Clinical Trials

Phenylephrine hydrochloride has been evaluated across numerous clinical trials spanning Early Phase 1 through Phase 4, alongside unassigned protocol designations, for cardiovascular, ophthalmic, and anesthetic indications. These investigations primarily address spinal anesthesia-induced hypotension, systemic hypoxia, cerebral oxygen saturation maintenance, and ocular mydriasis during cataract procedures. Sponsored by both academic medical centers and pharmaceutical corporations, these studies encompass a full spectrum of recruitment statuses, ranging from actively recruiting and completed to terminated and not yet recruiting.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06677970 RECRUITING
Acute Ischemic Stroke
Yonsei University
 2024-10-01 PHASE3
NCT06802224 RECRUITING
Anesthesia; Surgery With General Anesthesia; Noncardiac Surgery; Hypotension During Surgery; Acute Kidney Injury (AKI); Myocardial Injury After Noncardiac Surgery (MINS); Vasopressor
University of California, San Francisco
 2025-04-01 PHASE4
NCT01731444 RECRUITING
Blood Loss, Surgical
University of Manitoba
 2014-12-01 PHASE1
NCT07796282 NOT_YET_RECRUITING
Spine Surgery; Intraoperative Hypotension; Tissue Perfusion
Mayo Clinic
 2026-09 PHASE4
NCT06083948 RECRUITING
Hypotension
University of Aarhus
 2023-12-20 PHASE2; PHASE3
NCT05997732 RECRUITING
Vasoconstriction; Vasodilation
University of Alberta
 2023-10-31 PHASE4
NCT06770426 NOT_YET_RECRUITING
Acute Ischemic Stroke
Yonsei University
 2025-02 PHASE3
NCT02560805 RECRUITING
Stress Disorders, Post-Traumatic
Emory University
 2015-10 PHASE2
NCT06648850 NOT_YET_RECRUITING
Telogen Effluvium; Female Pattern Hair Loss; Female Pattern Hair Loss, Androgenic Alopecia; Male Pattern Baldness; Androgenetic Alopecia; Androgenetic Alopecia (AGA)
Applied Biology, Inc.
 2026-05-01 PHASE2; PHASE3
NCT07662408 RECRUITING
Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia; Orthopedic Hip Sugery in Eldely Patients
Sohag University
 2026-05-22 PHASE4
NCT04934748 ENROLLING_BY_INVITATION
Blood Pressure
The University of Texas Health Science Center, Houston
 2021-07-25 PHASE4
NCT03620942 ACTIVE_NOT_RECRUITING
Hypotension; Anesthesia
KK Women's and Children's Hospital
 2018-11-07
NCT04053478 RECRUITING
Hypotension
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2019-07-08
NCT06285396 RECRUITING
Postpartum Hemorrhage
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2024-03-18
NCT02118467 RECRUITING
Shock
University of Chicago
 2014-05-15 PHASE4
NCT02725060 ENROLLING_BY_INVITATION
Postural Orthostatic Tachycardia Syndrome; Postural Tachycardia Syndrome; Tachycardia; Arrhythmias, Cardiac; Autonomic Nervous System Diseases; Orthostatic Intolerance; Cardiovascular Diseases; Primary Dysautonomias
Vanderbilt University Medical Center
 2016-02
NCT04218773 SUSPENDED
Ischemic Stroke; Blood Pressure
Yale University
 2020-09-11 EARLY_PHASE1
NCT07420127 RECRUITING
Phenylephrine; Cesarean Birth
Rawalpindi Medical College
 2026-02-13 PHASE4
NCT07663149 COMPLETED
Shivering Caused by Spinal Anesthesia
Indonesia University
 2026-04-07
NCT04500899 RECRUITING
Mitral Regurgitation
Montefiore Medical Center
 2020-12-01 PHASE1; PHASE2
NCT06711432 RECRUITING
Tumor; Stroke
Zhejiang Cancer Hospital
 2024-09-18
NCT06508359 COMPLETED
Outcome
General Hospital of Ningxia Medical University
 2025-08-01
NCT06248593 RECRUITING
Cesarean Section Complications; Hypotension
Hassan II University
 2025-01-29 PHASE4
NCT06151470 UNKNOWN
Adverse Effect
General Hospital of Ningxia Medical University
 2025-07-01
NCT05941494 UNKNOWN
Anesthesia
Jason Chui
 2023-10-03 PHASE4
NCT06158035 UNKNOWN
Adverse Effect
General Hospital of Ningxia Medical University
 2025-07-01
NCT06334549 RECRUITING
Hypotension Drug-Induced
Dalian Municipal Central Hospital
 2024-03-05 PHASE4
NCT07075224 COMPLETED
Mydriasis
Unither Pharmaceuticals, France
 2025-11-01 PHASE1; PHASE2
NCT06539637 UNKNOWN
Cataract
DHS Consulting
 2023-09-01 EARLY_PHASE1
NCT07033845 RECRUITING
Chemotherapy Induced Alopecia; Chemotherapy Side Effects
Applied Biology, Inc.
