Clinical Trials

Olanzapine is evaluated across numerous clinical trials investigating central nervous system and supportive care indications, primarily targeting schizophrenia, schizoaffective disorder, treatment-resistant depression, bipolar I disorder, chemotherapy-induced nausea and vomiting, and treatment-associated weight gain. Spanning Early Phase 1 through Phase 4, these studies include recruiting, completed, terminated, and not yet recruiting trials. Clinical evaluation is supported by both major pharmaceutical sponsors and academic institutions.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07152184 NOT_YET_RECRUITING
Patient With Schizophrenia Spectrum Disorder; NLM Classification WM 203, Psychology:Schizophrenic Psychology; Schizophrenia Spectrum and Other Psychotic Disorders
University Hospital, Strasbourg, France
2026-10-01 PHASE2
NCT06995508 RECRUITING
Cancer-Associated Anorexia; Head and Neck Squamous Cell Carcinoma; Neck Squamous Cell Carcinoma of Unknown Primary
Roswell Park Cancer Institute
2025-12-24 PHASE2
NCT07722806 NOT_YET_RECRUITING
Cancer, Advanced Solid Tumors; Malnutrition
Kantonsspital Winterthur KSW
2026-08 PHASE2
NCT07581405 NOT_YET_RECRUITING
Gastric Adenocarcinoma; Gastric Cancer
University of Illinois at Chicago
2026-09 PHASE2
NCT07442890 NOT_YET_RECRUITING
Lung Cancer
Henan Cancer Hospital
2026-04-30
NCT07208305 RECRUITING
Nausea; Vomiting
Affiliated Hospital of Qinghai University
2026-02-03 PHASE3
NCT07047651 ACTIVE_NOT_RECRUITING
Treatment Resistant Schizophrenia; Treatment Resistant Bipolar Disorder
Dr. Stavroula Rakitzi
2025-06-04 PHASE4
NCT05635227 RECRUITING
Coronary Artery Disease; Aortic Valve Disease
Rigshospitalet, Denmark
2022-11-10
NCT07565428 RECRUITING
Negative Symptoms of Schizophrenia
Minerva Neurosciences
2026-04-23 PHASE3
NCT07699276 RECRUITING
Cancer (Solid Tumors); Vomiting; Cisplatin; Olanzapine
Mahidol University
2026-02-10 PHASE2
NCT06588413 RECRUITING
Multiple Myeloma; Autologous Stem Cell Transplantation
Augusta University
2024-09-17 PHASE3
NCT04478838 RECRUITING
Schizophrenia and Related Disorders; Drug Administration Schedule; Drug Therapy; Antipsychotic Agents
Centre for Addiction and Mental Health
2022-06-06 PHASE4
NCT07743827 RECRUITING
Olanzapine; Breast Cancer; Dexamethasone
Alexandria University
2026-05-10
NCT05895838 RECRUITING
Out-Of-Hospital Cardiac Arrest; Post-Cardiac Arrest Syndrome
Christian Hassager
2023-06-16 PHASE3
NCT07413809 RECRUITING
Multiple Myeloma
The Affiliated People's Hospital of Ningbo University
2025-10-31 PHASE3
NCT07662200 NOT_YET_RECRUITING
Germ Cell Cancer
Ottawa Hospital Research Institute
2026-08 EARLY_PHASE1
NCT05705492 RECRUITING
Advanced Malignant Solid Neoplasm; Advanced Biliary Tract Carcinoma; Advanced Esophageal Carcinoma; Metastatic Esophageal Carcinoma; Locally Advanced Colorectal Carcinoma; Locally Advanced Esophageal Carcinoma; Locally Advanced Gastric Carcinoma; Metastatic Colorectal Carcinoma (mCRC); Advanced Lung Carcinoma; Locally Advanced Hepatocellular Carcinoma
OHSU Knight Cancer Institute
2024-07-17 PHASE2
NCT07455955 RECRUITING
Breast Cancer
Chinese University of Hong Kong
2026-03-31 PHASE2
NCT06821945 RECRUITING
Schizophrenia
Boryung Pharmaceutical Co., Ltd
2025-05-30 PHASE2
NCT06740890 RECRUITING
Schizophenia Disorder; Schizoaffective Disorder; Bipolar Disorder I or II; Bipolar Disorder NOS
New York State Psychiatric Institute
2025-06-26 PHASE4
NCT06338683 RECRUITING
Advanced Cancer; Olanzapine; Progression Free Survival
Qinghai Red Cross Hospital
2024-03-20 PHASE3
NCT03781115 ACTIVE_NOT_RECRUITING
Schizophrenia
University of Arizona
2017-11-20 PHASE1
NCT05814640 RECRUITING
Depression; Sequestra
First Affiliated Hospital of Chongqing Medical University
2023-02-20 PHASE1; PHASE2
NCT07633236 RECRUITING
Oncology Patients Receiving Chemotherapy; Cachexia-Anorexia Syndrome; Oncology
Blokhin's Russian Cancer Research Center
2025-03-28 PHASE3
NCT06554613 RECRUITING
Non-Small Cell Lung Cancer
Second Affiliated Hospital of Nanchang University
2024-07-02 PHASE2
NCT05170919 ENROLLING_BY_INVITATION
Anorexia Nervosa with Significantly Low Body Weight
Englewood Hospital and Medical Center
2022-01-20 PHASE2
NCT06200181 RECRUITING
Misuse, Opioid
M.D. Anderson Cancer Center
2024-04-02 PHASE3
NCT07246187 RECRUITING
Cannabinoid Hyperemesis Syndrome
Mercy Bon Secours Saint Vincent Medical Center
2025-11-06 PHASE3
NCT06200168 RECRUITING
Electroacupuncture; Olanzapine-contained Four-drug Antiemetic; Nausea and Vomiting
Jiuda Zhao
2024-01-16 PHASE3
NCT07482891 RECRUITING
Chemotherapy-induced Nausea and Vomiting
Shanghai 6th People's Hospital
2026-03-10 PHASE4
NCT05303064 RECRUITING
Schizophrenia; Bipolar I Disorder
Alkermes, Inc.
2022-06-30 PHASE3
NCT06251635 RECRUITING
Insulin Resistance; Menstrual Cycle; Type 2 Diabetes; Antipsychotics
Centre for Addiction and Mental Health
2024-06-03
NCT03741478 ACTIVE_NOT_RECRUITING
Healthy Controls
Centre for Addiction and Mental Health
2019-10-22 PHASE1
NCT07035821 NOT_YET_RECRUITING
Breakthrough Chemotherapy-Induced Vomiting (CIV) in Pediatric Patients; Pediatric Cancer
Shanghai Children's Medical Center
2025-07-01 PHASE3
NCT05669742 RECRUITING
Sodium-glucose Transport Protein Two Inhibitor (SGLT2),Metabolic Deficits Caused by Antipsychotics
Tanta University
2023-05-25 PHASE3
NCT04939090 ACTIVE_NOT_RECRUITING
Advanced Malignant Solid Neoplasm; Anorexia; Hematopoietic and Lymphoid Cell Neoplasm
Alliance for Clinical Trials in Oncology
2022-01-03 PHASE3
NCT06649214 NOT_YET_RECRUITING
Schizophrenia
Qilu Pharmaceutical Co., Ltd.
