Levonorgestrel Clinical Trials

Size	Price	Qty
50mg	USD 147
1g	USD 670

Clinical Trials

Numerous clinical trials spanning Early Phase 1 to Phase 4 evaluate levonorgestrel for indications such as contraception, irregular periods, and intrauterine device insertion complications, alongside pharmacokinetic and drug-drug interaction assessments in healthy volunteers and patients with obesity, non-alcoholic steatohepatitis, or systemic scleroderma. Sponsored by various pharmaceutical corporations and academic institutions, these studies represent several recruitment statuses, including recruiting, active not recruiting, completed, and terminated.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07449299	NOT_YET_RECRUITING	Emergency Contraception; Contraception; COX-2 Inhibitor	University of Utah	2027-03	PHASE3
NCT07462663	NOT_YET_RECRUITING	Endometrial Cancer; Endometrial Cancer Stage I; Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I; Atypical Endometrial Hyperplasia; Endometrial Intraepithelial Neoplasia; Obesity & Overweight; BMI>40; Obesity; Obesity Grade III	Hospital Universitari de Bellvitge	2027-01	PHASE4
NCT07734155	NOT_YET_RECRUITING	Contraceptive Usage	Chemo Research	2026-12	PHASE3
NCT07627958	NOT_YET_RECRUITING	Vaginal Microbial Diversity	Seattle Children's Hospital	2026-07
NCT07781150	NOT_YET_RECRUITING	Obesity; Overweight; Atypical Endometrial Hyperplasia; Endometrial Carcinoma Stage I; Endometrioid Endometrial Cancer	Tongji Hospital	2026-11-01	PHASE2
NCT07536763	NOT_YET_RECRUITING	Contraception	Dr. Hang Wun Raymond Li	2026-07	PHASE3
NCT06620939	NOT_YET_RECRUITING	Endometrial Polyp	Zhang Jian	2024-12-01
NCT07222228	NOT_YET_RECRUITING	Healthy Women; Female Contraception	Premier Research	2026-04-01	PHASE2
NCT07107334	RECRUITING	Endometrioid Endometrial Adenocarcinoma	University of Florida	2026-04-07	PHASE2
NCT05903131	RECRUITING	Endometrial Hyperplasia; Grade 1 Endometrial Cancer	Washington University School of Medicine	2024-10-24	PHASE2
NCT04948489	WITHDRAWN	Endometriosis	Boston Children's Hospital	2026-01-01	PHASE2
NCT06162611	RECRUITING	Emergency Contraception	Lori Gawron	2023-11-06	PHASE4
NCT06727734	RECRUITING	Contraception	The University of Hong Kong	2025-01-18	PHASE3
NCT07013643	RECRUITING	Healthy Participants	AstraZeneca	2025-06-04	PHASE1
NCT07759635	RECRUITING	Female; Premenopausal	McMaster University	2026-07-22
NCT07794150	RECRUITING	Menopause; Healthy Female Participants	Corium Innovations, Inc.	2026-08-10	PHASE1
NCT07710729	RECRUITING	Overweight; Obesity	Novo Nordisk A/S	2026-07-17	PHASE1
NCT07525791	RECRUITING	Overweight; Obesity	Novo Nordisk A/S	2026-04-07	PHASE1
NCT05444582	RECRUITING	Contraception	University of Utah	2022-11-07	PHASE4
NCT05044962	RECRUITING	HIV Infections; Contraception; Drug-drug Interaction	University of Alabama at Birmingham	2021-11-26
NCT05058872	RECRUITING	Oral Hormonal Contraceptive Use; Neural Activity; Mood; Hedonic Function	University of Colorado, Denver	2021-10-01	PHASE4
NCT05233956	ACTIVE_NOT_RECRUITING	Anemia	FHI 360	2023-10-23
NCT07784894	NOT_YET_RECRUITING	Tuberculosis	GlaxoSmithKline	2026-09-01	PHASE1
NCT07539090	RECRUITING	Healthy Participants	Deciphera Pharmaceuticals, LLC	2026-06-05	PHASE1
NCT02397083	ACTIVE_NOT_RECRUITING	Atypical Endometrial Hyperplasia; FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma; FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma	M.D. Anderson Cancer Center	2015-09-23	PHASE2
NCT07414784	COMPLETED	Healthy Volunteer	AbbVie	2026-02-11	PHASE1
NCT03708809	WITHDRAWN	Contraception	Sheba Medical Center	2023-12-01
