Clinical Trials

Numerous clinical trials evaluate medroxyprogesterone acetate across all developmental stages, spanning Early Phase 1 through Phase 4. These investigations address diverse indications—including female infertility, HIV prevention, renal allograft transplantation, periodontal diseases, and systemic sclerosis—and encompass completed, recruiting, active, and terminated protocols. A wide network of entities sponsors these efforts, ranging from academic and clinical institutions to pharmaceutical companies.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04877288 RECRUITING
Renal Allograft Recipients
Bristol-Myers Squibb
2021-07-21 PHASE3
NCT07462663 NOT_YET_RECRUITING
Endometrial Cancer; Endometrial Cancer Stage I; Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I; Atypical Endometrial Hyperplasia; Endometrial Intraepithelial Neoplasia; Obesity & Overweight; BMI>40; Obesity; Obesity Grade III
Hospital Universitari de Bellvitge
2027-01 PHASE4
NCT07488949 RECRUITING
Chronic Endometritis
Fang Wang
2024-04-09
NCT06942156 NOT_YET_RECRUITING
Heart Transplant
Chong Kun Dang Pharmaceutical
2025-08-14 PHASE4
NCT05255653 RECRUITING
Endometrial Cancer
Leiden University Medical Center
2021-11-11 PHASE2; PHASE3
NCT06549855 RECRUITING
Endometrial Cancer; Endometrioid Carcinoma; Mismatch Repair Deficiency
Peking University People's Hospital
2024-09-02
NCT06868290 ACTIVE_NOT_RECRUITING
ANCA Associated Vasculitis (AAV)
Novartis Pharmaceuticals
2025-03-13 PHASE2
NCT06665256 ACTIVE_NOT_RECRUITING
Idiopathic Inflammatory Myopathies
Novartis Pharmaceuticals
2024-12-17 PHASE2
NCT07611214 RECRUITING
Lupus Nephritis
Aurinia Pharmaceuticals Inc.
2026-04-22 PHASE4
NCT07359859 RECRUITING
Hematologic Malignancies
Memorial Sloan Kettering Cancer Center
2026-01-20 PHASE2
NCT06665997 RECRUITING
Sickle Cell Disease (SCD); Vaso-Occlusive Pain Episode in Sickle Cell Disease
University of Pennsylvania
2025-06-26 PHASE4
NCT06468215 RECRUITING
Carcinoma, Endometrioid; Fertility Preservation
Peking University People's Hospital
2024-06-21
NCT07508787 RECRUITING
Renal Transplant Failure and Rejection
Nefro Avillion Clinical Development, LLC
2026-06-29 PHASE2
NCT06973668 RECRUITING
AML
M.D. Anderson Cancer Center
2025-07-22 PHASE2
NCT07570433 NOT_YET_RECRUITING
CMV Infection
Oriol Manuel
2026-04 PHASE4
NCT07319429 RECRUITING
Endometrial Cancer; Fertility
Fudan University
2026-01-25 PHASE2; PHASE3
NCT06297096 RECRUITING
Systemic Sclerosis; Interstitial Lung Disease
National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland
2025-07-01 PHASE3
NCT06979596 RECRUITING
Malignant Neoplasm
Merck Sharp & Dohme LLC
2025-08-11 PHASE2
NCT04888741 RECRUITING
Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndromes; Non Hodgkin Lymphoma; Hodgkin Lymphoma; Multiple Myeloma; Chronic Myelogenous Leukemia; Myelofibrosis
University of Birmingham
2021-02-22 PHASE2
NCT06258915 NOT_YET_RECRUITING
Non Infectious Uveitis
Assistance Publique - Hôpitaux de Paris
2024-03-01 PHASE3
NCT05044962 RECRUITING
HIV Infections; Contraception; Drug-drug Interaction
University of Alabama at Birmingham
2021-11-26
NCT05247268 RECRUITING
Endometrial Neoplasm Malignant Stage I
Fudan University
2022-03-11 PHASE2
NCT05060991 ACTIVE_NOT_RECRUITING
COVID-19; Immunosuppression; Vaccine Response Impaired
University of California, Davis
2021-09-24 PHASE4
NCT04997499 ACTIVE_NOT_RECRUITING
Medication Compliance; Contraception; Self-Evaluation
Tufts Medical Center
2021-09-29
NCT05365672 RECRUITING
Kidney Transplantation
TolerogenixX GmbH
2022-05-04 PHASE2
NCT05760144 RECRUITING
Contraception
Oregon Health and Science University
2023-07-01 EARLY_PHASE1
NCT07124195 NOT_YET_RECRUITING
Malignant Solid Tumors; Moderate to High Emetogenic Chemotherapy (MEC/HEC) Drugs
The First Affiliated Hospital of Xinxiang Medical College
2025-08-10 PHASE3
NCT05193565 ACTIVE_NOT_RECRUITING
Kidney Transplantation
Chong Kun Dang Pharmaceutical
2021-11-19 PHASE4
NCT06904274 WITHDRAWN
Endometrial Hyperplasia
Bayer
2025-11-24 PHASE3
NCT05669001 COMPLETED
Renal Transplantation
ITB-Med LLC
2023-12-28 PHASE2
NCT04547049 ACTIVE_NOT_RECRUITING
Leukemia; MDS
First Affiliated Hospital of Zhejiang University
2020-09-01 PHASE3
NCT03292861 ENROLLING_BY_INVITATION
Heart Transplantation
Cedars-Sinai Medical Center
2018-09-13 PHASE2
NCT07291648 COMPLETED
Tinnitus
University of Nottingham
2025-09-01
NCT05675787 UNKNOWN
