Clinical Trials

Numerous clinical trials evaluate quercetin across conditions including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, coronary artery disease, and COVID-19. Spanning Early Phase 1 through Phase 4, these studies encompass recruiting, active not recruiting, completed, and withdrawn statuses under academic, medical center, government, and industry sponsorship. Research investigating inflammatory markers and senolytic interventions underscores quercetin's clinical utility in respiratory and neurodegenerative disorders.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06940297 RECRUITING
Recurrent Multiple Myeloma; Refractory Multiple Myeloma
Mayo Clinic
 2025-09-18 PHASE2
NCT06683534 NOT_YET_RECRUITING
Microvascular Dysfunction; Microvasculature; Cardiovascular Diseases; Cardiovascular Diseases (CVD); Microvascular Health; Obesity and Overweight
Medical College of Wisconsin
 2026-07 PHASE2
NCT07433621 RECRUITING
XIAP Deficiency
Children's Hospital Medical Center, Cincinnati
 2026-02-26 PHASE1
NCT07628972 RECRUITING
Dyskeratosis Congenita; Telomere Disease
Children's Hospital Medical Center, Cincinnati
 2026-05-29 PHASE1
NCT07760506 NOT_YET_RECRUITING
Healthy Aging; Inflammaging; Metabolic Health; Quercetin; Coenzyme Q10
Applied Science & Performance Institute
 2026-08
NCT06615752 RECRUITING
Metastatic Castration-resistant Prostate Cancer (mCRPC)
Charles Drew University of Medicine and Science
 2026-10 PHASE1; PHASE2
NCT07466420 RECRUITING
Fibrotic Interstitial Lungs Diseases; Idiopathic Pulmonary Fibrosis (IPF); Progressive Pulmonary Fibrosis
Katerina M. Antoniou
 2026-01-26
NCT04685590 ACTIVE_NOT_RECRUITING
Alzheimer Disease, Early Onset; Mild Cognitive Impairment
Washington University School of Medicine
 2021-12-22 PHASE2
NCT05838560 ACTIVE_NOT_RECRUITING
Schizophrenia; Treatment Resistant Depression; Aging, Premature
Washington University School of Medicine
 2023-07-01 PHASE2
NCT07025226 RECRUITING
Glioma
Mayo Clinic
 2025-08-12 EARLY_PHASE1
NCT06470061 NOT_YET_RECRUITING
Alzheimer Disease; Mild Cognitive Impairment; Cognitive Decline
Zaparackas and Knepper LTD
 2024-07 PHASE2
NCT02848131 ENROLLING_BY_INVITATION
Chronic Kidney Disease
Mayo Clinic
 2016-07 PHASE2
NCT05653258 RECRUITING
Obesity; Healthy Lifestyle
Cedars-Sinai Medical Center
 2023-10-17 PHASE2; PHASE3
NCT07270120 NOT_YET_RECRUITING
Multiple Sclerosis (MS) Secondary Progressive
Ohio State University
 2026-01-15 PHASE1
NCT04733534 ACTIVE_NOT_RECRUITING
Frailty; Childhood Cancer
St. Jude Children's Research Hospital
 2022-06-06 PHASE2
NCT04785300 ACTIVE_NOT_RECRUITING
Mild Cognitive Impairment; Alzheimer Disease
Mayo Clinic
 2022-07-06 PHASE1; PHASE2
NCT07144293 ACTIVE_NOT_RECRUITING
HIV; Frailty; Prefrail; Aging Problems
National Institute of Allergy and Infectious Diseases (NIAID)
 2025-12-04 PHASE2
NCT06230861 RECRUITING
Cardiometabolic Syndrome
University of Central Lancashire
 2024-03-01
NCT07182526 RECRUITING
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Al-Mustansiriyah University
 2025-09-20 PHASE2
NCT07000734 COMPLETED
Aging; Cognitive Decline; Older Adults; Cardiovascular; Sedentary Behaviors; Immune Senescence; Motor Function
Washington University School of Medicine
 2025-07-28 PHASE2
