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Resveratrol (trans-Resveratrol) is a potent, biphasic allosteric SIRT1 and AMPK activator. It affects NF-κB, PI3K/Akt/mTOR, and Nrf2 signaling pathways by deacetylating key proteins and enhancing mitochondrial biogenesis, thereby inhibiting inflammation and tumor growth while promoting autophagy.