Rivaroxaban has been evaluated in numerous clinical trials spanning Early Phase 1 through Phase 4, including Phase 1 bioequivalence and Phase 4 drug-drug interaction studies. These trials assess safety and efficacy for deep vein thrombosis, pulmonary embolism, venous thromboembolism prophylaxis, and pediatric congenital heart disease following Fontan procedures, with statuses encompassing completed, active, recruiting, and not yet recruiting protocols. Sponsored by industry leaders like Bayer and Janssen alongside academic institutions such as Radboud University Medical Center and Brigham and Women's Hospital, these investigations represent a broad clinical landscape.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06953726 | RECRUITING | Atrial Fibrillation |
VA Office of Research and Development |
2026-06-01 | PHASE4 |
| NCT06953778 | NOT_YET_RECRUITING | Atrial Fibrillation |
VA Office of Research and Development |
2027-03-08 | |
| NCT07202897 | RECRUITING | Hypertrophic Cardiomyopathy (HCM) |
Rennes University Hospital |
2026-01-07 | PHASE3 |
| NCT06216769 | RECRUITING | Atrial Fibrillation |
Seoul National University Hospital |
2024-02-01 | |
| NCT07468448 | NOT_YET_RECRUITING | Ischemic Stroke; Intracranial Atherosclerosis |
Population Health Research Institute |
2026-09-30 | PHASE3 |
| NCT07318610 | RECRUITING | Peripheral Artery Disease (PAD) |
Regeneron Pharmaceuticals |
2026-07-10 | PHASE3 |
| NCT07511257 | RECRUITING | Coronary Artery Ectasia; Acute Coronary Syndromes (ACS); STEMI - ST Elevation Myocardial Infarction; NSTEMI - Non-ST Segment Elevation Myocardial Infarction (MI) |
Instituto Nacional de Cardiologia Ignacio Chavez |
2026-02-11 | PHASE4 |
| NCT06195540 | RECRUITING | Venous Thromboembolism; Deep Vein Thrombosis; Pulmonary Embolism; Lower Limb Trauma; Thromboprophylaxis; Immobilisation |
University Hospital, Angers |
2024-07-19 | PHASE3 |
| NCT05353140 | RECRUITING | Atrial Fibrillation; Percutaneous Coronary Intervention |
Xijing Hospital |
2022-09-01 | |
| NCT07746882 | NOT_YET_RECRUITING | Stroke; Acute Ischemic Stroke |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2026-08-15 | PHASE3 |
| NCT06370273 | RECRUITING | Thrombosis; Injury Leg |
Queen Mary University of London |
2024-11-12 | PHASE3 |
| NCT05180773 | RECRUITING | Peripartum Cardiomyopathy, Postpartum |
Dennis M. McNamara, MD, MS |
2022-07-27 | PHASE4 |
| NCT04263038 | RECRUITING | Pulmonary Embolism; Embolism; Embolism and Thrombosis; Lung Diseases; Cardiovascular Diseases; Respiratory Tract Diseases; Venous Thromboembolism; Anticoagulant-induced Bleeding; Bleeding |
Drahomir Aujesky |
2020-05-15 | PHASE4 |
| NCT07195812 | NOT_YET_RECRUITING | ST Elevation Myocardial Infarction; No-Reflow Phenomenon |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2025-10 | PHASE4 |
| NCT06812455 | RECRUITING | Radial Artery Occlusion |
AHEPA University Hospital |
2025-03-01 | PHASE4 |
| NCT05701917 | RECRUITING | Venous Thromboembolism; Deep Venous Thrombosis; Post-Thrombotic Syndrome |
Inari Medical |
2023-01-06 | |
| NCT07602062 | NOT_YET_RECRUITING | Portal Vein Thrombosis; Anticoagulant Therapy; Variceal Bleeding |
Shanghai Zhongshan Hospital |
2026-06-01 | |
| NCT04258488 | RECRUITING | AORTIC VALVE DISEASES; Thromboembolism |
Joon Bum Kim |
2022-02-21 | PHASE4 |
| NCT04642430 | RECRUITING | Atrial Fibrillation |
Ottawa Hospital Research Institute |
2021-07-06 | PHASE4 |
| NCT06957366 | RECRUITING | Atrial Fibrillation (AF); VTE |
McMaster University |
2025-04-01 | |
| NCT06780462 | RECRUITING | Behcet Syndrome |
Assistance Publique - Hôpitaux de Paris |
2025-06-24 | PHASE3 |
| NCT07246005 | NOT_YET_RECRUITING | Left Ventricular Thrombus |
Queen Mary University of London |
2026-12-01 | PHASE2 |
| NCT06901466 | RECRUITING | Mitral Regurgitation |
Chinese Academy of Medical Sciences, Fuwai Hospital |
2025-06-13 | PHASE4 |
| NCT03129490 | ACTIVE_NOT_RECRUITING | Atrial Fibrillation; Atrial Flutter |
Herlev and Gentofte Hospital |
2023-04-01 | PHASE4 |
| NCT06580223 | NOT_YET_RECRUITING | Multiple Myeloma; Venous Thromboembolism |
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology |
2025-09-01 | PHASE3 |
| NCT06396858 | NOT_YET_RECRUITING | Ischemic Stroke |
Brazilian Clinical Research Institute |
2026-07 | PHASE4 |
| NCT05198960 | RECRUITING | Polycythemia Vera; Essential Thrombocythemia; Prefibrotic/Early Primary Myelofibrosis; JAK2 V617F; High-risk Patients |
University Hospital, Brest |
2022-07-13 | PHASE3 |
| NCT07228663 | NOT_YET_RECRUITING | Hip Fracture Surgery; Cardiovascular Prevention; Venous Thromboembolism (VTE) |
McMaster University |
2025-12-01 | PHASE3 |
| NCT07796217 | RECRUITING | Cardiac Event; Coronary Artery Disease; Peripheral Artery Disease; Bleeding |
Seoul National University Bundang Hospital |
2023-11-15 | PHASE4 |
| NCT05735639 | RECRUITING | Venous Thromboembolism; Varicose Veins |
Imperial College London |
2024-01-22 | PHASE4 |
| NCT05643651 | RECRUITING | Kawasaki Disease; Coronary Artery Aneurysm |
Children's Hospital of Fudan University |
2025-06-01 | PHASE4 |
| NCT07613840 | RECRUITING | Peripheral Arterial Disease (PAD); Amputation; Thrombosis; Thrombosis (Stent Thrombosis); Platelet Aggregation Inhibitors; Thromboelastography (TEG); PRU(Platelet Reactivity Unit) |
Massachusetts General Hospital |
2025-04-29 | |
| NCT07456085 | ENROLLING_BY_INVITATION | Valvular Heart Disease Patients |
Rawalpindi Institute of Cardiology |
