Clinical Trials

Ibuprofen has been evaluated across numerous clinical trials spanning Early Phase 1 through Phase 4, focusing primarily on postoperative pain management, acute musculoskeletal pain, migraine, acute respiratory distress syndrome, and acute kidney injury. Spearheaded by academic institutions, hospital systems, and commercial entities, these completed, recruiting, and not yet recruiting studies assess postoperative analgesia, safety profiles, and acute interventions.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07682558 NOT_YET_RECRUITING
Cancer Pain; Cancer Palliative Care
University Hospital, Basel, Switzerland
 2026-10 PHASE3
NCT07337902 RECRUITING
Crohn's Disease (CD); Dysmenorrhea Primary
University of North Carolina, Chapel Hill
 2026-03-18
NCT07625267 WITHDRAWN
Acute Uncomplicated Diverticulitis
Montefiore Medical Center
 2026-07-01 PHASE4
NCT04059172 RECRUITING
Pain, Orofacial
University of Colorado, Denver
 2019-12-10 EARLY_PHASE1
NCT07620665 RECRUITING
Cholecystectomy, Laparoscopic; Cholecystectomy, Robotic
Gangnam Severance Hospital
 2026-06-10
NCT05512754 RECRUITING
Elevated Serum PSA
University of Chicago
 2022-08-01 PHASE4
NCT07539961 NOT_YET_RECRUITING
Calcific Tendinitis
University Hospital Dubrava
 2026-09-01
NCT03759028 RECRUITING
Supracondylar Humerus Fracture
University of California, Los Angeles
 2019-02-26 PHASE4
NCT05721027 RECRUITING
Radiculopathy, Lumbosacral Region; Back Pain With Radiation; Low Back Pain
Montefiore Medical Center
 2023-07-05 PHASE4
NCT07145645 RECRUITING
Musculoskeletal Injury; Pediatrics; Sprain and Strain of Ankle; Sprain Knee; Strain Knee
University of Calgary
 2026-04-02 PHASE3
NCT07600697 NOT_YET_RECRUITING
Pelvic Organ Prolapse (POP); Stress Urinary Incontinence (SUI); Postoperative Pain
University of California, Los Angeles
 2026-07-01 PHASE4
NCT07487246 RECRUITING
Pain Management; Abortion; Second Trimester Abortion; Dilation and Evacuation
Rush University Medical Center
 2026-06-29 PHASE2
NCT07225634 NOT_YET_RECRUITING
Acute Pain
AFT Pharmaceuticals, Ltd.
 2026-09 PHASE3
NCT06757075 RECRUITING
Pain, Postoperative
Boston University
 2025-04-16 PHASE4
NCT07603934 RECRUITING
Pulp Necrosis, Apical Periodontitis
Cairo University
 2025-12-15 EARLY_PHASE1
NCT07638644 NOT_YET_RECRUITING
Malocclusion
Bahria University
 2026-07-01
NCT04676802 RECRUITING
Pain, Postoperative; Osteoarthritis Thumb
Stanford University
 2021-12-27 PHASE2
NCT07512297 NOT_YET_RECRUITING
Urolithiasis; Kidney Stones; Ureteral Stones
University of Gaziantep
 2026-10-01 PHASE4
NCT06911359 RECRUITING
Knee Osteoarthritis (OA)
David Grant U.S. Air Force Medical Center
 2025-03-31 PHASE2
NCT05548582 ACTIVE_NOT_RECRUITING
Pain, Postoperative; Opioid Misuse; Opioid Use; Pain
Johns Hopkins University
 2023-01-12
NCT05919745 RECRUITING
Pain, Post Operative; Quality of Life
Marquette University
 2023-10-19 PHASE4
NCT07571252 RECRUITING
Post Operative Pain; Orthognathic Surgery
University of Puerto Rico
 2026-09 PHASE4
NCT07768514 ACTIVE_NOT_RECRUITING
Stomach Neoplasms
Seoul National University Bundang Hospital
 2025-11-21 PHASE2
NCT06671002 RECRUITING
Surgery; Pain, Post Operative
University of Michigan
 2025-01-10 PHASE4
NCT06398054 NOT_YET_RECRUITING
Pain
ASST Fatebenefratelli Sacco
 2024-10-01 PHASE4
NCT05842044 RECRUITING
Kidney Cancer; Renal Cancer; Renal Neoplasm
University of Miami
 2023-09-15 PHASE2
NCT07410078 RECRUITING
Pediatric Anesthesia; Premedication
Diskapi Yildirim Beyazit Education and Research Hospital
 2026-07-26
NCT07399184 NOT_YET_RECRUITING
Postoperative Delirium; Cerebral Oxygen Saturation; Postoperative Cognitive Dysfunction (POCD)
Ondokuz Mayıs University
 2026-02-15
NCT07393503 ENROLLING_BY_INVITATION
Musculoskeletal Pain
State University of New York at Buffalo
 2025-09-17 PHASE4
NCT07244029 RECRUITING
Postoperative Pain; Facial Swelling; Trismus
Oman Medical Speciality Board
 2026-01-01
NCT02703610 WITHDRAWN
Pain
Albany Medical College
 2024-07-01 PHASE4
NCT07102641 ACTIVE_NOT_RECRUITING
Cesarean Delivery; Postpartum Comfort; Postpartum Pain; Post-operative Pain; NSAIDs; Acetaminophen (D000082)
Thomas Jefferson University
 2025-08-26 PHASE4
NCT07143201 RECRUITING
Patent Ductus Arteriosus; Preterm
Hamilton Health Sciences Corporation
 2024-07-04 PHASE2
NCT07104097 COMPLETED
Hip Surgery
Papa Giovanni XXIII Hospital
 2025-10-06
NCT07732751 COMPLETED
Bruxism; Myofascial Pain
NEW Cyprus Health and Social Sciences University
 2026-02-06 PHASE4
NCT06479122 RECRUITING
Cesarean Section; Postoperative Pain
Seoul National University Hospital
 2024-10-09 PHASE4
NCT03978767 COMPLETED
Preeclampsia Severe; Preeclampsia Postpartum
Washington University School of Medicine
 2019-06-10 PHASE2
NCT07070050 RECRUITING
Analgesic Drugs; Analgesic, Nonopioid; Analgesic Efficacy; Analgetic Consumption; Postoperative Care; Pain Management
Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
 2025-05-05 PHASE4
NCT05629494 RECRUITING
Prostate Cancer; Prostate Inflammation; PSA
Albany Medical College
 2022-09-27 PHASE4
NCT06408519 COMPLETED
Pain, Acute
Bruno Minotti
 2024-05-23
NCT07345130 COMPLETED
Bioequivalence; Bioavailability
HALEON
 2025-12-17 PHASE1
NCT07424001 COMPLETED
Inguinal Hernia Unilateral; Delayed Neurocognitive Recovery; Postoperative Pain; Neuroinflammation; Preemptive Analgesia
Mehmet Çiğdem
 2025-09-27 PHASE4
NCT06496854 WITHDRAWN
Pain; IUD
University of Wisconsin, Madison
 2025-10 PHASE2
NCT05640674 TERMINATED
Supracondylar Humerus Fracture
Baylor College of Medicine
 2023-09-12 PHASE4
NCT05076110 COMPLETED
Hip Arthroscopy
Mayo Clinic
 2022-04-07 PHASE4
NCT04813991 WITHDRAWN
Perioperative Pain
Hackensack Meridian Health
 2022-03-15 PHASE3
NCT05935306 COMPLETED
Photobiomodulation; Endodontic Disease; Pain; Inflammation; Surgery
University of Nove de Julho
 2024-06-30
NCT06152796 UNKNOWN
Patent Ductus Arteriosus
Assiut University
 2023-12-01 PHASE2
NCT05575700 COMPLETED
Pain, Acute; Hip Arthropathy; Knee Arthropathy; Safety Issues; Analgesia; Analgesic Adverse Reaction; Postoperative Pain; Postoperative Complications
Naestved Hospital
 2023-04-17 PHASE4
NCT07114198 COMPLETED
Reversible Pulpitis; Ibuprofen
Inonu University
 2025-08-02 EARLY_PHASE1
NCT06505148 NOT_YET_RECRUITING
Pediatric Disorder
Baylor Research Institute
 2024-08-01 PHASE4
NCT07329413 COMPLETED
Symptomatic Apical Periodontitis; Temporomandibular Disorders (TMDs); Anterior Disc Displacement