2024-11 PHASE3
NCT03118986 COMPLETED
Vomiting in Infants and/or Children; Nausea; Hematopoietic System--Cancer; Oncology
The Hospital for Sick Children
2017-08-10 PHASE2
NCT04892199 ACTIVE_NOT_RECRUITING
Metabolic Disturbance; Schizophrenia; Type 2 Diabetes; Clozapine; GLP-1; Olanzapine
Anders Fink-Jensen, MD, DMSci
2021-09-01 PHASE4
NCT06517199 UNKNOWN
Anorexia; Cachexia
Mahidol University
2024-01-22 PHASE3
NCT06850454 RECRUITING
Chemotherapy Induced Nausea and Vomiting
Mahidol University
2025-01-10 PHASE3
NCT05676294 COMPLETED
Postoperative Nausea and Vomiting
Yale University
2023-06-26 PHASE2
NCT06315283 COMPLETED
Schizophrenia
Teva Branded Pharmaceutical Products R&D LLC
2024-03-20 PHASE1
NCT06175273 COMPLETED
Pediatric Cancer; Nutrition Related Cancer; Nutrition Aspect of Cancer; Muscle Loss; Malnutrition, Child
Corey Hawes
2024-01-31 PHASE2; PHASE3
NCT06331520 COMPLETED
Chemotherapy-induced Nausea and Vomiting; Highly Emetogenic Chemotherapy
Fudan University
2024-05-01 PHASE3
NCT05590923 TERMINATED
Chemotherapy-induced Nausea and Vomiting
The Guthrie Clinic
2022-12-07 PHASE4
NCT05964647 COMPLETED
Healthy
University Hospital, Basel, Switzerland
2024-02-01 PHASE1
NCT06253546 COMPLETED
Schizophrenia
Teva Branded Pharmaceutical Products R&D LLC
2024-03-28 PHASE1
NCT06500234 RECRUITING
Nutrition Disorders; Immunotherapy; Cancer; Survival, Prosthesis
Qingdao Central Hospital
2024-06-01 PHASE3
NCT06288854 UNKNOWN
Weight Gain
Department of Medical Services Ministry of Public Health of Thailand
2024-04-03
NCT04529226 UNKNOWN
Psychosis; Intellectual Disability
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
2020-11-26 PHASE2
NCT06319170 COMPLETED
Schizophrenia, Schizoaffective Disorder
Teva Branded Pharmaceutical Products R&D LLC
2024-03-28 PHASE1
NCT07190482 COMPLETED
Tinnitus; Tinnitus, Subjective
University of Sao Paulo
2023-10-01 PHASE1
NCT04833023 UNKNOWN
Haloperidol; Advanced Cancer; Hyperactive Delirium; Olanzapine; End-stage Organ Disease
Tan Tock Seng Hospital
2022-05-18 PHASE3
NCT04518319 SUSPENDED
Schizophrenia
Shanghai Mental Health Center
2020-10-01 PHASE2
NCT02088060 TERMINATED
Schizophrenia
Central Institute of Mental Health, Mannheim
2015-12-08 PHASE2
NCT05803642 UNKNOWN
Acute Agitation
Qilu Pharmaceutical Co., Ltd.
2023-03-28 PHASE3
NCT04750395 UNKNOWN
Delirium; Terminal Illness
HCA Hospice Care
2021-09-01 PHASE2
NCT05805800 COMPLETED
Chemotherapy-induced Nausea and Vomiting
Xingchen Peng
2023-04-15 PHASE3
NCT03367572 COMPLETED
Breast Carcinoma
University of Rochester NCORP Research Base
2018-04-19 PHASE3
NCT06288854 Not yet recruiting
Weight Gain
Rajavithi Hospital
2024-04-03 Not Applicable
NCT05693935 COMPLETED
Schizophrenia
Teva Branded Pharmaceutical Products R&D LLC
2023-01-24 PHASE3
NCT06357104 COMPLETED
COVID-19 Vaccine Adverse Reaction
Pachankis, Yang I., M.D.
2024-02-26 PHASE4
NCT06133114 WITHDRAWN
Suicide Crisis Syndrome; Psychological Distress
Icahn School of Medicine at Mount Sinai
2024-03-13 PHASE4
NCT05346731 UNKNOWN
Chemotherapy-induced Nausea and Vomiting
Federal Research Institute of Pediatric Hematology, Oncology and Immunology
2022-04-01 PHASE3
NCT06319170 Recruiting
Schizophrenia Schizoaffective Disorder
Teva Branded Pharmaceutical Products R&D Inc.
2024-03-28 Phase 1
NCT06315283 Recruiting
Schizophrenia
Teva Branded Pharmaceutical Products R&D Inc.
2024-03-20 Phase 1
NCT06253546 Recruiting
Schizophrenia
Teva Branded Pharmaceutical Products R&D Inc.
2024-03-28 Phase 1
NCT05542264 COMPLETED
Schizophrenia
Otsuka Pharmaceutical Development & Commercialization, Inc.
2022-11-15 PHASE1
NCT06107803 COMPLETED
Negative Symptoms in Schizophrenia
Minerva Neurosciences
2023-10-13 PHASE1
NCT04503668 TERMINATED
Gynecologic Cancer
University of Michigan Rogel Cancer Center
2020-12-28 PHASE3
NCT05244577 UNKNOWN
Olanzapine; CINV; Testicular Cancer by AJCC V6 and V7 Stage; Cisplatin
Shi Yanxia
2022-01-18 PHASE3
NCT06065722 UNKNOWN
Chemotherapy Induced Nausea and Vomiting
Simon Williamson Clinic
2023-09-09 PHASE2
NCT05403580 WITHDRAWN
Advanced Malignant Solid Neoplasm; Hematopoietic and Lymphoid Cell Neoplasm
Mayo Clinic
2022-06-03 PHASE3
NCT04341467 UNKNOWN
BPSD; Amisulpride; Olanzapine; Dementia of the Alzheimer Type
Tianjin Anding Hospital
2019-12-01
NCT06600477 COMPLETED
Healthy
Neurelis, Inc.
2023-10-16 PHASE1
NCT03030417 COMPLETED
Solid Tumors; Lymphoma
National Cancer Institute (NCI)
2017-02-27 PHASE1
NCT02708394 COMPLETED
Adverse Effect of Other Antipsychotics and Neuroleptics; Insulin Resistance
Wayne State University
2017-02-01 EARLY_PHASE1
NCT04216329 ACTIVE_NOT_RECRUITING
Gliosarcoma; Newly Diagnosed; Glioblastoma
National Cancer Institute (NCI)
2020-07-07 PHASE1
NCT05402111 COMPLETED
Schizophrenia
Otsuka Pharmaceutical Development & Commercialization, Inc.
2022-06-13 PHASE1
NCT03510325 COMPLETED
Schizophrenia
Shanghai Mental Health Center
2019-02-12 PHASE3
NCT05242874 COMPLETED
Chemotherapy-induced Nausea and Vomiting
Henan Cancer Hospital
2022-02-01 PHASE3
NCT05857566 COMPLETED
Drug-induced Weight Gain
Response Pharmaceuticals
2023-05-16 PHASE1
NCT04718727 COMPLETED
Postoperative Nausea
Amani Hassan Abdel-Wahab
2021-03-15 PHASE1; PHASE2
NCT05179772 WITHDRAWN
Opioid Use Disorder
University of Pennsylvania
2022-07-28 PHASE2
NCT05202275 UNKNOWN
Nausea; Vomiting; Head and Neck Squamous Cell Carcinoma; Radiotherapy Side Effect
Chinese Academy of Medical Sciences
2020-12-01 PHASE2
NCT05243251 COMPLETED
Anorexia
Cairo University
2021-12-25 PHASE3
NCT05547100 COMPLETED
Focus of Study is on Healthy Lactating Women
Alkermes, Inc.
