CAS No. 61-76-7
| IUPAC Name | 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol;hydrochloride | |
|---|---|---|
| CAS Number | 61-76-7 | |
| Molecular Formula |
C9H13NO2.HCl |
|
| Molecular Weight (MW) | 203.67 | |
| SMILES | CNCC(C1=CC(=CC=C1)O)O.Cl | |
| InChIKey | OCYSGIYOVXAGKQ-FVGYRXGTSA-N |
Phenylephrine HCl is a selective α1-adrenergic receptor agonist. Agonism of α1-adrenergic receptors stimulates the Gq protein-coupled signaling cascade, activating phospholipase C and elevating intracellular calcium levels. This signaling cascade induces vascular smooth muscle contraction and leads to pronounced vasoconstriction. Consequently, phenylephrine-mediated activation of this pathway serves as a primary driver of blood pressure elevation, vascular tone modulation, and mydriasis in biological systems. [1]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 41 mg/mL |
| Ethanol | 41 mg/mL |
| DMSO |
41 mg/mL
(201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 41 mg/mL |
| Ethanol | 41 mg/mL |
| DMSO |
41 mg/mL
(201.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 41 mg/mL |
| Ethanol | 41 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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