Recep Tayyip Erdogan University
 2025-03-10
NCT06980870 RECRUITING
Post-endodontic Pain; Ibuprofen; Dexamethasone
Armed Forces Institute of Dentistry, Pakistan
 2025-02-15 PHASE2
NCT07125911 COMPLETED
Irreversible Pulpitis With Apical Periodontitis
HITEC-Institute of Medical Sciences
 2024-04-07
NCT07133360 COMPLETED
Swelling Lips &Amp; Face; Pain; Trismus
Universidad Complutense de Madrid
 2025-02-01
NCT06781489 COMPLETED
Carpal Tunnel Syndrome
Universidad Europea de Madrid
 2025-02-19 PHASE4
NCT06778759 COMPLETED
Carpal Tunnel Syndrome
Universidad Europea de Madrid
 2025-02-19 PHASE4
NCT07233733 COMPLETED
Periodontal Diseases; Regeneration
Phạm Đình Thiên Khải
 2024-06-01
NCT05834569 TERMINATED
Delirium; Aged; Lung Neoplasms; Robotic Surgical Procedures; Thoracic Surgery, Video-Assisted
Korea University Guro Hospital
 2023-06-15 PHASE4
NCT03949478 UNKNOWN
Epilepsy; Epilepsies, Partial
University of Calgary
 2021-02-01 PHASE2
NCT06731556 COMPLETED
Tonsil Disease; Pain Management; Intranasal Drug Administration
Bezmialem Vakif University
 2024-12-15 PHASE3
NCT06906315 COMPLETED
Endodontic Treatment; Pulp Necrosis; Periapical Lesions; Postoperative Pain
University of Salamanca
 2024-11-04 PHASE4
NCT05488847 ACTIVE_NOT_RECRUITING
Shoulder Arthropathy; Shoulder Pain
Henry Ford Health System
 2022-06-25 PHASE4
NCT05325177 UNKNOWN
Patent Ductus Arteriosus After Premature Birth
Ottawa Hospital Research Institute
 2022-06-01 PHASE4
NCT07146997 COMPLETED
Symptomatic Irreversible Pulpitis
Zahoor khan
 2023-11-23 PHASE3
NCT03584152 COMPLETED
Pain, Postoperative
Stanford University
 2019-08-09 PHASE2
NCT06317064 COMPLETED
Primary Dysmenorrhea
Lahore Medical Research Center, LLP
 2024-03-15 PHASE3
NCT06061575 COMPLETED
Sepsis; Acetaminophen; Fever; Ibuprofen
Ankara City Hospital Bilkent
 2023-10-31 PHASE4
NCT05742763 WITHDRAWN
Osteoarthritis of the Knee; Degenerative Osteoarthritis; Knee Pain Chronic
QC Kinetix LLC
 2023-11-01 PHASE1; PHASE2
NCT05011149 UNKNOWN
Patent Ductus Arteriosus After Premature Birth
IWK Health Centre
 2022-01-10 PHASE3
NCT06149507 UNKNOWN
Celiac Disease in Children
Cairo University
 2024-03-01 PHASE4
NCT06060236 UNKNOWN
Pain; Bone Fracture
Ankara City Hospital Bilkent
 2023-09-01 PHASE4
NCT06514222 UNKNOWN
Post Operative Pain; Impacted Third Molar Tooth
University of Sharjah
 2024-07-01 EARLY_PHASE1
NCT06594224 COMPLETED
Pain Management
Muhammad Aamir Latif
 2024-03-01
NCT05012098 COMPLETED
Olfactory Neuroblastoma; Esthesioneuroblastoma; Neoplasm of the Nasal Cavity
National Cancer Institute (NCI)
 2022-06-21 PHASE2
NCT06214273 UNKNOWN
Chemotherapy Induced Oral Mucositis
Cairo University
 2024-04 PHASE2
NCT05983354 UNKNOWN
Acute Migraine Headache
Health Sciences North Research Institute
 2024-01-01
NCT05927922 COMPLETED
Mandibular Molar Teeth With Symptomatic Irreversible Pulpitis
Cairo University
 2023-06-20 PHASE1
NCT05109312 UNKNOWN
Analgesia
Heron Therapeutics
 2021-10-12 PHASE4
NCT06808529 COMPLETED
Dysmenorrhea Primary
Cairo University
 2024-01-30 EARLY_PHASE1
NCT05081102 COMPLETED
Pain
Eurofarma Laboratorios S.A.
 2024-03-27 PHASE3
NCT06077786 COMPLETED
Healthy Participants
H. Lundbeck A/S
 2023-10-13 PHASE1
NCT06478758 COMPLETED
Acute Post-operative Pain
Giresun University
 2024-02-01 PHASE4
NCT06126029 UNKNOWN
Knee Osteoarthritis; Metformin
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2023-10-15 PHASE2
NCT05819619 TERMINATED
Nausea; Pain
Hackensack Meridian Health
 2023-07-20 EARLY_PHASE1
NCT04123717 COMPLETED
Fever
Hamad Medical Corporation
 2019-10-11 EARLY_PHASE1
NCT06046105 UNKNOWN
Postoperative Pain, Acute
Ain Shams University
 2023-09-15 PHASE2; PHASE3
NCT02603848 UNKNOWN
Inguinal Surgery
McMaster University
 2017-02-27
NCT04646967 COMPLETED
Pain, Postoperative; Phimosis; Paraphimosis; Balanitis
Alberta Children's Hospital
 2022-11-25 PHASE2
NCT06146491 UNKNOWN
Pain, Postoperative
B.P. Koirala Institute of Health Sciences
 2023-08-10 PHASE4
NCT05248152 UNKNOWN
Postoperative Pain
University Medical Centre Ljubljana
 2022-01-13
NCT04905563 TERMINATED
Supracondylar Humerus Fracture
Le Bonheur Children's Hospital
 2021-06-07 PHASE4
NCT05374057 UNKNOWN
Acute Neck Pain
University Hospital, Akershus
 2022-05-23 PHASE4
NCT06187584 COMPLETED
Supracondylar Humerus Fracture
Children's Mercy Hospital Kansas City
 2019-04-15 PHASE4
NCT04575519 TERMINATED
Tuberculosis, Pulmonary; Tuberculosis, MDR; Tuberculosis Infection
Fundació Institut Germans Trias i Pujol
 2021-03-04 PHASE2
NCT04986839 UNKNOWN
Patent Ductus Arteriosus
Manchester University NHS Foundation Trust
 2021-09-03 PHASE2; PHASE3
NCT04874675 SUSPENDED
Impacted Third Molar Tooth; PAIN
University of Zimbabwe
 2023-03
NCT05782608 COMPLETED
Ibuprofen; Ketorolac; Colorectal Cancer
Cairo University
 2023-04-01
NCT04726085 TERMINATED
Preterm Labor
Woman's
 2021-02-01
NCT05941130 UNKNOWN
Molar, Third; Third Molar Surgery; Soft Tissue Swelling; Pain, Postoperative; Quality of Life
Implantology Institute
 2022-07-01 PHASE4
NCT06006663 UNKNOWN
Effective Intracanal Medicaments Against Enterococcus Faecalis
Tanta University
 2023-08-26 PHASE2; PHASE3
NCT06232785 COMPLETED
Motion Sickness; Postoperative Nausea and Vomiting; Ibuprofen
Second Hospital of Jilin University
 2022-02-01 PHASE4
NCT05907993 COMPLETED
Pain, Postoperative
Alexandria University
 2023-02-01 PHASE4
NCT05923775 UNKNOWN
Molar, Third
Cihan Topan
 2023-03-01
NCT06180070 COMPLETED
Migraine; Headache; Backache
Humanis Saglık Anonim Sirketi
 2023-08-29 PHASE1
NCT06247462 COMPLETED
Acute Kidney Injury
University of New Mexico
 2023-06-01 PHASE1
NCT06291337 COMPLETED
Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants; Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants
Rutgers, The State University of New Jersey
 2020-06-01
NCT06146491 Recruiting
Pain Postoperative
B.P. Koirala Institute of Health Sciences
 2023-08-10 Phase 4
NCT05928520 Not yet recruiting
Pain Management
Al-Azhar University
 2023-08-01 Phase 3
NCT02689024 TERMINATED
Hip Fractures; Anesthesia
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2016-05 PHASE4
NCT05366777 COMPLETED
Postoperative Pain
Seoul National University Hospital
 2022-10-03
NCT04879823 TERMINATED
Adenotonsillectomy; Analgesia; Surgery
David Chi, MD
 2021-08-05 PHASE3
NCT04637529 COMPLETED
Osteoarthritis
Apsen Farmaceutica S.A.