2022-09-14 PHASE1
NCT05213143 TERMINATED
Schizophrenia
Marubeni Pharmaceuticals (Suzhou) Co., Ltd.
2021-12-30 PHASE4
NCT03571126 UNKNOWN
Chemotherapy-induced Nausea and Vomiting; Lung Cancer
Zunyi Medical College
2019-05-09 PHASE4
NCT04437017 COMPLETED
Chemotherapy-induced Nausea and Vomiting
Fifth Affiliated Hospital, Sun Yat-Sen University
2020-02-03 PHASE3
NCT04535141 COMPLETED
Chemotherapy-induced Nausea and Vomiting
UNC Lineberger Comprehensive Cancer Center
2020-08-18 PHASE3
NCT02939287 COMPLETED
Nausea; Vomiting
Rush University Medical Center
2017-09-23 PHASE3
NCT04669132 COMPLETED
Nausea Post Chemotherapy
Instituto Brasileiro de Controle do Cancer
2020-12-17 PHASE2
NCT03187769 COMPLETED
Schizophrenia; Schizophreniform Disorders; Bipolar I Disorder
Alkermes, Inc.
2017-06-08 PHASE3
NCT03578081 COMPLETED
Malignant Neoplasm
Alliance for Clinical Trials in Oncology
2018-11-20 PHASE3
NCT03857581 UNKNOWN
Psychosis; Substance Use Disorders
Augusta University
2020-07 PHASE4
NCT04232423 COMPLETED
Complete Response Rate to Chemotherapy-induced Nausea and Vomiting Prophylaxis
Department of Medical Services Ministry of Public Health of Thailand
2020-03-01 PHASE3
NCT04876521 COMPLETED
Post-Schizophrenic Depression
All India Institute of Medical Sciences, Bhubaneswar
2019-10-14 PHASE4
NCT06200584 COMPLETED
Antipsychotics and Neuroleptics Toxicity
Dr Rabia Arshad
2021-01-01
NCT03960151 WITHDRAWN
Germ Cell Tumor
Costantine Albany
2018-05 PHASE2
NCT03575637 UNKNOWN
Gastric Cancer
Peking University
2018-07 PHASE2
NCT03079219 COMPLETED
Breast Cancer
CCTU
2017-03-23 PHASE3
NCT03631004 COMPLETED
Postoperative Nausea; Postoperative Nausea and Vomiting
Instituto do Cancer do Estado de São Paulo
2018-10-01 PHASE2; PHASE3
NCT04536558 UNKNOWN
Solid Tumor Patients Receiving High Emetic Risk Multi-day Chemotherapy
Sun Yat-sen University
2020-10-01 PHASE3
NCT05123976 COMPLETED
Pharmacokinetics
Joint Stock Company "Farmak"
2020-10-21 PHASE1
NCT03679182 UNKNOWN
Nausea; Vomiting; End Stage Cancer
Khon Kaen University
2018-09-01 PHASE2
NCT03876938 UNKNOWN
Antiemetic for Highly Emetogenic Chemotherapy
Mahidol University
2019-03-01 PHASE3
NCT03790085 UNKNOWN
Schizophrenia; Major Depressive Disorder; Anxiety Disorders
Tianjin Medical University General Hospital
2018-09-01 EARLY_PHASE1
NCT03877562 COMPLETED
Antipsychotic-induced Weight Gain
Corcept Therapeutics
2019-04-01 PHASE1
NCT04181385 UNKNOWN
Healthy
University Health Network, Toronto
2019-01-01 PHASE2; PHASE3
NCT04075955 COMPLETED
Chemotherapy-induced Nausea and Vomiting
CR-CSSS Champlain-Charles-Le Moyne
2019-04-29 PHASE3
NCT02861859 COMPLETED
Breast Cancer
Ottawa Hospital Research Institute
2016-12 PHASE3
NCT02431702 COMPLETED
Schizophrenia; Psychotic Disorders
Janssen Scientific Affairs, LLC
2015-07-08 PHASE3
NCT02536846 COMPLETED
Healthy
Dost Ongur
2017-11-17 PHASE4
NCT03557931 COMPLETED
Schizophrenia
Astellas Pharma Global Development, Inc.
2018-07-13 PHASE2
NCT02755116 COMPLETED
Postoperative Nausea and Vomiting
Jaime B Hyman
2016-04 PHASE2
NCT02380118 TERMINATED
Acute Agitation, Behavioural Emergency
The University of Hong Kong
2014-12 PHASE4
NCT03219710 COMPLETED
Chemotherapy-induced Nausea and Vomiting
All India Institute of Medical Sciences
2017-07-01 PHASE3
NCT03137121 COMPLETED
Advanced Cancer
University of Alabama at Birmingham
2017-07-12 PHASE2; PHASE3
NCT01625923 TERMINATED
Idiopathic Gastroparesis
University of Michigan
2013-01
NCT02562287 UNKNOWN
Bipolar Disorder
Hospital de Clinicas de Porto Alegre
2015-10 PHASE4
NCT03478605 UNKNOWN
Emesis; Vomiting; Nausea Post Chemotherapy; Nausea; Chemotherapy-induced Nausea and Vomiting
Blokhin's Russian Cancer Research Center
2018-05-25 PHASE2
NCT03568500 COMPLETED
Schizophrenia; Schizoaffective Disorder; First Episode Psychosis
Otsuka Pharmaceutical Development & Commercialization, Inc.
2018-05-21 PHASE4
NCT01609153 COMPLETED
Schizophrenia; Schizoaffective Disorder
Heinrich-Heine University, Duesseldorf
2012-06 PHASE4
NCT02287259 COMPLETED
Bipolar Disorder
Tadashi Hasegawa
2014-11 PHASE4
NCT03230864 TERMINATED
Treatment-resistant Schizophrenia
H. Lundbeck A/S
2017-07-20 PHASE3
NCT04076371 COMPLETED
Schizophrenia
Beijing HuiLongGuan Hospital
2012-01
NCT02435654 COMPLETED
Early-onset Schizophrenia
Kunming Medical University
2015-08 PHASE4
NCT02694328 COMPLETED
Schizophrenia
Alkermes, Inc.
2016-03-02 PHASE3
NCT03624322 COMPLETED
Acute Agitation
Impel Pharmaceuticals
2018-08-05 PHASE1
NCT02717195 COMPLETED
Schizophrenia
H. Lundbeck A/S
2016-04 PHASE3
NCT03246620 TERMINATED
Acute Agitation; Behavioural Emergency
The University of Hong Kong
2017-09-01 PHASE4
NCT03066622 COMPLETED
Headache
HealthPartners Institute
2016-07 PHASE4
NCT03304457 COMPLETED
Schizophrenia
All India Institute of Medical Sciences, Bhubaneswar
2017-08-25 PHASE4
NCT02282085 UNKNOWN
Schizophrenia
Matt Byerly
2014-12 PHASE4
NCT02635984 COMPLETED
Complications of Bone Marrow Transplant; Hematologic Neoplasms
Augusta University
2015-11 PHASE3
NCT01446328 COMPLETED
Schizophrenia; Psychotic Disorders
Haukeland University Hospital
2011-10 PHASE4
NCT01427608 COMPLETED
Psychotic Depression
Weill Medical College of Cornell University
2011-10 PHASE4
NCT02970643 UNKNOWN
Chemotherapy-induced Nausea and Vomiting
Hee Jun Kim
2016-07
NCT02918825 COMPLETED
Schizophrenia
Beijing HuiLongGuan Hospital
2016-09-01
NCT02051387 COMPLETED
Schizophrenia
Central Institute of Mental Health, Mannheim
2013-01 PHASE1
NCT02922426 COMPLETED
Healthy Volunteers
Alkermes, Inc.