NCT07502417	COMPLETED	Healthy Volunteer	AbbVie	2026-03-27	PHASE1
NCT06935968	NOT_YET_RECRUITING	Hemoglobin; Deficiency	Assiut University	2025-05-01
NCT07388511	COMPLETED	Healthy Participants	Blueprint Medicines Corporation	2026-02-05	PHASE1
NCT04143659	ACTIVE_NOT_RECRUITING	Healthy Women; Female Contraception	Premier Research	2020-03-03	PHASE1
NCT03557619	UNKNOWN	Hematologic Malignancies	AbbVie	2019-07-30	PHASE1
NCT05316493	RECRUITING	Atypical Endometrial Hyperplasia; Fertility Issues; Overweight and Obesity	Xiaojun Chen	2022-06-13	PHASE2; PHASE3
NCT07272889	COMPLETED	Healthy Volunteer Study	Atea Pharmaceuticals, Inc.	2025-12-04	PHASE1
NCT06942936	COMPLETED	Healthy Participants	AstraZeneca	2025-05-28	PHASE1
NCT07680985	COMPLETED	Adenomyosis	Wenzhou People's Hospital	2023-07-20
NCT03463252	RECRUITING	Endometrial Cancer; Atypical Endometrial Hyperplasia	West China Second University Hospital	2018-04-01	PHASE2; PHASE3
NCT05172999	COMPLETED	Atypical Endometrial Hyperplasia; Obesity; Fertility Issues	Fudan University	2022-01-08	PHASE2; PHASE3
NCT06306131	COMPLETED	Pregnancy Prevention	InnovaGyn, Inc.	2023-12-10	PHASE2
NCT06513104	COMPLETED	Diabetes Mellitus, Type 2	Novo Nordisk A/S	2024-07-18	PHASE1
NCT06019533	COMPLETED	Contraception	Chemo Research	2023-08-09	PHASE3
NCT06492889	UNKNOWN	Pregnancy Early; Pregnancy Related	Gynuity Health Projects	2024-07-22	PHASE2; PHASE3
NCT07229209	COMPLETED	Abnormal Uterine Bleeding; Cesarean Section Complications; Uterine Scar	Benha University	2025-02-05
NCT06461039	COMPLETED	Obesity	Novo Nordisk A/S	2024-06-14	PHASE1
NCT06799884	COMPLETED	Drug Drug Interaction	Idorsia Pharmaceuticals Ltd.	2025-01-18	PHASE1
NCT06671405	COMPLETED	Dyslipidaemia	AstraZeneca	2024-09-25	PHASE1
NCT05896384	COMPLETED	Healthy	Boehringer Ingelheim	2023-12-21	PHASE1
NCT06657105	COMPLETED	Healthy Participants	AstraZeneca	2024-11-01	PHASE1
NCT06188026	COMPLETED	Healthy Volunteers (Non-alcoholic Steatohepatitis)	Novo Nordisk A/S	2023-12-18	PHASE1
NCT04007874	UNKNOWN	Migraine; Migraine;Menstrual	Leiden University Medical Center	2019-09-10	PHASE3
NCT05695352	COMPLETED	Pregnancy Prevention	InnovaGyn, Inc.	2022-06-28	PHASE2
NCT05041699	COMPLETED	Pharmacokinetics; Safety Issues; Bleeding	International Partnership for Microbicides, Inc.	2022-06-20	PHASE1
NCT04897217	WITHDRAWN	Endometrial Hyperplasia	Wake Forest University Health Sciences	2023-06-30	PHASE3
NCT06689150	COMPLETED	Menstrual Bleeding, Heavy	Al-Azhar University	2023-08-10
NCT05700812	COMPLETED	IUD; IUD Insertion Complication; IUD; Complications	University of California, Davis	2023-02-01
NCT06354257	COMPLETED	Tuberculosis	GlaxoSmithKline	2024-04-05	PHASE1
NCT05565573	UNKNOWN	Fertility Sparing	Hua Li	2022-11-01	PHASE2; PHASE3
NCT06380205	COMPLETED	Healthy Participants	Incyte Corporation	2024-05-07	PHASE1
NCT05343546	UNKNOWN	Incomplete Abortion; Intrauterine Contraception; Misoprostol	Makerere University	2022-06
NCT06380205	Recruiting	Healthy Participants	Incyte Corporation	2024-05-07	Phase 1
NCT06500390	RECRUITING	Levonorgestrel Adverse Reaction; Temporomandibular Joint Disorders; Temporomandibular Disorder	Marmara University	2024-01-15
NCT06071442	COMPLETED	Healthy Participants	Alexion Pharmaceuticals, Inc.	2024-01-17	PHASE1
NCT06581679	COMPLETED	Adenomyosis	Zagazig University	2023-12-15
NCT06188026	Recruiting	Healthy Volunteers (Non-alcoholic Steatohepatitis)	Novo Nordisk A/S	2023-12-18	Phase 1
NCT05896384	Recruiting	Healthy	Boehringer Ingelheim	2023-12-07	Phase 1