 2022-08-05 PHASE2
NCT06948513 COMPLETED
Pain Management
Zitelli & Brodland Skin Cancer Center
 2022-12-22 PHASE3
NCT06188143 COMPLETED
Pain, Postoperative
Phramongkutklao College of Medicine and Hospital
 2022-12-22
NCT05801900 UNKNOWN
Postoperative Pain; Bariatric Surgery Candidate
Cairo University
 2023-04
NCT06247462 Completed
Acute Kidney Injury
University of New Mexico
 2023-06-01 Phase 1
NCT05586373 COMPLETED
Preeclampsia
Instituto Materno Infantil Prof. Fernando Figueira
 2022-10-15 PHASE4
NCT04772781 COMPLETED
Low Back Pain, Mechanical; Low Back Pain; Acute Low Back Pain
Apsen Farmaceutica S.A.
 2022-06-03 PHASE2
NCT04320914 UNKNOWN
Osteo Arthritis Knee
Maharishi Markendeswar University (Deemed to be University)
 2020-09-28
NCT05737069 COMPLETED
Pain
HALEON
 2023-04-19 PHASE1
NCT05544734 COMPLETED
Nail Diseases; Nail Abnormality
Weill Medical College of Cornell University
 2022-11-10 PHASE4
NCT05013567 UNKNOWN
Musculoskeletal Pain; Acute Pain; Stretch; Sprains
Brainfarma Industria Química e Farmacêutica S/A
 2022-08 PHASE3
NCT02330926 COMPLETED
Cachexia; Neoplasms
Norwegian University of Science and Technology
 2015-04 PHASE3
NCT05575700 Recruiting
Pain Acute|Hip Arthropathy|Knee Arthropathy|Safety Issues|Analgesia|Analgesic Adverse Reaction|Postoperative Pain|Postoperative Complications
Naestved Hospital
 2023-04-17 Phase 4
NCT05674721 COMPLETED
Pain
HALEON
 2023-01-05 PHASE1
NCT05763836 UNKNOWN
Supratentorial Brain Tumor
Ankara University
 2022-11-01 PHASE4
NCT05602064 COMPLETED
Post-operative Pain
Alexandria University
 2022-11-01 PHASE4
NCT05496868 Recruiting
Acute Respiratory Distress Syndrome Adult
Dompé Farmaceutici S.p.A
 2023-02-07 Phase 2
NCT03385057 WITHDRAWN
Tonsillectomy With or Without Adenoidectomy
Massachusetts Eye and Ear Infirmary
 2018-09 PHASE1
NCT06064175 COMPLETED
Low Back Pain, Mechanical; Ibuprofen; Analgesia; Pain Management
Ankara City Hospital Bilkent
 2022-01-01 PHASE4
NCT05241496 UNKNOWN
Lidocaine Toxicity
Marina Ramsis Aziz Ghaly
 2021-12-15
NCT03824119 UNKNOWN
Preeclampsia; Gestational Hypertension; Superimposed Preeclampsia; Chronic Hypertension in Obstetric Context
University of Southern California
 2018-12-11 PHASE4
NCT03060434 ACTIVE_NOT_RECRUITING
Lumbar Radiculopathy; Lumbar Disc Herniation; Lumbar Disc Disease
St Joseph University, Beirut, Lebanon
 2018-06-01 PHASE4
NCT05479175 UNKNOWN
Postoperative Pain
Yuzuncu Yil University
 2022-05-01
NCT05349929 UNKNOWN
Irreversible Pulpitis
Qazvin University Of Medical Sciences
 2022-05 PHASE2
NCT04321655 UNKNOWN
Knee Osteoarthritis
Asir John Samuel
 2022-04-01
NCT05222724 COMPLETED
Low Back Pain
Aziende Chimiche Riunite Angelini Francesco S.p.A
 2021-12-01 PHASE4
NCT05053009 UNKNOWN
Anesthesia
Cairo University
 2021-11
NCT02588027 COMPLETED
Rotator Cuff Tear Arthropathy
University of California, San Francisco
 2015-10
NCT06574516 COMPLETED
Pain
King Abdullah University Hospital
 2021-11-04
NCT05971186 COMPLETED
Dysmenorrhea Primary; Menstrual Pain; Ibuprofen
Universitas Padjadjaran
 2022-06-30 PHASE2
NCT02571543 COMPLETED
Ovulation; Ovulation Inhibition; Ovulation Inhibition/Drug Effects; Pregnancy; Fertilization in Vitro/Methods
Insel Gruppe AG, University Hospital Bern
 2016-01 PHASE2
NCT04622839 COMPLETED
Shoulder Pain
Johns Hopkins University
 2020-12-01
NCT04122443 COMPLETED
Musculoskeletal Pain
Montefiore Medical Center
 2019-12-01 PHASE4
NCT04358497 UNKNOWN
Pelvic Congestive Syndrome; Pelvic Varices; Venous Disease
Hospital de Clínicas Dr. Manuel Quintela
 2020-10-01 PHASE4
NCT06109415 COMPLETED
Postoperative Pain; Total Shoulder Arthroplasty; Multimodal Analgesia
Heron Therapeutics
 2021-10-20 PHASE4
NCT04964622 COMPLETED
Irreversible Pulpitis
Cairo University
 2021-12-01 PHASE1; PHASE2
NCT04653506 COMPLETED
Pain
Tel-Aviv Sourasky Medical Center
 2020-11-28
NCT04087317 COMPLETED
Pain; Post Partum Depression; Opioid Use; Breast Feeding
Rambam Health Care Campus
 2020-06-01
NCT04423107 UNKNOWN
Hypospadias
University of Oklahoma
 2020-07-01 PHASE3
NCT03868137 UNKNOWN
Pelvic Pain; IUD
Orlando VA Medical Center
 2020-09-28
NCT02884219 COMPLETED
Patent Ductus Arteriosus
Radboud University Medical Center
 2016-12-23
NCT03893175 COMPLETED
Impacted Third Molar Tooth; Pain, Acute
University of Pennsylvania
 2019-05-10 PHASE1
NCT04941443 TERMINATED
Pain; Medical Abortion
Boston Medical Center
 2021-10-04 PHASE4
NCT01974609 COMPLETED
Carpal Tunnel
Horizon Health Network
 2016-03 PHASE4
NCT05695664 COMPLETED
Intravenous Drug Usage; Ibuprofen; Ketorolac; Knee Arthroscopy; Postoperative Pain
Benazir Bhutto Hospital, Rawalpindi
 2021-08-01 EARLY_PHASE1
NCT05097768 COMPLETED
Symptomatic Irreversible Pulpitis
Alfarabi Colleges
 2021-08-15
NCT03955211 COMPLETED
Analgesia
Heron Therapeutics
 2019-06-24 PHASE2
NCT04533568 COMPLETED
Migraine Without Aura
Kecioren Education and Training Hospital
 2020-09-01 PHASE4
NCT04485403 UNKNOWN
PCOS; Hyperandrogenism; Inflammation
Poznan University of Medical Sciences
 2019-09-01 PHASE2
NCT03792295 WITHDRAWN
Hernia, Abdominal; Pain
Khashayar Vaziri
 2021-07-01 PHASE2
NCT03789058 UNKNOWN
Operation Site Inflammation; Pain, Postoperative; Teeth, Impacted
Jordan University of Science and Technology
 2018-04-19 PHASE2; PHASE3
NCT03692416 UNKNOWN
Vasculitis
Assiut University
 2018-11-11 PHASE3
NCT03907176 COMPLETED
Analgesia
Heron Therapeutics
 2019-04-04 PHASE3
NCT03953729 UNKNOWN
Pain; Anxiety
University of Sao Paulo
 2019-04-01 EARLY_PHASE1
NCT06231212 COMPLETED
Temporomandibular Disorder
Chulalongkorn University
 2020-08-05 PHASE2; PHASE3
NCT02929589 TERMINATED
Pain; Hernia
Mike O'Callaghan Military Hospital
 2018-07-05 PHASE3
NCT02904304 SUSPENDED
Cold
Ache Laboratorios Farmaceuticos S.A.
