHASE3
NCT02984852 COMPLETED
Healthy
Janssen Scientific Affairs, LLC
 2016-12 PHASE1
NCT02604199 TERMINATED
Hepatitis B
Arrowhead Pharmaceuticals
 2015-09 PHASE2
NCT02180438 COMPLETED
HIV-2 Infection
University of Washington
 2014-09 PHASE4
NCT01745822 COMPLETED
Hepatitis B Chronic Infection; Pregnancy
Institut de Recherche pour le Developpement
 2013-01 PHASE3
NCT02474303 COMPLETED
HIV/AIDS
Réseau Africain de Recherche sur le SIDA
 2015-07
NCT02577029 TERMINATED
Hepatitis B; Hepatitis D
Arrowhead Pharmaceuticals
 2015-12 PHASE2
NCT02738008 TERMINATED
Hepatitis B
Arrowhead Pharmaceuticals
 2016-03 PHASE2
NCT02206555 COMPLETED
HIV
Kirby Institute
 2014-11-14 PHASE4
NCT01641367 COMPLETED
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2013-02-22 PHASE4
NCT02797522 TERMINATED
Hepatitis B
Arrowhead Pharmaceuticals
 2016-06 PHASE1
NCT02449733 COMPLETED
HIV
Emory University
 2015-05
NCT01061151 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2011-03-01 PHASE3
NCT02238860 UNKNOWN
Cirrhosis Due to Hepatitis B
Asian Institute Of Medical Sciences
 2014-09 PHASE4
NCT02556333 TERMINATED
HIV
National Institute of Allergy and Infectious Diseases (NIAID)
 2015-09-16 PHASE2
NCT02560649 UNKNOWN
Chronic Hepatitis B
Ruijin Hospital
 2015-05 PHASE4
NCT02198443 COMPLETED
HIV
Fundacion Clinic per a la Recerca Biomédica
 2015-06-06 PHASE4
NCT02219672 UNKNOWN
AIDS/HIV PROBLEM
Peking Union Medical College
 2014-07 PHASE3
NCT02345226 COMPLETED
HIV-1 Infection
Gilead Sciences
 2015-01-26 PHASE3
NCT02345252 COMPLETED
HIV-1 Infection
Gilead Sciences
 2015-01-26 PHASE3
NCT01632891 COMPLETED
HIV-1 Infection; Pf Subclinical Parasitemia
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2014-01-10 PHASE1; PHASE2
NCT01751646 COMPLETED
HIV Infection
University of North Carolina, Chapel Hill
 2012-10
NCT01781806 COMPLETED
HIV Prevention
University of California, Los Angeles
 2013-05 PHASE4
NCT02093585 COMPLETED
HIV
Jan Gerstoft
 2014-01 PHASE4
NCT02159599 COMPLETED
HIV Infection
Fundacion SEIMC-GESIDA
 2014-07 PHASE4
NCT01732367 COMPLETED
Chronic Hepatitis B
Keimyung University Dongsan Medical Center
 2012-11 PHASE4
NCT02174276 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2014-07-24 PHASE2
NCT01003990 COMPLETED
HIV
Bristol-Myers Squibb
 2002-10 PHASE3
NCT02235662 COMPLETED
HIV; Contraception
CONRAD
 2014-10 PHASE1
NCT01291459 UNKNOWN
HIV
Association Pour la Recherche en Infectiologie
 2011-09 PHASE2
NCT02589457 COMPLETED
Chronic Hepatitis B
Chong Kun Dang Pharmaceutical
 2015-10 PHASE1
NCT01940471 COMPLETED
HBeAg-positive Chronic Hepatitis B
Gilead Sciences
 2013-09-11 PHASE3
NCT02211690 COMPLETED
Human Immunodeficiency Virus
Andrew Carr
 2014-08 PHASE4
NCT00936715 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2009-08 PHASE2
NCT01772823 COMPLETED
HIV Infection
University of North Carolina, Chapel Hill
 2012-11 PHASE2
NCT01769456 COMPLETED
HIV Infection
University of North Carolina, Chapel Hill
 2013-03 PHASE2
NCT01709084 COMPLETED
Human Immunodeficiency Virus-type 1 Infection
Janssen-Cilag International NV