NCT02035787	COMPLETED	Complex Atypical Hyperplasia; Endometrial Cancer	UNC Lineberger Comprehensive Cancer Center	2014-02-27	PHASE2
NCT06783192	COMPLETED	Human Immunodeficiency Virus (HIV); HIV Pre-Exposure Prophylaxis	Merck Sharp & Dohme LLC	2023-08-14	PHASE1
NCT05613777	COMPLETED	Healthy	Boehringer Ingelheim	2022-11-24	PHASE1
NCT04910711	UNKNOWN	Human Immunodeficiency Virus; Contraception; ART	Botswana Harvard AIDS Institute Partnership	2021-10-21	PHASE4
NCT05770297	UNKNOWN	Endometriosis; Dysmenorrhea	Indonesia University	2022-07-12
NCT05700812	Recruiting	IUD\|IUD Insertion Complication\|IUD; Complications	University of California Davis	2023-02-01	Not Applicable
NCT05505162	COMPLETED	Healthy Female Participants	AstraZeneca	2022-08-24	PHASE1
NCT05671653	Terminated	Obesity	Pfizer	2023-01-19	Phase 1
NCT04814927	COMPLETED	Mucosal Inflammation; Contraceptive; Complications, Intrauterine	Eastern Virginia Medical School	2021-03-01	PHASE4
NCT04385667	COMPLETED	Atypical Endometrial Hyperplasia	Zagazig University	2020-05-20	PHASE2; PHASE3
NCT05594186	COMPLETED	Intermenstrual Bleeding	Saudi German Hospital - Madinah	2019-03-01
NCT03614494	COMPLETED	Emergency Contraception	Dr. Hang Wun Raymond Li	2018-08-20	PHASE2; PHASE3
NCT01686126	ACTIVE_NOT_RECRUITING	Complex Endometrial Hyperplasia With Atypia; Grade 1 Endometrial Endometrioid Adenocarcinoma	Queensland Centre for Gynaecological Cancer	2012-12	PHASE2
NCT03745144	COMPLETED	Relapsing Multiple Sclerosis (RMS)	Merck KGaA, Darmstadt, Germany	2019-01-17	PHASE1
NCT05153564	COMPLETED	Diabetes Mellitus, Type 2	Novo Nordisk A/S	2021-12-13	PHASE1
NCT05093205	COMPLETED	Healthy Adults	Pfizer	2021-10-25	PHASE1
NCT02799641	COMPLETED	Contraception	TriHealth Inc.	2016-07
NCT04972396	COMPLETED	NASH - Nonalcoholic Steatohepatitis	Altimmune, Inc.	2021-09-15	PHASE1
NCT03537768	TERMINATED	Contraception	Kimberly Myer	2018-07-12	PHASE4
NCT03043924	COMPLETED	Polycystic Ovary Syndrome	University Hospital, Lille	2017-09-26
NCT05282940	COMPLETED	Therapeutic Equivalency	Laboratorios Andromaco S.A.	2022-02-26	PHASE1
NCT02556411	UNKNOWN	Adenomyosis; Chronic Pelvic Pain	University of Cagliari	2021-06-01
NCT04663568	TERMINATED	Tubal Ligation	Assiut University	2020-12-01
NCT04676776	UNKNOWN	Missed Menstrual Period	Gynuity Health Projects	2021-01-25	PHASE2
NCT07739589	COMPLETED	Residual Drug Amount of EE and LNG	Insud Pharma	2021-10-25	PHASE4
NCT04500028	COMPLETED	IUCD Complication	Aswan University Hospital	2020-08-01	PHASE4
NCT03642210	COMPLETED	Menorrhagia	Medicines360	2019-01-17	PHASE3
NCT00995150	TERMINATED	Contraception	Medicines360	2009-11	PHASE3
NCT04517890	UNKNOWN	IUCD Complication	Aswan University Hospital	2020-09-01
NCT04872244	COMPLETED	Isthmocele; Post-menstrual Spotting Bleeding; Pelvic Pain	Gaziosmanpasa Research and Education Hospital	2019-11-03
NCT02985541	COMPLETED	Contraception	Bayer	2016-12-22	PHASE3
NCT04339348	COMPLETED	Contraception	Cairo University	2020-04-30	PHASE3
NCT02863445	COMPLETED	Obesity	Oregon Health and Science University	2017-07-06	PHASE4
NCT03317795	COMPLETED	Heavy Menstrual Bleeding; Menorrhagia; Uterine Fibroids	Shannon K. Laughlin-Tommaso	2017-11-14	PHASE4
NCT03992937	COMPLETED	Endometrial Hyperplasia Without Atypia	Kocaeli University	2019-06-20
NCT04194905	COMPLETED	Bioequivalence	Laboratorios Andromaco S.A.	2020-11-21	PHASE1
NCT04267250	COMPLETED	Healthy Female Volunteers	Pfizer	2020-08-24	PHASE1
NCT03819114	COMPLETED	HIV Infections; Tuberculosis	Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections	2019-05-06	PHASE2
NCT04230070	COMPLETED	Bioequivalence	Laboratorios Andromaco S.A.	2020-10-24	PHASE1