 2020-12 PHASE3
NCT04866355 COMPLETED
Women With Primary Dysmenorrhea
University of Alcala
 2021-02-28
NCT04447924 COMPLETED
Reduction of Small Intestinal Ulceration Risk
Chr Hansen
 2020-06-22
NCT04334629 WITHDRAWN
Coronavirus; Respiratory Distress Syndrome; SARS-CoV Infection
King's College London
 2020-05-26 PHASE4
NCT05024825 TERMINATED
Pain, Postoperative
Albany Medical College
 2017-08-04 PHASE4
NCT02686021 COMPLETED
Pain, Postoperative
University Hospital, Basel, Switzerland
 2016-02-15 PHASE4
NCT04424420 UNKNOWN
Empathy
Prof. Jürgen Brockmöller
 2019-11-07 PHASE1
NCT05329454 COMPLETED
Chronic Pain
Overseas Pharmaceuticals, Ltd.
 2020-12-24 PHASE1
NCT03861611 COMPLETED
Back Pain Without Radiation; Low Back Pain
Montefiore Medical Center
 2019-07-12 PHASE4
NCT04570644 COMPLETED
Healthy Volunteers; Alzheimer Disease
AZTherapies, Inc.
 2020-08-28 PHASE1
NCT02932579 TERMINATED
Pain
University of Rochester
 2017-07-01 PHASE4
NCT03418805 TERMINATED
Pain Control
Overseas Pharmaceuticals, Ltd.
 2017-12-11 PHASE1
NCT03571737 COMPLETED
Acute Musculoskeletal Disease; Sprains; Sprains and Strains; Injuries; Emergencies; Trauma; Acute Pain
East Carolina University
 2018-06-23 PHASE3
NCT04419948 UNKNOWN
Diabetes Mellitus, Adult-Onset; Platelet Dysfunction; Postprandial Hyperglycemia; Lipidemia; Inflammation; Oxidative Stress
Harokopio University
 2019-05-16
NCT03701074 TERMINATED
Patent Ductus Arteriosus; Preterm Infant; Bronchopulmonary Dysplasia
University of South Alabama
 2018-12-15 PHASE2
NCT04730297 COMPLETED
To Control Pain After Third Molar Surgery
University of Roma La Sapienza
 2018-01-01 PHASE4
NCT02638506 TERMINATED
Headaches
St. Justine's Hospital
 2016-01 PHASE4
NCT04119739 COMPLETED
Carpal Tunnel Syndrome
Francisco Unda Solano
 2020-04-14 PHASE4
NCT04429282 UNKNOWN
Ibuprofen; Nonsteroidal Anti-inflammatory Drug; Intravenous; Injectable; Pain; Analgesic
Yi Feng, MD
 2020-06-10 PHASE3
NCT03618823 TERMINATED
Adenotonsillectomy; Post-operative Analgesia; Opioid Use
David Chi, MD
 2018-10-25 PHASE1; PHASE2
NCT07644065 COMPLETED
Impacted Third Molar; Postoperative Pain; Neuroinflammation; Anxiety
Plovdiv Medical University
 2019-09-30
NCT03929640 TERMINATED
Pain, Postoperative; Opioid Use
Milton S. Hershey Medical Center
 2019-08-05 PHASE3
NCT04282941 UNKNOWN
Persistent Ductus Arteriosus
Instituto de Investigación Hospital Universitario La Paz
 2017-02-20 PHASE3
NCT03959969 COMPLETED
Opioid Use, Unspecified
Medstar Health Research Institute
 2019-07-17
NCT01238120 COMPLETED
Cancer-related Cognitive Difficulties
University of Rochester
 2010-11 PHASE2
NCT04025203 COMPLETED
Carpal Tunnel Syndrome
Francisco Unda Solano
 2019-08-01 PHASE4
NCT03088800 COMPLETED
Pain Management
Antonios Likourezos
 2018-04-30 PHASE2
NCT02056223 SUSPENDED
Ductus Arteriosus Patent; Respiratory Distress Syndrome
University of Padova
 2017-01-09 PHASE2; PHASE3
NCT03722238 TERMINATED
Pain
Pfizer
 2018-12-27 PHASE3
NCT03011567 COMPLETED
Hypertension, Pregnancy-Induced
MemorialCare Health System
 2017-01
NCT03554018 COMPLETED
Low Back Pain
Montefiore Medical Center
 2018-10-16 PHASE3
NCT03332524 TERMINATED
Sunburn
Sephoris Pharmaceuticals LLC
 2018-01-15 PHASE2
NCT03619785 UNKNOWN
Rib Fractures; Rib Fracture Multiple
Andrew A Herring
 2018-11-06 PHASE4
NCT03988075 COMPLETED
Pain; Thyroidectomy
Medstar Health Research Institute
 2018-07-24
NCT02128191 COMPLETED
Bronchopulmonary Dysplasia (BPD)
Samsung Medical Center
 2014-07 PHASE2
NCT03865147 UNKNOWN
Wounds Injuries; Anesthesia, Local
Medical Ethics UK Ltd
 2019-01-15 PHASE2
NCT02583399 COMPLETED
Pain; Fever
Cumberland Pharmaceuticals
 2017-08-08 PHASE4
NCT03952715 UNKNOWN
Healthy; Placebo Response
University of Haifa
 2018-04-17
NCT03441269 COMPLETED
Pain, Acute
Antonios Likourezos
 2018-11-01 PHASE4
NCT03008876 COMPLETED
Patent Ductus Arteriosus
Albany Medical College
 2017-01-01
NCT03103022 COMPLETED
Patent Ductus Arteriosus; Neonate
University of Florida
 2017-06-12 PHASE1
NCT03697746 UNKNOWN
Dysmenorrhea
Pamukkale University
 2018-10-01
NCT03352362 COMPLETED
Inguinal Hernia
Yonsei University
 2017-12-15
NCT04227652 COMPLETED
Sepsis; Severe Sepsis; Septic Shock
University Hospital Ostrava
 2013-09-03
NCT03783312 COMPLETED
Postoperative Pain; Myalgia; Headache
Inonu University
 2018-12-20
NCT03509675 COMPLETED
Oral Lichen Planus; Oral Lichenoid Mucositis; Oral Lichenoid Reaction
University of Washington
 2018-04-29 PHASE2; PHASE3
NCT02422966 COMPLETED
Ductus Arteriosus, Patent
Aziende Chimiche Riunite Angelini Francesco S.p.A
 2015-12 PHASE2
NCT02745925 COMPLETED
Obesity
Swiss Federal Institute of Technology
 2016-04
NCT01891084 COMPLETED
Influenza
The University of Hong Kong
 2013-07 PHASE4
NCT02153177 WITHDRAWN
Rotator Cuff Tear
University of Chicago
 2015-01 PHASE4
NCT02807623 COMPLETED
Immune System and Related Disorders
Womack Army Medical Center
 2016-09
NCT02477007 COMPLETED
Pain; Long-bone Fractures
Assistance Publique - Hôpitaux de Paris
 2015-12-03 PHASE3
NCT03695367 COMPLETED
Postoperative Pain
Heron Therapeutics
 2018-10-01 PHASE2
NCT05428306 COMPLETED
Healthy
Laboratorios Silanes S.A. de C.V.
