CAS No. 94-62-2

Batch: Purity:99.92
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Piperine Chemical Structure
Chemical Structure
Check the Piperine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one
CAS Number 94-62-2
Molecular Formula

C17H19NO3
Molecular Weight (MW) 285.34
SMILES C1CCN(CC1)C(=O)C=CC=CC2=CC3=C(C=C2)OCO3
InChIKey MXXWOMGUGJBKIW-YPCIICBESA-N

Ordering Information

Biological Activity

Piperine is a naturally occurring alkaloid that acts as an agonist and desensitizer of the transient receptor potential vanilloid 1 (TRPV1) channel while modulating inflammatory signaling pathways. It inhibits activation of the NF-κB pathway, suppressing the expression of pro-inflammatory cytokines and downstream inflammatory mediators. Through these mechanisms, piperine exhibits anti-inflammatory, antioxidant, and immunomodulatory biological activities across various cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 57 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 57 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.