2016-09 PHASE1
NCT02374567 TERMINATED
Dementia; Depression; Schizophrenia; Psychosomatic Disorders; Anxiety Disorders
Hannover Medical School
2015-01 PHASE3
NCT02643355 COMPLETED
Substance Withdrawal Syndrome
Hennepin Healthcare Research Institute
2015-11
NCT02634346 COMPLETED
Schizophrenia
Alkermes, Inc.
2015-12 PHASE3
NCT02007928 COMPLETED
Dissociative Disorders; Schizophrenia
Centre Hospitalier Universitaire de Nice
2013-04
NCT00632645 COMPLETED
Huntington Disease
Assistance Publique - Hôpitaux de Paris
2009-04 PHASE3
NCT01539733 COMPLETED
Delirium; Advanced Cancer
Amsterdam UMC, location VUmc
2010-03
NCT02161718 COMPLETED
Schizophrenia; Alcohol Use Disorder
Alkermes, Inc.
2014-05 PHASE2
NCT01185743 COMPLETED
Schizophrenia; Diabetes
Medical University of Vienna
2010-07 PHASE4
NCT03019887 COMPLETED
Schizophrenia Relapse
Juntendo University
2011-04
NCT02850445 UNKNOWN
Schizophrenia
Guangzhou Psychiatric Hospital
2012-01
NCT02650102 UNKNOWN
Schizophrenia
Shanxi Medical University
2013-01 PHASE1; PHASE2
NCT02634463 COMPLETED
Immunoassay; Antipsychotic
Janssen Research & Development, LLC
2015-11-09 PHASE1
NCT02484911 COMPLETED
Chemotherapy-induced Nausea and Vomiting
First Affiliated Hospital of Harbin Medical University
2015-05 PHASE3
NCT02307396 COMPLETED
Schizophrenia; Schizophrenia and Disorders With Psychotic Features; Schizoaffective Disorders
Technical University of Munich
2015-02-01 PHASE4
NCT01170117 COMPLETED
Anorexia Nervosa
New York State Psychiatric Institute
2010-08
NCT01248195 COMPLETED
Schizophrenia; Schizophreniform Disorder; Schizoaffective Disorder
Rene Kahn
2011-05 PHASE4
NCT02704962 COMPLETED
Schizophrenia
Kaohsiung Kai-Suan Psychiatric Hospital
2012-01 PHASE4
NCT03216941 COMPLETED
Psychomotor Agitation; Psychiatric Disorder; Emergency Psychiatric; Tranquilizers
Universidad Nacional de Rosario
2015-01-01 PHASE4
NCT02462473 TERMINATED
Schizophrenia; Schizoaffective Disorder
Janssen Research & Development, LLC
2015-05 PHASE2
NCT02129478 COMPLETED
Chemotherapy-induced Nausea and Vomiting
The Hospital for Sick Children
2014-03 PHASE2
NCT01893229 UNKNOWN
Bipolar Disorder
Guiyun Xu
2013-09 PHASE4
NCT00202293 COMPLETED
Bipolar Disorder; Schizoaffective Disorder
Melbourne Health
2001-10-01 PHASE4
NCT01687478 TERMINATED
Treatment Resistant Depression
Eli Lilly and Company
2012-09 PHASE3
NCT02290470 UNKNOWN
Nausea; Vomiting
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
2014-04 PHASE2
NCT02400866 UNKNOWN
Cancer
Korean South West Oncology Group
2015-05 PHASE2
NCT00716755 COMPLETED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder; Delusional Disorder; Psychotic Disorder
Centre for Addiction and Mental Health
2009-10
NCT02593734 COMPLETED
Schizophrenia; Mood Disorders,; Anxiety Disorder
University of Ghana Medical School
2013-07 PHASE4
NCT00845507 COMPLETED
Weight Gain
University of Cincinnati
2008-12 PHASE4
NCT02116530 COMPLETED
Hematopoietic/Lymphoid Cancer; Nausea and Vomiting; Unspecified Adult Solid Tumor, Protocol Specific
Alliance for Clinical Trials in Oncology
2014-08-20 PHASE3
NCT01617200 COMPLETED
Schizophrenia
Forest Laboratories
2012-12 PHASE3
NCT02097823 COMPLETED
Chemotherapy Induced Nausea and Vomiting
Indiana University
2014-02 PHASE2
NCT02137616 UNKNOWN
Psychotic Disorders
Central South University
2012-06
NCT02040883 UNKNOWN
Schizophrenia
Qingyun Yin
2014-02 PHASE4
NCT02447835 COMPLETED
Normal Non-fluency
Michael Rickels
2012-08 PHASE1
NCT01903837 COMPLETED
Schizophrenia
Alkermes, Inc.
2013-06 PHASE2
NCT02087579 COMPLETED
Psychotic Disorders; Schizophrenia; Bipolar Disorder; Depressive Disorder
Janssen Research & Development, LLC
2014-02 PHASE1
NCT01617187 COMPLETED
Schizophrenia
Organon and Co
2012-12-04 PHASE3
NCT01920802 COMPLETED
Healthy
New York State Psychiatric Institute
2012-11 PHASE4
NCT01389908 UNKNOWN
Schizophrenia; Schizoaffective Disorders
Shalvata Mental Health Center
2011-06
NCT02192723 COMPLETED
Schizophrenia
Beijing HuiLongGuan Hospital
2012-06
NCT01029769 COMPLETED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
Technical University of Munich
2009-12
NCT00806234 COMPLETED
Psychotic Disorders
Johns Hopkins University
2009-01 PHASE4
NCT00489593 COMPLETED
Advanced Cancer; Weight Loss
M.D. Anderson Cancer Center
2006-10 PHASE1
NCT01157351 COMPLETED
Schizophrenia
Janssen Scientific Affairs, LLC
2010-05 PHASE4
NCT01148264 TERMINATED
Emesis
Karin Jordan
2010-07 PHASE2
NCT01164059 COMPLETED
Schizophrenia
University of Bremen
2010-02 PHASE4
NCT01184443 TERMINATED
Eating Disorder
Children's Hospital of Eastern Ontario
2010-08 PHASE3
NCT01592201 TERMINATED
Schizophrenia
Janssen Korea, Ltd., Korea
2012-07 PHASE4
NCT00982020 COMPLETED
Bipolar I Disorder; Schizophrenia
Eli Lilly and Company
2009-09 PHASE4
NCT01990755 COMPLETED
Anorexia Nervosa; Bulimia Nervosa
University of Turin, Italy
2010-05
NCT01496183 COMPLETED
Healthy
State University of New York at Buffalo
2007-10
NCT01593774 COMPLETED
Schizophrenia
Guilan University of Medical Sciences
2012-05 PHASE2
NCT00816894 COMPLETED
Schizophrenia
Herzog Hospital
2009-01 PHASE2
NCT00885690 TERMINATED
Schizophrenia
University of Aarhus
2009-04
NCT01129674 TERMINATED
Schizophrenia
Eli Lilly and Company
2010-06 PHASE2; PHASE3
NCT01491490 TERMINATED
Schizophrenia
GW Research Ltd
2011-10 PHASE2
NCT01193166 WITHDRAWN
Schizophrenia
Ortho-McNeil Janssen Scientific Affairs, LLC
2010-08 PHASE4
NCT01234779 COMPLETED
Schizophrenia
Hoffmann-La Roche
2011-02 PHASE2
NCT00876772 COMPLETED
Amyotrophic Lateral Sclerosis (ALS)
Charite University, Berlin, Germany
2011-03 PHASE2; PHASE3
NCT00988728 WITHDRAWN
Schizophrenia
Merck Sharp & Dohme LLC
2011-02 PHASE2
NCT00910988 COMPLETED
Hyperglycemia; Hyperlipidemia
Washington University School of Medicine
2009-02
NCT01052389 COMPLETED