NCT02957292	COMPLETED	Contraception	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau	2016-06-01	PHASE4
NCT04339361	UNKNOWN	Contraception	Cairo University	2020-04-25	PHASE4
NCT04355598	UNKNOWN	Contraception	Cairo University	2020-04-30	PHASE4
NCT04312061	UNKNOWN	Contraception	Cairo University	2020-03-30	PHASE3
NCT04311658	UNKNOWN	Contraception	Cairo University	2020-03-30	PHASE3
NCT04309643	COMPLETED	Healthy Volunteers	Concert Pharmaceuticals	2020-06-09	PHASE1
NCT03241888	COMPLETED	Atypical Endometrial Hyperplasia	Fudan University	2017-07-04	PHASE2; PHASE3
NCT03241914	COMPLETED	Endometrial Neoplasm Malignant Stage I	Fudan University	2017-07-04	PHASE2; PHASE3
NCT04074174	COMPLETED	Overweight; Obesity	Novo Nordisk A/S	2019-09-12	PHASE1
NCT03455075	COMPLETED	Healthy; Men; Male Contraception	Premier Research	2018-04-16	PHASE2
NCT02175030	COMPLETED	Contraception	University of Utah	2016-08	PHASE4
NCT04142762	COMPLETED	Chronic Hepatitis B	Assembly Biosciences	2019-10-18	PHASE1
NCT04045548	COMPLETED	Intrauterine Device	Cairo University	2019-08-10	PHASE4
NCT03954366	COMPLETED	Neoplasms	pharmaand GmbH	2019-04-25	PHASE1
NCT02722421	COMPLETED	HIV; Contraception	University of Nebraska	2017-04-06	PHASE2
NCT02357368	COMPLETED	HIV; Contraception	Lisa Haddad	2015-02	PHASE4
NCT04018274	COMPLETED	Healthy	Pfizer	2019-08-09	PHASE1
NCT03675581	COMPLETED	Scleroderma, Systemic	Boehringer Ingelheim	2018-11-08	PHASE1
NCT03709355	COMPLETED	HIV-1-infection	Viriom	2018-11-14	PHASE1
NCT03467347	COMPLETED	Healthy; Contraception; Contraceptive Usage; Women	International Partnership for Microbicides, Inc.	2018-07-17	PHASE1
NCT03762382	UNKNOWN	HIV; Contraception; Prevention; Anti-Retroviral Agent	CONRAD	2018-12-12	PHASE2
NCT03984825	COMPLETED	HIV Infections	ViiV Healthcare	2019-06-13	PHASE1
NCT02002260	UNKNOWN	Abnormal Uterine Bleeding; Abnormal Uterine Bleeding, Ovulatory Dysfunction; Abnormal Uterine Bleeding, Endometrial Hemostatic Dysfunction	Women and Infants Hospital of Rhode Island	2013-02
NCT03589027	UNKNOWN	HIV-1-infection; Contraception	Makerere University	2018-08-07	PHASE2
NCT03562624	COMPLETED	Contraception	Bayer	2018-06-22	PHASE2
NCT03662516	COMPLETED	Healthy Females	Pfizer	2018-09-26	PHASE1
NCT03279120	COMPLETED	Anti-Infective Agents; Anti-Retroviral Agents; Contraceptive Usage	CONRAD	2017-09-28	PHASE1
NCT01539720	COMPLETED	Pregnancy, Unplanned; Pregnancy; Accident	Planned Parenthood of the St. Louis Region and Southwest Missouri	2012-12
NCT02550067	COMPLETED	HIV; Contraception	FHI 360	2015-12-14
NCT03506399	WITHDRAWN	Healthy	Eli Lilly and Company	2018-06	PHASE1
NCT03074045	COMPLETED	Contraception	Bayer	2017-03-13	PHASE3
NCT03111342	COMPLETED	Pain, Acute; Anesthesia, Local; IUD Insertion Complication	University of Sao Paulo	2017-06-01	PHASE4
NCT03547024	COMPLETED	Healthy	Janssen-Cilag International NV	2018-06-08	PHASE1
NCT02882191	COMPLETED	Contraception	Sebela Women's Health Inc.	2016-11	PHASE2
NCT03301207	COMPLETED	Leukemia, Lymphocytic, Chronic, B-Cell	Janssen Research & Development, LLC	2017-10-20	PHASE1
NCT01721798	COMPLETED	HIV	FHI 360	2013-11-10
NCT03353857	COMPLETED	Biological Availability	Bayer	2017-11-29	PHASE1
NCT02475265	COMPLETED	Anorexia Nervosa; Osteoporosis	Massachusetts General Hospital	2015-07	PHASE2
NCT03210246	COMPLETED	Clinical Trial ,Phase I	Bayer	2017-07-17	PHASE1
NCT03353012	COMPLETED	Breastfeeding; Post Partum	Chulalongkorn University	2018-01-01	PHASE4
NCT03324685	COMPLETED	Drug Interactions	Biogen	2017-11-11	PHASE1