 2025-06-30 EARLY_PHASE1
NCT07327320 COMPLETED
Anesthesia; Spinal; Cesarean Section; Hypotension, Controlled
Tam Anh Research Institute
 2024-06-06 PHASE4
NCT04576663 UNKNOWN
Adverse Effect
General Hospital of Ningxia Medical University
 2023-10-01
NCT05118672 COMPLETED
Cold; Flu Symptom
Eurofarma Laboratorios S.A.
 2025-03-26 PHASE3
NCT06158009 UNKNOWN
Adverse Effect
General Hospital of Ningxia Medical University
 2025-04-01
NCT06151522 UNKNOWN
Adverse Effect
General Hospital of Ningxia Medical University
 2025-04-01
NCT06158022 COMPLETED
Adverse Effect
General Hospital of Ningxia Medical University
 2024-10-03
NCT07153601 COMPLETED
Hypotenstion; Cesarean Resection; Anesthesia Spinal; Pregnancy Complications; Cardiovascular
Universitas Sumatera Utara
 2025-02-07
NCT06158048 COMPLETED
Adverse Effect
General Hospital of Ningxia Medical University
 2025-01-01
NCT05070650 WITHDRAWN
Common Cold
Sandoz
 2024-09-20 PHASE3
NCT05035498 UNKNOWN
Hemodynamic Instability
General Hospital of Ningxia Medical University
 2024-02-01
NCT05890027 COMPLETED
Ptosis, Eyelid
University of Miami
 2024-03-19 PHASE4
NCT06836986 RECRUITING
Spinal Anesthesia Induced Hypotension
Dow University of Health Sciences
 2024-12-31
NCT07495670 COMPLETED
Diabetes (DM); Retinopathy, Diabetic; Pupil Dilation
Burapha University
 2024-11-04
NCT05414877 UNKNOWN
Carotid Endarterectomy
Beijing Tiantan Hospital
 2023-09-30
NCT06053398 COMPLETED
Hypotension
University of Texas Southwestern Medical Center
 2023-11-21 EARLY_PHASE1
NCT02323399 UNKNOWN
Hypotension
West-Ward Pharmaceutical
 2015-02 PHASE4
NCT04089072 UNKNOWN
Septic Shock
Carilion Clinic
 2019-12-01 PHASE2
NCT05665881 COMPLETED
Carotid Endarterectomy
Beijing Tiantan Hospital
 2023-01-07
NCT05011357 COMPLETED
Intraoperative Hypotension
University of Texas Southwestern Medical Center
 2021-09-10 EARLY_PHASE1
NCT05158699 TERMINATED
Macular Edema; Cystoid Macular Edema; Retinal Disease; Cataract; Lens Diseases; Eye Diseases
Luigi Rondas
 2021-10-13 PHASE3
NCT05492968 UNKNOWN
Cardiac Output, Low; Cardiac Output, High; Perfusion; Complications
Medical University of Vienna
 2022-09-01 PHASE4
NCT04602767 UNKNOWN
Acute Kidney Injury
Thomas Jefferson University
 2020-10-15 PHASE4
NCT05706727 COMPLETED
Hemodynamic Stability
KIST Medical and Teaching Hospital
 2023-03-23 PHASE3
NCT07795710 COMPLETED
Ephedrine; Norepinephrine
Minia University
 2024-01-30
NCT05035485 COMPLETED
Hemodynamic Instability
General Hospital of Ningxia Medical University
 2022-09-13
NCT06217796 COMPLETED
Mydriasis
Eyenovia Inc.