2025-11-13 | PHASE3 |
| NCT05487950 | NOT_YET_RECRUITING | Excessive Supraventricular Ectopies or Short Atrial Runs (ESVEA) |
Assistance Publique - Hôpitaux de Paris |
2023-04-05 | PHASE4 |
| NCT06925698 | NOT_YET_RECRUITING | Behcet Disease; Behcet Disease and Vascular Involvement; Deep Venous Thromboses; Post Thrombotic Syndrome |
Marmara University |
2025-04-30 | PHASE3 |
| NCT03129555 | ACTIVE_NOT_RECRUITING | Deep Vein Thrombosis; Pulmonary Embolism |
Herlev and Gentofte Hospital |
2023-04-01 | PHASE4 |
| NCT06961630 | RECRUITING | Myocardial Injury After Noncardiac Surgery |
NYU Langone Health |
2025-10-07 | EARLY_PHASE1 |
| NCT05047172 | ACTIVE_NOT_RECRUITING | Intracranial Arteriosclerosis; Stroke |
University of Florida |
2022-08-02 | PHASE3 |
| NCT05410275 | RECRUITING | Chronic Hemodialysis Patients |
University Hospital, Tours |
2025-01-08 | PHASE3 |
| NCT06108414 | RECRUITING | Atrial Fibrillation; Anticoagulant Adverse Reaction; Stroke; Major Adverse Cardiac Events |
China National Center for Cardiovascular Diseases |
2024-09-01 | PHASE4 |
| NCT04694248 | RECRUITING | Deep Vein Thrombosis; Iliac Vein Thrombosis; Iliac Vein Obstruction; Iliac Vein Stenosis; Iliac Vein Compression Syndrome |
First Affiliated Hospital of Zhejiang University |
2021-11-03 | |
| NCT06013020 | RECRUITING | STEMI - ST Elevation Myocardial Infarction |
Zunyi Medical College |
2024-04-01 | PHASE4 |
| NCT07404436 | RECRUITING | Idiopathic Membranous Nephropathy |
Beijing Friendship Hospital |
2024-01-05 | PHASE4 |
| NCT05029063 | RECRUITING | Venous Thromboembolism; Cancer |
Ottawa Hospital Research Institute |
2022-10-05 | PHASE3 |
| NCT04874428 | RECRUITING | Liver Cirrhosis |
Insel Gruppe AG, University Hospital Bern |
2021-05-19 | PHASE1 |
| NCT05638867 | RECRUITING | Coronary Artery Disease; Percutaneous Coronary Intervention; Acute Coronary Syndrome |
China National Center for Cardiovascular Diseases |
2023-11-25 | PHASE4 |
| NCT06551402 | RECRUITING | Cerebral Venous Sinus Thrombosis |
Kafrelsheikh University |
2024-08-09 | PHASE3 |
| NCT05920343 | RECRUITING | Venous Thromboembolism; Urologic Cancer |
Ottawa Hospital Research Institute |
2024-11-04 | PHASE2; PHASE3 |
| NCT02921022 | ACTIVE_NOT_RECRUITING | Pancreatic Cancer; Advanced Pancreatic Ductal Adenocarcinoma |
Memorial Sloan Kettering Cancer Center |
2016-10 | |
| NCT05892042 | RECRUITING | ST-segment Elevation Myocardial Infarction (STEMI); Left Ventricular Thrombus |
Jilin University |
2023-05-01 | |
| NCT06965998 | RECRUITING | SVT; Thrombosis; Superficial Vein Thrombosis |
Ottawa Hospital Research Institute |
2025-08-06 | PHASE2; PHASE3 |
| NCT06187311 | RECRUITING | Atrial Fibrillation; Anticoagulant Adverse Reaction |
Korea University Anam Hospital |
2023-01-12 | PHASE4 |
| NCT07312851 | COMPLETED | Healthy Participants |
AstraZeneca |
2026-01-19 | PHASE1 |
| NCT05035277 | COMPLETED | Aortic Stenosis |
Oslo University Hospital |
2021-12-04 | PHASE3 |
| NCT07270263 | RECRUITING | Lymphoma; Leukemia; Multiple Myeloma (MM), Lymphoma, Large B-Cell, Diffuse (DLBCL), Lymphoma; Venous Thromboembolic Disease; VTE (Venous Thromboembolism); PE - Pulmonary Embolism; Hematologic Malignacies |
Medical University of Gdansk |
2024-11-22 | |
| NCT06449469 | ACTIVE_NOT_RECRUITING | Aortic Valve Stenosis; Cardiovascular Diseases; Heart Diseases; Heart Valve Diseases; Valve Disease, Aortic |
Rigshospitalet, Denmark |
2021-05-01 | |
| NCT05794399 | RECRUITING | Left Ventricular Thrombus; Myocardial Infarction |
Shahid Gangalal National Heart Centre |
2023-06-19 | PHASE4 |
| NCT06476301 | NOT_YET_RECRUITING | Anticoagulation |
RenJi Hospital |
2024-08-01 | PHASE4 |
| NCT07618988 | COMPLETED | Pediatric Venous Thromboembolism |
Ain Shams University |
2024-08-03 | PHASE4 |
| NCT07523347 | COMPLETED | Cerebrosinovenous Thrombosis |
Muhammad Aamir Latif |
2023-12-01 | |
| NCT07774273 | COMPLETED | Pulmonary Embolism Acute; Venous Thromboembolism (VTE) |
Combined military hospital lahore |
2021-01-01 | |
| NCT06978439 | RECRUITING | Kawasaki Disease; Pilot Study; Coronary Artery Aneurysm; Rivaroxaban |
Children's Hospital of Fudan University |
2024-01-10 | PHASE4 |
| NCT06689241 | RECRUITING | Morbid Obesity; Bariatric Surgery Candidate |
Alexandria University |
2024-10-01 | |
| NCT07243080 | RECRUITING | Deep Venous Thromboses; Laparotomy Patients |
Mayo Hospital Lahore |
2025-10-10 | PHASE4 |
| NCT03969953 | COMPLETED | Chronic Kidney Diseases; Dialysis-dependent Kidney Failure; Cardiovascular Disease |
The George Institute |
2021-01-18 | PHASE3 |
| NCT05449327 | COMPLETED | Venous Thromboembolism; Arthroplasty |
Chiayi Christian Hospital |
2023-02-01 | |
| NCT02810704 | COMPLETED | Pulmonary Embolism; Venous Thrombosis |
Dartmouth-Hitchcock Medical Center |
2016-12 | PHASE4 |
| NCT02168829 | COMPLETED | Atrial Fibrillation; Stroke |
Ottawa Heart Institute Research Corporation |
2016-01 | PHASE4 |
| NCT03568890 | ACTIVE_NOT_RECRUITING | Left Atrial Appendage Closure; Thrombosis; Stroke; TIA; Bleeding |
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec |
2018-09-01 | PHASE4 |
| NCT03684564 | COMPLETED | Antiphospholipid Syndrome; Systemic Lupus Erythematosus; Stroke; Ischemic Stroke; Brain Ischemia |
University College, London |
2021-07-09 | PHASE2 |
| NCT05960721 | RECRUITING | Atrial Fibrillation |
Xijing Hospital |
2023-07-06 | |
| NCT06873321 | RECRUITING | Peripheral Arterial Disease; Venous Thormboembolism; Cardiovascular Diseases; Vascular Surgery Patient with PAD / Carotid Stenosis |