Atypical Endometrial Hyperplasia; Endometrial Carcinoma Stage I
Peking University People's Hospital
2023-01-06 PHASE2
NCT06816901 COMPLETED
Postpartum Contraception; Depot Medroxyprogesterone Acetate; Lactation; DMPA
University of California, San Diego
2025-03-26 PHASE4
NCT02416388 RECRUITING
Acute Myeloid Leukemia (AML)
University Hospital, Angers
2015-01 PHASE2; PHASE3
NCT04893798 COMPLETED
Healthy
Pfizer
2021-09-16 PHASE1
NCT06637189 NOT_YET_RECRUITING
Stimulation in the Ovary; Embryo; Oocyte; Oocyte Retrieval; Fertilization in Vitro; Blastocyst; PGT-A
Ginefiv
2024-10-15 PHASE4
NCT03246906 TERMINATED
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Aggressive Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia; Diffuse Large B-Cell Lymphoma; Mantle Cell Lymphoma; Myelodysplastic Syndrome; Myelodysplastic/Myeloproliferative Neoplasm; Prolymphocytic Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Recurrent Waldenstrom Macroglobulinemia; Hematologic and Lymphocytic Disorder; Blastic Plasmacytoid Dendritic Cell Neoplasm
Fred Hutchinson Cancer Center
2017-09-11 PHASE2
NCT03942887 UNKNOWN
ANCA Associated Vasculitis
Leiden University Medical Center
2019-05-03 PHASE3
NCT04414735 UNKNOWN
Kidney Transplant Rejection
Fundacion Clinic per a la Recerca Biomédica
2022-08-17
NCT04997811 UNKNOWN
Myelodysplastic Syndromes (MDS)
Prof. Janet Dunn
2021-12-21 PHASE2
NCT07470632 COMPLETED
Exam Anxiety
Near East University, Turkey
2025-01-05
NCT06365437 TERMINATED
Kidney Transplantation
ITB-Med LLC
2021-06-06 PHASE2
NCT01428973 UNKNOWN
Graft-Versus-Host Disease; Hematological Malignancies
University of Liege
2011-09 PHASE2
NCT05767086 COMPLETED
Infertility
Bezmialem Vakif University
2023-03-15
NCT06304220 UNKNOWN
Infertility, Female; Fertility Disorders
NextFertility
2024-07
NCT05178563 Not yet recruiting
Inflammation|Periodontal Diseases
University College London
2024-09-01 Not Applicable
NCT06145438 COMPLETED
Endometriosis Ovary
Universitas Diponegoro
2023-09-04 PHASE3
NCT06067217 UNKNOWN
Abnormal Uterine Bleeding; Tranexamic Acid; Estrogen; Depot Medroxyprogesterone Acetate
Department of Medical Services Ministry of Public Health of Thailand
2023-09-30
NCT06584773 UNKNOWN
Disorder Related to Renal Transplantation
University of Sao Paulo General Hospital
2015-06 PHASE4
NCT05565573 UNKNOWN
Fertility Sparing
Hua Li
2022-11-01 PHASE2; PHASE3
NCT06297096 Not yet recruiting
Systemic Sclerosis|Interstitial Lung Disease
National Institute of Geriatrics Rheumatology and Rehabilitation Poland|Medical Research Agency Poland
2024-04-01 Phase 3
NCT06193135 Not yet recruiting
Infertility Female|Reproductive Sterility
Instituto Valenciano de Infertilidad IVI VALENCIA
2024-03-01 Not Applicable
NCT04773392 TERMINATED
Kidney Transplantation; Kidney Transplant Rejection
University of Southern California
2021-11-23 PHASE4
NCT05166967 COMPLETED
Haploidentical Hematopoietic Stem Cell Transplantation
Chinese PLA General Hospital
2022-01-01 PHASE3
NCT04669678 COMPLETED
HIV Infections; Contraception; Drug-drug Interaction
University of Alabama at Birmingham
2021-11-17 PHASE4
NCT05158608 UNKNOWN
Graft Versus Host Disease; Hematologic Malignancy; Cyclophosphamide Adverse Reaction
National Research Center for Hematology, Russia
2022-01-01 PHASE3
NCT04726553 UNKNOWN
Systemic Lupus Erythematosus (SLE)
Oklahoma Medical Research Foundation
2021-01-20 EARLY_PHASE1
NCT04927390 UNKNOWN
Systemic Sclerosis; Limited Cutaneous Systemic Sclerosis
University College, London
2021-12-08 PHASE2
NCT05726903 COMPLETED
Gender Dysphoria, Adolescent
University of Colorado, Denver
2022-12-06 PHASE4
NCT04311632 COMPLETED
Kidney Transplantation
ITB-Med LLC
2021-05-26 PHASE2
NCT05505435 COMPLETED
Contraception
Northwestern University
2022-08-01 PHASE4
NCT03899103 COMPLETED
Steroid-Dependent Nephrotic Syndrome
Nilratan Sircar Medical College
2019-05-15 PHASE3
NCT04910711 UNKNOWN
Human Immunodeficiency Virus; Contraception; ART
Botswana Harvard AIDS Institute Partnership
2021-10-21 PHASE4
NCT04225988 COMPLETED
Kidney Transplant Rejection
Cedars-Sinai Medical Center
2020-01-09 PHASE4
NCT05973253 COMPLETED
Photorefractive Keratectomy
Isfahan University of Medical Sciences
2023-04-21 PHASE2; PHASE3
NCT03386539 COMPLETED
Pediatric Heart Transplantation; Immunosuppression; Chronic Kidney Diseases; Cardiac Allograft Vasculopathy; Heart Transplant Failure and Rejection; Post-transplant Lymphoproliferative Disorder; Heart Transplant Infection