NCT02824224	COMPLETED	Menorrhagia; Metrorrhagia; Medicated Intrauterine Devices	Oregon Health and Science University	2016-09-06	PHASE4
NCT01941134	WITHDRAWN	Bariatric Surgery Candidate; Contraception	Johns Hopkins University	2013-04	PHASE4
NCT03037944	UNKNOWN	Adenomyosis	Ain Shams Maternity Hospital	2016-03-01	EARLY_PHASE1
NCT03193307	COMPLETED	Healthy	Boehringer Ingelheim	2017-06-29	PHASE1
NCT02751385	TERMINATED	Carcinoma, Non-Small-Cell Lung	Boehringer Ingelheim	2016-05-20	PHASE1
NCT03249402	COMPLETED	Healthy	Janssen-Cilag International NV	2017-08-14	PHASE1
NCT02451826	UNKNOWN	Ovulation Inhibition	Population Council	2015-05	PHASE1; PHASE2
NCT02599077	SUSPENDED	Endometriosis	Fundación Santa Fe de Bogota	2015-11	PHASE2; PHASE3
NCT02697851	TERMINATED	HIV	St Stephens Aids Trust	2016-07	PHASE1
NCT02957630	COMPLETED	Contraception; Liver Metabolism; Hemostasis Parameter	Estetra	2016-09	PHASE1; PHASE2
NCT02855346	COMPLETED	HIV Prevention	International Partnership for Microbicides, Inc.	2017-05-03	PHASE1
NCT02480647	COMPLETED	Endometriosis	University of Campinas, Brazil	2016-05	PHASE4
NCT02577601	COMPLETED	Contraception	Oregon Health and Science University	2015-09-08	PHASE4
NCT02846142	COMPLETED	Healthy Volunteer	Proteostasis Therapeutics, Inc.	2016-06	PHASE1
NCT02845219	COMPLETED	Diabetes; Diabetes Mellitus, Type 2	Novo Nordisk A/S	2016-07	PHASE1
NCT01990703	COMPLETED	Contraception	University of Utah	2014-01	PHASE4
NCT02531321	TERMINATED	Contraception; HIV	University of Southern California	2015-08	PHASE4
NCT02203331	COMPLETED	Endometriosis	Bayer	2014-10-16	PHASE2
NCT02616146	TERMINATED	Contraception	Organon and Co	2015-12-01	PHASE3
NCT01943058	WITHDRAWN	Atypical Endometrial Hyperplasia; Endometrial Adenocarcinoma; Recurrent Endometrial Carcinoma; Stage IA Endometrial Carcinoma; Stage IB Endometrial Carcinoma; Stage II Endometrial Carcinoma; Stage IIIA Endometrial Carcinoma; Stage IIIB Endometrial Carcinoma; Stage IIIC Endometrial Carcinoma; Stage IVA Endometrial Carcinoma; Stage IVB Endometrial Carcinoma	University of Southern California	2014-03	PHASE2
NCT02403401	COMPLETED	Contraception	Bayer	2015-05-15	PHASE3
NCT03104309	COMPLETED	Adenomyosis	Assiut University	2015-06
NCT00788671	ACTIVE_NOT_RECRUITING	Atypical Endometrial Hyperplasia; Stage I Uterine Corpus Cancer AJCC v7; Stage IA Uterine Corpus Cancer AJCC v7; Stage IB Uterine Corpus Cancer AJCC v7; Stage II Uterine Corpus Cancer AJCC v7	M.D. Anderson Cancer Center	2008-11-03	PHASE2
NCT02121067	COMPLETED	Contraception; Malposition of Intrauterine Contraceptive Device	University of North Carolina, Chapel Hill	2014-09	PHASE4
NCT02341027	COMPLETED	Contraceptive Implant Utilization; Lactation	University of California, San Francisco	2015-01
NCT02534688	COMPLETED	Endometriosis	King Chulalongkorn Memorial Hospital	2015-06	PHASE4
NCT02894151	COMPLETED	Clinically Diagnosed Endometriotic Patient Was Defined as a Woman Who Has Pelvic Pain and at Least One Evidence of PV or TVS	Chulalongkorn University	2015-04	PHASE2
NCT02545452	COMPLETED	Endometriosis	Bayer	2015-09-15	PHASE1
NCT02326922	COMPLETED	Dysfunctional Uterine Bleeding	Ain Shams Maternity Hospital	2014-06	PHASE1; PHASE2
NCT02689804	COMPLETED	Contraception	Columbia University	2015-07-10	PHASE4
NCT03305081	TERMINATED	Contraception	Tulane University School of Medicine	2014-10-22
NCT02235662	COMPLETED	HIV; Contraception	CONRAD	2014-10	PHASE1
NCT01165307	COMPLETED	Menorrhagia	Abimbola Famuyide	2009-08	PHASE4
NCT01480778	COMPLETED	Irregular Periods	Azidus Brasil	2014-07	PHASE3
NCT02159326	COMPLETED	Drug Interactions	Bayer	2014-06	PHASE1