Science Valley Research Institute |
2024-02-24 | PHASE4 |
| NCT05009862 | COMPLETED | Peripheral Arterial Disease |
Vanderbilt University Medical Center |
2022-04-19 | PHASE4 |
| NCT03630055 | TERMINATED | Radial Artery Occlusion |
Ottawa Heart Institute Research Corporation |
2018-10-03 | PHASE3 |
| NCT06103266 | UNKNOWN | Atrial Fibrillation; Coronary Artery Disease |
J.P.S Henriques |
2024-01 | PHASE4 |
| NCT03266783 | COMPLETED | Venous Thromboembolism |
Ottawa Hospital Research Institute |
2017-12-13 | PHASE4 |
| NCT04075240 | COMPLETED | Venous Thromboembolism |
Sudeep Shivakumar |
2021-02-04 | PHASE3 |
| NCT06444178 | COMPLETED | Healthy Volunteers |
Regeneron Pharmaceuticals |
2024-09-30 | PHASE1 |
| NCT06145269 | UNKNOWN | Acute DVT of Lower Extremity |
Assiut University |
2023-12-01 | EARLY_PHASE1 |
| NCT03749057 | COMPLETED | Cerebral Infarction; TIA |
General Hospital of Shenyang Military Region |
2018-11-20 | PHASE4 |
| NCT05546320 | COMPLETED | Patent Foramen Ovale; Migraine |
Chinese Academy of Medical Sciences, Fuwai Hospital |
2022-10-15 | PHASE2 |
| NCT05775965 | RECRUITING | Hip Fractures |
University of Calgary |
2024-05-21 | PHASE2 |
| NCT05718531 | UNKNOWN | Coronary Artery Ectasia |
Assiut University |
2023-02-01 | PHASE3 |
| NCT06220123 | COMPLETED | Preventing Postoperative Venous Thromboembolism in Patients Undergoing Ovarian Cancer Surgery |
Beijing Suncadia Pharmaceuticals Co., Ltd |
2024-02-16 | PHASE2 |
| NCT04067505 | UNKNOWN | May-Thurner Syndrome |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2020-05-18 | PHASE3 |
| NCT06517563 | COMPLETED | Coagulation Disorder |
VarmX B.V. |
2024-08-14 | PHASE1 |
| NCT06065592 | UNKNOWN | Cancer; Solid Tumor; Thromboembolism; Cardiovascular Diseases; Immune System Diseases; Inflammatory Diseases; Colon Cancer; Breast Cancer; Prostate Cancer; Hepatocellular Carcinoma; Lung Cancer; Chemotherapy; Immunotherapy |
Lebanese University |
2019-02-01 | PHASE1 |
| NCT05700266 | UNKNOWN | Ischemic Stroke; Intracranial Atherosclerosis; Stenosis |
The First Affiliated Hospital with Nanjing Medical University |
2023-12-30 | PHASE2; PHASE3 |
| NCT03463317 | COMPLETED | Atrial Fibrillation |
Charite University, Berlin, Germany |
2018-02-28 | PHASE4 |
| NCT05797376 | COMPLETED | Atherosclerosis of Artery; Coronary Artery Disease; Peripheral Arterial Disease; Carotid Stenosis |
Asan Medical Center |
2021-08-24 | PHASE4 |
| NCT04135677 | UNKNOWN | Left Atrial Appendage Thrombosis; Thrombi; Stroke |
Shanghai Zhongshan Hospital |
2022-11-11 | PHASE4 |
| NCT05033314 | TERMINATED | Sickle Cell Disease; Central Venous Catheter Thrombosis; Venous Thromboembolism |
University Health Network, Toronto |
2022-06-07 | PHASE3 |
| NCT05671276 | UNKNOWN | Atrial Fibrillation; Left Atrial Appendage Occlusion; Silent Cerebral Embolism |
The First Affiliated Hospital with Nanjing Medical University |
2022-02-01 | PHASE4 |
| NCT06531122 | UNKNOWN | Cerebral Venous Thrombosis |
Kafrelsheikh University |
2021-08-01 | PHASE3 |
| NCT06196918 | UNKNOWN | Glioma, Malignant |
Nanfang Hospital, Southern Medical University |
2023-11-01 | |
| NCT06372483 | ACTIVE_NOT_RECRUITING | Coagulation Disorder |
VarmX B.V. |
2024-02-21 | PHASE1 |
| NCT04999176 | UNKNOWN | Cancer; Rivaroxaban; Venous Thromboembolism; Thromboprophylaxis |
André Luiz Malavasi Longo de Oliveira |
2020-10-22 | PHASE3 |
| NCT05973188 | UNKNOWN | Left Ventricular Thrombus |
Peshawar Institute of Cardiology |
2023-05-01 | PHASE4 |
| NCT04684212 | WITHDRAWN | Atrial Fibrillation; Left Atrial Appendage Thrombosis; CVA |
Brian O'Neill MD |
2024-06-01 | |
| NCT04970576 | COMPLETED | Acute Coronary Syndrome; Left Ventricular Thrombus |
National Institute of Cardiovascular Diseases, Pakistan |
2021-06-25 | PHASE4 |
| NCT03996772 | COMPLETED | Atrial Fibrillation; Intracerebral Hemorrhage |
Imperial College London |
2019-06-03 | PHASE3 |
| NCT02387229 | TERMINATED | ATRIAL FIBRILLATION |
Montreal Heart Institute |
2015-03 | PHASE3 |
| NCT06193863 | Not yet recruiting | Prevention of Venous Thromboembolism|Congenital Heart Disease|Fontan Procedure|Children |
Bayer|Janssen Research & Development LLC |
2024-05-31 | -- |
| NCT06195540 | Not yet recruiting | Venous Thromboembolism|Deep Vein Thrombosis|Pulmonary Embolism|Lower Limb Trauma|Thromboprophylaxis|Immobilisation |
University Hospital Angers |
2024-05-31 | Phase 3 |
| NCT06314763 | COMPLETED | Drug Drug Interaction Study |
Radboud University Medical Center |
2023-11-09 | PHASE4 |
| NCT04128956 | TERMINATED | Venous Thromboses; Stent Stenosis |
University of Zurich |
2020-03-11 | PHASE2 |
| NCT04755283 | ACTIVE_NOT_RECRUITING | Atrial Fibrillation (AF); Stroke |
Anthos Therapeutics, Inc. |
2021-02-02 | PHASE2 |
| NCT05093504 | TERMINATED | Hemorrhage, Surgical; Hemorrhage Postoperative; Blood Loss, Surgical; Blood Loss, Postoperative |
CytoSorbents, Inc |
2021-12-27 | |
| NCT04794569 | TERMINATED | Deep Vein Thrombosis; Post Thrombotic Syndrome |
Sunnybrook Health Sciences Centre |
2021-11-15 | PHASE4 |
| NCT03005444 | UNKNOWN | Liver Cirrhosis |
Air Force Military Medical University, China |
2017-06-14 | |
| NCT03522259 | COMPLETED | Bariatric Surgery |
Insel Gruppe AG, University Hospital Bern |
2018-07-19 | PHASE2 |
| NCT05491460 | UNKNOWN | Anticoagulant Therapy |
Doasense GmbH |
2022-07-01 | PHASE1 |
| NCT05744804 | UNKNOWN | Patient With Anterior Myocardial Infarction |