Boston Children's Hospital
2018-01-29 PHASE3
NCT04280601 COMPLETED
ANCA-associated Vasculitis; Granulomatosis With Polyangiitis; Microscopic Polyangiitis; Eosinophilic Granulomatosis With Polyangiitis
Christian Pagnoux
2020-08-01
NCT04989348 COMPLETED
IVF
Shanghai First Maternity and Infant Hospital
2021-08-04
NCT04669210 COMPLETED
Graft-versus-host-disease; Stem Cell Transplant Complications; Acute Myeloid Leukemia; Acute Lymphoid Leukemia
St. Petersburg State Pavlov Medical University
2020-11-03 PHASE2
NCT04444843 UNKNOWN
Kidney Transplant Recipients
First Affiliated Hospital Xi'an Jiaotong University
2021-01-22 PHASE4
NCT04814927 COMPLETED
Mucosal Inflammation; Contraceptive; Complications, Intrauterine
Eastern Virginia Medical School
2021-03-01 PHASE4
NCT05491343 UNKNOWN
Arteriovenous Malformations
HaEmek Medical Center, Israel
2022-08 PHASE4
NCT04414761 COMPLETED
IVF; GnRH Antagonist; PPOS
ShangHai Ji Ai Genetics & IVF Institute
2020-06-04 PHASE3
NCT04903054 WITHDRAWN
Kidney Transplantation; Renal Transplant Recipients
National Institute of Allergy and Infectious Diseases (NIAID)
2022-01-10 PHASE2
NCT03959241 COMPLETED
Acute Leukemia; Chronic Myelogenous Leukemia (CML); Myelodysplasia; Lymphoma
Medical College of Wisconsin
2019-06-25 PHASE3
NCT02426502 UNKNOWN
End-Stage Renal Disease
University of British Columbia
2016-04
NCT04778618 UNKNOWN
Haploidentical Hematopoietic Stem Cell Transplantation
Chinese PLA General Hospital
2020-12-01 PHASE2
NCT03794492 COMPLETED
Kidney Transplant
Chong Kun Dang Pharmaceutical
2018-03-31 PHASE4
NCT04682353 COMPLETED
Contraception
Teva Branded Pharmaceutical Products R&D, Inc.
2020-12-14 PHASE1
NCT03675139 COMPLETED
Endometrial Hyperplasia Without Atypia
Xiaojun Chen
2019-02-26 PHASE3
NCT04710017 COMPLETED
Uterine Bleeding
Assiut University
2021-02-01
NCT04654741 UNKNOWN
IVF; Infertility
Casa di Cura Privata Villa Mafalda
2020-09-01 PHASE4
NCT04021420 UNKNOWN
Melanoma; Metastatic Melanoma
Assistance Publique - Hôpitaux de Paris
2019-10-24 PHASE1; PHASE2
NCT03591380 TERMINATED
Kidney Transplantation
University of Wisconsin, Madison
2019-05-14 PHASE2
NCT02617108 UNKNOWN
Uterine Septum
Fu Xing Hospital, Capital Medical University
2019-12
NCT04424602 COMPLETED
Lupus Nephritis
Al-Azhar University
2021-04-05 PHASE4
NCT01822288 COMPLETED
Menopausal Syndromes
Far Eastern Memorial Hospital
2012-11-16 PHASE4
NCT00423514 COMPLETED
Graft Versus Host Disease; Leukemia; Myelodysplastic Syndromes
Memorial Sloan Kettering Cancer Center
2006-11-20 PHASE1; PHASE2
NCT02449161 TERMINATED
Menorrhagia
Guy Waddell
2015-08 PHASE3
NCT03468478 COMPLETED
Kidney Transplant Infection
Hospital do Rim e Hipertensão
2017-06-18 PHASE4
NCT03671473 WITHDRAWN
Carpal Tunnel Syndrome
Tri-Service General Hospital (TSGH)
2019-01-01
NCT03395756 COMPLETED
Emergency Contraception; Contraception
University of Southern California
2018-08-31 EARLY_PHASE1
NCT02943655 COMPLETED
Improve Quality of Life; Heavy Menstrual Bleeding
Assiut University
2017-11-01 PHASE3
NCT03712345 TERMINATED
Granulomatosis With Polyangiitis (GPA); Microscopic Polyangiitis (MPA)
InflaRx GmbH
2018-10-15 PHASE2
NCT01935128 COMPLETED
Renal Transplant
University of Toledo Health Science Campus
2013-07-03 PHASE4
NCT01265017 WITHDRAWN
Type 1 Diabetes
Sansum Diabetes Research Institute
2012-07 PHASE1
NCT02432339 UNKNOWN
Psychological Stress; Hypertension, Renal
Augusta University
2014-04-22 PHASE1; PHASE2
NCT02357368 COMPLETED
HIV; Contraception
Lisa Haddad
2015-02 PHASE4
NCT02974686 TERMINATED
Kidney Transplant Rejection; Gastrointestinal Disorder, Functional
Washington University School of Medicine
2016-11 PHASE4
NCT01936519 COMPLETED
Immunosuppression; Renal Failure
Milton S. Hershey Medical Center
2013-12-16
NCT03300960 COMPLETED
Infertility
Instituto Valenciano de Infertilidad, IVI VALENCIA
2017-10-20 PHASE3
NCT03644225 COMPLETED
Systemic Sclerosis
Oliver Distler
2018-06-11
NCT02991768 TERMINATED
Diarrhea
University of Kansas Medical Center
2017-01-27 PHASE2
NCT02435901 COMPLETED
Sickle Cell Disease; Beta Thalassemia-Major
Northwell Health
2008-12 PHASE1; PHASE2
NCT01265537 COMPLETED
Acute Graft Rejection; Diabetes
University of British Columbia
2011-06-24
NCT03911583 UNKNOWN
Overweight; Obesity
Universidad de Córdoba
2016-01-01
NCT02817464 COMPLETED
Pregnancy; Contraception
Teva Branded Pharmaceutical Products R&D, Inc.