 2018-10-23 PHASE1
NCT03080493 COMPLETED
Abortion, Induced; Cervical Preparation; Pain
University of California, Davis
 2017-03-20 PHASE4
NCT03639571 COMPLETED
Healthy
Medherant Ltd
 2018-08-09 PHASE1
NCT03404518 COMPLETED
Outpatient Surgery; Pain, Postoperative
Loma Linda University
 2018-02-21 PHASE3
NCT02241512 TERMINATED
Post-ERCP Acute Pancreatitis
University of Texas Southwestern Medical Center
 2014-09 PHASE2
NCT04070001 COMPLETED
Crowding, Tooth
Yeşim KAYA
 2017-08-01
NCT02432456 COMPLETED
Wounds and Injuries; Rib Fractures
Medical College of Wisconsin
 2015-09 PHASE4
NCT03241030 COMPLETED
Herpangina; Gingivostomatitis; Hand, Foot and Mouth Disease
University of Texas at Austin
 2017-09-12 PHASE2
NCT03169127 UNKNOWN
Pain; Other Surgical Procedures; Impacted Third Molar Tooth
University of Sao Paulo
 2016-04-01 PHASE4
NCT03068897 COMPLETED
Low Back Pain
Montefiore Medical Center
 2017-05-03 PHASE4
NCT02288923 COMPLETED
Arthritis Knee
Royal Devon and Exeter NHS Foundation Trust
 2015-03
NCT02344225 COMPLETED
Retinopathy of Prematurity
State University of New York - Downstate Medical Center
 2015-01-01 PHASE2
NCT03423329 COMPLETED
Anesthesia, Local
Ain Shams University
 2018-01-20
NCT02863575 COMPLETED
Pain
Pfizer
 2017-10-24 PHASE3
NCT03224403 COMPLETED
Post-operative Dental Pain
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
 2017-07-19 PHASE3
NCT02006576 COMPLETED
Emphysema
University of Nebraska
 2014-01-01 PHASE2
NCT02647788 COMPLETED
Pain, Postoperative
University of Pennsylvania
 2015-12 PHASE4
NCT03055507 COMPLETED
Chronic Rhinosinusitis (Diagnosis)
University of Washington
 2017-04-01 PHASE2; PHASE3
NCT03658720 TERMINATED
Healthy
Reckitt Benckiser Healthcare (UK) Limited
 2017-12-19
NCT02761980 COMPLETED
Fever
Pfizer
 2016-12-06 PHASE3
NCT03068260 COMPLETED
Postoperative Pain
Zealand University Hospital
 2017-03-15 PHASE4
NCT03223519 COMPLETED
Delayed Onset Muscle Soreness, DOMS
Spherium Biomed
 2017-07-12 PHASE2
NCT03243032 WITHDRAWN
Pain, Postoperative
Satheesh Elangovan
 2017-10-06 EARLY_PHASE1
NCT03170726 UNKNOWN
Preemptive Intravenous Ibuprofen; Intraoperative Analgesia
Erzincan University
 2017-05-15
NCT03170713 UNKNOWN
Trismus; Edema
Erzincan University
 2017-05-15
NCT02571361 COMPLETED
Pain, Postoperative
Daniel Hägi-Pedersen
 2015-11 PHASE4
NCT03003000 COMPLETED
Back Pain; Neck Pain
Boehringer Ingelheim
 2016-12-20 PHASE3
NCT02096913 COMPLETED
Spinal Cord Injury
Jan M. Schwab, MD, PhD
 2013-06 PHASE1
NCT03597308 COMPLETED
Post-operative Pain
Rothman Institute Orthopaedics
 2017-03-17
NCT02689063 COMPLETED
Post Operative Pain
AFT Pharmaceuticals, Ltd.
 2016-10-26 PHASE3
NCT02268955 COMPLETED
Biliary Colic
Valleywise Health
 2014-09-09
NCT03180879 COMPLETED
Healthy
Reckitt Benckiser Healthcare (UK) Limited
 2017-04-10 PHASE1
NCT02935894 COMPLETED
Stability & Variability of Lipid-derived Molecules in Sweat
USDA, Western Human Nutrition Research Center
 2016-11-28
NCT02276911 TERMINATED
Cervical Spondylosis; Lumbar Spondylosis
St. Joseph's Hospital and Medical Center, Phoenix
 2015-03-01 PHASE2
NCT01230411 COMPLETED
Episodic Migraine
Thomas Jefferson University
 2011-06 PHASE4
NCT02605187 COMPLETED
Postoperative Pain
Stanford University
 2015-11
NCT03631433 COMPLETED
Pain, Postoperative
Ohio State University
 2016-02-10 PHASE4
NCT02863614 COMPLETED
Subfertility; Infertility
University of Sao Paulo
 2015-05
NCT02519023 COMPLETED
Acute Pain
University of Minnesota
 2016-07 PHASE4
NCT02974361 COMPLETED
Pharmacokinetics
Oxford Pharmascience Ltd
 2016-12 PHASE1
NCT04203771 COMPLETED
Surgery--Complications; Molar, Third
AB Biotics, SA
 2016-06
NCT01785108 COMPLETED
Diabetes Mellitus, Type 1
Johnny Ludvigsson
 2013-02 PHASE2
NCT02076893 TERMINATED
Pain
Children's Hospitals and Clinics of Minnesota
 2014-03 PHASE4
NCT02963701 COMPLETED
Healthy Volunteers
Boehringer Ingelheim
 2016-12-20 PHASE1
NCT03184766 COMPLETED
Healthy
Reckitt Benckiser Healthcare (UK) Limited
 2016-08-10 PHASE1
NCT00223691 COMPLETED
Autonomic Failure; Orthostatic Hypotension
Vanderbilt University
 2002-03 PHASE1
NCT02778958 COMPLETED
Bariatric Surgery Candidate; Obesity, Morbid
Inonu University
 2016-01 PHASE4
NCT02836509 UNKNOWN
Low Back Pain
Pamukkale University
 2016-09 PHASE4
NCT02602483 COMPLETED
Temporomandibular Joint Disorders
Spherium Biomed
 2015-12 PHASE1; PHASE2
NCT02296840 TERMINATED
Recurrent Tonsillitis; Obstructive Sleep Apnea; Sleep Disordered Breathing; Adverse Reaction to Drug
Emory University
 2014-11 PHASE4
NCT02806869 COMPLETED
Human Gastrointestinal Physiology Data
University of Michigan
 2015-01
NCT02521415 COMPLETED
Bone Fracture
Wake Forest University Health Sciences
 2015-12 PHASE2
NCT01938144 WITHDRAWN
Common Cold
Pfizer
 2016-04 PHASE3
NCT02735122 COMPLETED
Post Operative Dental Pain
Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division
 2016-04-30 PHASE3
NCT02233582 COMPLETED
High Altitude
University of California, San Francisco
 2014-09 PHASE1
NCT03018015 COMPLETED
Bioequivalence
SocraTec R&D GmbH
 2016-09 PHASE1
NCT03295968 COMPLETED
Appetitive Behavior; Pediatric Obesity
University of Toronto
 2016-03
NCT02668822 TERMINATED
Dysmenorrhea
Organon and Co
 2016-02-09 PHASE3
NCT01686802 COMPLETED
Post-operative Pain
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2012-09 PHASE2
NCT02227316 COMPLETED
Symptomatic Uterine Fibroids and Adenomyosis
University of California, Los Angeles
 2014-08 PHASE4
NCT02455518 COMPLETED
Pain
Montefiore Medical Center
 2015-07 PHASE4
NCT02443142 WITHDRAWN
Brain Concussion
Northwestern University
 2015-05-01 PHASE2
NCT02902289 COMPLETED
Healthy
Aziende Chimiche Riunite Angelini Francesco S.p.A
 2016-06 PHASE1
NCT01849926 COMPLETED
Acute Cystitis (Excl in Pregnancy)
University of Oslo
 2013-04 PHASE4
NCT02611583 WITHDRAWN
Low Back Pain
Albert Einstein Healthcare Network
 2016-06-24
NCT01092676 COMPLETED
Ibuprofen; Ankle Injuries
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2010-02
NCT02902302 COMPLETED
Healthy
Aziende Chimiche Riunite Angelini Francesco S.p.A
 2016-05 PHASE1
NCT01567072 COMPLETED
Forearm Fracture
Marius Aliuskevicius
 2012-04 PHASE3
NCT02912650 COMPLETED
Post-surgical Pain Following Extraction of Molar Teeth
Pfizer
 2015-09 PHASE3
NCT05256147 TERMINATED
Vitiligo
Henry Ford Health System
 2015-08
NCT03496324 COMPLETED
Bioequivalence of the Test Formulation
Reckitt Benckiser Healthcare (UK) Limited
 2016-02-29 PHASE1
NCT00346216 COMPLETED
Arthritis, Rheumatoid
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2006-10-04 PHASE4
NCT02205489 COMPLETED
Relapsing-remitting Multiple Sclerosis
Genzyme, a Sanofi Company
 2014-10 PHASE4
NCT01837810 UNKNOWN
Secondary Post Tonsillectomy Hemorrhage; Primary Post Tonsillectomy Hemorrhage
Brooke Army Medical Center
 2013-04
NCT01478022 COMPLETED
Duchenne Muscular Dystrophy (DMD)
Parent Project, Italy
 2011-10 PHASE1
NCT02212990 COMPLETED
Fever
Duke University
 2014-09
NCT02272725 COMPLETED
Acute Kidney Injury; Exercise-associated Hyponatremia; Perceived Exertion
Stanford University
 2015-03 PHASE3
NCT02815189 COMPLETED
Pain
Universidad Autonoma de Baja California
 2014-02 PHASE2
NCT02141139 UNKNOWN
Breast Neoplasms
Samsung Medical Center
 2014-09 PHASE3
NCT02629354 COMPLETED
Healthy
Boehringer Ingelheim
 2015-11 PHASE1
NCT02294071 UNKNOWN
Fever
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2014-12 PHASE4
NCT02373254 COMPLETED
Ankle Fracture
University of California, Davis
 2015-01 EARLY_PHASE1
NCT02507219 COMPLETED
Major Depressive Disorder
Laureate Institute for Brain Research, Inc.