Sohag University |
2023-03-01 | |
| NCT03428373 | UNKNOWN | Multiple Myeloma in Relapse; Multiple Myeloma Progression; Multiple Myeloma Stage II; Multiple Myeloma Stage I; Multiple Myeloma With Failed Remission; Multiple Myeloma Stage III |
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
2019-01-17 | PHASE2; PHASE3 |
| NCT05116995 | UNKNOWN | Thrombosis; Myocardial Infarction |
Nova Scotia Health Authority |
2021-11-01 | PHASE4 |
| NCT06314763 | Completed | Drug Drug Interaction Study |
Radboud University Medical Center|Amgen |
2023-11-09 | Phase 4 |
| NCT03702582 | COMPLETED | Atrial Fibrillation; Stroke; Bleeding |
Massachusetts General Hospital |
2019-04-30 | PHASE3 |
| NCT04142125 | COMPLETED | Ischemic Stroke; Intracranial Atherosclerotic Disease |
Population Health Research Institute |
2020-02-03 | PHASE3 |
| NCT04990791 | COMPLETED | Coronary Syndrome |
Sheffield Teaching Hospitals NHS Foundation Trust |
2021-08-26 | PHASE4 |
| NCT06986369 | COMPLETED | Atherosclerosis, Coronary |
The University of Hong Kong |
2021-05-04 | PHASE4 |
| NCT05750758 | COMPLETED | Acute Coronary Syndrome |
Henan Institute of Cardiovascular Epidemiology |
2023-02-20 | |
| NCT06558045 | COMPLETED | Healthy |
Dexa Medica Group |
2023-07-06 | PHASE1 |
| NCT05723510 | COMPLETED | Healthy |
HK inno.N Corporation |
2023-03-06 | PHASE1 |
| NCT03331484 | COMPLETED | Atrial Fibrillation; Acute Coronary Syndrome |
Ottawa Heart Institute Research Corporation |
2018-11-01 | PHASE3 |
| NCT05233124 | UNKNOWN | Acute Coronary Syndrome; Coronary Artery Ectasia |
Instituto Nacional de Cardiologia Ignacio Chavez |
2021-09-01 | PHASE2 |
| NCT04967573 | UNKNOWN | Venous Thrombosis |
Shanghai Zhongshan Hospital |
2021-08-01 | PHASE3 |
| NCT07077954 | COMPLETED | Deep Vein Thrombosis (DVT) |
Children Hospital and Institute of Child Health, Lahore |
2023-01-20 | PHASE1 |
| NCT06558058 | COMPLETED | Healthy |
Dexa Medica Group |
2023-06-08 | PHASE1 |
| NCT05303818 | UNKNOWN | Deep Venous Thrombosis; Colonic Cancer |
Hospital do Servidor Publico Estadual |
2022-06-01 | PHASE4 |
| NCT05308030 | UNKNOWN | Peripheral Arterial Disease |
Assiut University |
2022-08-01 | EARLY_PHASE1 |
| NCT04273516 | COMPLETED | Stroke; Prevention |
Mazandaran University of Medical Sciences |
2020-08-22 | PHASE2; PHASE3 |
| NCT05546957 | COMPLETED | Healthy Volunteer |
Regeneron Pharmaceuticals |
2023-01-05 | |
| NCT05573958 | UNKNOWN | Acute Coronary Syndrome |
Sarmad Zahoor |
2022-10-01 | PHASE4 |
| NCT05077683 | COMPLETED | Myocardial Infarction, Acute; Left Ventricular Thrombus |
Assistance Publique - Hôpitaux de Paris |
2021-10-10 | PHASE3 |
| NCT05152420 | COMPLETED | Coagulation Disorder |
VarmX B.V. |
2021-10-29 | PHASE1 |
| NCT05705089 | COMPLETED | Left Ventricular Thrombus; ST Segment Elevation Myocardial Infarction |
Rajaie Cardiovascular Medical and Research Center |
2020-07-30 | PHASE3 |
| NCT04073316 | UNKNOWN | Nonvalvular Atrial Fibrillation |
University Hospital, Angers |
2020-02-13 | PHASE4 |
| NCT04002011 | WITHDRAWN | Anticoagulant-induced Bleeding |
Laval University |
2022-03-09 | PHASE2 |
| NCT04324463 | COMPLETED | Coronavirus; Severe Acute Respiratory Syndrome |
Population Health Research Institute |
2020-04-21 | PHASE3 |
| NCT04994223 | UNKNOWN | Combined Anticoagulation and Antithrombotic Therapy; PAD - Peripheral Arterial Disease |
Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi |
2021-07-02 | EARLY_PHASE1 |
| NCT03148457 | COMPLETED | Ischaemic Stroke |
Insel Gruppe AG, University Hospital Bern |
2017-11-06 | |
| NCT03864406 | COMPLETED | Healthy Volunteers |
National Institutes of Health Clinical Center (CC) |
2019-06-04 | PHASE1 |
| NCT04853719 | COMPLETED | Peripheral Artery Disease; Intermittent Claudication |
Science Valley Research Institute |
2021-04-20 | PHASE4 |
| NCT02974920 | UNKNOWN | Aortic Stenosis; Aortic Regurgitation; Thrombosis |
Christian Torp-Pedersen |
2017-01-01 | PHASE4 |
| NCT04970381 | COMPLETED | Ventricular Mural Thrombosis |
China National Center for Cardiovascular Diseases |
2020-09-27 | |
| NCT03178864 | COMPLETED | Cerebral Venous Thrombosis |
University of British Columbia |
2019-03-12 | PHASE2 |
| NCT04767776 | COMPLETED | Healthy |
Centre Hospitalier Universitaire de Saint Etienne |
2022-01-03 | PHASE1 |
| NCT04805710 | UNKNOWN | Rivaroxaban |
Shenyang Northern Hospital |
2021-03-17 | PHASE4 |
| NCT02832544 | COMPLETED | Rheumatic Heart Disease |
Population Health Research Institute |
2016-08-22 | PHASE3 |
| NCT04757857 | TERMINATED | COVID-19 |
Hospital Alemão Oswaldo Cruz |
2020-09-29 | PHASE4 |
| NCT04180436 | COMPLETED | Bariatric Surgery; Morbid Obesity |
University Hospital, Brest |
2020-01-15 | PHASE1 |
| NCT04508023 | TERMINATED | Coronavirus Disease 2019 (COVID-19) |
Janssen Research & Development, LLC |
2020-08-13 | PHASE3 |
| NCT05088928 | UNKNOWN | COVID-19 |
Scotmann Pharmaceuticals |
2022-03-01 | PHASE2 |
| NCT04838808 | COMPLETED | Type II Myocardial Infarction |
University of Alberta |
2021-04-05 | PHASE2; PHASE3 |
| NCT06019741 | COMPLETED | Post Coronary Bypass Surgery Patients |
Shiraz University of Medical Sciences |
2021-02-01 | PHASE4 |
| NCT05210725 | UNKNOWN | Coronary Artery Disease |
Radboud University Medical Center |
2022-03-01 | PHASE4 |
| NCT02832531 | WITHDRAWN | Rheumatic Heart Disease |
Population Health Research Institute |
2022-01 | PHASE3 |
| NCT03764241 | UNKNOWN | ST Segment Elevation Myocardial Infarction; Left Ventricular Thrombus |
