CAS No. 58-27-5
Batch:
Purity:99.88
Chemical Structure
Check the
Menadione (Vitamin K3)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methylnaphthalene-1,4-dione | |
|---|---|---|
| CAS Number | 58-27-5 | |
| Molecular Formula |
C11H8O2 |
|
| Molecular Weight (MW) | 172.18 | |
| SMILES | CC1=CC(=O)C2=CC=CC=C2C1=O | |
| InChIKey | MJVAVZPDRWSRRC-UHFFFAOYSA-N |
Menadione (Vitamin K3) is a synthetic naphthoquinone derivative that acts as an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ. By suppressing these enzymatic targets, menadione impairs cell cycle progression and mitochondrial DNA synthesis. This inhibition triggers intracellular reactive oxygen species accumulation, induces severe oxidative stress, and ultimately promotes apoptotic cell death. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
34 mg/mL
(197.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 34 mg/mL |
| Water | Insoluble |
| DMSO |
34 mg/mL
(197.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 34 mg/mL |
| Water | Insoluble |
| DMSO |
34 mg/mL
(197.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Menadione (Vitamin K3) Clinical Trials
- Menadione (Vitamin K3) Solubility in DMSO
- Menadione (Vitamin K3) Storage
- Menadione (Vitamin K3) Stability
- Menadione (Vitamin K3) Molecular Weight
- Menadione (Vitamin K3) SMILES
- Menadione (Vitamin K3) Chemical Structure (2D and 3D)
- Menadione (Vitamin K3) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.