CAS No. 132539-06-1

Batch: Purity:99.99
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Olanzapine Chemical Structure
Chemical Structure
Check the Olanzapine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
CAS Number 132539-06-1
Molecular Formula

C17H20N4S
Molecular Weight (MW) 312.43975
SMILES CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CCN(CC4)C
InChIKey KVWDHTXUZHCGIO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Olanzapine is an atypical antipsychotic agent that acts as an antagonist at 5-HT2 serotonin receptors and D2 dopamine receptors, exhibiting higher affinity for 5-HT2 receptors over D2 receptors. It also displays binding affinity toward histamine H1, muscarinic cholinergic, and alpha-adrenergic receptors, as well as weak interactions with GABAA receptors. Blockade of these receptors modulates central serotonergic and dopaminergic signaling pathways, regulating neurochemical responses and sedative phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 62 mg/mL (198.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 15 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.