Schizophrenia
Mario Negri Institute for Pharmacological Research
2007-07 PHASE4
NCT00440843 WITHDRAWN
Schizophrenia; Schizoaffective Disorder
VA Connecticut Healthcare System
2007-02 PHASE3
NCT00981526 COMPLETED
Schizophrenia; Schizoaffective Disorder
University of Massachusetts, Worcester
2009-03 PHASE4
NCT01607762 COMPLETED
Healthy
Janssen Research & Development, LLC
2012-02 PHASE1
NCT00958568 COMPLETED
Treatment Resistant Depression
Eli Lilly and Company
2009-08 PHASE3
NCT00844857 COMPLETED
Bipolar Depression
Eli Lilly and Company
2009-04 PHASE4
NCT01207414 COMPLETED
Schizophrenia
Novartis
2010-08 PHASE4
NCT00833300 TERMINATED
Delirium; Agitation
Richard Hall
2008-06
NCT01503398 COMPLETED
Fasting
Dr. Reddy's Laboratories Limited
2011-08 PHASE1
NCT01503424 COMPLETED
Fed
Dr. Reddy's Laboratories Limited
2011-08 PHASE1
NCT00690235 COMPLETED
Schizophrenia; Schizoaffective Disorder; Diabetes; Weight Gain
University of Texas Southwestern Medical Center
2007-11 PHASE4
NCT01977300 COMPLETED
Bipolar I Disorder
University of British Columbia
2003-01 PHASE3
NCT00682448 COMPLETED
Metabolic Complications
Rush University Medical Center
2007-08 PHASE4
NCT00183404 COMPLETED
Autism
Drexel University
2004-09 PHASE2; PHASE3
NCT00970281 COMPLETED
Schizophrenia
Eli Lilly and Company
2009-09 PHASE3
NCT01485692 COMPLETED
Psychomotor Agitation
University of Sao Paulo
2009-02
NCT01057849 UNKNOWN
Schizophrenia
Peking University
2008-09
NCT00509067 COMPLETED
Schizophrenia
Georgetown University
2007-11 PHASE2
NCT00205699 COMPLETED
Aggression; Attention Deficit-Hyperactivity; Oppositional Defiant Disorder; Pervasive Development Disorders; Bipolar Disorder
Washington University School of Medicine
2006-04 PHASE4
NCT00363376 COMPLETED
Weight Gain
Lindner Center of HOPE
2008-01 PHASE3
NCT00330863 COMPLETED
Schizophrenia; Schizoaffective Disorder
Northwell Health
2006-05 PHASE4
NCT00741026 COMPLETED
Insulin Resistance; Diabetes Mellitus
Milton S. Hershey Medical Center
2008-08
NCT00088465 COMPLETED
Schizophrenic Disorders; Schizoaffective Disorder
Eli Lilly and Company
2004-08 PHASE3
NCT01168336 COMPLETED
Healthy
OBEcure Ltd.
2010-07 PHASE1
NCT00512070 COMPLETED
Schizophrenia; Schizoaffective Disorder; Bipolar Disorder; Obesity; Metabolic Syndrome
Seattle Institute for Biomedical and Clinical Research
2007-07
NCT00245206 COMPLETED
Schizophrenia; Alzheimer's Disease; Dementia
Veterans Medical Research Foundation
2005-08 PHASE4
NCT00692185 COMPLETED
Eating Disorders
New York State Psychiatric Institute
2005-10 PHASE2
NCT00618748 COMPLETED
Bipolar I Disorder
Eli Lilly and Company
2008-02 PHASE3
NCT00977301 COMPLETED
HIV Infections
Radboud University Medical Center
2009-11 PHASE1
NCT00918021 COMPLETED
Schizophrenia; Schizoaffective Disorder
Niuvanniemi Hospital
2009-06 PHASE4
NCT00186017 COMPLETED
Bipolar Disorder
Stanford University
2005-07 PHASE4
NCT00845026 COMPLETED
Schizophrenia
Denovo Biopharma LLC
2009-03 PHASE2
NCT00746785 COMPLETED
Alcohol Dependence
The Mind Research Network
2002-09 PHASE3
NCT00490971 COMPLETED
Bipolar Disorder
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2006-05 PHASE3
NCT00827918 COMPLETED
Schizophrenia
Merck Sharp & Dohme LLC
2009-03 PHASE2
NCT01411930 COMPLETED
Diabetes
Veterans Medical Research Foundation
2009-03 PHASE4
NCT00510146 COMPLETED
Depression, Bipolar
Eli Lilly and Company
2007-08 PHASE3
NCT00384332 COMPLETED
Bipolar Depression
Vanderbilt University
2007-01 PHASE4
NCT00446992 COMPLETED
Schizophrenia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
2006-04 PHASE1; PHASE2
NCT00728195 COMPLETED
Schizophrenia
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2008-11 PHASE2
NCT00932529 COMPLETED
Psychotic Disorders
University of Bergen
2003-02 PHASE4
NCT00273624 WITHDRAWN
Therapy-resistant Depression
University Hospital Freiburg
2005-06 PHASE3
NCT00615433 COMPLETED
Schizophrenia
Sumitomo Pharma America, Inc.
2008-01 PHASE3
NCT00672464 WITHDRAWN
Schizophrenia; Schizoaffective Disorder
Duke University
2008-04 PHASE4
NCT00895921 COMPLETED
Diabetes
Veterans Medical Research Foundation
2008-11 PHASE4
NCT00737191 WITHDRAWN
Hematopoietic/Lymphoid Cancer; Pain; Unspecified Adult Solid Tumor, Protocol Specific
Mayo Clinic
2008-08
NCT00423878 COMPLETED
Schizophrenia; Schizoaffective Disorder
National Institute of Mental Health (NIMH)
2007-01 PHASE4
NCT00770744 COMPLETED
Schizophrenia
H. Lundbeck A/S
2008-09 PHASE2
NCT00320489 COMPLETED
Schizophrenia
Eli Lilly and Company
2006-04 PHASE3
NCT00802100 COMPLETED
Schizophrenia
National Institute of Mental Health (NIMH)
2008-12 PHASE4
NCT00439634 TERMINATED
Schizophrenia
Sanofi
2007-02 PHASE2
NCT00287352 COMPLETED
Psychotic Disorder; Schizophreniform Disorder; Schizophrenia; Schizoaffective Disorder; Mood Disorders With Psychotic Features
University of North Carolina, Chapel Hill
2005-05 PHASE1
NCT00394095 COMPLETED
Bipolar Disorder; Weight Gain
University of Cincinnati
2006-12 PHASE4
NCT01864551 COMPLETED
Bipolar Disorder
Tri-Service General Hospital (TSGH)
2008-08 PHASE4
NCT00797277 COMPLETED
Schizophrenia; Schizoaffective Disorder; Agitation
National Taiwan University Hospital
2006-07 PHASE3
NCT00188942 COMPLETED
Major Depressive Disorder
University Health Network, Toronto
2005-02 PHASE4
NCT00266630 COMPLETED
Manic or Mixed Episode Associated With Bipolar I Disorder
Eli Lilly and Company
2005-11 PHASE3
NCT00520507 COMPLETED
Bipolar Disorder; Depression; Depressive Disorder
Queen's University
2007-10 PHASE4
NCT00645099 COMPLETED
Schizophrenia
Janssen-Cilag International NV
2007-10 PHASE3
NCT00174265 COMPLETED
Schizophrenia
Organon and Co
2005-07 PHASE3
NCT00391222 COMPLETED
Bipolar Disorder
Janssen Pharmaceutica N.V., Belgium
2006-11 PHASE3
NCT00852956 COMPLETED
Healthy
OBEcure Ltd.