NCT06018467 ACTIVE_NOT_RECRUITING
Osteopenia, Osteoporosis; Age-related Bone Loss
Odense University Hospital
 2023-09-06 PHASE2
NCT07487623 RECRUITING
Liver Disease Chronic; HEPATITIS C VIRUS CHRONIC INFECTION
University of Guadalajara
 2025-10-11
NCT05506488 COMPLETED
NAFLD; NASH With Fibrosis; Liver Fibrosis
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2023-07-05 PHASE1; PHASE2
NCT06974058 COMPLETED
Long COVID
Liaquat University of Medical & Health Sciences
 2025-07-22
NCT07380178 COMPLETED
Rhinitis, Allergic, Perennial
Universitas Sebelas Maret
 2025-04-01
NCT03476330 COMPLETED
Fanconi Anemia; Squamous Cell Carcinoma
Children's Hospital Medical Center, Cincinnati
 2018-05-08 PHASE2
NCT06003270 UNKNOWN
Chronic Obstructive Pulmonary Disease; Emphysema; Chronic Bronchitis With Airway Obstruction
Temple University
 2023-11-01 PHASE2
NCT06982248 ACTIVE_NOT_RECRUITING
Periodontal Pocket
Mansoura University
 2024-08-15 PHASE2
NCT06650891 COMPLETED
Post Operative Pain; Cesarean Section Complications
Future University in Egypt
 2024-10-30 PHASE3
NCT06355037 UNKNOWN
Triple-negative Breast Cancer
Fudan University
 2024-05-20 PHASE2
NCT05062486 COMPLETED
Age-related Macular Degeneration
Paul A Knepper, MD PhD
 2021-10-04 PHASE2
NCT05276895 SUSPENDED
Osteoarthritis
Assiut University
 2022-07-01
NCT06775392 COMPLETED
Periodontal Pocket
Krishnadevaraya College of Dental Sciences & Hospital
 2024-01-04 PHASE1
NCT03989271 UNKNOWN
Chronic Obstructive Pulmonary Disease
Temple University
 2019-10-01 PHASE1; PHASE2
NCT05928546 UNKNOWN
Inflammation Gum
Assiut University
 2024-02-20 PHASE1
NCT06591767 COMPLETED
Hyperuricemia
Liaquat University of Medical & Health Sciences
 2023-10-01
NCT05724329 ACTIVE_NOT_RECRUITING
Head and Neck Squamous Cell Carcinomas
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2023-02-05 PHASE2
NCT06659016 COMPLETED
Urinary Tract Infection (Diagnosis)
University of Campania Luigi Vanvitelli
 2023-02-01 PHASE4
NCT05422885 COMPLETED
Aging
Lewis Lipsitz
 2022-05-20 PHASE1; PHASE2
NCT05601180 COMPLETED
Asthma; Chronic Obstructive Pulmonary Disease; Long COVID
Beker Laboratories
 2022-10-27
NCT05983224 UNKNOWN
Endometriosis
National Nutrition and Food Technology Institute
 2023-08-15
NCT05680662 UNKNOWN
Breast Cancer Female; Triple Negative Breast Cancer
Ministry of Health, Saudi Arabia
 2023-01-01 EARLY_PHASE1
NCT04252625 TERMINATED
Prostate Adenocarcinoma
University of Utah
 2022-11-14 PHASE2
NCT05877235 COMPLETED
Coronary Artery Disease; Menopause
InCor Heart Institute
 2021-10-03
NCT04907253 COMPLETED
Coronary Artery Disease
Montreal Heart Institute
 2021-06-04 PHASE2
NCT04994561 WITHDRAWN
Aging
Vitality in Aging Research Group, Inc.
 2022-06 PHASE1
NCT05456022 UNKNOWN
Oral Cancer
Cairo University
 2022-07 PHASE2
NCT04258410 WITHDRAWN
Menopause Related Conditions
Wake Forest University Health Sciences
 2022-09 PHASE4
NCT04622865 UNKNOWN
SARS-CoV 2; COVID-19; Coronavirus Disease 2019
AB Science
 2020-06-01 PHASE2
NCT06003270 Recruiting
Chronic Obstructive Pulmonary Disease|Emphysema|Chronic Bronchitis With Airway Obstruction
Temple University|National Center for Complementary and Integrative Health (NCCIH)|Quercegen Pharmaceuticals
 2023-11-01 Phase 2
NCT04313634 COMPLETED
Healthy
Sundeep Khosla, M.D.