 2013-10-02 PHASE3
NCT01929759 COMPLETED
HIV Disease
Massachusetts General Hospital
 2014-01
NCT01940341 COMPLETED
HBeAg-negative Chronic Hepatitis B
Gilead Sciences
 2013-09-12 PHASE3
NCT01910402 COMPLETED
Infection, Human Immunodeficiency Virus; HIV Infections
ViiV Healthcare
 2013-08-22 PHASE3
NCT01490671 WITHDRAWN
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE2
NCT01968551 COMPLETED
HIV-1; HIV Infections; Acquired Immunodeficiency Syndrome
Gilead Sciences
 2013-09-03 PHASE3
NCT01967940 COMPLETED
HIV; HIV Infections; Acquired Immunodeficiency Syndrome
Gilead Sciences
 2013-10-25 PHASE3
NCT02296853 COMPLETED
Hepatitis B Virus
Gilead Sciences
 2014-12-22 PHASE1
NCT01691768 COMPLETED
HIV
Centre for the AIDS Programme of Research in South Africa
 2012-10 PHASE2; PHASE3
NCT02071082 COMPLETED
HIV; HBV
Gilead Sciences
 2014-02-25 PHASE3
NCT01351740 COMPLETED
HIV Infection
University of British Columbia
 2011-07 PHASE4
NCT01327651 COMPLETED
HIV Infections
HIV Prevention Trials Network
 2011-08 PHASE2
NCT02670772 COMPLETED
Acquired Immune Deficiency Syndrome; Human Immunodeficiency Virus
Willem Daniel Francois Venter
 2012-07 PHASE3
NCT01813162 COMPLETED
HIV Prevention
CONRAD
 2013-12 PHASE1
NCT01778413 COMPLETED
HIV
Anna Cruceta
 2013-06-03 PHASE4
NCT02006264 COMPLETED
HIV
Albert Einstein College of Medicine
 2013-11-19 PHASE1
NCT02065986 COMPLETED
HIV
MRC [ycm]
 2012-10 PHASE4
NCT01387022 COMPLETED
Antiretroviral Treatment Outcomes
Centre for the AIDS Programme of Research in South Africa
 2011-06
NCT02583464 COMPLETED
Acquired Immunodeficiency Syndrome
Laboratorio Elea Phoenix S.A.
 2014-09 PHASE1
NCT01810315 COMPLETED
HIV Prevention
CONRAD
 2013-09 PHASE1
NCT02203461 COMPLETED
Insulin Resistance
Technical University of Munich
 2014-07 PHASE1
NCT01797445 COMPLETED
HIV; HIV Infections
Gilead Sciences
 2013-03-12 PHASE3
NCT01780506 COMPLETED
HIV; HIV Infections
Gilead Sciences
 2012-12-26 PHASE3
NCT01386294 COMPLETED
HIV Prevention
CONRAD
 2011-10 PHASE3
NCT01277601 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2011-04 PHASE4
NCT01694017 COMPLETED
HIV
Tufts University
 2012-11 PHASE4
NCT01515813 WITHDRAWN
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2011-11 PHASE2
NCT01258439 COMPLETED
HIV; Cardiovascular Disease
St Vincent's Hospital, Sydney
 2010-11 PHASE4
NCT01533272 COMPLETED
HIV Infection
Hospital Clinic of Barcelona
 2012-02 PHASE4
NCT01343225 UNKNOWN
HIV
East Carolina University
 2011-05 PHASE4
NCT01488526 COMPLETED
Hepatitis B Infection; Chronic Infection; Viremia
New Discovery LLC
 2012-03-01 PHASE4
NCT01040091 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2009-12 PHASE1
NCT02039323 COMPLETED
Healthy Adult Females
University of North Carolina, Chapel Hill
 2014-02 PHASE1
NCT01421368 COMPLETED
HIV Prevention
CONRAD
 2012-03 PHASE1
NCT01458977 COMPLETED
HIV; Dyslipidemia
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
 2012-01 PHASE4
NCT01525628 COMPLETED
Hepatitis C, Chronic
Boehringer Ingelheim
 2012-04 PHASE1
NCT01575418 COMPLETED