NCT02021097	UNKNOWN	Oral Contraceptive	Regenex Pharmaceutical, China	2012-02	PHASE3
NCT01594879	UNKNOWN	Endometrial Cancer	Korean Gynecologic Oncology Group	2012-01	PHASE2
NCT02170038	COMPLETED	Pharmacokinetics	Bayer	2014-06	PHASE1
NCT03027648	COMPLETED	Adenomyosis	Peking Union Medical College Hospital	2006-12
NCT02159131	COMPLETED	Infections, Human Immunodeficiency Virus and Hepatitis	ViiV Healthcare	2014-08	PHASE1
NCT01286948	COMPLETED	Female Contraception	Population Council	2011-01	PHASE1
NCT01789879	COMPLETED	HIV; Contraception	University of Nebraska	2014-03-04	PHASE2
NCT02085863	COMPLETED	Pharmacokinetics; Pharmacodynamics	Teva Branded Pharmaceutical Products R&D, Inc.	2014-02	PHASE1
NCT01161095	WITHDRAWN	Contraception; Postpartum Period	United States Naval Medical Center, Portsmouth	2010-07-01
NCT01594476	TERMINATED	Contraception	Oregon Health and Science University	2012-03	PHASE4
NCT02362373	COMPLETED	Epilepsy; Contraception	Columbia University	2011-08	PHASE4
NCT01941615	TERMINATED	Healthy	Boehringer Ingelheim	2013-11	PHASE1
NCT00445887	COMPLETED	Ovarian Carcinoma	Gynecologic Oncology Group	2008-03-10	PHASE2
NCT01074892	COMPLETED	Endometrial Hyperplasia	University Hospital of North Norway	2005-05	PHASE4
NCT01805817	WITHDRAWN	Contraceptive Methods Comparison	Istanbul Training and Research Hospital	2012-12	PHASE4
NCT03359057	COMPLETED	Contraception	Galeno Desenvolvimento de Pesquisas Clínicas	2013-02-26	PHASE3
NCT02155166	COMPLETED	Pain	University of Sao Paulo	2012-02
NCT00884260	COMPLETED	Contraception	Bayer	2009-04	PHASE3
NCT01434160	COMPLETED	Contraception	Bayer	2011-09	PHASE3
NCT01555931	COMPLETED	Postpartum Contraception	University of North Carolina, Chapel Hill	2012-03	PHASE4
NCT01601366	COMPLETED	Adenomyosis	Omar Mamdouh Shaaban	2012-04	PHASE2
NCT01254292	COMPLETED	Contraception	Bayer	2011-01-06	PHASE3
NCT01391052	UNKNOWN	Heavy Menstrual Bleeding; Menorrhagia; Hypermenorrhea	Scott and White Hospital & Clinic	2011-01	PHASE4
NCT01615354	COMPLETED	Healthy Volunteer	Hoffmann-La Roche	2012-07	PHASE1
NCT01234818	UNKNOWN	Endometrial Hyperplasia	Korean Gynecologic Oncology Group	2010-11	PHASE2
NCT00393198	COMPLETED	Contraception; Menorrhagia	Bayer	2006-10	PHASE4
NCT01623466	COMPLETED	Healthy	Agile Therapeutics	2012-07	PHASE1; PHASE2
NCT02158845	COMPLETED	Endometriosis	University of Sao Paulo	2010-02	PHASE4
NCT01570244	COMPLETED	Hepatitis C, Chronic	Boehringer Ingelheim	2012-04	PHASE1
NCT01569113	COMPLETED	Emergency Contraception	HRA Pharma	2012-03	PHASE4
NCT00924560	COMPLETED	Bone Mineral Density	Duramed Research	2009-06	PHASE2
NCT00584610	UNKNOWN	Blood Coagulation Disorders	University of Vermont	2007-12
NCT01166412	COMPLETED	Contraception	Premier Research	2010-12	PHASE1; PHASE2
NCT01546454	COMPLETED	Coronary Heart Disease	Oregon Health and Science University	2012-02
NCT02173808	COMPLETED	Contraceptive Usage	Premier Research	2011-05	PHASE1
NCT01501448	COMPLETED	Infertility	IVI Madrid	2012-01	PHASE4
NCT01291004	COMPLETED	Follicle Development; Ovarian Follicle; Follicle Count; Follicle Size; Oral Contraceptive	Teva Branded Pharmaceutical Products R&D, Inc.	2011-01-31	PHASE1
NCT01324505	COMPLETED	Diabetes; Diabetes Mellitus, Type 2	Novo Nordisk A/S	2011-03	PHASE1
NCT01295294	COMPLETED	Uterine Hemorrhage	Bayer	2011-03	PHASE4
NCT01252186	COMPLETED	Hemostasis; Oral Contraceptive	Teva Women's Health	2010-11	PHASE2
NCT01240811	COMPLETED	Genital Tract Mucosal Immunity; Genital Tract Microflora	Sharon Achilles	2010-11
NCT00123175	WITHDRAWN	Endometrial Hyperplasia	Milton S. Hershey Medical Center	2009-09	PHASE1; PHASE2