2016-10-26 PHASE1
NCT02383589 COMPLETED
Pemphigus Vulgaris
Hoffmann-La Roche
2015-05-26 PHASE3
NCT02550067 COMPLETED
HIV; Contraception
FHI 360
2015-12-14
NCT02456584 COMPLETED
Contraception
FHI 360
2015-09 PHASE1
NCT02433522 COMPLETED
ANCA-associated Vasculitides
Assistance Publique - Hôpitaux de Paris
2015-03-31 PHASE3
NCT01541176 COMPLETED
Renal Transplant
Nantes University Hospital
2012-04 PHASE4
NCT03255941 COMPLETED
Contraception
FHI 360
2018-03-19 EARLY_PHASE1
NCT02103764 UNKNOWN
Dysfunctional Uterine Bleeding
Mahidol University
2013-08 PHASE3
NCT03018249 COMPLETED
FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma; FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma; FIGO Grade 3 Endometrial Endometrioid Adenocarcinoma
National Cancer Institute (NCI)
2017-10-11 EARLY_PHASE1
NCT03197961 COMPLETED
HIV/AIDS; Contraception
Sharon Achilles
2017-11-17 EARLY_PHASE1
NCT02042690 COMPLETED
Acute Lymphoblastic Leukemia
Peking University
2014-07 PHASE3
NCT02228681 COMPLETED
Advanced, Persistent, or Recurrent Endometrial Cancer
GOG Foundation
2015-05-21 PHASE2
NCT01824693 COMPLETED
Juvenile Myelomonocytic Leukemia
Children's Oncology Group
2013-06-24 PHASE2
NCT03309176 COMPLETED
Ovulation Disorder
Radboud University Medical Center
2016-06-21 PHASE4
NCT01878786 TERMINATED
Delayed Graft Function
Matthew Cooper
2013-06 PHASE2; PHASE3
NCT02208037 COMPLETED
Acute Leukemia; Chronic Myelogenous Leukemia; Myelodysplasia; Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Hodgkin's Lymphoma
National Heart, Lung, and Blood Institute (NHLBI)
2014-08 PHASE2
NCT02411084 TERMINATED
Graft vs Host Disease
Adienne SA
2016-02 PHASE3
NCT02896205 COMPLETED
Systemic Sclerosis; Scleroderma; Interstitial Lung Disease
Post Graduate Institute of Medical Education and Research, Chandigarh
2016-10 PHASE3
NCT02412436 COMPLETED
HIV-1 Infection; Tuberculosis
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
2015-11-03 PHASE2
NCT02122198 COMPLETED
Cognitive Impairment; Executive Dysfunction; Endothelial Dysfunction; Cardiovascular Disease
University of Colorado, Denver
2014-09-08
NCT03443089 COMPLETED
Contraception
Galeno Desenvolvimento de Pesquisas Clínicas
2017-03-31 PHASE1
NCT02509767 COMPLETED
Contraception
Planned Parenthood Federation of America
2015-08 PHASE4
NCT02103660 COMPLETED
HIV; Contraception
Centers for Disease Control and Prevention
2014-04-08 PHASE4
NCT01580865 COMPLETED
Lupus Nephritis
Ramathibodi Hospital
2012-05
NCT01463202 COMPLETED
Contraception; Postpartum Depression; Lactation
Beatrice Chen
2011-11 PHASE4
NCT01950819 COMPLETED
End Stage Renal Disease (ESRD); Chronic Kidney Disease (CKD); Hemodialysis; Renal Replacement Therapy; Renal Transplantation
Novartis Pharmaceuticals
2013-12-03 PHASE4
NCT02083991 COMPLETED
Diabetes Mellitus
Vastra Gotaland Region
2013-01 PHASE4
NCT02152345 COMPLETED
Implant or Graft; Rejection
Columbia University
2014-06 PHASE4
NCT02390362 TERMINATED
Frequent Relapsing Nephrotic Syndrome; Steroid Dependent Nephrotic Syndrome
Nationwide Children's Hospital
2015-01 PHASE3
NCT02272647 COMPLETED
Healthy
Mayo Clinic
2014-12 PHASE1
NCT01544491 COMPLETED
Prevention of Acute Rejection in Paediatric Recipients of a Renal Transplant
Novartis Pharmaceuticals
2012-08-17 PHASE3
NCT02561767 UNKNOWN
Kidney Transplantation; Acute Kidney Tubular Necrosis
First Affiliated Hospital, Sun Yat-Sen University
2015-10 PHASE1; PHASE2
NCT01875224 UNKNOWN
New Onset Diabetes After Transplant; Kidney Transplantation
University of Arizona
2013-08 PHASE4
NCT01707849 COMPLETED
Hepatitis C Recurrence After Liver Transplant
Hospital Vall d'Hebron
2012-10 PHASE3
NCT00494741 COMPLETED
Kidney Transplant
Mario Negri Institute for Pharmacological Research
2007-05 PHASE4
NCT01860183 COMPLETED
Kidney Transplantation; Kidney Failure
Clinical Hospital Merkur
2013-05 PHASE4
NCT01299116 COMPLETED
Contraception
FHI 360
2011-12 PHASE4
NCT02534688 COMPLETED
Endometriosis
King Chulalongkorn Memorial Hospital
2015-06 PHASE4
NCT02894151 COMPLETED
Clinically Diagnosed Endometriotic Patient Was Defined as a Woman Who Has Pelvic Pain and at Least One Evidence of PV or TVS
Chulalongkorn University
2015-04 PHASE2
NCT02335203 UNKNOWN
Grade 1 Endometrial Endometrioid Adenocarcinoma; Grade 2 Endometrial Endometrioid Adenocarcinoma; Complex Atypical Endometrial Hyperplasia
Women and Infants Hospital of Rhode Island
2015-02 PHASE2
NCT01895049 COMPLETED
Kidney Transplantation; Cytomegalovirus
Helio Tedesco Silva Junior
2013-08 PHASE4
NCT01766375 UNKNOWN