HIV Prevention
Ian McGowan
 2013-03 PHASE1
NCT01701882 COMPLETED
HIV
St Stephens Aids Trust
 2012-09 PHASE3
NCT01475838 COMPLETED
Acquired Immunodeficiency Syndrome; HIV Infections
Gilead Sciences
 2011-11 PHASE3
NCT00924898 COMPLETED
Acute HIV Infection; HIV Infections
University of North Carolina, Chapel Hill
 2005-01 PHASE4
NCT01332227 COMPLETED
HIV, Combination Therapy
Bristol-Myers Squibb
 2011-10 PHASE4
NCT01330199 COMPLETED
Healthy Adult Females
University of North Carolina, Chapel Hill
 2012-02 PHASE1
NCT00119106 COMPLETED
HIV Infections
Centers for Disease Control and Prevention
 2005-06 PHASE2; PHASE3
NCT01751555 COMPLETED
Hiv
National Center for AIDS/STD Control and Prevention, China CDC
 2011-02 PHASE4
NCT01475851 COMPLETED
Hepatitis B, Chronic
GlaxoSmithKline
 2011-12 PHASE3
NCT01160120 COMPLETED
HIV
The HIV Netherlands Australia Thailand Research Collaboration
 2010-06 PHASE2
NCT01283360 COMPLETED
High Risk MSM; HIV Negative; 18-30 Years of Age
CONRAD
 2010-10 PHASE1
NCT01274780 COMPLETED
HIV-1
Juan A. Arnaiz
 2011-05 PHASE4
NCT01671787 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2012-03 PHASE1
NCT01489046 TERMINATED
HIV-1 Infection
Bristol-Myers Squibb
 2011-02 PHASE2
NCT01384734 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2011-07-26 PHASE2
NCT01583439 TERMINATED
HIV Infections
Harvard School of Public Health (HSPH)
 2012-09
NCT01620944 TERMINATED
HIV
Bristol-Myers Squibb
 2012-07-31 PHASE3
NCT01728935 COMPLETED
Chronic Hepatitis B
The University of Hong Kong
 2008-04
NCT01533259 COMPLETED
Acquired Immunodeficiency Syndrome; HIV Infections
Gilead Sciences
 2012-01 PHASE3
NCT01300234 COMPLETED
Hepatitis B
GlaxoSmithKline
 2011-03-30 PHASE3
NCT01497899 COMPLETED
Acquired Immunodeficiency Syndrome; HIV Infections
Gilead Sciences
 2011-12-28 PHASE2
NCT01270802 COMPLETED
HIV
Indiana University
 2011-04 PHASE4
NCT00608569 COMPLETED
HIV Infections
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2009-03
NCT00705679 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2009-08 PHASE2
NCT00734344 COMPLETED
Acute HIV Infection
University of Alabama at Birmingham
 2008-09
NCT00939874 COMPLETED
HIV; Osteopenia; Osteoporosis; HIV Infections
St Vincent's Hospital, Sydney
 2009-10 PHASE4
NCT01153217 COMPLETED
HIV
Germans Trias i Pujol Hospital
 2010-07 PHASE3
NCT01102972 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2010-04 PHASE4
NCT01602822 TERMINATED
HIV
Kenneth H. Mayer, MD
 2012-02 PHASE4
NCT01294761 COMPLETED
HIV Infections
National Center for Global Health and Medicine, Japan
 2011-02
NCT00507507 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2007-09 PHASE2
NCT01480622 COMPLETED
Hepatitis B, Chronic
GlaxoSmithKline
 2011-12-05 PHASE1
NCT00651209 COMPLETED
Hepatitis B, Chronic
Novartis Pharmaceuticals
 2008-02 PHASE4
NCT01108510 COMPLETED
HIV; HIV Infections
Gilead Sciences
 2010-04 PHASE3
NCT00822315 COMPLETED
HIV Infections; Tuberculosis
ANRS, Emerging Infectious Diseases
 2009-07 PHASE2
NCT00994773 COMPLETED
Hepatitis B
Bader, Ted, M.D.