 2020-06-09 PHASE2
NCT02652052 COMPLETED
Stem Cell Transplant
Mayo Clinic
 2016-03-01 PHASE1
NCT05730660 COMPLETED
Chronic Fatigue Symptoms; Sleep; Physical Performance; Body Composition
Azienda di Servizi alla Persona di Pavia
 2022-09-01
NCT04536090 WITHDRAWN
COVID-19
Institut de Recherches Cliniques de Montreal
 2022-01 PHASE2
NCT05297032 TERMINATED
Quercetin; Lipid Metabolism; Aging
Thorne HealthTech, Inc
 2022-03-24
NCT05611827 COMPLETED
Pharmacokinetics
Factors Group of Nutritional Companies Inc.
 2022-01-31
NCT04514510 COMPLETED
Sickle Cell Disease
National Heart, Lung, and Blood Institute (NHLBI)
 2020-11-02 PHASE2
NCT03943459 UNKNOWN
Coronary Artery Disease Progression
InCor Heart Institute
 2019-08-02 PHASE3
NCT04603690 COMPLETED
Covid-19
Liaquat University of Medical & Health Sciences
 2021-08-16
NCT05130671 COMPLETED
COVID-19
King Edward Medical University
 2021-10-25
NCT04946383 UNKNOWN
Aging
TruDiagnostic
 2020-12-16 PHASE2
NCT04063124 COMPLETED
Alzheimer Disease
The University of Texas Health Science Center at San Antonio
 2020-02-14 PHASE1; PHASE2
NCT01720147 COMPLETED
Fanconi Anemia
Children's Hospital Medical Center, Cincinnati
 2012-07 PHASE1
NCT04861298 COMPLETED
COVID-19
King Edward Medical University
 2021-01-11
NCT04853199 COMPLETED
SARS (Severe Acute Respiratory Syndrome)
Hôpital Universitaire Sahloul
 2021-06-01 EARLY_PHASE1
NCT04907253 Active not recruiting
Coronary Artery Disease
Montreal Heart Institute
 2021-06-04 Phase 2
NCT04851821 COMPLETED
a Randomized Double-blind Study; Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2); PHYTOTHERAPIE
Hôpital Universitaire Sahloul
 2021-01-04 PHASE1
NCT05037240 COMPLETED
Covid19
Azienda di Servizi alla Persona di Pavia
 2021-01-12
NCT04578158 COMPLETED
COVID-19
Liaquat University of Medical & Health Sciences
 2020-09-29 PHASE3
NCT04474626 Withdrawn
Sickle Cell Disease|Sickle Cell-Beta0-Thalassemia
Jeffrey Zwicker MD|Quercegen Pharmaceuticals|Dana-Farber Cancer Institute
 2020-12 Phase 2
NCT04377789 COMPLETED
COVID-19
Kanuni Sultan Suleyman Training and Research Hospital
 2020-03-20
NCT04468139 UNKNOWN
Covid-19
Ministry of Health, Saudi Arabia
 2020-06-20 PHASE4
NCT05371340 COMPLETED
Osteoporosis, Postmenopausal
Kennesaw State University
 2019-08-27
NCT02989129 WITHDRAWN
Polyneuropathies and Other Disorders of the Peripheral Nervous System; Chemotherapy Induced Neuropathic Pain
M.D. Anderson Cancer Center
 2018-04 EARLY_PHASE1
NCT04723849 COMPLETED
Childhood Obesity
Universita di Verona
 2019-02-01
NCT04063124 Completed
Alzheimer Disease
The University of Texas Health Science Center at San Antonio|Mayo Clinic
 2020-02-14 Phase 1|Phase 2
NCT01722669 COMPLETED
Healthy
Beth Israel Deaconess Medical Center
 2012-05 EARLY_PHASE1
NCT04161872 COMPLETED
Hyperuricemia
University of Pavia
 2018-10-01 PHASE4
NCT03989271 Recruiting
Chronic Obstructive Pulmonary Disease
Temple University|National Institutes of Health (NIH)|Quercegen Pharmaceuticals|National Center for Complementary and Integrative Health (NCCIH)
 2019-10-01 Phase 1|Phase 2
NCT02874989 COMPLETED
Idiopathic Pulmonary Fibrosis (IPF)