RenJi Hospital |
2020-02-01 | PHASE3 |
| NCT03786757 | UNKNOWN | ST Segment Elevation Myocardial Infarction; Left Ventricular Thrombus |
RenJi Hospital |
2019-04-01 | PHASE3 |
| NCT04309240 | UNKNOWN | Rivaroxaban; Thromboprophylaxis; Cancer |
LiuZhou People's Hospital |
2020-03-08 | PHASE3 |
| NCT04689919 | COMPLETED | Bioequivalence |
University of Karachi |
2022-02-19 | PHASE1 |
| NCT05515120 | COMPLETED | Venous Thromboembolism; Anticoagulant-induced Bleeding; Venous Thromboses; Pulmonary Embolism |
Instituto Mexicano del Seguro Social |
2021-01-03 | PHASE2; PHASE3 |
| NCT05300555 | UNKNOWN | Atrial Fibrillation New Onset |
University of Sao Paulo General Hospital |
2021-01-05 | PHASE4 |
| NCT03792152 | UNKNOWN | Atrial Fibrillation; Left Atrial Appendage Thrombosis; Rivaroxaban |
The Second Affiliated Hospital of Chongqing Medical University |
2019-06-01 | |
| NCT05128591 | COMPLETED | Embolism and Thrombosis |
Addpharma Inc. |
2021-11-09 | PHASE1 |
| NCT04218656 | COMPLETED | Peripheral Artery Disease |
Radboud University Medical Center |
2020-06-08 | PHASE4 |
| NCT04351724 | UNKNOWN | COVID-19 |
Medical University of Vienna |
2020-04-16 | PHASE2; PHASE3 |
| NCT03775746 | UNKNOWN | Acute Coronary Syndrome |
East and North Hertfordshire NHS Trust |
2019-01-08 | PHASE4 |
| NCT04333407 | TERMINATED | COVID-19 |
Imperial College London |
2020-04-03 | |
| NCT03363035 | COMPLETED | Acute Coronary Syndrome; Myocardial Infarction; Myocardial Ischemia; Unstable Angina |
Second Xiangya Hospital of Central South University |
2018-01-15 | PHASE4 |
| NCT03139487 | UNKNOWN | Cancer-associated Thrombosis; Esophageal Cancer; Stomach Cancer; Hepatocellular Carcinoma; Pancreatic Cancer; Duodenal Cancer; Esophagogastric Junction Cancer; Malignant Gastrointestinal Stromal Tumor; Ampulla of Vater Cancer; Biliary Cancer (Cholangiocarcinoma, Gall Bladder Cancer) |
Asan Medical Center |
2017-08-07 | PHASE2 |
| NCT04256525 | UNKNOWN | Venous Thrombosis Due to Central Venous Access Device (Disorder); Prophylactic Anticoagulation; Patients With Tumor |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2020-05-01 | PHASE4 |
| NCT04416048 | TERMINATED | COVID-19 |
Charite University, Berlin, Germany |
2020-11-30 | PHASE2 |
| NCT04662684 | COMPLETED | Covid19; Venous Thromboembolism |
Science Valley Research Institute |
2020-10-16 | PHASE3 |
| NCT03055026 | COMPLETED | Prevention of Venous Thromboembolism |
Fadoi Foundation, Italy |
2017-05-03 | PHASE3 |
| NCT04640181 | COMPLETED | Covid19 |
St. David's HealthCare |
2020-12-01 | PHASE2 |
| NCT04715295 | UNKNOWN | COVID-19 |
Yaounde Central Hospital |
2020-10-05 | PHASE4 |
| NCT03926156 | TERMINATED | Mitral Stenosis; Rheumatic Heart Disease; Atrial Fibrillation; Anticoagulant Adverse Reaction |
Rajaie Cardiovascular Medical and Research Center |
2019-05-22 | PHASE3 |
| NCT04397289 | COMPLETED | Liver Cirrhosis; Portal Hypertension; Anticoagulant-induced Bleeding; Thrombosis |
First Affiliated Hospital Xi'an Jiaotong University |
2018-02-12 | PHASE1; PHASE2 |
| NCT04394377 | COMPLETED | Coronavirus Infection |
Brazilian Clinical Research Institute |
2020-06-21 | PHASE4 |
| NCT04504032 | TERMINATED | COVID-19 |
Gates Medical Research Institute |
2020-09-02 | PHASE2 |
| NCT04753489 | UNKNOWN | Bioequivalence |
Pharmtechnology LLC |
2021-02-13 | PHASE1 |
| NCT04059679 | UNKNOWN | Coronary Artery Disease; Peripheral Artery Disease |
LifeBridge Health |
2020-01-30 | PHASE4 |
| NCT04729998 | UNKNOWN | Bioequivalence |
Pharmtechnology LLC |
2021-01-30 | PHASE1 |
| NCT04192552 | UNKNOWN | Atrial Fibrillation |
McMaster University |
2020-01-09 | |
| NCT04169269 | UNKNOWN | Deep Vein Thrombosis; Venous Thromboembolism |
Florida Orthopaedic Institute |
2020-01-13 | PHASE4 |
| NCT03181386 | COMPLETED | Atrial Fibrillation; Periodontal Disease; Hemorrhage |
University of Sao Paulo General Hospital |
2017-05-03 | PHASE3 |
| NCT07699796 | COMPLETED | Venous Thrombosis Deep (Limbs); Venous Insufficiency (Chronic)(Peripheral); Varicose Veins Leg; Venous Thrombosis |
Heart, Artery, and Vein Center of Fresno |
2018-03-06 | PHASE4 |
| NCT02744092 | COMPLETED | Cancer; Venous Thromboembolism; Deep Vein Thrombosis (DVT); Pulmonary Embolism (PE); Blood Clot |
Alliance Foundation Trials, LLC. |
2016-12-13 | |
| NCT04023630 | UNKNOWN | Atrial Fibrillation; Acute Coronary Syndromes |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2019-10-01 | PHASE4 |
| NCT03799822 | COMPLETED | Atrial Fibrillation |
Onze Lieve Vrouw Hospital |
2017-05-01 | PHASE4 |
| NCT02303795 | COMPLETED | Valvular Heart Disease |
Hospital do Coracao |
2015-08 | PHASE2 |
| NCT02846532 | COMPLETED | Thrombosis |
Janssen Research & Development, LLC |
2016-11-16 | PHASE3 |
| NCT03193502 | UNKNOWN | Portal Vein Thrombosis |
Sherief Abd-Elsalam |
2014-05-01 | PHASE3 |
| NCT03506815 | COMPLETED | Upper Extremity Deep Vein Thrombosis; Central Venous Catheter Thrombosis; Cancer |
Ottawa Hospital Research Institute |
2019-03-15 | PHASE3 |
| NCT03926780 | COMPLETED | Anticoagulants; Increased; Left Ventricular Thrombosis |
The Young Investigator Group of Cardiovascular Research |
2018-12-01 | PHASE3 |
| NCT03566303 | TERMINATED | Prostheses and Implants; Stroke; Valve Heart Disease; Anticoagulants and Bleeding Disorders |
Hospital Geral Roberto Santos |
2018-07-10 | PHASE2; PHASE3 |
| NCT04569279 | COMPLETED | Cerebral Vein Thrombosis |