 2009-12 PHASE1
NCT01106586 COMPLETED
HIV; HIV Infections
Gilead Sciences
 2010-04 PHASE3
NCT01095796 COMPLETED
HIV; HIV Infections
Gilead Sciences
 2010-03 PHASE3
NCT01231555 TERMINATED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2010-11-18 PHASE2
NCT01260610 WITHDRAWN
Chronic Hepatitis B
Institute of Liver and Biliary Sciences, India
 2011-06
NCT01340196 COMPLETED
HIV Infections
Boehringer Ingelheim
 2011-04 PHASE1
NCT00507689 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2007-09 PHASE2
NCT00391638 COMPLETED
Hepatitis B; HIV Infections
French National Agency for Research on AIDS and Viral Hepatitis
 2007-01 PHASE2; PHASE3
NCT01014481 TERMINATED
HIV Infections; Tuberculosis
Bamrasnaradura Infectious Diseases Institute
 2009-10 PHASE4
NCT00298363 COMPLETED
Chronic Hepatitis B
Gilead Sciences
 2006-04 PHASE2
NCT01928407 COMPLETED
HIV-1 Infection; Immunosuppression-related Infectious Disease
Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
 2011-02-23 PHASE4
NCT00734162 COMPLETED
Hepatitis B Virus (HBV)
Gilead Sciences
 2008-12 PHASE3
NCT00724711 COMPLETED
HIV Infection
Gilead Sciences
 2008-07 PHASE4
NCT01205139 COMPLETED
Hepatitis C Virus
Tibotec Pharmaceuticals, Ireland
 2010-11 PHASE1
NCT00409019 WITHDRAWN
Chronic Hepatitis B
Novartis Pharmaceuticals
 PHASE4
NCT00335322 COMPLETED
Human Immunodeficiency Virus (HIV)
Kirby Institute
 2007-02 PHASE4
NCT00389207 COMPLETED
HIV Infections
Boehringer Ingelheim
 2006-10 PHASE3
NCT00410202 COMPLETED
Hepatitis B, Chronic
Bristol-Myers Squibb
 2008-03 PHASE3
NCT00869960 COMPLETED
Healthy
University of Alabama at Birmingham
 2009-03 PHASE4
NCT00615745 COMPLETED
HIV Infections
Gilead Sciences
 2008-04 PHASE4
NCT00958100 COMPLETED
HIV/AIDS; Antiretroviral Therapy; HIV Infections
Catholic University of the Sacred Heart
 2009-08 PHASE2
NCT01108926 COMPLETED
HIV Infection; HIV Infections
St Stephens Aids Trust
 2010-06 PHASE1
NCT00346567 COMPLETED
HIV Infections
Rigshospitalet, Denmark
 2006-06
NCT00647244 COMPLETED
HIV Infections
Aarhus University Hospital
 2008-06 PHASE4
NCT00827112 COMPLETED
Human Immunodeficiency Virus-1
ViiV Healthcare
 2009-03 PHASE2
NCT00442962 COMPLETED
HIV Infections
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2007-05 PHASE4
NCT00552240 COMPLETED
HIV Infections
Boehringer Ingelheim
 2007-09 PHASE4
NCT00863668 WITHDRAWN
HIV Infection; HIV Infections
University of Minnesota
 2009-03
NCT00594646 COMPLETED
HIV Infections
Fenway Community Health
 2008-02 PHASE4
NCT00951015 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2009-07-30 PHASE2
NCT00662545 COMPLETED
HIV Infections; Hepatitis B
University of California, San Francisco
 2008-04 PHASE4
NCT00540449 COMPLETED
HIV Infections; HIV-1; Human Immunodeficiency Virus Type 1
Tibotec Pharmaceuticals, Ireland
 2008-05 PHASE3
NCT00768989 TERMINATED
HIV
Bristol-Myers Squibb
 2008-11 PHASE2
NCT00441298 COMPLETED