 2023-11-28 PHASE4
NCT05035472 UNKNOWN
Adverse Effect
General Hospital of Ningxia Medical University
 2023-01-01
NCT03864094 COMPLETED
Hemodynamic Instability; Anesthesia, General; Anesthesia, Intravenous
Helse Fonna
 2022-03-15 PHASE4
NCT05881915 COMPLETED
Hypotension During Surgery
Cairo University
 2023-06-01
NCT02245230 TERMINATED
Hypertension; Hypertension, Essential
Vanderbilt University
 2015-01 PHASE1
NCT04144465 COMPLETED
Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Suez Canal University
 2019-11-01
NCT06220942 Recruiting
Anesthesia
Ain Shams University
 2023-10-05 --
NCT05841251 UNKNOWN
Intraoperative Bleeding; Coblation Turbinoplasty
Assiut University
 2023-05-01
NCT04972123 COMPLETED
Syncope, Vasovagal
University of Wisconsin, Madison
 2021-07-20 PHASE2
NCT05935657 Not yet recruiting
Remimazolam|Spinal Anesthesia
Pusan National University Yangsan Hospital
 2023-08 Not Applicable
NCT04829799 WITHDRAWN
Pain Reduction
University of Florida
 2022-02 PHASE4
NCT05525416 COMPLETED
Vasodilation; Vasoconstriction
University of Alberta
 2022-07-28
NCT03953677 TERMINATED
Septic Shock; Vasopressor Resistance
Centre Hospitalier Universitaire Dijon
 2019-10-27 PHASE3
NCT05043077 COMPLETED
Retinopathy of Prematurity
Aristotle University Of Thessaloniki
 2021-09-07 PHASE4
NCT05035888 COMPLETED
Adverse Effect
General Hospital of Ningxia Medical University
 2022-09-05
NCT01791816 COMPLETED
Vasovagal Syncope; Postural Tachycardia Syndrome
New York Medical College
 2013-02 EARLY_PHASE1
NCT05651399 Recruiting
Remimazolam|Propofol|Orthopedic Procedures|Sedatives|Anesthesia Spinal
Asan Medical Center
 2022-12-26 Phase 4
NCT04839224 TERMINATED
Acute Ischemic Stroke
Yonsei University
 2021-04-05 PHASE3
NCT03719001 COMPLETED
Vascular Diseases
University of California, San Francisco
 2018-10-23 EARLY_PHASE1
NCT04367103 COMPLETED
Hypotension; Cesarean Section
Assiut University
 2021-04-10
NCT04789330 COMPLETED
Anesthesia; Surgery; Hypotension
University of California, San Francisco
 2021-07-01 PHASE4
NCT03248791 UNKNOWN
Cesarean Section Complications; Spinal Anesthesia
Cairo University
 2017-08-20 PHASE4
NCT05049278 COMPLETED
Blood Flow; Anastomotic Failure of Flap; Flap Necrosis; Flap Ischemia
Seoul National University Hospital
 2021-09-24
NCT05001048 COMPLETED
Vasodilation; Vasoconstriction
University of Alberta
 2019-08-04
NCT04991662 COMPLETED
Cesarean Section Complications
Xuzhou Medical University
 2021-10-10 PHASE4
NCT04556357 COMPLETED
Adverse Effect
General Hospital of Ningxia Medical University
 2020-09-22
NCT04777383 TERMINATED
Cardiovascular Diseases; Vascular Diseases
University Hospital, Linkoeping
 2019-04-01
NCT04214145 COMPLETED
Cerebral Oxygen Saturation
Seoul National University Hospital
 2020-01-07
NCT04928183 COMPLETED
Vasodilation; Vasoconstriction
University of Alberta
 2021-06-10
NCT03972683 WITHDRAWN
Vasoconstriction; Vasodilation
Colorado State University
 2019-04-16 EARLY_PHASE1
NCT02904304 SUSPENDED
Cold
Ache Laboratorios Farmaceuticos S.A.
 2020-12 PHASE3
NCT03864133 COMPLETED
Cataract
Wake Forest University Health Sciences
 2019-07-08 PHASE4
NCT04040790 TERMINATED
Low Vision
University Ghent
 2019-09-16
NCT04907474 COMPLETED
Mydriasis
Eyenovia Inc.