Acute Myeloid Leukemia
Guangxi Medical University
2012-08 PHASE3
NCT01067300 UNKNOWN
Leukemia
Assistance Publique Hopitaux De Marseille
2010-02 PHASE3
NCT01410448 COMPLETED
Kidney Transplantation
Novartis Pharmaceuticals
2011-11 PHASE3
NCT02036554 UNKNOWN
Kidney; Complications, Allograft
Seoul St. Mary's Hospital
2013-03 PHASE4
NCT02058875 WITHDRAWN
Cardiovascular Disease; Cardiovascular Outcomes; Kidney Transplant Recipients; Kidney Transplantation
University of Saskatchewan
2014-02 PHASE4
NCT00933231 COMPLETED
Kidney Transplantation
Astellas Pharma Inc
2009-08-17 PHASE3
NCT00997893 COMPLETED
Menopause; Hot Flashes
University of Illinois at Chicago
2009-12 PHASE2
NCT02340013 COMPLETED
Infertility
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
2013-07 PHASE4
NCT01461824 COMPLETED
Weight Gain; Disorder of Bone Density and Structure, Unspecified; Uterine Bleeding
Nationwide Children's Hospital
2011-09 PHASE3
NCT02872818 COMPLETED
Apoptotic Signal Pathways in Endometrial Hyperplasia
Kayseri Education and Research Hospital
2014-10 PHASE4
NCT02123108 COMPLETED
Liver Transplantation
University of California, Los Angeles
2011-01 PHASE4
NCT01594879 UNKNOWN
Endometrial Cancer
Korean Gynecologic Oncology Group
2012-01 PHASE2
NCT00103792 COMPLETED
Wegener's Granulomatosis; Vasculitis
University Medical Center Groningen
2004-12 PHASE3
NCT01134952 COMPLETED
Hepatitis C
London Health Sciences Centre
2010-06 PHASE4
NCT01244659 WITHDRAWN
Renal Transplant
EMS
2014-05 PHASE3
NCT01197040 COMPLETED
Nephrotic Syndrome
Assistance Publique - Hôpitaux de Paris
2009-10 PHASE3
NCT00371319 COMPLETED
Lupus Nephritis
Tuen Mun Hospital
2005-09 PHASE4
NCT01776203 TERMINATED
Dysfunctional Uterine Bleeding
Kaiser Permanente
2012-01 PHASE4
NCT01766518 UNKNOWN
Evidence of Liver Transplantation
Chong Kun Dang Pharmaceutical
2009-11 PHASE4
NCT00412360 COMPLETED
Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia; Chronic Myelogenous Leukemia; Myelodysplastic Syndrome; Natural Killer Cell Lymphoblastic Leukemia/Lymphoma
Medical College of Wisconsin
2006-12 PHASE3
NCT01421368 COMPLETED
HIV Prevention
CONRAD
2012-03 PHASE1
NCT01169701 COMPLETED
Renal Transplant
Novartis Pharmaceuticals
2010-08 PHASE4
NCT00075478 COMPLETED
Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia in Remission; Aggressive Non-Hodgkin Lymphoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Diffuse Large B-Cell Lymphoma; Hematopoietic and Lymphoid Cell Neoplasm; Indolent Non-Hodgkin Lymphoma; Mantle Cell Lymphoma; Myelodysplastic/Myeloproliferative Neoplasm; Plasma Cell Myeloma; Refractory Chronic Lymphocytic Leukemia; Refractory Hodgkin Lymphoma; Waldenstrom Macroglobulinemia
Fred Hutchinson Cancer Center
2003-10 PHASE3
NCT01410162 COMPLETED
Renal Transplant; Kidney Pancreas Transplant
Norman Muirhead
2010-12 PHASE4
NCT01074892 COMPLETED
Endometrial Hyperplasia
University Hospital of North Norway
2005-05 PHASE4
NCT01630252 COMPLETED
Endometriosis
PregLem SA
2012-06 PHASE2
NCT00693446 UNKNOWN
Pancreas Transplantation; Kidney Transplantation
Nantes University Hospital
2004-04 PHASE4
NCT01187953 COMPLETED
Renal Failure
Veloxis Pharmaceuticals
2010-09 PHASE3
NCT01791413 COMPLETED
Endometriosis
Mahidol University
2012-03 PHASE1; PHASE2
NCT00332839 TERMINATED
Renal Transplantation
Novartis Pharmaceuticals
2005-11 PHASE4
NCT00956293 TERMINATED
Renal Transplantation
Novartis Pharmaceuticals
2009-07 PHASE4
NCT00743574 COMPLETED
Polycystic Ovarian Syndrome; Vitamin D Deficiency
Yale University
2008-08
NCT01296152 COMPLETED
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
2011-05 PHASE2
NCT01276834 TERMINATED
Renal Transplantation
Dianet Dialysis Centers
2010-09 PHASE4
NCT01399242 UNKNOWN
Disorder Related to Renal Transplantation
Hospital Universitário São José
2011-08 PHASE4
NCT01230502 TERMINATED
Liver Transplant
University of Wisconsin, Madison
2011-11
NCT00322101 COMPLETED
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Acute Myeloid Leukemia/Transient Myeloproliferative Disorder; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Childhood Acute Myeloid Leukemia in Remission; Childhood Myelodysplastic Syndromes; de Novo Myelodysplastic Syndromes; Myelodysplastic Syndrome With Isolated Del(5q); Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes
Fred Hutchinson Cancer Center
2006-01 PHASE3
NCT00490555 COMPLETED
Healthy
University of Washington
2009-01 PHASE2; PHASE3
NCT00817687 COMPLETED
Kidney Transplantation
Hoffmann-La Roche
2009-01 PHASE4
NCT01109979 COMPLETED
Cardiovascular Diseases