2009-02 PHASE1
NCT00508157 TERMINATED
Metabolic Syndrome; Schizophrenia
Bristol-Myers Squibb
2007-11 PHASE4
NCT00438776 COMPLETED
Pathological Gambling
Lindner Center of HOPE
2007-02 PHASE3
NCT00044655 COMPLETED
Schizophrenia
Icahn School of Medicine at Mount Sinai
2001-07 PHASE4
NCT00686998 COMPLETED
Schizophrenia
AstraZeneca
2008-05 PHASE2
NCT00934908 WITHDRAWN
Bipolar Disorder; Schizophrenia
Medical University of South Carolina
2009-03
NCT00129220 COMPLETED
Bipolar Disorder
Eli Lilly and Company
2005-07 PHASE3
NCT01996501 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
PHASE1
NCT01996488 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
PHASE1
NCT03730857 COMPLETED
Schizophrenia
Calo Psychiatric Center
2008-01 PHASE1
NCT00493233 COMPLETED
Schizophrenia
Centre for Addiction and Mental Health
2006-11
NCT00734435 TERMINATED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
Orexigen Therapeutics, Inc
2008-09 PHASE2
NCT00515723 COMPLETED
Schizophrenia; Schizoaffective Disorder; Type 2 Diabetes Mellitus; Hyperglycemia
Washington University School of Medicine
2001-09
NCT00145496 COMPLETED
Schizophrenia
Organon and Co
2004-12 PHASE3
NCT00520923 COMPLETED
Schizophrenia
Eli Lilly and Company
2007-09 PHASE2
NCT00225498 COMPLETED
Schizophrenia
Northwell Health
2002-06
NCT00401973 COMPLETED
Schizophrenia; Schizoaffective Disorders
Eli Lilly and Company
2006-11 PHASE3
NCT00349973 COMPLETED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
University of Maryland, Baltimore
2001-05
NCT00428168 TERMINATED
Weight Gain
OBEcure Ltd.
2007-03 PHASE2
NCT00640510 COMPLETED
Schizophrenia
Eli Lilly and Company
2008-03 PHASE3
NCT00056472 COMPLETED
Major Depressive Disorder With Psychotic Features
Weill Medical College of Cornell University
2003-01 PHASE3
NCT00290121 COMPLETED
Schizophrenia
Université de Montréal
2006-09 PHASE4
NCT00190749 COMPLETED
Schizophrenia; Schizoaffective Disorder
Eli Lilly and Company
2003-10 PHASE4
NCT00001656 COMPLETED
Childhood Schizophrenia; Psychotic Disorder; Schizophrenia
National Institute of Mental Health (NIMH)
1997-06 PHASE4
NCT00124930 TERMINATED
Nausea; Neoplasms
Alberta Health services
2005-05 PHASE3
NCT00678457 COMPLETED
Alcohol Dependence
University of Virginia
2007-01 PHASE2
NCT00259272 COMPLETED
Bipolar Disorder I or II
Eli Lilly and Company
2005-11 PHASE3
NCT00275301 COMPLETED
Borderline Personality Disorder
University of Minnesota
2005-12
NCT00864045 COMPLETED
Schizophrenia
H. Lundbeck A/S
2007-03 PHASE3
NCT00759421 COMPLETED
Schizophrenia
H. Lundbeck A/S
2006-10 PHASE3
NCT00759460 COMPLETED
Schizophrenia
H. Lundbeck A/S
2007-03 PHASE3
NCT00176436 COMPLETED
Schizophrenia
University of Maryland, Baltimore
2004-02 PHASE4
NCT00402324 COMPLETED
Bipolar I Disorder
Eli Lilly and Company
2006-12 PHASE4
NCT00347425 COMPLETED
Schizophrenia and Schizoaffective Disorder
Solvay Pharmaceuticals
2006-12 PHASE3
NCT00568672 WITHDRAWN
Relapse Rate of a Major Depressive Episode; Safety of Olanzapine in Subjects With Major Depression
Charite University, Berlin, Germany
2007-10 PHASE3
NCT00926965 COMPLETED
Tardive Dyskinesia; Neurocognitive Function
Taipei Veterans General Hospital, Taiwan
2003-01 PHASE4
NCT00265343 COMPLETED
Schizophrenia
Organon and Co
2005-12 PHASE3
NCT00654576 COMPLETED
Schizophrenia
Central South University
2005-02 PHASE4
NCT01149577 COMPLETED
Schizophrenia; Sleep
Central Institute of Psychiatry, Ranchi, India
2007-08 PHASE4
NCT00337662 COMPLETED
Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorder
Eli Lilly and Company
2006-05 PHASE4
NCT00303602 COMPLETED
Schizophrenia; Schizoaffective Disorder; Bipolar Disorder
Eli Lilly and Company
2006-03 PHASE4
NCT00396565 COMPLETED
Schizophrenia
Janssen Pharmaceutical K.K.
2006-07 PHASE3
NCT00419653 TERMINATED
Schizophrenia
University of Jena
2003-01 PHASE4
NCT00324051 COMPLETED
Schizophrenia
Eli Lilly and Company
2006-05 PHASE4
NCT00636896 COMPLETED
Weight Gain
Neuropsychiatric Research Institute, Fargo, North Dakota
2006-07
NCT00699946 COMPLETED
Delirium
The New England Baptist Hospital
2005-01
NCT00512291 COMPLETED
Advanced Cancer
M.D. Anderson Cancer Center
2005-06
NCT00329108 TERMINATED
Acute Mania; Bipolar Disorder, Manic
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
2006-11 PHASE4
NCT00351936 COMPLETED
Schizophrenia
North Suffolk Mental Health Association
2005-12 PHASE4
NCT00216632 COMPLETED
Schizophrenia; Psychotic Disorders
Janssen Pharmaceutica N.V., Belgium
2005-03 PHASE4
NCT00212836 COMPLETED
Schizophrenia
Organon and Co
2005-04-21 PHASE3
NCT00223418 COMPLETED
Schizophenia Disorder; Schizoaffective Disorder
The University of Texas Health Science Center at San Antonio
2004-01
NCT00179062 COMPLETED
Schizophrenia; Schizoaffective Disorder; Depressive Disorder, Major; Bipolar Disorder
Vanderbilt University
2000-02
NCT00156091 COMPLETED
Schizophrenia
Organon and Co
2005-04 PHASE3
NCT00053703 COMPLETED
Schizophrenia
University of North Carolina, Chapel Hill
2002-02 PHASE4
NCT00000374 COMPLETED
Schizophrenia
Northwell Health
1998-09 PHASE4
NCT00183612 TERMINATED
Bipolar Disorder; Psychotic Disorders
Massachusetts General Hospital
2000-05
NCT00159783 COMPLETED
Bipolar Disorder
Organon and Co
2005-07 PHASE3
NCT00148564 COMPLETED
Schizophrenia
Charite University, Berlin, Germany
2004-03 PHASE4
NCT01503450 COMPLETED
Fed
Dr. Reddy's Laboratories Limited
2006-11 PHASE1
NCT00193713 COMPLETED
Schizophrenia
Solvay Pharmaceuticals
2005-05 PHASE3
NCT01503437 COMPLETED
Fasting
Dr. Reddy's Laboratories Limited
2006-11 PHASE1
NCT00205725 COMPLETED
Schizophrenia; Type 2 Diabetes Mellitus
Washington University School of Medicine
2000-11
NCT01160991 COMPLETED
Schizophrenia; Diabetes; Insulin Resistance
Central Institute of Mental Health, Mannheim
2004-05
NCT00205738 COMPLETED
Schizophrenia; Type 2 Diabetes Mellitus
Washington University School of Medicine
2000-07
NCT00212771 COMPLETED
Schizophrenia; Schizoaffective Disorder
Organon and Co
2004-09 PHASE3
NCT00685334 COMPLETED
Eating Disorders
New York State Psychiatric Institute
2003-11 PHASE4
NCT00095524 COMPLETED
Body Weight Change; Schizophrenia; Schizoaffective Disorder; Psychotic Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc.