 2021-05-24 PHASE4
NCT04404946 COMPLETED
Hypotension Symptomatic; Vasoconstriction; Cesarean Section Complications; Obstetric Anesthesia Problems
Aretaieion University Hospital
 2020-05-23
NCT04419662 COMPLETED
Ultrasonography, Renal; Cardiac Surgery; Hemodynamics; Phenylephrine; Renal Perfusion; Echocardiography; Anesthesia
Aarhus University Hospital
 2020-05-25 PHASE4
NCT03846765 COMPLETED
Nfuence of Vasoactive Medication on Spinal Oxygenation
University Hospital, Ghent
 2019-07-04 PHASE4
NCT04026685 COMPLETED
Maternal Haemodynamic Stability
University Hospital, Basel, Switzerland
 2020-01-09
NCT03849508 COMPLETED
Cesarean Section Complications; Spinal Anesthesia
Centre Hospitalier Régional d'Orléans
 2019-02-27 PHASE4
NCT00748059 COMPLETED
Autonomic Nervous System Diseases; Orthostatic Hypotension; Dopamine Beta-Hydroxylase Deficiency; Orthostatic Intolerance
Vanderbilt University Medical Center
 1996-12 PHASE1
NCT03682198 COMPLETED
Neurosurgery; Elective Craniotomy; General Anaesthesia
University Hospital Bispebjerg and Frederiksberg
 2018-09-24
NCT04623684 COMPLETED
Retinopathy of Prematurity
Aristotle University Of Thessaloniki
 2020-03-24 PHASE4
NCT05348980 COMPLETED
Hypotension; Anesthesia
Rehman Medical Institute - RMI
 2020-01-01 PHASE4
NCT03872570 UNKNOWN
Arterial Hypotension
Algemeen Ziekenhuis Maria Middelares
 2019-06-01 PHASE4
NCT03702400 COMPLETED
Hypotension; Spinal Anesthesia
Hospital dos Servidores do Estado do Rio de Janeiro
 2018-10-01 PHASE2
NCT04631315 COMPLETED
Cataract
Laboratorios Poen
 2019-03-24 PHASE4
NCT03248817 UNKNOWN
Cesarean Section Complications; Spinal Anesthesia
Cairo University
 2017-09-28 PHASE4
NCT04789005 COMPLETED
Spinal Induced-hypotension
Tribhuvan University Teaching Hospital, Institute Of Medicine.
 2019-11-10 PHASE3
NCT03047109 COMPLETED
Spinal Hypotension
Assiut University
 2017-02-07 PHASE2; PHASE3
NCT04195321 COMPLETED
Spinal Induced Hypotension; Elderly
Kasr El Aini Hospital
 2020-01-01 PHASE4
NCT03098680 TERMINATED
Drug-Related Side Effects and Adverse Reactions; Cardiovascular System Disease
Cambridge University Hospitals NHS Foundation Trust
 2017-04-24 PHASE1
NCT03680404 COMPLETED
Cardiovascular Diseases; Cardiovascular Risk Factor; Vasoconstriction
The University of Texas at Arlington
 2018-10-01 PHASE1
NCT03729076 COMPLETED
Pregnancy; Cesarean Delivery; Hypotension
Seoul National University Hospital
 2018-11-16
NCT04067817 UNKNOWN
Hypotension
The Second Affiliated Hospital of Dalian Medical University
 2019-10-06 PHASE3
NCT04133961 COMPLETED
Postoperative Shivering
Universiti Kebangsaan Malaysia Medical Centre
 2019-06-12
NCT03816072 COMPLETED
Cerebrovascular Circulation
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2019-01-07
NCT03833895 COMPLETED
Cesarean Section Complications
China International Neuroscience Institution
 2019-02-20 PHASE2; PHASE3
NCT03842046 COMPLETED
Hypotension Symptomatic; Obstetric Anesthesia Problems; Cesarean Section Complications; Vasoconstriction
Aretaieion University Hospital
 2019-02-16
NCT03959176 COMPLETED
Intraocular Pressure
Wake Forest University Health Sciences
 2019-07-20 PHASE4
NCT02635555 COMPLETED
Complications; Cesarean Section; Hypotension
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2016-04
NCT03615508 TERMINATED
Horner Syndrome
Denver Health and Hospital Authority
 2018-09-21 PHASE4
NCT03638726 UNKNOWN
Cataract; Mydriasis; Adverse Drug Event
Dar El Oyoun Hospital
 2018-09-28 PHASE4
NCT03858465 COMPLETED
Hip Fractures; Elderly Patients; Spinal Anesthesia; Lower Limb Surgery
Medical University of Warsaw
 2019-02-01
NCT03751098 COMPLETED
Mydriasis
Eyenovia Inc.