Damascus University |
2017-09-01 | PHASE3 |
| NCT02066662 | COMPLETED | Atrial Fibrillation or Pulmonary Embolism; Need of Long Term Oral Anticoagulation Therapy (OAT); Existent Coronary or Valvular Calcification, or Both and Agatston Score > 50 in at Least One Location |
RWTH Aachen University |
2013-07 | PHASE4 |
| NCT03718429 | COMPLETED | Coronary Artery Disease; Peripheral Arterial Disease; Atrial Fibrillation |
University of Florida |
2019-01-14 | PHASE4 |
| NCT02829957 | COMPLETED | Venous Thromboembolism; Menstruation |
Indiana University |
2016-09 | PHASE2; PHASE3 |
| NCT03747081 | UNKNOWN | Cerebral Venous Thrombosis |
Isfahan University of Medical Sciences |
2018-09-01 | PHASE1; PHASE2 |
| NCT03605433 | UNKNOWN | Coronary Artery Disease; Saphenous Vein Graft Patency |
Unidade Local de Saúde de Coimbra, EPE |
2018-12-01 | PHASE3 |
| NCT02643212 | UNKNOWN | Cirrhosis |
David Garcia Cinca |
2016-05 | PHASE3 |
| NCT02504216 | COMPLETED | Peripheral Artery Disease |
Bayer |
2015-08-18 | PHASE3 |
| NCT03172910 | COMPLETED | Healthy |
Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. |
2017-05-08 | PHASE2 |
| NCT04424381 | COMPLETED | Healthy Subjects |
The Affiliated Hospital of Qingdao University |
2019-06-04 | PHASE1 |
| NCT03490994 | UNKNOWN | Acute Heart Failure |
Yonsei University |
2018-04-10 | PHASE4 |
| NCT03310021 | COMPLETED | Bleeding |
Portola Pharmaceuticals |
2017-08-28 | PHASE2 |
| NCT03277001 | UNKNOWN | Acute Exacerbation Copd; Venous Thromboembolism |
Huashan Hospital |
2017-10-01 | |
| NCT03413618 | COMPLETED | Deep Vein Thrombosis; Postthrombotic Syndrome |
Pirogov Russian National Research Medical University |
2017-12-20 | PHASE4 |
| NCT02583191 | TERMINATED | Venous Thromboembolism; Cancer |
AIO-Studien-gGmbH |
2016-03-23 | PHASE3 |
| NCT02627053 | UNKNOWN | Portal Vein Thrombosis; Mesenteric Vein Thrombosis; Splenic Vein Thrombosis |
Università degli Studi dell'Insubria |
2015-12 | PHASE3 |
| NCT02722447 | UNKNOWN | Deep Vein Thrombosis |
Walter Ageno |
2017-01 | PHASE3 |
| NCT03196349 | TERMINATED | Venous Thromboembolism |
Duke University |
2018-08-01 | PHASE4 |
| NCT03796377 | COMPLETED | Drug Interaction Study |
Insel Gruppe AG, University Hospital Bern |
2019-02-13 | PHASE1 |
| NCT02935855 | COMPLETED | Diabetes |
University of Pavia |
2015-09 | PHASE4 |
| NCT04511611 | COMPLETED | Clinical Pharmacology |
Bayer |
2019-01-24 | PHASE1 |
| NCT04511637 | COMPLETED | Clinical Pharmacology |
Bayer |
2019-01-21 | PHASE1 |
| NCT02234843 | COMPLETED | Venous Thromboembolism |
Bayer |
2014-11-13 | PHASE3 |
| NCT02610933 | COMPLETED | Vascular Calcification |
Onze Lieve Vrouw Hospital |
2015-11 | PHASE4 |
| NCT02164578 | COMPLETED | Type 2 Diabetic Patients |
GWT-TUD GmbH |
2015-04 | PHASE3 |
| NCT02970773 | WITHDRAWN | Spinal Cord Injuries; Thromboembolism |
Swiss Paraplegic Research, Nottwil |
2017-12-04 | PHASE4 |
| NCT02123524 | COMPLETED | Symptomatic Superficial Vein Thrombosis |
McMaster University |
2014-11-11 | PHASE3 |
| NCT02704598 | UNKNOWN | Deep Venous Thrombosis |
Hospital do Servidor Publico Estadual |
2016-03 | |
| NCT02833948 | COMPLETED | Aortic Valve Stenosis; Cardiovascular Diseases; Heart Valve Diseases; Ventricular Outflow Obstruction; Thrombosis |
ECRI bv |
2016-05 | PHASE3 |
| NCT02666157 | UNKNOWN | Atrial Fibrillation |
National Cheng-Kung University Hospital |
2016-01 | PHASE4 |
| NCT02024230 | COMPLETED | Coronary Artery Disease; Atrial Fibrillation; Stroke; Fetal Blood Loss; Major Bleeding; All Cause Mortality |
Fujita Health University |
2014-01 | PHASE4 |
| NCT02486445 | COMPLETED | Deep Venous Thrombosis |
Ostfold Hospital Trust |
2015-03 | PHASE3 |
| NCT02556203 | TERMINATED | Transcatheter Aortic Valve Replacement |
Bayer |
2015-12-16 | PHASE3 |
| NCT03273322 | COMPLETED | Atrial Fibrillation; Atrial Appendage; Hemorrhage |
Assistance Publique - Hôpitaux de Paris |
2017-09-13 | PHASE2; PHASE3 |
| NCT02072668 | COMPLETED | Sickle Cell Anemia; Sickle Cell-Beta0-Thalassemia |
University of North Carolina, Chapel Hill |
2014-02 | PHASE2 |
| NCT03328832 | COMPLETED | Osteoarthritis, Knee |
Chang Gung Memorial Hospital |
2017-09-12 | PHASE4 |
| NCT02555878 | COMPLETED | Neoplasms |
Janssen Research & Development, LLC |
2015-09-11 | PHASE3 |
| NCT03282643 | COMPLETED | Neoplasms |
Capital Medical University |
2016-02-16 | PHASE1; PHASE2 |
| NCT02497716 | COMPLETED | Thrombosis |
Bayer |
2015-11-04 | PHASE1 |
| NCT02723981 | WITHDRAWN | Stable Angina; Unstable Angina; STEMI; NSTEMI; Coronary Disease |
IHF GmbH - Institut für Herzinfarktforschung |
2016-04 | PHASE4 |
| NCT02746185 | COMPLETED | Neoplasm; Venous Thromboembolism |
Assistance Publique - Hôpitaux de Paris |
2016-09 | PHASE3 |
| NCT01877915 | COMPLETED | Heart Failure; Coronary Artery Disease |
Janssen Research & Development, LLC |
2013-09-10 | PHASE3 |
| NCT02401594 | TERMINATED | Non-major Orthopaedic Surgery |
Centre Hospitalier Universitaire de Saint Etienne |
2015-12-08 | PHASE3 |
| NCT02376010 | COMPLETED | Atherosclerosis |
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center |
2015-04-02 | PHASE4 |
| NCT02996435 | COMPLETED | Atrial Fibrillation |
Janssen Scientific Affairs, LLC |
2016-12-21 | PHASE4 |
| NCT02111564 | COMPLETED | Heart Failure; Respiratory Insufficiency; Stroke Acute; Infectious Diseases; Rheumatic Diseases |
Janssen Research & Development, LLC |
2014-01-07 | PHASE3 |
| NCT02313909 | TERMINATED | Stroke |
Bayer |