NCT01388582	COMPLETED	Underweight	University of Campinas, Brazil	2011-04	PHASE4
NCT00781456	COMPLETED	Migraine	Duramed Research	2009-01	PHASE2
NCT01320917	UNKNOWN	Contraception Desired; Obesity	University of Sao Paulo	2009-02	PHASE4
NCT01328184	COMPLETED	Healthy	Boehringer Ingelheim	2011-04	PHASE1
NCT00528112	COMPLETED	Contraception	Bayer	2007-08	PHASE3
NCT01598662	TERMINATED	Contraception	University of Louisville	2009-07
NCT00635362	TERMINATED	Healthy	University of Chicago	2007-05
NCT00909857	COMPLETED	Primary Dysmenorrhea	Bayer	2009-04	PHASE3
NCT00922233	COMPLETED	Healthy	FHI 360	2010-01	PHASE3
NCT01230242	TERMINATED	Estimating Rates of Expulsion	Rebecca Hunt	2010-09-07
NCT00570440	COMPLETED	Pregnancy Prevention	FHI 360	2007-08	PHASE4
NCT00433004	COMPLETED	Post Partum	University of Pennsylvania	2007-02	PHASE4
NCT00997932	COMPLETED	Unplanned Pregnancy	University of North Carolina, Chapel Hill	2009-06	PHASE4
NCT00933179	COMPLETED	Contraception	Bayer	2009-06	PHASE2
NCT01595022	COMPLETED	Contraception	Bayer	2010-01	PHASE1
NCT00920985	COMPLETED	Contraception	Bayer	2009-06	PHASE3
NCT00764881	COMPLETED	Contraception; Libido	Bayer	2009-01	PHASE3
NCT01137708	COMPLETED	Healthy	Pfizer	2010-06	PHASE1
NCT00237042	COMPLETED	Temporomandibular Joint Disorders	University of Washington	2005-10
NCT01088178	WITHDRAWN	Contraception	United States Naval Medical Center, Portsmouth	2009-11
NCT01157754	COMPLETED	Infertility	IVI Madrid	2009-06
NCT00789802	COMPLETED	Contraception; Bleeding	Washington University School of Medicine	2008-11
NCT00455845	COMPLETED	Endometriosis; Pelvic Pain; Dysmenorrhea	Mahidol University	2007-04	PHASE3
NCT00475228	COMPLETED	Contraceptive Usage	University of Pittsburgh	2007-03	PHASE4
NCT01073904	COMPLETED	Contraceptives, Postcoital	Bayer	2009-09	PHASE1
NCT00511342	COMPLETED	Contraception	Organon and Co	2006-09	PHASE3
NCT00669396	COMPLETED	Pregnancy	University of Utah	2008-04
NCT00551616	COMPLETED	Contraception	HRA Pharma	2007-04	PHASE3
NCT01297179	COMPLETED	Healthy Volunteers; Pharmacokinetics of Mirabegron	Astellas Pharma Inc	2008-10	PHASE1
NCT01096498	COMPLETED	Contraception; Contraception, Postcoital	Bayer	2009-02	PHASE1
NCT01096485	COMPLETED	Contraception; Contraception, Postcoital	Bayer	2009-02	PHASE1
NCT00482963	COMPLETED	HIV Infections; Contraception; Pharmacokinetics	University of Colorado, Denver	2007-05	PHASE1
NCT00653159	COMPLETED	Contraception	University of Chicago	2007-07	PHASE4
NCT00185380	COMPLETED	Contraception	Bayer	2005-04	PHASE2
NCT02175394	COMPLETED	Healthy	Boehringer Ingelheim	2008-07	PHASE1
NCT00566644	TERMINATED	Endometrial Cancer; Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)	St George's, University of London	2007-07	PHASE3
NCT00196313	COMPLETED	Dysmenorrhea	Duramed Research	2005-05	PHASE2
NCT00966264	COMPLETED	Menorrhagia	University of Helsinki	1994-10	PHASE3
NCT00685906	COMPLETED	Healthy	AstraZeneca	2008-04	PHASE1
NCT00476021	COMPLETED	Contraception	University of Pittsburgh	2007-05
NCT00360490	COMPLETED	Menorrhagia	Bayer	2006-07	PHASE3
NCT00621543	COMPLETED	Intrauterine Device Expulsion; Medical Abortion; Induced Abortion	Boston University	2006-03
NCT00131885	COMPLETED	Contraception	University of Utah	2005-08	PHASE4
NCT00185458	COMPLETED	Menopause	Bayer	2000-05	PHASE3
NCT01714193	COMPLETED	Healthy	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	2008-02	PHASE1
NCT01250210	COMPLETED	Ovulation Suppression	Agile Therapeutics	2007-09	PHASE2
NCT00511355	COMPLETED	Contraception	Organon and Co	2006-10	PHASE3