 2018-12-01 PHASE3
NCT03751631 COMPLETED
Mydriasis
Eyenovia Inc.
 2018-11-15 PHASE3
NCT04005664 COMPLETED
Cesarean Section Complications; Anesthesia Complication
University of KwaZulu
 2018-05-01
NCT02895035 TERMINATED
Cataract
Milton S. Hershey Medical Center
 2016-09-01 PHASE4
NCT02428062 SUSPENDED
Post-operative Cognitive Dysfunction
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
 2014-10 PHASE2; PHASE3
NCT03302039 COMPLETED
Cesarean Section Complications; Spinal Anesthesia
Cairo University
 2017-10-06 PHASE4
NCT02965924 COMPLETED
Assess Phenylephrine on EVP and IOP
Mayo Clinic
 2016-10
NCT03507387 COMPLETED
Elective Cesarean Section; Spinal Anesthesia
Xuzhou Medical University
 2018-04-01
NCT02909140 TERMINATED
Cataract
Johns Hopkins University
 2016-09
NCT03328533 COMPLETED
Cesarean Section Complications; Spinal Anesthesia
Cairo University
 2017-11-10 PHASE4
NCT03163914 COMPLETED
Spinal Anesthesia
Cukurova University
 2017-07-19 PHASE4
NCT03339726 TERMINATED
Common Cold
Johnson & Johnson Consumer Inc. (J&JCI)
 2017-11-30 PHASE2
NCT02373137 UNKNOWN
Keratoplasty; Grafting, Corneal; Transplantation, Corneal; Transplantation, Cornea; Keratoplasty, Lamellar
Oregon Health and Science University
 2015-01-22 PHASE4
NCT03415243 COMPLETED
Common Cold
GlaxoSmithKline
 2018-03-01 PHASE1
NCT03421860 COMPLETED
Cardiac Output, Low
University Tunis El Manar
 2017-02-23 PHASE4
NCT02726620 COMPLETED
Hypotension
Vanderbilt University Medical Center
 2017-01-05
NCT01600235 UNKNOWN
Stroke, Acute; Progressing Stroke
Samsung Medical Center
 2012-06 PHASE3
NCT02277730 COMPLETED
Hypotension
KK Women's and Children's Hospital
 2013-05 PHASE2; PHASE3
NCT02713087 COMPLETED
Brain Tumor
University of Aarhus
 2015-09 PHASE4
NCT03139708 COMPLETED
Intraocular Pressure
Wake Forest University Health Sciences
 2016-09 PHASE1
NCT03767296 COMPLETED
Influence of Vasoactive Medication on Spinal Oxygenation
University Hospital, Ghent
 2017-02-06 PHASE4
NCT02748265 COMPLETED
Oxygenation During One Lung Ventilation
University Health Network, Toronto
 2016-03 PHASE4
NCT03213353 COMPLETED
Bioequivalence; Healthy Volunteers
Johnson & Johnson Consumer and Personal Products Worldwide
 2017-07-03 PHASE1
NCT02969239 UNKNOWN
Hypotension
Jeju National University Hospital
 2016-01 PHASE4
NCT02857153 UNKNOWN
Aging; Surgery; Blood Pressure; Anesthesia; Blood Loss, Surgical; Postoperative Delirium
Hu Anmin
 2016-07
NCT02958215 COMPLETED
Anesthesia, Obstetrical; Anesthesia, Spinal
Assiut University
 2016-06 PHASE2
NCT02730364 WITHDRAWN
Infections, Respiratory Tract
GlaxoSmithKline
 2017-02-01 PHASE3
NCT02678234 WITHDRAWN
Infections, Respiratory Tract
GlaxoSmithKline
 2017-02-01 PHASE3
NCT02962986 COMPLETED
Hypotension
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2017-01
NCT02806492 COMPLETED
Cerebral Perfusion; Cerebral Oxygenation; Cardiopulmonary Bypass
UMC Utrecht
 2016-01
NCT03015857 COMPLETED
Adverse Anesthesia Outcome
Kasr El Aini Hospital
 2017-01 PHASE2
NCT02979405 COMPLETED
Hypotension Drug-Induced
Universidad Industrial de Santander
 2017-01-17 PHASE4
NCT02101047 WITHDRAWN
Complications; Cesarean Section; Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Wake Forest University Health Sciences
 2015-08
NCT02285634 COMPLETED
Epistaxis; Blood Pressure
Mayo Clinic
 2014-11
NCT00458003 COMPLETED
Preeclampsia; Hypotension
Northwestern University
 2006-07
NCT03215797 COMPLETED
Hypotension; Fluid Therapy
The Second Affiliated Hospital of Dalian Medical University
 2016-09 PHASE3
NCT02946125 COMPLETED
Mydriasis
Eyenovia Inc.