2004-03 PHASE3
NCT00048802 COMPLETED
Bipolar Disorder
Northwell Health
2002-08 PHASE4
NCT00149292 COMPLETED
Schizophrenia
Denovo Biopharma LLC
2005-08-23 PHASE2
NCT00260962 COMPLETED
Anorexia Nervosa
Ottawa Hospital Research Institute
2000-09 PHASE2
NCT00143182 COMPLETED
Bipolar Disorder
Organon and Co
2005-01-07 PHASE3
NCT00304616 COMPLETED
Schizophrenia
Korea Otsuka Pharmaceutical Co., Ltd.
2004-10 PHASE4
NCT00048828 COMPLETED
Schizophrenia
Northwell Health
2001-10 PHASE4
NCT00159744 COMPLETED
Bipolar Disorder
Organon and Co
2004-11-30 PHASE3
NCT00156117 COMPLETED
Schizophrenia
Organon and Co
2005-05-12 PHASE3
NCT00159796 COMPLETED
Bipolar Disorder
Organon and Co
2004-12-14 PHASE3
NCT00212784 COMPLETED
Schizophrenia; Schizoaffective Disorder
Organon and Co
2003-09-04 PHASE3
NCT00203307 TERMINATED
Migraine
Thomas Jefferson University
2004-05
NCT00194064 TERMINATED
Bipolar Disorder
University Hospitals Cleveland Medical Center
2002-07 PHASE3
NCT00151424 COMPLETED
Schizophrenia
Organon and Co
2005-02-15 PHASE3
NCT00211562 TERMINATED
Schizophrenia
Augusta University
2005-10 PHASE3
NCT00230828 COMPLETED
Schizophrenia
Solvay Pharmaceuticals
2005-05 PHASE3
NCT00237913 COMPLETED
Schizophrenia
Otsuka Pharmaceutical Development & Commercialization, Inc.
2004-07 PHASE3
NCT01234454 COMPLETED
Schizophrenia
University of North Carolina, Chapel Hill
2002-01
NCT00183625 COMPLETED
Schizophrenia
University of California, Los Angeles
2000-06 PHASE4
NCT00767715 TERMINATED
Bipolar Disorder
Eli Lilly and Company
2004-10 PHASE4
NCT00235352 COMPLETED
Schizophrenia
North Suffolk Mental Health Association
2002-02 PHASE2; PHASE3
NCT00034892 COMPLETED
Schizophrenia; Psychotic Disorders; Mental Health; Mental Disorders
AstraZeneca
2002-03 PHASE3
NCT00592930 COMPLETED
Anorexia Nervosa
Northwell Health
2000-06 PHASE4
NCT00625170 COMPLETED
Insulin Resistance; Dyslipidemia
Leiden University Medical Center
2004-05
NCT00255879 COMPLETED
Dyskinesia, Drug-Induced
University of California, San Diego
1999-01 PHASE1
NCT01123408 COMPLETED
Schizophrenia
Nathan Kline Institute for Psychiatric Research
1999-06
NCT01282632 COMPLETED
Subjects Had Unipolar, Non-psychotic Major Depression
Sunnybrook Health Sciences Centre
2002-08 PHASE1; PHASE2
NCT00182013 COMPLETED
Bipolar Spectrum Disorder
Massachusetts General Hospital
2001-06 PHASE4
NCT00712686 COMPLETED
Schizophrenia
Otsuka Pharmaceutical Development & Commercialization, Inc.
2000-06 PHASE3
NCT00621998 COMPLETED
Neuroleptic-Induced Tardive Dyskinesia
Taoyuan Psychiatric Center, Ministry of Health and Welfare, Executive Yuan, R.O.C. Taiwan
2000-07 PHASE4
NCT00648921 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
2003-06 PHASE1
NCT00647777 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
2003-06 PHASE1
NCT00647972 TERMINATED
Healthy
Mylan Pharmaceuticals Inc
2003-05 PHASE1
NCT00000373 COMPLETED
Obsessive-Compulsive Disorder
University of Florida
1992-09 PHASE4
NCT00237861 COMPLETED
Schizophrenia
Yale University
PHASE4
NCT00169065 COMPLETED
Schizophrenia
Harvard Medical School (HMS and HSDM)
1998-08 PHASE4
NCT00007774 COMPLETED
Schizoaffective Disorder; Schizophrenia
US Department of Veterans Affairs
1998-03 PHASE4
NCT00485680 COMPLETED
Bipolar Disorder
Eli Lilly and Company
2003-12 PHASE3
NCT00231335 COMPLETED
Schizophrenia; Schizoaffective Disorder
Emory University
2006-03 PHASE4
NCT00486005 COMPLETED
Schizophrenia
Eli Lilly and Company
2003-02 PHASE4
NCT00485810 COMPLETED
Schizophrenia
Eli Lilly and Company
2004-06 PHASE1; PHASE2
NCT01303601 COMPLETED
Bipolar Disorder; Depression, Bipolar
China Medical University, China
2009-01 PHASE4
NCT00091650 COMPLETED
Borderline Personality Disorder
Eli Lilly and Company
2004-03 PHASE3
NCT00150215 COMPLETED
Schizophrenia
Pfizer
2005-07 PHASE1
NCT00179231 COMPLETED
Schizophrenia; Schizoaffective Disorder
Vanderbilt University
2000-05
NCT00239109 COMPLETED
Schizophrenia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
2003-04 PHASE4
NCT00103571 COMPLETED
Schizophrenia
Eli Lilly and Company
2004-07 PHASE4
NCT00078039 COMPLETED
Schizophrenia
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2004-03 PHASE3
NCT00297960 COMPLETED
Healthy Male Volunteers
Medical University of Vienna
2005-04 PHASE4
NCT00259870 COMPLETED
Schizophrenia
GlaxoSmithKline
2005-09 PHASE2
NCT00006195 UNKNOWN
Schizophrenia
National Center for Research Resources (NCRR)
NCT00182507 COMPLETED
Trichotillomania
Hamilton Health Sciences Corporation
2000-06 PHASE4
NCT00036088 COMPLETED
Schizophrenia
Eli Lilly and Company
2001-08 PHASE4
NCT00210769 COMPLETED
Schizophrenia
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2004-01 PHASE3
NCT00089869 COMPLETED
Schizophrenia
Eli Lilly and Company
PHASE1; PHASE2
NCT00015548 COMPLETED
Alzheimer's Disease
National Institute of Mental Health (NIMH)
2001-03
NCT00018668 COMPLETED
Schizophrenia
US Department of Veterans Affairs
2000-10 PHASE4
NCT00088049 COMPLETED
Schizophrenia
Eli Lilly and Company
2003-10 PHASE4
NCT00094549 COMPLETED
Bipolar Disorder
Eli Lilly and Company
2004-10 PHASE4
NCT00100776 COMPLETED
Schizophrenia; Schizoaffective Disorder
Eli Lilly and Company
2003-09 PHASE4
NCT00077714 COMPLETED
Schizophrenia
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2004-01 PHASE3
NCT00485901 COMPLETED
Schizophrenia
Eli Lilly and Company
2004-07 PHASE3
NCT00380224 COMPLETED
Schizophrenia
Wyeth is now a wholly owned subsidiary of Pfizer
2006-07 PHASE3
NCT00088491 COMPLETED
Schizophrenic Disorders
Eli Lilly and Company
2004-06 PHASE3
NCT00034580 COMPLETED
Bipolar Disorder
Eli Lilly and Company
2001-08 PHASE4
NCT00065273 COMPLETED
Mental Retardation; Developmental Delay Disorder
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
1998-07 PHASE3
NCT00057408 COMPLETED
Autistic Disorder
FDA Office of Orphan Products Development
2003-05 PHASE2
NCT00287820 COMPLETED
Schizophrenia; Diabetes; Metabolic Syndrome; Hyperglycemia
Nathan Kline Institute for Psychiatric Research
2004-02 PHASE4
NCT00159770 COMPLETED
Schizophrenia; Schizoaffective Disorder; Psychotic Disorders
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
2001-11 PHASE3
NCT00455442 COMPLETED
Weight-Gain Prevention
Corcept Therapeutics
2007-03 PHASE2
NCT00050206 COMPLETED
Bipolar Disorder
Eli Lilly and Company
2002-11 PHASE4
NCT00350467 COMPLETED
Acute Schizophrenia
Xian-Janssen Pharmaceutical Ltd.