NCT00196365	COMPLETED	Dysmenorrhea	Duramed Research	2005-01	PHASE3
NCT00117260	WITHDRAWN	Osteopenia	Duramed Research	2005-07	PHASE3
NCT00318799	COMPLETED	Pregnancy, Unplanned	Bayer	2006-04	PHASE2
NCT01508858	COMPLETED	Diabetes; Diabetes Mellitus, Type 2	Novo Nordisk A/S	2006-11	PHASE1
NCT00490087	COMPLETED	Atypical Endometrial Polyps; Atypical Endometrial Hyperplasia	IRCCS Burlo Garofolo	1999-01	PHASE3
NCT00319163	COMPLETED	Healthy	Wyeth is now a wholly owned subsidiary of Pfizer	2006-05	PHASE1
NCT00196352	COMPLETED	Contraception	Duramed Research	2003-05	PHASE3
NCT00161681	COMPLETED	Premenstrual Syndrome	Wyeth is now a wholly owned subsidiary of Pfizer	2005-07	PHASE3
NCT00254800	COMPLETED	Type 2 Diabetes Mellitus	AstraZeneca	2005-11	PHASE1
NCT00662454	COMPLETED	Contraception; Body Weight	Oregon Health and Science University	2006-01	PHASE4
NCT00245921	COMPLETED	Contraception	Wyeth is now a wholly owned subsidiary of Pfizer	2003-02	PHASE3
NCT01044056	COMPLETED	Contraception	Organon and Co	2004-03	PHASE4
NCT00204451	COMPLETED	Contraception	University of Saskatchewan	2005-07	PHASE4
NCT00271583	COMPLETED	Emergency Contraception	University of Pittsburgh	1999-09	PHASE2; PHASE3
NCT00185224	COMPLETED	Contraception	Bayer	2005-03	PHASE2
NCT00447863	WITHDRAWN	Contraception	Wyeth is now a wholly owned subsidiary of Pfizer	2007-08	PHASE1
NCT00213096	COMPLETED	Contraception	Population Council	2003-03	PHASE2
NCT00195559	COMPLETED	Premenstrual Syndrome; Menstruation Disturbances	Wyeth is now a wholly owned subsidiary of Pfizer	2005-09	PHASE3
NCT00096694	COMPLETED	HIV Infections	National Institute of Allergy and Infectious Diseases (NIAID)
NCT00206622	COMPLETED	Hot Flashes	Bayer	2004-12	PHASE4
NCT00254189	COMPLETED	Ovulation	Wyeth is now a wholly owned subsidiary of Pfizer	2002-12	PHASE2
NCT00006324	COMPLETED	HIV Infections	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	1999-12
NCT00696202	COMPLETED	Medicated Intrauterine Devices; Contraception	Bayer	2003-09	PHASE4
NCT00185367	COMPLETED	Contraception	Bayer	2005-03	PHASE3
NCT00128934	COMPLETED	Menstruation Disturbances; Premenstrual Syndrome	Wyeth is now a wholly owned subsidiary of Pfizer	2005-08	PHASE3
NCT00915668	WITHDRAWN	Pharmacokinetics; Drug Interactions; Healthy	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.		PHASE1
NCT00117273	COMPLETED	Healthy	Duramed Research	2005-06	PHASE3
NCT00489463	COMPLETED	Healthy	Hospital de Clinicas de Porto Alegre	2004-01
NCT00064766	UNKNOWN	Endometrial Bleeding; Periodontal Disease	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	2003-02	PHASE4
NCT00220324	COMPLETED	Contraception	Bayer	2004-02	PHASE3
NCT00520455	COMPLETED	Pregnancy	University of Washington	2004-01
NCT00248963	COMPLETED	Oral Contraceptive	Wyeth is now a wholly owned subsidiary of Pfizer		PHASE3

(data from https://clinicaltrials.gov, updated on 2026-03-04)

Check the Levonorgestrel product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Levonorgestrel, a synthetic 19-nortestosterone derivative, acts as a potent progestin agonist by selectively binding to nuclear progesterone receptors, which subsequently downregulates the secretion of hypothalamic gonadotropin-releasing hormone and prevents the pre-ovulatory luteinizing hormone surge. This targeted suppression of follicular maturation and inhibition of ovulation prevent fertilization, directly underlying its evaluation in clinical trials focused on contraception, intrauterine device insertion, and the management of irregular periods.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).