 2015-07 PHASE2; PHASE3
NCT02902913 COMPLETED
Cardiovascular Diseases
University of California, Davis
 2015-01
NCT01982799 WITHDRAWN
Odontalgia
University of Minnesota
 2014-02
NCT02521207 COMPLETED
Gastroduodenal Erosions
Oxford Pharmascience Ltd
 2015-07 PHASE1
NCT03497715 TERMINATED
Healthy Subjects
Reckitt Benckiser Healthcare (UK) Limited
 2015-04-14 PHASE1
NCT02324985 COMPLETED
Pain; Delayed Onset Muscle Soreness
Aponia Laboratories, Inc.
 2015-01 PHASE2
NCT02110719 COMPLETED
Narcotic Use; Pain; Constipation; Nausea
Hartford Hospital
 2014-03 PHASE4
NCT02064894 COMPLETED
Musculoskeletal Injury
St. Justine's Hospital
 2013-07-08
NCT01586299 UNKNOWN
Pleuro-pneumonia
Rabin Medical Center
 2012-03
NCT02666846 COMPLETED
Pain
Futura Medical Developments Ltd.
 2015-03 PHASE1
NCT02294019 COMPLETED
Patient Compliance
Pfizer
 2014-11 PHASE3
NCT02320708 COMPLETED
Dental Pain
Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.
 2014-12-31 PHASE2
NCT02327234 COMPLETED
Atopic Asthma
University of Saskatchewan
 2014-12
NCT02349607 COMPLETED
Healthy
Pfizer
 2015-01 PHASE1
NCT02358707 UNKNOWN
Osteoarthritis, Knee
Cukurova University
 2014-05
NCT01563185 COMPLETED
Juvenile Idiopathic Arthritis
Amgen
 2012-04 PHASE4
NCT02482155 COMPLETED
Healthy
Aziende Chimiche Riunite Angelini Francesco S.p.A
 2015-02 PHASE1
NCT01707251 COMPLETED
Obesity
Jacobi Medical Center
 2012-10 PHASE4
NCT02327338 COMPLETED
Heat; Pain
Future Sciene Technology
 2014-11 PHASE4
NCT01988298 COMPLETED
Hypertension
Complejo Hospitalario Dr. Arnulfo Arias Madrid
 2013-10 PHASE2; PHASE3
NCT01945034 COMPLETED
Ankle Injuries
Pfizer
 2013-11 PHASE3
NCT02339129 COMPLETED
Delayed Onset Muscle Soreness
Strategic Science & Technologies, LLC
 2014-11 PHASE2
NCT02417506 COMPLETED
Osteoarthritis of Knee
Vedic Lifesciences Pvt. Ltd.
 2014-08
NCT02089529 COMPLETED
Axial Spondyloarthritis
University Hospital of North Norway
 2014-01
NCT02244437 COMPLETED
Acute Mountain Sickness, Blood Oxygen Saturation, Headache
Mountain Medicine Society of Nepal
 2014-10 PHASE4
NCT00921700 COMPLETED
Pain, Postoperative
Ullevaal University Hospital
 2009-06 PHASE4
NCT02452450 COMPLETED
Healthy Volunteer Study
Reckitt Benckiser Healthcare (UK) Limited
 2014-01 PHASE1
NCT01200069 TERMINATED
Depression, Myalgia
Rutgers, The State University of New Jersey
 2010-07 PHASE4
NCT02417337 COMPLETED
Pain; Postoperative Pain; Irreversible Pulpitis
University of Khartoum
 2012-08 PHASE2
NCT01901393 COMPLETED
Pain
Cumberland Pharmaceuticals
 2013-07 PHASE4
NCT01938040 COMPLETED
Gallbladder Disease
University of Medicine and Dentistry of New Jersey
 2013-05 PHASE4
NCT02538237 COMPLETED
Periodontitis
Islamic Azad University, Sanandaj
 2013-11 PHASE2; PHASE3
NCT02461056 COMPLETED
Breast Cancer
Samsung Medical Center
 2014-06
NCT02254525 TERMINATED
Postoperative Pain
Biomendi S.A.U.
 2012-05 PHASE3
NCT03429738 COMPLETED
Pain, Head; Pain, Acute; Pain, Back; Fever
Institut für Pharmakologie und Präventive Medizin
 2014-04-27 PHASE1
NCT02096926 COMPLETED
Dental Pain
Lotus Clinical Research, LLC
 2014-03 PHASE4
NCT02086097 COMPLETED
Irreversible Pulpitis
Daniel Chavarría Bolaños
 2013-08 PHASE4
NCT02268058 COMPLETED
Concussion; Headache
McMaster Children's Hospital
 2013-10
NCT01794923 COMPLETED
Pain
Pfizer
 2013-06-13 PHASE3
NCT02050958 COMPLETED
NSAID Related Gastric Irritation
Oxford Pharmascience Ltd
 2014-02 PHASE1
NCT01929031 COMPLETED
Pain, Postoperative; Tooth Diseases
Boehringer Ingelheim
 2013-08 PHASE3
NCT00880373 TERMINATED
Sickle Cell Disease
London North West Healthcare NHS Trust
 2011-03 PHASE4
NCT01690780 COMPLETED
Upper Extremity Fractures; Analgesia Post Fracture
Naveen Poonai
 2012-09
NCT01488955 COMPLETED
Urinary Tract Infection
Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
 2012-02 PHASE4
NCT01874626 COMPLETED
Acute Ankle Sprain
Strategic Science & Technologies, LLC
 2013-06 PHASE3
NCT01680939 UNKNOWN
Pediatric Obstructive Sleep Apnea Syndrome
Hamilton Health Sciences Corporation
 2012-05 PHASE3
NCT01605240 UNKNOWN
Fracture; Pain
University of Manitoba
 2012-07
NCT01900795 TERMINATED
Postsurgical Pain Due to Third Molar Extraction
Purdue Pharma LP
 2013-07 PHASE2
NCT01986660 COMPLETED
Healthy
Strategic Science & Technologies, LLC
 2013-10 PHASE1
NCT01670656 COMPLETED
Dysmenorrhea
Organon and Co
 2013-01-21 PHASE2
NCT02069665 COMPLETED
Pneumonia
Liaoning University of Traditional Chinese Medicine
 2011-12
NCT02155166 COMPLETED
Pain
University of Sao Paulo
 2012-02
NCT01268670 SUSPENDED
Laceration; Pain
Children's Hospitals and Clinics of Minnesota
 2012-07
NCT01789606 COMPLETED
Analgesia
Pfizer
 2012-09-24 PHASE3
NCT01785862 COMPLETED
Acute Sore Throat Pain
Pierre Fabre Medicament
 2013-02 PHASE3
NCT01859377 COMPLETED
Healthy Volunteers
Pierre Fabre Medicament
 2013-05 PHASE1
NCT01426971 WITHDRAWN
Pain
Sanofi
 2012-12 PHASE3
NCT01716052 TERMINATED
Pain
Kenneth A. Kist,
 2012-07
NCT01377441 TERMINATED
Inflammatory Response
NYU Langone Health
 2011-09 PHASE4
NCT02113566 COMPLETED
Delayed Onset Muscle Soreness
Jean Brown Research
 2013-02 PHASE4
NCT01787448 COMPLETED
Pain
Pfizer
 2013-01 PHASE1
NCT01392378 COMPLETED
Pneumococcal Vaccines
Pfizer
 2011-08 PHASE4
NCT02441530 COMPLETED
Primary Dysmenorrhoea
Bezmialem Vakif University
 2012-11 PHASE3
NCT01514175 UNKNOWN
Chronic Pelvic Pain
Culpeper Surgery Center
 2012-01 PHASE4
NCT01650519 COMPLETED
Arthroscopic Knee Surgery
Cumberland Pharmaceuticals
 2012-09 PHASE4
NCT01334957 COMPLETED
Pain
Cumberland Pharmaceuticals
 2011-06 PHASE4
NCT01536158 COMPLETED
Patent Ductus Arteriosus
Zekai Tahir Burak Women's Health Research and Education Hospital
 2012-02 PHASE4
NCT01172405 UNKNOWN
Headache
Mantecorp Industria Quimica e Farmaceutica Ltd.