2014-12-23 | PHASE3 |
| NCT03299296 | UNKNOWN | Thromboses, Deep Vein; Surgery--Complications |
Ahmed AbdelMoneim Hassan Ali |
2017-01-01 | PHASE3 |
| NCT02157272 | TERMINATED | Antiphospholipid Syndrome |
University of Padova |
2014-12 | PHASE3 |
| NCT02926170 | COMPLETED | Antiphospholipid Syndrome |
Hospital Universitari Vall d'Hebron Research Institute |
2013-03-13 | PHASE3 |
| NCT02564718 | COMPLETED | Thromboembolism |
Bayer |
2015-11-19 | PHASE1; PHASE2 |
| NCT02642419 | UNKNOWN | Atrial Fibrillation |
Japan Cardiovascular Research Foundation |
2015-01 | PHASE4 |
| NCT02559856 | COMPLETED | Venous Thromboembolism |
Ottawa Hospital Research Institute |
2016-05 | PHASE4 |
| NCT03673605 | WITHDRAWN | Mitral Valve Stenosis; Atrial Fibrillation |
PharmEvo Pvt Ltd |
2016-12-30 | PHASE4 |
| NCT01675076 | COMPLETED | Hematoma |
Ottawa Heart Institute Research Corporation |
2013-01 | PHASE3 |
| NCT02549963 | UNKNOWN | Atrial Fibrillation; Stroke |
Shulin Wu |
2015-10 | PHASE4 |
| NCT02116036 | COMPLETED | Antiphospholipid Antibody Syndrome |
St. Joseph's Healthcare Hamilton |
2014-09 | PHASE4 |
| NCT03083704 | COMPLETED | Bleeding |
Portola Pharmaceuticals |
2017-02-26 | PHASE1 |
| NCT04727021 | COMPLETED | Healthy Volunteers |
Bayer |
2017-07-04 | PHASE1 |
| NCT02128841 | TERMINATED | Aortic Valve Disease; Heart Valve Prosthesis Implantation; Anticoagulants |
Insel Gruppe AG, University Hospital Bern |
2012-09 | PHASE2 |
| NCT02403596 | COMPLETED | Blood Loss After a Total Hip Replacement |
University Hospital, Brest |
2015-10-20 | PHASE3 |
| NCT04720092 | COMPLETED | Thromboembolic Disorders |
Bayer |
2017-07-05 | PHASE1 |
| NCT01776424 | COMPLETED | Prevention & Control |
Bayer |
2013-02-28 | PHASE3 |
| NCT02260622 | COMPLETED | Critical Limb Ischemia |
Ottawa Hospital Research Institute |
2014-10 | PHASE2 |
| NCT02309411 | COMPLETED | Venous Thromboembolism |
Bayer |
2015-01-15 | PHASE2 |
| NCT02584660 | COMPLETED | Pulmonary Embolism |
Janssen Scientific Affairs, LLC |
2015-10-15 | PHASE4 |
| NCT02161965 | COMPLETED | Permanent Atrial Fibrillation; Venous Thrombosis; Pulmonary Embolism; Anticoagulation Treatment at Least > or = to 12-month |
University Hospital, Angers |
2013-05-21 | PHASE4 |
| NCT00562289 | COMPLETED | Ischemic Stroke; Patent Foramen Ovale; Atrial Septal Aneurysm; Migraine |
Assistance Publique - Hôpitaux de Paris |
2007-12 | PHASE3 |
| NCT01989845 | COMPLETED | Rivaroxaban; Cancer-associated Thrombosis; Recurrence; Bleeding |
Seoul National University Hospital |
2013-10 | PHASE4 |
| NCT02293395 | COMPLETED | Acute Coronary Syndrome |
Janssen Research & Development, LLC |
2015-04-20 | PHASE2 |
| NCT02064439 | COMPLETED | Pulmonary Embolism; Thromboembolism; Thrombosis; Venous Thrombosis; Venous Thromboembolism |
Bayer |
2014-03-05 | PHASE3 |
| NCT01684423 | COMPLETED | Venous Thrombosis |
Bayer |
2013-02-19 | PHASE2 |
| NCT03201367 | COMPLETED | Portal Vein Thrombosis |
Zagazig University |
2014-05-01 | |
| NCT01830543 | COMPLETED | Atrial Fibrillation; Percutaneous Coronary Intervention |
Janssen Scientific Affairs, LLC |
2013-05-10 | PHASE3 |
| NCT01720108 | COMPLETED | Venous Thromboembolism |
David Anderson |
2013-02-24 | PHASE3 |
| NCT02506985 | TERMINATED | Pulmonary Embolism; Venous Thrombosis |
Susan Smyth |
2015-07 | PHASE4 |
| NCT02561923 | COMPLETED | Healthy |
Janssen Scientific Affairs, LLC |
2015-08-27 | PHASE1 |
| NCT02832947 | COMPLETED | Prophylaxis of Venous Thromboembolism |
Insel Gruppe AG, University Hospital Bern |
2016-02 | PHASE1 |
| NCT02453802 | UNKNOWN | Osteoarthritis, Knee |
Chang Gung Memorial Hospital |
2015-06 | PHASE4 |
| NCT01499953 | COMPLETED | Superficial Vein Thrombosis |
GWT-TUD GmbH |
2012-04 | PHASE3 |
| NCT01708850 | COMPLETED | Neoplasm; Central Venous Catheter Thrombosis |
London Health Sciences Centre |
2012-11 | PHASE4 |
| NCT02054936 | WITHDRAWN | Complications; Arthroplasty |
University of Michigan |
2014-03 | PHASE4 |
| NCT02334254 | UNKNOWN | Atrial Fibrillation |
Beijing Anzhen Hospital |
2013-08 | PHASE4 |
| NCT02271399 | COMPLETED | Venous Thromboembolism |
Hanyang University Seoul Hospital |
2014-10 | PHASE2 |
| NCT02042534 | COMPLETED | Ischemic Stroke; Transient Ischemic Attack |
Asan Medical Center |
2014-01 | PHASE2 |
| NCT02058199 | TERMINATED | Gastric Bypass Status |
State University of New York - Upstate Medical University |
2014-12 | PHASE1 |
| NCT02438098 | COMPLETED | Prophylaxis of Venous Thromboembolism |
Insel Gruppe AG, University Hospital Bern |
2015-06 | PHASE1 |
| NCT02331602 | UNKNOWN | Atrial Fibrillation |
Yokohama City University Medical Center |
2013-07 | PHASE4 |
| NCT02539953 | WITHDRAWN | Hypotension |
King's College Hospital NHS Trust |
2015-04 | |
| NCT01923818 | UNKNOWN | Ischemic Stroke; TIA |
Xijing Hospital |
2013-09 | PHASE2; PHASE3 |
| NCT03578146 | COMPLETED | Healthy Volunteers |
Portola Pharmaceuticals |
2012-12 | PHASE2 |
| NCT02220725 | COMPLETED | Bleeding |
Portola Pharmaceuticals |
2014-05 | PHASE3 |
| NCT01145859 | COMPLETED | Venous Thrombosis; Pediatrics |
Bayer |
2010-11 | PHASE1 |
| NCT01598168 | TERMINATED | Heparin-induced Thrombocytopenia |
McMaster University |
2013-01 | PHASE3 |
| NCT02367027 | COMPLETED | Pharmacokinetics |
Bayer |
2015-02 | PHASE1 |
| NCT02289703 | COMPLETED | End-Stage Renal Disease |
Janssen Research & Development, LLC |
2015-01 | PHASE1 |
| NCT03071380 | COMPLETED | Healthy |
Genuine Research Center, Egypt |
2015-02 | PHASE1 |
