CAS No. 144701-48-4
| IUPAC Name | 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid | |
|---|---|---|
| CAS Number | 144701-48-4 | |
| Molecular Formula |
C33H30N4O2 |
|
| Molecular Weight (MW) | 514.62 | |
| SMILES | CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C(=O)O)C=C(C=C2C)C5=NC6=CC=CC=C6N5C | |
| InChIKey | RMMXLENWKUUMAY-UHFFFAOYSA-N |
Telmisartan is an angiotensin II type 1 (AT1) receptor antagonist that exhibits 3000-fold higher selectivity for AT1 over AT2 receptors. It inhibits the renin-angiotensin system and additionally acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-γ). Through PPAR-γ activation and AT1 receptor blockade, telmisartan regulates glucose metabolism, reduces vascular inflammation, and improves insulin sensitivity in cardiovascular and metabolic models. [1][2]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(29.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
13 mg/mL
(25.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
17 mg/mL
(33.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
13 mg/mL
(25.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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