 2010-10 PHASE3
NCT00792818 COMPLETED
Osteoarthritis
Mahidol University
 2008-12 PHASE3
NCT01606527 UNKNOWN
Spectrum of Altitude-associated Neurologic Forms of Altitude
Naval Health Research Center
 2012-07 PHASE2
NCT01559259 COMPLETED
Pain
Pfizer
 2012-04-10 PHASE2
NCT01563289 COMPLETED
Pain
Orion Corporation, Orion Pharma
 2012-02 PHASE3
NCT01400737 UNKNOWN
Oral Ibuprofen Prophylaxis in Very Low Birth Weight Infants
Zekai Tahir Burak Women's Health Research and Education Hospital
 2011-07
NCT01332253 COMPLETED
Tonsillectomy
Cumberland Pharmaceuticals
 2011-07 PHASE3
NCT00728117 COMPLETED
Patent Ductus Arteriosus
University of California, San Francisco
 2008-07
NCT01529346 COMPLETED
Postoperative Dental Pain
Pfizer
 2011-12-12 PHASE2
NCT01070745 WITHDRAWN
Patent Ductus Arteriosus
Shaare Zedek Medical Center
 2010-06 PHASE2
NCT01066676 COMPLETED
Osteoarthritis of the Hip or Knee
Gebro Pharma GmbH
 2009-10 PHASE4
NCT01149564 UNKNOWN
Extremely Premature Infants; PDA; Oral Ibuprofen; IV Ibuprofen
China Medical University Hospital
 2009-12 PHASE1; PHASE2
NCT01462370 COMPLETED
Dysmenorrhea
Organon and Co
 2011-11 PHASE3
NCT01595282 COMPLETED
Pain
Planned Parenthood League of Massachusetts
 2011-06
NCT00258791 WITHDRAWN
Mental Disorders
Norwegian University of Science and Technology
 2012-01
NCT01512160 TERMINATED
Post-surgical Dental Pain
Pfizer
 2011-10 PHASE2
NCT01362491 COMPLETED
Pain
Pfizer
 2011-06 PHASE3
NCT01758913 COMPLETED
Patent Ductus Arteriosus
Taipei Medical University Hospital
 2007-02
NCT01944085 COMPLETED
Elbow Fracture
KK Women's and Children's Hospital
 2008-10
NCT00462722 COMPLETED
Aging; Physical Fitness
University of Colorado, Denver
 2007-07
NCT00833365 TERMINATED
Patent Ductus Arteriosus; Prematurity
University of Utah
 2009-01
NCT01466517 COMPLETED
Healthy
Pfizer
 2011-11 PHASE4
NCT01307020 COMPLETED
Pain
Menarini Group
 2011-02 PHASE2
NCT01330459 COMPLETED
Pain
Elizabeth Micks
 2011-02 PHASE4
NCT01429935 UNKNOWN
Impacted Third Molar Tooth
Qazvin University Of Medical Sciences
 2010-06 PHASE2
NCT01373697 UNKNOWN
Muscular Atrophy; Sprains; Tendonitis
Laboratório Teuto Brasileiro S/A
 2011-06 PHASE3
NCT01350596 COMPLETED
Healthy
Pfizer
 2011-05 PHASE4
NCT01035346 TERMINATED
Infection
Pfizer
 2010-01 PHASE3
NCT01266161 COMPLETED
Pain
Pfizer
 2010-11-22 PHASE3
NCT01316978 COMPLETED
Pain
McNeil AB
 2011-02 PHASE1
NCT00986882 COMPLETED
Postoperative Pain
Novartis
 2009-09 PHASE2
NCT00729976 UNKNOWN
Fever
Assaf-Harofeh Medical Center
 2008-09 PHASE4
NCT01172522 COMPLETED
Edema
The Connecticut Sinus Center, PC
 2010-09 PHASE2
NCT01077973 COMPLETED
Pain
Pfizer
 2010-03 PHASE3
NCT00997074 COMPLETED
Pain; Pregnancy
Sheba Medical Center
 2009-10 PHASE3
NCT00961753 TERMINATED
Patent Ductus Arteriosus
OSF Healthcare System
 2009-08 PHASE4
NCT01097902 COMPLETED
Pain; Inflammation
Martin Angst
 2010-02 PHASE1
NCT01170637 COMPLETED
Healthy
Boehringer Ingelheim
 2010-07 PHASE1
NCT00802685 TERMINATED
Patent Ductus Arteriosus
University of Miami
 2007-11
NCT01098747 COMPLETED
Pain
Pfizer
 2010-04 PHASE3
NCT01055249 COMPLETED
Pain; Inflammation; Healthy Volunteers
X-pert Med GmbH
 2010-01 PHASE1
NCT01243996 COMPLETED
Ductus Arteriosus, Patent
University of Florence
 2008-06 PHASE2; PHASE3
NCT01755702 TERMINATED
Headache, Tension-Type
GlaxoSmithKline
 2009-07 PHASE2; PHASE3
NCT01593163 COMPLETED
Patent Ductus Arteriosus
Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
 2009-05 PHASE3
NCT00962663 COMPLETED
Healthy
Pfizer
 2009-08 PHASE1
NCT00855777 UNKNOWN
Dental Extraction
Universita di Verona
 2009-04 PHASE4
NCT00938509 UNKNOWN
Fever
Soroka University Medical Center
 2009-07 PHASE4
NCT01189773 COMPLETED
Trauma
St. Justine's Hospital
 2008-02 PHASE4
NCT01229449 COMPLETED
Post-operative Pain
Reckitt Benckiser LLC
 2009-01 PHASE3
NCT00644319 UNKNOWN
Metastatic Cancer
Oxford University Hospitals NHS Trust
 2007-03 PHASE2
NCT00951561 COMPLETED
Dysmenorrhea
Another Way Products
 2006-11
NCT00758836 COMPLETED
Migraine
Merck Sharp & Dohme LLC
 2008-12-03 PHASE2
NCT00913627 COMPLETED
Pain
Pfizer
 2009-05-07 PHASE2
NCT00239746 UNKNOWN
Alzheimer's Disease
National Institute on Aging (NIA)
 2005-10 PHASE1
NCT00812422 COMPLETED
Fever; Respiratory Tract Infection
Inje University
 2008-02 PHASE3
NCT00606489 COMPLETED
Burns
Cumberland Pharmaceuticals
 2007-11 PHASE3
NCT00531882 COMPLETED
Cystic Fibrosis
University Hospitals Cleveland Medical Center
 2007-09
NCT00740857 COMPLETED
Pain
Wyeth is now a wholly owned subsidiary of Pfizer
 2008-08 PHASE4
NCT00613106 COMPLETED
Osteoarthritis; Rheumatoid Arthritis; Chronic Low Back Pain; Chronic Regional Pain Syndrome; Chronic Soft Tissue Pain
Amgen
 2007-09 PHASE3
NCT00707057 COMPLETED
Pain; Post-Operative Pain; Third Molar Extraction
SCOLR Pharma, Inc.