Brigham and Women's Hospital
2009-12 PHASE4
NCT01288131 TERMINATED
Anti-r-HuEpo Associated PRCA Subjects
Chulalongkorn University
2009-01 PHASE3
NCT00370019 WITHDRAWN
Premature Ovarian Failure
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
2006-08-25 PHASE2
NCT01191203 COMPLETED
HIV
Emory University
2010-07
NCT00577122 COMPLETED
Estrogen Receptor-negative Breast Cancer; Progesterone Receptor-negative Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Indiana University
2007-07 PHASE2
NCT01143207 COMPLETED
Contraception
FHI 360
2010-05
NCT00737659 UNKNOWN
Renal Transplant
Rabin Medical Center
2008-08 PHASE4
NCT00204022 COMPLETED
Lupus Nephritis
Frédéric A. Houssiau, MD, PhD
2001-02 PHASE3
NCT00717314 COMPLETED
Liver Transplantation
Hoffmann-La Roche
2008-05 PHASE4
NCT00604357 COMPLETED
End Stage Liver Disease; Impaired Renal Function
University of Regensburg
2008-12 PHASE3
NCT00300274 COMPLETED
Graft Rejection
Novartis Pharmaceuticals
2006-01 PHASE3
NCT00307671 COMPLETED
Vasculitis; Wegener's Granulomatosis; Microscopic Polyangiitis; Churg-Strauss Syndrome; Polyarteritis Nodosa
Assistance Publique - Hôpitaux de Paris
2005-07 PHASE4
NCT01231451 WITHDRAWN
HIV Infection
St Stephens Aids Trust
2010-12 PHASE1
NCT00246129 COMPLETED
Kidney Transplantation; Kidney Diseases; Kidney Failure
EMagnusson
2005-10 PHASE4
NCT01056042 COMPLETED
Endometriosis
Prince of Songkla University
2007-06 PHASE4
NCT00808132 COMPLETED
Menopause; Osteoporosis
Pfizer
2009-01 PHASE3
NCT00316810 COMPLETED
Pancreas-Kidney Transplantation
Dr. Claudia Bösmüller
2006-04 PHASE3
NCT00739830 COMPLETED
Endometrial Cancer
Merck Sharp & Dohme LLC
2008-08 PHASE2
NCT00758602 COMPLETED
Kidney Transplantation
Hoffmann-La Roche
2008-09 PHASE4
NCT01019369 COMPLETED
Contraception
Carolyn L. Westhoff
2010-03
NCT01953796 COMPLETED
Polycystic Ovary Syndrome
Kufa University
2010-05
NCT00311311 TERMINATED
Atherosclerosis; Kidney Failure
Pfizer
2006-04 PHASE3
NCT01148420 COMPLETED
Dysfunctional Uterine Bleeding
Women's Health Care Clinic, Torrance, California
2009-01 PHASE4
NCT00064025 COMPLETED
Endometrial Adenocarcinoma; Endometrial Adenosquamous Carcinoma; Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation; Recurrent Uterine Corpus Carcinoma; Stage I Uterine Corpus Cancer; Stage II Uterine Corpus Cancer; Stage III Uterine Corpus Cancer; Stage IV Uterine Corpus Cancer
Gynecologic Oncology Group
2004-04 PHASE2
NCT01254799 COMPLETED
Uterine Hemorrhage
Omar Mamdouh Shaaban
2008-01 PHASE3
NCT01033864 COMPLETED
Kidney Transplantation
Hoffmann-La Roche
2009-11 PHASE4
NCT01183247 COMPLETED
Comparative Study; Immunosuppressive Agents
University Hospital, Basel, Switzerland
2008-07 PHASE4
NCT00928811 TERMINATED
End Stage Renal Disease
Drexel University College of Medicine
2009-05 PHASE2; PHASE3
NCT00582738 TERMINATED
Recurrent Hepatitis C
Novartis Pharmaceuticals
2007-12 PHASE2
NCT00040846 COMPLETED
Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Peripheral T-cell Lymphoma; Previously Treated Myelodysplastic Syndromes; Progressive Hairy Cell Leukemia, Initial Treatment; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Splenic Marginal Zone Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Mycosis Fungoides/Sezary Syndrome; Stage I Small Lymphocytic Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Mycosis Fungoides/Sezary Syndrome; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Childhood Anaplastic Large Cell Lymphoma; Stage III Childhood Large Cell Lymphoma; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Mycosis Fungoides/Sezary Syndrome; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Childhood Anaplastic Large Cell Lymphoma; Stage IV Childhood Large Cell Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Waldenström Macroglobulinemia
Fred Hutchinson Cancer Center
2001-11 PHASE2
NCT00240994 COMPLETED
Kidney Failure, Chronic; Kidney Transplantation; Immunosuppression
National Institute of Allergy and Infectious Diseases (NIAID)
2005-01 PHASE2
NCT00170846 COMPLETED
Renal Transplantation
Novartis Pharmaceuticals
2005-02 PHASE4
NCT00720408 COMPLETED
Liver Transplantation; Transplantation Immunology; Host vs Graft Reaction
Astellas Pharma Inc
2007-12 PHASE3
NCT00251004 COMPLETED
Kidney Transplantation; Graft Rejection
Novartis
2005-10 PHASE3
NCT00351377 COMPLETED
Autoimmune Disease
Novartis Pharmaceuticals
2006-06 PHASE3
NCT00299221 COMPLETED
Immunosuppression
Newark Beth Israel Medical Center
2004-04 PHASE4
NCT00596947 TERMINATED