 2016-10 PHASE2
NCT01393548 COMPLETED
Nasal Congestion and Inflammations; Rhinitis
Ache Laboratorios Farmaceuticos S.A.
 2014-08 PHASE3
NCT02132312 COMPLETED
Unilateral Cataract Extraction; Congenital Cataract
Omeros Corporation
 2014-07 PHASE3
NCT02665221 TERMINATED
Multiple Sclerosis
NYU Langone Health
 2015-07 PHASE4
NCT02854787 COMPLETED
Anesthesia, Spinal and Epidural; Adverse Effect; Hypotension; Complications, Cesarean Section
University Tunis El Manar
 2016-05 PHASE4
NCT02585570 COMPLETED
Disorder of Shoulder; Anesthesia
Inje University
 2015-10
NCT02025426 TERMINATED
Pre-eclampsia
Duke University
 2012-09 PHASE4
NCT02675868 COMPLETED
Endotoxemia
Radboud University Medical Center
 2016-01 PHASE4
NCT02739399 COMPLETED
Arterial Hypotension; Anaesthesia
Algemeen Ziekenhuis Maria Middelares
 2016-02 PHASE4
NCT02759510 UNKNOWN
Cardiac Output,Low; Hemodynamic Instability; Obstetrical Complication of Anesthesia
RenJi Hospital
 2016-06 EARLY_PHASE1
NCT01813149 TERMINATED
Complex Regional Pain Syndrome (CRPS)
The Cleveland Clinic
 2012-08
NCT02532270 UNKNOWN
Hypotension
Fudan University
 2015-09
NCT02802683 COMPLETED
Hypotension
Seoul National University Hospital
 2015-09 PHASE4
NCT02434146 TERMINATED
Neoplasm; Oral Mucosa; Transplant-Related Disorder
University of Wisconsin, Madison
 2015-05-14 PHASE1; PHASE2
NCT02701582 COMPLETED
Intracranial Aneurysm; Brain Edema; Scoliosis; Surgery
NYU Langone Health
 2014-03
NCT01243970 TERMINATED
Spinal Anesthesia; Pregnancy
University College London Hospitals
 2012-04 PHASE4
NCT02203630 TERMINATED
Septic Shock; Sepsis; Shock; Tachycardia; Arrhythmia
Vanderbilt University Medical Center
 2014-08 PHASE4
NCT01448057 COMPLETED
Upper Respiratory Tract Infection; Nasal Congestion; Rhinorrhea; Sneezing
Novartis
 2013-07 PHASE3
NCT02354833 COMPLETED
Effects of; Anesthesia, in Labor and Delivery
West Virginia University
 2014-08 PHASE4
NCT02376192 COMPLETED
Pregnancy
IWK Health Centre
 2014-01 PHASE4
NCT01481740 COMPLETED
Hypotension
IWK Health Centre
 2010-11 PHASE4
NCT01393561 COMPLETED
Nasal Congestion and Inflammations; Rhinitis
Ache Laboratorios Farmaceuticos S.A.