HIV Infections
Centre for the AIDS Programme of Research in South Africa
 2007-05 PHASE2
NCT00474435 UNKNOWN
Tuberculosis; HIV Infections
African Poverty Related Infection Oriented Research Initiative
 2008-11 PHASE2
NCT00302822 COMPLETED
HIV Infections; AIDS
French National Agency for Research on AIDS and Viral Hepatitis
 2006-04 PHASE3
NCT00414635 COMPLETED
HIV Infections
Community Research Initiative of New England
 2006-08 PHASE4
NCT00594373 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE1
NCT00115609 COMPLETED
HIV Infections; Tuberculosis
French National Agency for Research on AIDS and Viral Hepatitis
 2006-01 PHASE3
NCT00118898 COMPLETED
HIV Infections
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2005-09 PHASE3
NCT00711009 COMPLETED
Human Immunodeficiency Virus Infection
Abbott
 2008-07 PHASE3
NCT00772902 COMPLETED
HIV-1
Gilead Sciences
 2008-10 PHASE4
NCT00885664 COMPLETED
HIV Infections
University of Cincinnati
 2005-10 PHASE4
NCT00131677 COMPLETED
HIV Infection
Centers for Disease Control and Prevention
 2005-02 PHASE2
NCT00334256 COMPLETED
HIV Infection; Pregnancy
French National Agency for Research on AIDS and Viral Hepatitis
 2006-10 PHASE2
NCT01074645 COMPLETED
Acute on Chronic Liver Failure; Hepatitis B
Govind Ballabh Pant Hospital
 2007-11 PHASE4
NCT00528957 COMPLETED
HIV Infections
Gilead Sciences
 2006-12-28 PHASE3
NCT00605384 TERMINATED
Chronic Hepatitis B
Bristol-Myers Squibb
 2008-08 PHASE3
NCT00823342 TERMINATED
HBe Negative Chronic Hepatitis B; Hepatitis B Viral Infection
French National Agency for Research on AIDS and Viral Hepatitis
 2008-12-14 PHASE3
NCT00476463 COMPLETED
Hepatitis B Virus; HIV Infections
The HIV Netherlands Australia Thailand Research Collaboration
 2005-04 PHASE2
NCT00528060 COMPLETED
HIV Infections
French National Agency for Research on AIDS and Viral Hepatitis
 2008-01 PHASE2
NCT00344461 COMPLETED
HIV
University of Maryland, Baltimore
 2004-03 PHASE4
NCT00534352 COMPLETED
HIV-1 Infection
Tibotec, Inc
 2008-01 PHASE2
NCT00561496 COMPLETED
HIV Infections
CONRAD
 2007-03 PHASE1
NCT00244712 COMPLETED
HIV Infection
GlaxoSmithKline
 2005-07 PHASE4
NCT00051831 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 2003-10
NCT00120367 COMPLETED
Leukoencephalopathy, Progressive Multifocal; HIV Infections
French National Agency for Research on AIDS and Viral Hepatitis
 2005-04 PHASE2
NCT00105079 COMPLETED
HIV Infections
Hoffmann-La Roche
 2005-04 PHASE3
NCT00323492 COMPLETED
HIV Infections
Gilead Sciences
 2005-09 PHASE4
NCT00204308 COMPLETED
HIV; Pregnancy
University of North Carolina, Chapel Hill
 2005-03 PHASE2
NCT00344760 COMPLETED
HIV Infections
University of Maryland, Baltimore
 2005-01 PHASE4
NCT00221286 TERMINATED
Chronic Hepatitis B; HIV Infections
University Hospital, Bonn
 2004-09 PHASE3
NCT00323687 COMPLETED
HIV-1 Infection
Gilead Sciences
 2004-09 PHASE4
NCT00365339 COMPLETED