Transplants and Implants
University of Pennsylvania
2005-10 PHASE4
NCT00113269 COMPLETED
Kidney Transplantation
Astellas Pharma Inc
2005-05 PHASE4
NCT00413920 COMPLETED
Renal Transplantation
Novartis
2007-04 PHASE3
NCT02005562 COMPLETED
Kidney Transplantation
Hoffmann-La Roche
2006-05 PHASE3
NCT00481819 COMPLETED
Kidney Transplantation
Astellas Pharma Inc
2007-07 PHASE3
NCT00653159 COMPLETED
Contraception
University of Chicago
2007-07 PHASE4
NCT00369278 COMPLETED
Renal Transplantation
Novartis Pharmaceuticals
2006-06 PHASE3
NCT00437658 COMPLETED
Endometriosis
AbbVie
2006-12-11 PHASE2
NCT00420342 COMPLETED
Postmenopause; Hypertension; Pre-Hypertension
Bayer
2007-01 PHASE2
NCT00195273 COMPLETED
Graft vs Host Disease; Kidney Transplantation
Wyeth is now a wholly owned subsidiary of Pfizer
2004-11 PHASE3
NCT00309218 COMPLETED
Kidney Diseases
Klinik für Kinder- und Jugendmedizin
1999-03 PHASE3
NCT00360490 COMPLETED
Menorrhagia
Bayer
2006-07 PHASE3
NCT01411592 UNKNOWN
Restauration in Situ; Final Loss of Restauration; Debonded Restauration
University of Kiel
2006-10
NCT00668603 COMPLETED
Postmenopausal Vasomotor Symptoms; Cardiovascular Disease
University of Helsinki
2005-08
NCT00321113 COMPLETED
KIDNEY TRANSPLANTATION
Astellas Pharma Inc
2004-09 PHASE3
NCT00828542 COMPLETED
Breastfeeding; Contraception
University of Sao Paulo
2007-07
NCT00337493 COMPLETED
Kidney Transplantation
Hoffmann-La Roche
2005-12 PHASE4
NCT00191113 COMPLETED
Turner Syndrome
Eli Lilly and Company
1989-02 PHASE3
NCT01011751 COMPLETED
Adenocarcinoma, Prostate
Takeda
2004-04 PHASE3
NCT02554955 COMPLETED
Heart Transplantation
Hoffmann-La Roche
2004-02 PHASE4
NCT00066157 COMPLETED
Alzheimer Disease
University of Wisconsin, Madison
2001-09 PHASE2; PHASE3
NCT01283841 COMPLETED
Fasting
Dr. Reddy's Laboratories Limited
2007-11 PHASE1
NCT01283867 COMPLETED
FED
Dr. Reddy's Laboratories Limited
2007-11 PHASE1
NCT00543634 COMPLETED
Postmenopause
Wyeth is now a wholly owned subsidiary of Pfizer
2007-10 PHASE1
NCT00275522 COMPLETED
Kidney Transplant
Mayo Clinic
2005-12 PHASE4
NCT00033358 COMPLETED
Endometrial Cancer
National Cancer Institute (NCI)
2002-02 PHASE2
NCT00775047 COMPLETED
Contraception
University of North Carolina, Chapel Hill
2006-08
NCT00214266 COMPLETED
Renal Transplantation
University of Wisconsin, Madison
2005-01 PHASE2
NCT00295594 COMPLETED
Liver Transplantation
Astellas Pharma Inc
2005-03 PHASE3
NCT00105235 COMPLETED
Liver Disease; Liver Transplantation
National Institute of Allergy and Infectious Diseases (NIAID)
2005-06 PHASE2
NCT00083824 COMPLETED
Cardiovascular Diseases; Coronary Disease; Heart Diseases; Coronary Arteriosclerosis
Tufts University
2004-03 PHASE2; PHASE3
NCT00905242 COMPLETED
Kidney Transplantation
East Carolina University
2006-03 PHASE4
NCT00002920 COMPLETED
Breast Cancer; Endometrial Cancer
SWOG Cancer Research Network
1997-03 PHASE3
NCT00189839 COMPLETED
Kidney Transplantation
Astellas Pharma Inc
2004-08 PHASE3
NCT00187941 COMPLETED
Transplantation, Renal; Immunosuppression
University of Florida
2005-08 EARLY_PHASE1
NCT00141037 COMPLETED
Kidney Diseases; Kidney Transplantation; Kidney Transplant; Renal Transplantation; Renal Transplant
National Institute of Allergy and Infectious Diseases (NIAID)
2004-03 PHASE1; PHASE2
NCT00284921 TERMINATED
De Novo Kidney Transplant
Novartis Pharmaceuticals
2004-04 PHASE3
NCT00296309 COMPLETED
Kidney Transplantation
Astellas Pharma Inc
2004-10 PHASE3
NCT00912678 COMPLETED
Kidney Transplantation
University of Luebeck
2002-03 PHASE4
NCT00296361 COMPLETED
Kidney Transplantation
Astellas Pharma Inc
2004-10 PHASE3
NCT00106639 COMPLETED
Kidney Transplantation
Pfizer
2005-05 PHASE2
NCT00240955 COMPLETED
Renal Transplantation
Novartis
2004-03 PHASE4
NCT00161447 COMPLETED
Contraception
University of Washington
2004-05 PHASE1; PHASE2
NCT00003179 TERMINATED
Endometrial Cancer
Gynecologic Oncology Group
1998-11 PHASE2
NCT00030914 COMPLETED
Hot Flashes
Alliance for Clinical Trials in Oncology
2002-04 PHASE3
NCT00089947 COMPLETED
Renal Transplantation; Graft Rejection
Genzyme, a Sanofi Company
2003-06 PHASE2
NCT00000897 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00745108 COMPLETED
Postmenopausal Women
Organon and Co
2001-10-01 PHASE3
NCT00238901 COMPLETED
Liver Transplant
Novartis
2002-12 PHASE3
NCT00156650 COMPLETED
Contraception
University of Washington
2004-12 PHASE1; PHASE2
NCT00154232 COMPLETED
Renal Transplantation
Novartis Pharmaceuticals
2004-06 PHASE4
NCT00166244 COMPLETED
De Novo Renal Transplant Recipient.