 2014-07 PHASE3
NCT02177539 UNKNOWN
Refractive Errors
Pontificia Universidad Catolica de Chile
 2014-05 PHASE4
NCT02245191 UNKNOWN
Preeclampsia
University of Sao Paulo General Hospital
 2014-07
NCT02201121 COMPLETED
Circulation; Drug Dose; Calculated SAP
Chinese PLA General Hospital
 2014-03
NCT05439460 COMPLETED
Pulmonary Arterial Hypertension
Stanford University
 2012-01 PHASE4
NCT02009007 UNKNOWN
Hypoxia; Hypotension
Samsung Medical Center
 2012-12 PHASE1
NCT02062710 COMPLETED
Cough Reflex Sensitivity
Montefiore Medical Center
 2014-01 PHASE4
NCT01794273 COMPLETED
Endovascular Carotid Surgery; Preoperative Hypotension
University Hospital, Clermont-Ferrand
 2012-07 PHASE4
NCT01533662 COMPLETED
Orthopedic Surgery of Lower Limb
University Hospital, Toulouse
 2011-03 PHASE2
NCT01378325 COMPLETED
Anesthetic Complication Spinal
American University of Beirut Medical Center
 2012-07 PHASE4
NCT01333891 TERMINATED
Healthy
Medical University of Vienna
 2012-12
NCT01278238 COMPLETED
Caesarean Section
Anestesiavdelingen Baerum Sykehus
 2010-01
NCT04025918 COMPLETED
Hypotension
KK Women's and Children's Hospital
 2011-10 PHASE2; PHASE3
NCT01509521 COMPLETED
Complications; Cesarean Section
Naestved Hospital
 2012-02 PHASE4
NCT04534452 COMPLETED
Nasal Congestion Due to Allergic Rhinitis
Bayer
 2012-05-12 PHASE3
NCT00690222 TERMINATED
Cataract; Phacoemulsification; Mydriasis; Pseudoexfoliation Syndrome
Nova Scotia Health Authority
 2008-03
NCT01609491 COMPLETED
Bloodpressure
University Medical Center Groningen
 2012-01
NCT01576809 COMPLETED
Upper Respiratory Infections
Novartis
 2012-03 PHASE3
NCT01451294 UNKNOWN
Intra-operative Hypotension; Carotid Stenosis
G.J. de Borst
 2011-11
NCT01413958 COMPLETED
Seasonal Allergic Rhinitis
Bayer
 2011-08 PHASE3
NCT04838665 COMPLETED
Retinopathy of Prematurity
University of the Philippines
 2011-09-30 PHASE4
NCT01158326 COMPLETED
Common Cold; Influenza
Hospital de Clinicas de Porto Alegre
 2010-08 PHASE3
NCT01080625 COMPLETED
Hypotension After Reperfusion in Liver Transplantation
Seoul National University Hospital
 2010-04
NCT00914394 TERMINATED
Healthy
Medical University of Vienna
 2010-10
NCT01354418 COMPLETED
Nasal Congestion
Bayer
 2011-05 PHASE1
NCT01332578 COMPLETED
Influenza; Common Cold
GlaxoSmithKline
 2011-05 PHASE4
NCT01330017 COMPLETED
Rhinitis; Seasonal Rhinitis
Bayer
 2011-03 PHASE2
NCT01216410 COMPLETED
Cesarean Delivery
Duke University
 2008-12
NCT00624650 COMPLETED
Acute Lung Injury
Oregon Health and Science University
 2008-02 PHASE2
NCT00838695 COMPLETED
Vascular Reaction to Medications
Vanderbilt University
 2009-01
NCT01092975 TERMINATED
Mucositis; Stomatitis
University of Wisconsin, Madison
 2010-03 PHASE1
NCT01026961 WITHDRAWN
Heart Rate; Blood Pressure; Arrhythmias
Novartis
 2010-09 PHASE1; PHASE2
NCT00356265 TERMINATED
Chronic Kidney Disease; Hypertension
University of Michigan
 2006-07
NCT01431612 COMPLETED
Ovarian Cyst
Sodertalje Hospital
 2008-11 PHASE1; PHASE2
NCT00996190 COMPLETED
Cesarean Section; Cardiac Output; Hypotension
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2009-11 PHASE4
NCT01112462 COMPLETED
Respiratory Tract Infections
McNeil AB
 2010-03 PHASE1
NCT00806741 COMPLETED
Healthy
Medical University of Vienna
 2009-09
NCT00846651 COMPLETED
Hypotension
Milton S. Hershey Medical Center
 2009-02 PHASE4
NCT00972998 COMPLETED
Incontinence
RDD Pharma Ltd
 2009-09 PHASE1; PHASE2
NCT01024543 COMPLETED
Insulin Sensitivity; Microcirculation
Maastricht University Medical Center
 2006-10
NCT00940836 UNKNOWN
Common Cold; Flu-like Syndrome