HIV Infections
Bristol-Myers Squibb
 2006-04 PHASE1
NCT00335192 COMPLETED
HIV
Germans Trias i Pujol Hospital
 2005-01 PHASE4
NCT00053638 COMPLETED
HIV Infection
GlaxoSmithKline
 2003-02 PHASE3
NCT00038506 COMPLETED
HIV Infection
ViiV Healthcare
 2002-03 PHASE4
NCT00044577 COMPLETED
Infection, Human Immunodeficiency Virus I; HIV Infection
ViiV Healthcare
 2002-07-16 PHASE3
NCT00046033 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE2
NCT00036634 COMPLETED
HIV Infections
Gilead Sciences
 2002-03 PHASE1; PHASE2
NCT00158821 COMPLETED
HIV Infections
Gilead Sciences
 2000-03 PHASE3
NCT00324688 COMPLETED
HIV Infections
Gilead Sciences
 2003-03 PHASE4
NCT00122512 TERMINATED
HIV Infections
FHI 360
 PHASE2
NCT00011089 UNKNOWN
HIV Infections
Gilead Sciences
 2001-02
NCT00002180 COMPLETED
HIV Infections
Gilead Sciences
 PHASE1
NCT01368783 UNKNOWN
Atazanavir
Asan Medical Center
 2011-06 PHASE1
NCT00312832 COMPLETED
HIV Infections; Lipoatrophy
Hospital Clinic of Barcelona
 2004-01
NCT00111943 COMPLETED
HIV Infections; Hepatitis B, Chronic
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE2
NCT00088309 COMPLETED
HIV Infections
National Cancer Institute (NCI)
 2004-06 PHASE2
NCT00540605 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE1
NCT00122577 TERMINATED
HIV Infections
French National Agency for Research on AIDS and Viral Hepatitis
 2002-03 PHASE2
NCT00127959 COMPLETED
HIV Infections; Hepatitis B
International Antiviral Therapy Evaluation Center
 2004-03 PHASE4
NCT00007436 UNKNOWN
HIV Infections
Gilead Sciences
 PHASE3
NCT00016588 COMPLETED
HIV Infections
Gilead Sciences
 2001-05
NCT00158457 COMPLETED
HIV Infection
French National Agency for Research on AIDS and Viral Hepatitis
 2004-06 PHASE3
NCT00002396 UNKNOWN
HIV Infections
Gilead Sciences
 PHASE1
NCT00024986 COMPLETED
HIV Infection
National Cancer Institute (NCI)
 2001-10 PHASE1
NCT00121017 WITHDRAWN
HIV Infection; Hepatitis C
Abbott
 PHASE2
NCT00036452 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE2
NCT00111150 TERMINATED
HIV Infection
Centers for Disease Control and Prevention
 2005-09 PHASE2; PHASE3
NCT00389194 COMPLETED
HIV Infections
International Antiviral Therapy Evaluation Center
 2006-04 PHASE4

(data from https://clinicaltrials.gov, updated on 2026-08-14)

Check the Tenofovir product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Tenofovir acts as a nucleotide analogue reverse transcriptase inhibitor that competitively binds to viral reverse transcriptase and incorporates into viral DNA, terminating target nucleic acid chain elongation and suppressing viral replication. By halting viral genome propagation and elevating CD4 cell counts, this mechanism provides therapeutic efficacy against human immunodeficiency virus (HIV) infections and chronic hepatitis B virus infections under investigation in clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.