| NCT01986192 | UNKNOWN | Ileofemoral Deep Vein Thrombosis |
Seoul National University Hospital |
2013-11 | |
| NCT01839357 | COMPLETED | Atrial Fibrillation |
Bayer |
2013-08 | PHASE3 |
| NCT01729871 | COMPLETED | Atrial Fibrillation |
Janssen Scientific Affairs, LLC |
2013-02 | PHASE3 |
| NCT01431456 | COMPLETED | Venous Thromboembolism |
Martini Hospital Groningen |
2013-09 | PHASE3 |
| NCT01747746 | COMPLETED | Atrial Fibrillation; Stroke; Thrombo-embolism; Bleeding |
Cook County Health |
2012-10 | PHASE4 |
| NCT02458729 | COMPLETED | Osteoarthritis, Knee |
Chang Gung Memorial Hospital |
2012-08 | PHASE4 |
| NCT01627665 | COMPLETED | Healthy Volunteers |
Assistance Publique - Hôpitaux de Paris |
2011-10 | PHASE2; PHASE3 |
| NCT02085824 | UNKNOWN | Hip Osteoarthritis; Blood Loss |
Centre of Postgraduate Medical Education |
2012-07 | |
| NCT02537405 | COMPLETED | Embolism, Atrial Fibrillation and Venous Thrombosis |
Bayer |
2014-02 | PHASE1 |
| NCT01629381 | COMPLETED | Venous Thromboembolism; Haemorrhage |
University of Padova |
2012-05 | PHASE2 |
| NCT01954238 | COMPLETED | Healthy Volunteers |
Green Cross Corporation |
2013-08 | PHASE1 |
| NCT02537457 | COMPLETED | Embolism, Atrial Fibrillation and Venous Thrombosis |
Bayer |
2014-01 | PHASE1 |
| NCT01674647 | COMPLETED | Atrial Fibrillation |
Bayer |
2012-10 | PHASE3 |
| NCT01516840 | COMPLETED | Deep Vein Thrombosis |
Bayer |
2012-03 | PHASE3 |
| NCT01516814 | COMPLETED | Pulmonary Embolism |
Bayer |
2012-02 | PHASE3 |
| NCT01853800 | COMPLETED | Biological Availability |
Bayer |
2013-05 | PHASE1 |
| NCT01812200 | COMPLETED | Atrial Fibrillation; Acute Coronary Syndrome |
Medical University of Vienna |
2012-10 | PHASE4 |
| NCT01442792 | COMPLETED | Cardiovascular Disease; Coronary Artery Disease |
Bayer |
2011-10-12 | PHASE2 |
| NCT02379663 | COMPLETED | Osteoarthritis, Hip; Femur Head Necrosis; Femoral Neck Fractures |
Samsung Medical Center |
2012-01 | PHASE4 |
| NCT01478282 | UNKNOWN | Thrombosis; Anticoagulant-induced Bleeding; Anticoagulant Overdosage; Hemorrhage |
Gines Escolar |
2012-01 | PHASE4 |
| NCT01656330 | COMPLETED | Healthy |
Janssen Research & Development, LLC |
2012-07 | PHASE1 |
| NCT01400646 | COMPLETED | Healthy |
Janssen Research & Development, LLC |
2011-10 | PHASE1 |
| NCT01309438 | COMPLETED | Healthy; Renal Insufficiency |
Janssen Research & Development, LLC |
2011-02 | PHASE1 |
| NCT01344954 | COMPLETED | Prophylaxis of Venous Thromboembolic Events |
ThromboGenics |
2011-04 | PHASE2 |
| NCT01379300 | COMPLETED | Thrombosis |
Merck Sharp & Dohme LLC |
2011-05 | PHASE1 |
| NCT01464450 | COMPLETED | Pharmacokinetics; Bioavailability; Healthy Participants |
Janssen Scientific Affairs, LLC |
2011-10 | PHASE1 |
| NCT00809965 | COMPLETED | Acute Coronary Syndrome; Myocardial Infarction; Myocardial Ischemia; Unstable Angina |
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. |
2008-11 | PHASE3 |
| NCT00439777 | COMPLETED | Pulmonary Embolism |
Bayer |
2007-03 | PHASE3 |
| NCT01205932 | COMPLETED | Venous Thromboembolism |
Bayer |
2010-09 | PHASE3 |
| NCT00786422 | COMPLETED | Venous Thrombosis; Deep Vein Thrombosis |
Bayer |
2009-05 | PHASE2 |
| NCT01206972 | COMPLETED | Venous Thromboembolism |
Bayer |
2010-10 | PHASE3 |
| NCT01210755 | COMPLETED | Venous Thromboembolism |
University Hospital, Grenoble |
2010-11 | PHASE4 |
| NCT01094886 | COMPLETED | Arthritis; Osteoarthritis, Knee; Osteoarthritis, Hip; Thromboembolism |
Ortho-McNeil Janssen Scientific Affairs, LLC |
2010-03 | PHASE3 |
| NCT00403767 | COMPLETED | Atrial Fibrillation; Stroke; Embolism |
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. |
2006-12 | PHASE3 |
| NCT00571649 | COMPLETED | Venous Thromboembolism |
Bayer |
2007-12 | PHASE3 |
| NCT00440193 | COMPLETED | Venous Thrombosis |
Bayer |
2007-03 | PHASE3 |
| NCT00494871 | COMPLETED | Atrial Fibrillation |
Bayer |
2007-06 | PHASE3 |
| NCT01507051 | COMPLETED | Venous Thrombosis |
Bayer |
2008-11 | PHASE1 |
| NCT01436526 | COMPLETED | Therapeutic Equivalency |
Bayer |
2009-08 | PHASE1 |
| NCT00402597 | COMPLETED | Acute Coronary Syndrome |
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. |
2006-11 | PHASE2 |
| NCT00332020 | COMPLETED | Prevention; Venous Thromboembolism |
Bayer |
2006-02 | PHASE3 |
| NCT00329628 | COMPLETED | Venous Thromboembolism |
Bayer |
2006-02 | PHASE3 |
| NCT00362232 | COMPLETED | Venous Thromboembolism |
Bayer |
2006-06 | PHASE3 |
| NCT00361894 | COMPLETED | Prevention; Venous Thromboembolism |
Bayer |
2006-02 | PHASE3 |
| NCT00839163 | COMPLETED | Venous Thrombosis; Deep Vein Thrombosis |
Bayer |
2004-03 | PHASE2 |
| NCT00396786 | COMPLETED | Venous Thromboembolism |
Bayer |
2004-11 | PHASE2 |
| NCT00779064 | COMPLETED | Atrial Fibrillation |
Bayer |
2004-07 | PHASE2 |
| NCT00402467 | COMPLETED | Venous Thromboembolism |
Bayer |
2004-02 | PHASE2 |
| NCT00839826 | COMPLETED | Thromboembolism; Prevention |
Bayer |
2002-12 | PHASE2 |
| NCT00973323 | COMPLETED | Atrial Fibrillation |
Bayer |
2005-09 | PHASE2 |
| NCT00973245 | COMPLETED | Atrial Fibrillation |
Bayer |
2006-07 | PHASE2 |
| NCT00398905 | COMPLETED | Venous Thromboembolism |
Bayer |
2004-01 | PHASE2 |
| NCT00395772 | COMPLETED | Venous Thromboembolism |
Bayer |
2004-12 | PHASE2 |
(data from https://clinicaltrials.gov, updated on 2026-06-22)
Check the
Rivaroxaban
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
Note: Technical data last updated: Sep 1, 2026.