Hospital de Clinicas de Porto Alegre
 2009-06 PHASE3
NCT00976209 COMPLETED
Vasomotor Rhinitis; Seasonal Allergic Rhinitis
Bayer
 2009-08 PHASE3
NCT01389518 COMPLETED
Flu
Hospital de Clinicas de Porto Alegre
 2009-05 PHASE3
NCT01006863 COMPLETED
Hypotension; Valve Surgery
King Faisal University
 2004-03 PHASE2
NCT00877175 COMPLETED
Preterm Infants
Khon Kaen University
 2009-03 PHASE4
NCT02885168 COMPLETED
Septic Shock
Central Hospital, Nancy, France
 2008-02 PHASE4
NCT00874120 COMPLETED
Blood Pressure; Human Experimentation
Bayer
 2008-12 PHASE3
NCT00796328 TERMINATED
Spinal Induced Hypotension in Cesarean Delivery
IWK Health Centre
 2008-11 PHASE4
NCT00762567 COMPLETED
Rhinitis
Johnson & Johnson Consumer and Personal Products Worldwide
 2008-09 PHASE1
NCT00781157 COMPLETED
Hypotension
IWK Health Centre
 2008-01 PHASE4
NCT00603720 COMPLETED
Cardiovascular Diseases
Washington University School of Medicine
 2005-09
NCT00639015 COMPLETED
Septic Shock
University of Roma La Sapienza
 2007-11 PHASE2
NCT01169688 COMPLETED
Pupil Dilation Prior to Cataract Surgery In-patient; Pupil Dilation Prior to Cataract Surgery Out-patient
Northwest Kansas Surgery Center
 2007-12
NCT00642135 TERMINATED
Retinal Anomalies; Premature Birth
Assistance Publique - Hôpitaux de Paris
 2006-01 PHASE3
NCT01054027 COMPLETED
Retinopathy of Prematurity (ROP)
Georgetown University
 2007-03
NCT00225043 COMPLETED
Healthy
New York Presbyterian Brooklyn Methodist Hospital
 2005-06
NCT00585091 COMPLETED
Heart Failure
University of Utah
 2003-10
NCT00374881 COMPLETED
Acute Pain
BioLineRx, Ltd.
 2006-09 PHASE1; PHASE2
NCT00240058 COMPLETED
Blood Pressure
Crystal A. Gadegbeku
 2005-07
NCT00276016 COMPLETED
Rhinitis, Allergic, Seasonal
Organon and Co
 2006-01 PHASE3
NCT02266537 COMPLETED
Healthy
Boehringer Ingelheim
 2005-11 PHASE1
NCT00373802 COMPLETED
Bronchiolitis
Akron Children's Hospital
 2005-01 PHASE2
NCT00120432 COMPLETED
Eye Diseases
Khon Kaen University
 2004-12 PHASE3
NCT00420797 WITHDRAWN
Faecal Incontinence
S.L.A. Pharma AG
 2007-02 PHASE3
NCT00431392 COMPLETED
Regional Blood Flow; Ocular Physiology
Medical University of Vienna
 2001-09 PHASE2
NCT00501878 COMPLETED
Diabetes Mellitus
Khon Kaen University
 2007-05 PHASE4
NCT00227448 COMPLETED
Acute Ischemic Stroke
Johns Hopkins University
 2003-06 PHASE2
NCT00481442 COMPLETED
Septic Shock
University of Roma La Sapienza
 2007-01 PHASE2
NCT00379691 COMPLETED
Hypotension; Nausea
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2006-08
NCT00199784 COMPLETED
Healthy
Oslo University Hospital
 2005-06 PHASE4
NCT00294606 UNKNOWN
Vasopressor Agents; Endarterectomy, Carotid; Echocardiography, Transesophageal
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2006-02
NCT00100412 COMPLETED
Gulf War Syndrome; Chronic Fatigue Syndrome; Post-Traumatic Stress Disorder
US Department of Veterans Affairs
 1999-10

(data from https://clinicaltrials.gov, updated on 2026-02-13)

Check the Phenylephrine HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Phenylephrine hydrochloride selectively binds to and activates vascular α1-adrenergic receptors, stimulating Gq protein-coupled signaling that increases intracellular calcium concentrations within vascular smooth muscle cells. This signaling cascade triggers robust arterial vasoconstriction and systemic vascular resistance elevation, providing critical hemodynamic support for managing anesthesia-induced hypotension and preventing intraoperative complications in surgical patients.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.