2006-06 PHASE3
NCT00088036 COMPLETED
Borderline Personality Disorder
Eli Lilly and Company
2004-02 PHASE3
NCT00191828 COMPLETED
Weight Gain
Eli Lilly and Company
2003-03 PHASE4
NCT00650793 COMPLETED
Schizophrenia
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2004-03 PHASE3
NCT00485498 COMPLETED
Schizophrenia
Eli Lilly and Company
2003-04 PHASE4
NCT00351000 COMPLETED
Schizophrenia
North Suffolk Mental Health Association
2005-01 PHASE4
NCT00534183 COMPLETED
Metabolic Syndrome; Diabetes; Obesity
Central Institute of Psychiatry, Ranchi, India
2006-06
NCT00145444 COMPLETED
Schizophrenia; Psychotic Disorders
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
2003-03 PHASE3
NCT00169702 COMPLETED
Schizophrenia
Heinrich-Heine University, Duesseldorf
2003-06
NCT00182442 COMPLETED
Schizophrenia
Hamilton Health Sciences Corporation
2003-10 PHASE4
NCT00014001 COMPLETED
Schizophrenia
National Institute of Mental Health (NIMH)
2000-12 PHASE4
NCT00083668 COMPLETED
Schizophrenia
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2004-04 PHASE3
NCT00331825 COMPLETED
Schizophrenia; Extrapyramidal Syndrome
Taoyuan Psychiatric Center, Ministry of Health and Welfare, Executive Yuan, R.O.C. Taiwan
2000-07 PHASE4
NCT00191399 COMPLETED
Depression, Bipolar
Eli Lilly and Company
2004-05 PHASE4
NCT00378183 COMPLETED
Schizoaffective Disorder; Schizophrenia
Janssen, LP
2001-02 PHASE4
NCT00236379 COMPLETED
Schizophrenia; Diabetes Mellitus
Janssen, LP
PHASE4
NCT00071253 TERMINATED
Bipolar Disorder
Abbott
2003-07 PHASE4
NCT00418171 COMPLETED
Schizophrenia
Pfizer
2002-02 PHASE4
NCT00113594 COMPLETED
Schizophrenia; Bipolar Disorder
Eli Lilly and Company
2005-06 PHASE3
NCT00094640 COMPLETED
Schizophrenia; Schizoaffective Disorder
Eli Lilly and Company
PHASE1
NCT00044187 COMPLETED
Schizophrenia; Psychotic Disorders; Bipolar Disorder
Eli Lilly and Company
2001-04 PHASE4
NCT00108368 COMPLETED
Schizophrenia; Psychotic Disorders
US Department of Veterans Affairs
2003-10 PHASE4
NCT00088478 COMPLETED
Schizophrenia
Eli Lilly and Company
2004-06 PHASE3
NCT00221481 WITHDRAWN
Bipolar Disorder
Mayo Clinic
PHASE4
NCT00177567 COMPLETED
Bipolar Disorder
University of Pittsburgh
2001-07 PHASE4
NCT00433121 COMPLETED
Dementia
Sykehuset Innlandet HF
2006-09 PHASE4
NCT00236457 COMPLETED
Schizophrenia; Psychotic Disorders
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2000-11 PHASE3
NCT00316238 COMPLETED
Schizophrenia
Eli Lilly and Company
2006-04 PHASE2
NCT00208819 COMPLETED
Senile Dementia, Alzheimer Type; Dementia, Alzheimer Type; Alzheimer Disease; Dementia
Emory University
2003-09 PHASE4
NCT00191555 COMPLETED
Schizophrenia
Eli Lilly and Company
2003-08 PHASE4
NCT00090012 COMPLETED
Schizophrenia; Schizoaffective Disorder
Eli Lilly and Company
2004-07 PHASE4
NCT00035321 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
2002-04 PHASE3
NCT00051298 COMPLETED
Schizophrenia
Eli Lilly and Company
2002-11 PHASE3
NCT00483964 COMPLETED
Schizophrenia
Q.Mundewadi Ayurvedic Research & Charitable Trust
2005-09 PHASE2
NCT00222495 COMPLETED
Psychotic Disorders; Schizophrenia; Schizophreniform Disorders; Schizoaffective Disorders
University of Minnesota
2002-08
NCT00485771 COMPLETED
Bipolar Disorder
Eli Lilly and Company
2003-11 PHASE4
NCT00073164 COMPLETED
Schizophrenia
Abbott
2003-07 PHASE2
NCT00034801 COMPLETED
Depression; Schizophrenia; Schizoaffective Disorder
Eli Lilly and Company
2001-09 PHASE4
NCT00181935 COMPLETED
Bipolar Disorder; Mania
Massachusetts General Hospital
2001-03 PHASE4
NCT00191997 COMPLETED
Bipolar Disorder
Eli Lilly and Company
2004-10 PHASE4
NCT00265551 COMPLETED
Schizophrenia
Wyeth is now a wholly owned subsidiary of Pfizer
2006-01 PHASE2
NCT00190892 COMPLETED
Bipolar Disorder
Eli Lilly and Company
2004-09 PHASE4
NCT00485823 COMPLETED
Schizophrenic Disorders
Eli Lilly and Company
2002-12 PHASE4

(data from https://clinicaltrials.gov, updated on 2026-05-26)

Check the Olanzapine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Olanzapine binds with high affinity to 5-HT2 serotonin and D2 dopamine receptors, blocking downstream monoaminergic signal transduction and modulating postsynaptic neurotransmission in cortical and limbic circuits. This competitive antagonism normalizes central dopaminergic and serotonergic signaling, providing clinical relevance in the suppression of psychotic symptoms, mood stabilization, and alleviation of chemotherapy-induced nausea observed in clinical trials for schizophrenia, bipolar I disorder, and supportive oncology care.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.