 2008-06 PHASE3
NCT00450216 COMPLETED
Ulcer
Amgen
 2007-03 PHASE3
NCT00115336 TERMINATED
Hematologic Diseases; Anemia, Sickle Cell
Children's Hospital Medical Center, Cincinnati
 2005-01 PHASE4
NCT00299039 COMPLETED
Pain; Breast Diseases
Nova Scotia Health Authority
 2006-05 PHASE3
NCT01053338 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2008-04 PHASE1
NCT00631111 COMPLETED
Pain
Wyeth is now a wholly owned subsidiary of Pfizer
 2007-11 PHASE3
NCT01118273 COMPLETED
Sleep
Bayer
 2008-01 PHASE4
NCT00225732 COMPLETED
Pain
Cumberland Pharmaceuticals
 2005-01 PHASE3
NCT00484744 COMPLETED
Orthodontic Pain
University of Missouri, Kansas City
 2007-06 PHASE4
NCT00895843 COMPLETED
Postoperative Pain; Wisdom Tooth
University of Manchester
 2006-11
NCT00993863 COMPLETED
Acute Pain
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
 2007-06 PHASE2
NCT00642330 COMPLETED
Patent Ductus Arteriosus
Hopital La Rabta
 2007-01 PHASE4
NCT00411190 COMPLETED
Osteoarthritis
GlaxoSmithKline
 2006-10-19 PHASE1
NCT00864526 COMPLETED
Healthy
Actavis Inc.
 2006-10 PHASE1
NCT00864357 COMPLETED
Healthy
Actavis Inc.
 2006-10 PHASE1
NCT00267176 COMPLETED
Osteoarthritis; Controlled Hypertension
Novartis Pharmaceuticals
 2005-11 PHASE4
NCT00631514 COMPLETED
Hypertension
University of Split
 2005-01 PHASE4
NCT00624871 COMPLETED
Hypoxic Ischemic Encephalopathy; Perinatal Asphyxia
Al-Azhar University
 2004-04
NCT00292747 TERMINATED
Dysmenorrhea
Sanofi
 2005-05-25 PHASE4
NCT00219700 COMPLETED
Osteoarthritis
PLx Pharma
 2005-01 PHASE2
NCT01131000 COMPLETED
Fever
Cumberland Pharmaceuticals
 2002-06 PHASE3
NCT00763997 COMPLETED
Platelet Aggregation
Ruhr University of Bochum
 2004-02
NCT01132222 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2004-09 PHASE1
NCT01131780 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2004-10 PHASE1
NCT00921830 COMPLETED
Healthy
Johnson & Johnson Consumer and Personal Products Worldwide
 2004-04 PHASE1
NCT00790270 COMPLETED
Cervical Strain
Stony Brook University
 2003-01 PHASE2
NCT00804440 COMPLETED
Bioequivalency
Perrigo Company
 2004-01 PHASE1
NCT00092755 COMPLETED
Osteoarthritis
Organon and Co
 2003-04-09 PHASE3
NCT00803946 COMPLETED
Bioequivalency
Perrigo Company
 2003-11 PHASE1
NCT00620867 COMPLETED
Osteoarthritis, Knee
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2002-10 PHASE4
NCT01149954 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2003-01 PHASE1
NCT01149941 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2002-11 PHASE1
NCT02183012 COMPLETED
Healthy
Boehringer Ingelheim
 2002-08 PHASE1
NCT02187588 COMPLETED
Pain
Boehringer Ingelheim
 1998-02 PHASE2
NCT01436188 COMPLETED
Healthy; Alzheimer Disease
Janssen Research & Development, LLC
 2011-09 EARLY_PHASE1
NCT00317655 COMPLETED
Back Pain
Ferrosan AS
 2006-04 PHASE4
NCT01104844 WITHDRAWN
Dental Pain
AFT Pharmaceuticals, Ltd.
 PHASE2
NCT00004440 COMPLETED
Cystic Fibrosis
FDA Office of Orphan Products Development
 1996-08
NCT00240825 COMPLETED
Pain
Johnson & Johnson Consumer and Personal Products Worldwide
 PHASE4
NCT00640809 COMPLETED
Bowel Diseases, Inflammatory
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2003-10 PHASE4
NCT00240864 COMPLETED
Pain
Johnson & Johnson Consumer and Personal Products Worldwide
 PHASE4
NCT01188317 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2010-06 PHASE1
NCT01420666 WITHDRAWN
Osteoarthritis
AFT Pharmaceuticals, Ltd.
 PHASE3
NCT00240838 COMPLETED
Pain
Johnson & Johnson Consumer and Personal Products Worldwide
 2003-05 PHASE4
NCT00046358 COMPLETED
Alzheimer Disease
National Institute of Mental Health (NIMH)
 2002-09 PHASE4
NCT00568217 COMPLETED
Recurrence of Febrile Seizure
University of Oulu
 1997-09 PHASE4
NCT00372801 COMPLETED
Osteoarthritis
GlaxoSmithKline
 2005-08 PHASE1
NCT00442585 COMPLETED
Drug Interactions
Gebro Pharma GmbH
 2006-09 PHASE1
NCT00217191 COMPLETED
Premature Infants; Patent Ductus Arteriosus
Maternite Regionale Universitaire
 2004-09 PHASE4
NCT00630929 COMPLETED
Osteoarthritis, Knee
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2003-01 PHASE4
NCT01464983 COMPLETED
Headache; Tension-Type Headache; Tension-Type Headache (Episodic)
Bayer
 2004-01 PHASE4
NCT00382083 COMPLETED
Breast Pain
Mountain States Tumor and Medical Research Institute
 2006-03 PHASE4
NCT00243815 COMPLETED
IUD Removal
FHI 360
 2002-06 PHASE3
NCT00638807 COMPLETED
Osteoarthritis, Knee
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2003-12 PHASE4
NCT00261586 COMPLETED
Analgesics
Johnson & Johnson Consumer and Personal Products Worldwide
 PHASE4
NCT00111046 UNKNOWN
Choroidal Melanoma; Melanoma; Eye Neoplasms
Royal Liverpool University Hospital
 2001-02 PHASE1; PHASE2
NCT00145730 COMPLETED
Osteoarthritis, Hip; Arthroplasty, Replacement, Hip; Arthritis, Rheumatoid
The George Institute
 2002-02 PHASE4
NCT00245375 COMPLETED
Laparoscopic Cholecystectomy; Inguinal Hernia; Abdominal Hernia; Umbilical Hernia
Nova Scotia Health Authority
 2005-01
NCT00121563 COMPLETED
Pain
National Institute of Nursing Research (NINR)
 2005-07 PHASE2
NCT00246389 COMPLETED
Pain; Spasm
McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.
 PHASE4
NCT00167713 COMPLETED
Fever
Albert Schweitzer Hospital
 2003-04 PHASE4

(data from https://clinicaltrials.gov, updated on 2026-08-19)

Check the Ibuprofen (NSC 256857) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Ibuprofen is a nonsteroidal anti-inflammatory drug that inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with IC50 values of 13 μM and 370 μM, respectively, blocking the synthesis of pro-inflammatory prostaglandins from arachidonic acid. Consequently, reduced prostaglandin accumulation diminishes localized inflammatory signaling, vascular permeability, and pain receptor sensitization, providing therapeutic efficacy in managing conditions such as postoperative pain, acute musculoskeletal pain, and migraine.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.