Erasmus Medical Center
2003-05 PHASE4
NCT00363116 COMPLETED
Acute Allograft Rejection in Simultaneous Kidney/Pancreas Transplant Recipients
University of Cincinnati
1999-04 PHASE4
NCT00693381 COMPLETED
Kidney Transplantation
Astellas Pharma Inc
2003-02 PHASE3
NCT00830414 COMPLETED
Healthy
Teva Pharmaceuticals USA
2002-04 PHASE1
NCT00026286 COMPLETED
Breast Cancer; Hot Flashes; Menopausal Symptoms
Eastern Cooperative Oncology Group
2000-11-28 PHASE3
NCT03097120 COMPLETED
Heart Disease
Wake Forest University Health Sciences
1995-01 PHASE3
NCT01472315 COMPLETED
Sleep Apnea
Turku University Hospital
2000-01 PHASE2; PHASE3
NCT00000605 COMPLETED
Cardiovascular Diseases; Coronary Arteriosclerosis; Coronary Disease; Heart Diseases; Myocardial Ischemia; Postmenopause
National Heart, Lung, and Blood Institute (NHLBI)
1996-08 PHASE3
NCT00416429 COMPLETED
Kidney Cancer
Centre Leon Berard
PHASE3
NCT00319566 COMPLETED
Coronary Heart Disease
University of California, San Francisco
1992-07 PHASE3
NCT00004650 COMPLETED
Osteoporosis
National Institute of Dental and Craniofacial Research (NIDCR)
1993-08 PHASE3
NCT00006324 COMPLETED
HIV Infections
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
1999-12
NCT00044837 TERMINATED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00291369 COMPLETED
Metastatic Renal Cell Carcinoma
Centre Leon Berard
1999-12 PHASE3
NCT00729768 WITHDRAWN
Kidney Transplantation
Genentech, Inc.
PHASE2; PHASE3
NCT00006133 COMPLETED
Systemic Lupus Erythematosus
National Center for Research Resources (NCRR)
2000-06
NCT00169299 UNKNOWN
Vasomotor Symptoms Associated With Menopause
Kaiser Permanente
2001-06 PHASE4
NCT00000466 COMPLETED
Bone Diseases; Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus; Heart Diseases; Hypercholesterolemia; Hypertension; Myocardial Ischemia; Osteoporosis; Thrombosis; Postmenopause
National Heart, Lung, and Blood Institute (NHLBI)
1987-09 PHASE3
NCT00401219 COMPLETED
Estrogen Replacement Therapy
Wyeth is now a wholly owned subsidiary of Pfizer
2006-11 PHASE1
NCT00140543 COMPLETED
Diabetes Mellitus, Type 1; Diabetic Nephropathy
EUROSPK Study Group
2002-02 PHASE3
NCT00332553 COMPLETED
Vasomotor Symptoms; Endometrial Safety
Eli Lilly and Company
2002-02 PHASE2
NCT00261820 COMPLETED
Graft Rejection; Kidney Failure; Kidney Transplantation
Wyeth is now a wholly owned subsidiary of Pfizer
PHASE4
NCT00000559 COMPLETED
Cardiovascular Diseases; Coronary Disease; Heart Diseases; Myocardial Ischemia; Postmenopause
National Heart, Lung, and Blood Institute (NHLBI)
1995-03 PHASE3
NCT00472927 COMPLETED
Postmenopause
Wyeth is now a wholly owned subsidiary of Pfizer
2007-05 PHASE1
NCT00309270 COMPLETED
Kidney Transplant
Mario Negri Institute for Pharmacological Research
2003-02 PHASE2
NCT00350480 COMPLETED
Uterine Hemorrhage; Menorrhagia
Kaiser Permanente
2003-04
NCT00463450 COMPLETED
Hormone Replacement Therapy
Bayer
2002-05 PHASE3
NCT00004567 COMPLETED
Vasculitis; Wegener's Granulomatosis
National Institute of Allergy and Infectious Diseases (NIAID)
2000-02 PHASE2
NCT00188955 COMPLETED
Kidney Transplantation
University of Manitoba
2004-03 PHASE4
NCT00431119 COMPLETED
Bullous Pemphigoid
University Hospital Muenster
1997-10 PHASE2
NCT00195988 COMPLETED
Liver Transplantation
Children's Memorial Health Institute, Poland
2002-09 PHASE4
NCT00849238 WITHDRAWN
Primary Liver Transplant
University of Wisconsin, Madison
NCT00392093 COMPLETED
Systemic Lupus Erythematosus
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
1997-11 PHASE4
NCT00381251 COMPLETED
Postmenopausal Osteoporosis; Postmenopause
Wyeth is now a wholly owned subsidiary of Pfizer
2006-09 PHASE1
NCT00016601 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2001-06
NCT00404794 COMPLETED
Lupus Nephritis; Glomerulonephritis, Membranous
Hospital Authority, Hong Kong
2005-11 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-08-31)

Check the Medroxyprogesterone Acetate (MPA) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Medroxyprogesterone acetate selectively binds to and activates the nuclear progesterone receptor with high potency, driving transcriptional regulation of progesterone-responsive genes and suppressing pituitary gonadotropin secretion. This blockade of gonadotropin release inhibits ovulation and alters endometrial differentiation, mediating its therapeutic efficacy in reproductive suppression and female infertility management.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.