Wake Forest University Health Sciences
 2016-12-16 PHASE1
NCT03493997 COMPLETED
Prostate Cancer
Study Group for Urogenital Diseases, Italy
 2017-04-04 PHASE2
NCT02463357 COMPLETED
Mountain Sickness
University of Colorado, Denver
 2015-08 PHASE4
NCT02226484 COMPLETED
Gastroesophageal Reflux Disease; GERD; Acid Reflux; Reflux
University of North Carolina, Chapel Hill
 2014-08 PHASE1
NCT01912820 COMPLETED
Adenocarcinoma of the Prostate; Recurrent Prostate Cancer; Stage I Prostate Cancer; Stage IIA Prostate Cancer; Stage IIB Prostate Cancer; Stage III Prostate Cancer; Stage IV Prostate Cancer
Jonsson Comprehensive Cancer Center
 2014-01-01 PHASE1
NCT00065676 COMPLETED
Obesity; Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 2010-04-30 PHASE2
NCT01708278 COMPLETED
Chronic Obstructive Pulmonary Disease
University of Michigan
 2014-02 PHASE1
NCT01438320 COMPLETED
Chronic Hepatitis C
University of California, Los Angeles
 2011-07 PHASE1
NCT01881919 COMPLETED
Hyperuricemia; Gout; Kidney Calculi; Diabetes; Cardiovascular Disease
University of Leeds
 2013-02 EARLY_PHASE1
NCT01839344 COMPLETED
Diabetes Mellitus, Type 2
Bastyr University
 2013-05 PHASE2
NCT01538316 UNKNOWN
Primary Prevention of Prostate Cancer
University of Hohenheim
 2012-03
NCT01691404 COMPLETED
Hypertension; Endothelial Dysfunction
Wageningen University
 2012-09
NCT01847521 COMPLETED
Autism Spectrum Disorders
Attikon Hospital
 2011-12 PHASE2
NCT01376011 COMPLETED
Stroke; Problem of Aging
Brigham and Women's Hospital
 2009-06 EARLY_PHASE1
NCT01732393 COMPLETED
Chemotherapy Induced Oral Mucositis
Mashhad University of Medical Sciences
 2010-01 PHASE1; PHASE2
NCT01106170 COMPLETED
Blood Pressure
University of Utah
 2010-03 PHASE1
NCT01375101 UNKNOWN
Atrophic Oral Lichen Planus; Erosive Oral Lichen Planus
Mashhad University of Medical Sciences
 2010-04 PHASE1
NCT01348204 COMPLETED
Cystic Fibrosis
University of Alabama at Birmingham
 2010-03 PHASE2
NCT01168739 COMPLETED
Heat Acclimation and Thermotolerance
University of New Mexico
 2009-09
NCT00913081 COMPLETED
Flushing
University of Pennsylvania
 2009-02 PHASE4
NCT00455416 UNKNOWN
Follicular Lymphoma
Oslo University Hospital
 2007-04 PHASE2
NCT00003365 TERMINATED
Colorectal Cancer
University of Medicine and Dentistry of New Jersey
 1996-08
NCT00402623 COMPLETED
Sarcoidosis
Maastricht University Medical Center
 2006-01

(data from https://clinicaltrials.gov, updated on 2026-08-26)

Check the Quercetin Dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Quercetin functions as a stimulator of recombinant SIRT1 and an inhibitor of phosphoinositide 3-kinase (PI3K) isoforms γ, δ, and β with IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM, respectively, thereby suppressing downstream lipid phosphorylation cascades and modulating protein deacetylation. This enzymatic modulation suppresses oxidative stress and downregulates cellular pro-inflammatory pathways, mitigating tissue damage in clinical trial conditions such as chronic obstructive pulmonary disease and vascular inflammation.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.