Numerous clinical trials evaluate furosemide across diverse conditions, including cardiac amyloidosis, end-stage renal disease on dialysis, cardiogenic acute pulmonary edema, kidney stones, and transient tachypnea of the newborn. Spanning Phase 1 pharmacokinetic investigations to Phase 4 evaluations, these studies are conducted by academic medical centers, university hospitals, and industry sponsors such as Astellas Pharma Europe and InventisBio. The portfolio encompasses active, recruiting, suspended, and completed trials assessing the therapeutic efficacy and pharmacological interactions of forced diuresis.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06941415 | RECRUITING | Cirrhosis |
Stacy Johnson |
2026-06-03 | PHASE3 |
| NCT07737964 | NOT_YET_RECRUITING | Heart Failure |
University Hospital, Montpellier |
2026-10 | PHASE3 |
| NCT06229990 | RECRUITING | Acute Kidney Injury |
Chiang Mai University |
2024-01-01 | PHASE4 |
| NCT07018297 | NOT_YET_RECRUITING | Heart Failure; Acute Decompensated Heart Failure |
University of Texas Southwestern Medical Center |
2026-08 | PHASE3 |
| NCT07726134 | NOT_YET_RECRUITING | Delayed Graft Function; Kidney Transplantation |
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
2026-08 | |
| NCT07167862 | NOT_YET_RECRUITING | Preeclampsia; Preeclampsia Postpartum; Preeclampsia Severe or Mild |
University of California, Irvine |
2026-06-15 | PHASE4 |
| NCT07568574 | ENROLLING_BY_INVITATION | Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes |
Enhanced Emirates Limited |
2026-03-12 | |
| NCT06407401 | NOT_YET_RECRUITING | ER+ Breast Cancer; HER2-negative Breast Cancer; Breast Cancer Stage I; Breast Cancer Stage II; Breast Cancer Stage III; Drug-Related Side Effects and Adverse Reactions; Musculoskeletal Pain |
European Organisation for Research and Treatment of Cancer - EORTC |
2024-12 | PHASE3 |
| NCT07469722 | NOT_YET_RECRUITING | Acute Heart Failure (AHF); Congestive Heart Failure Acute; Diuretic Effect; Lung Ultrasonography Score; Ultrasonography, Doppler; Point-of-care Ultrasound (POCUS) |
Hospital de Clinicas de Porto Alegre |
2026-03-23 | PHASE2; PHASE3 |
| NCT06094816 | RECRUITING | Salt-Sensitivity of Blood Pressure |
University of Delaware |
2024-03-05 | PHASE4 |
| NCT07631780 | NOT_YET_RECRUITING | Worsening Heart Failure; Congestion; Heart Failure |
Nurgul Ablakimova |
2026-06 | |
| NCT04706910 | RECRUITING | Congenital Hyperinsulinism; Neuroblastoma; Parkinson Disease; Lewy Body Disease; Neuroendocrine Tumors; Brain Tumor |
University of Alberta |
2021-01-20 | PHASE3 |
| NCT07596329 | NOT_YET_RECRUITING | Heart Failure; Renal Disease, Chronic |
University of Monastir |
2026-09-01 | PHASE3 |
| NCT07077772 | RECRUITING | Cardiac Surgery; Diuresis; Congestion, Venous; Sodium Depletion; Fluid Over-load |
Centre Hospitalier Universitaire, Amiens |
2025-06-25 | |
| NCT07577596 | RECRUITING | Acute Heart Failure; Volume Overload |
University of Aarhus |
2026-06-30 | PHASE4 |
| NCT06898515 | RECRUITING | Acute Decompensated Heart Failure |
Reprieve Cardiovascular, Inc |
2025-07-14 | PHASE3 |
| NCT05276219 | RECRUITING | Pulmonary Edema; Congestive Heart Failure; Acute Heart Failure |
Rigshospitalet, Denmark |
2023-09-14 | PHASE4 |
| NCT07550790 | RECRUITING | Heart Failure Acute; Renal Dysfunction |
Jin Joo Park |
2026-07-01 | |
| NCT07263035 | RECRUITING | Heart Failure; Heart Failure - NYHA II - IV; Heart Failure Acute; Acute Heart Failure (AHF) |
Lakeland Regional Health Systems, Inc. |
2026-04-01 | PHASE4 |
| NCT04180397 | RECRUITING | Fluid Overload |
Morten H. Bestle |
2020-08-17 | PHASE4 |
| NCT05470283 | ACTIVE_NOT_RECRUITING | Tumor; Metastatic Melanoma; Melanoma |
M.D. Anderson Cancer Center |
2022-09-07 | PHASE1 |
| NCT06273397 | NOT_YET_RECRUITING | Heart Failure Acute; Decompensated Heart Failure |
Clinica Alemana de Santiago |
2024-05-01 | |
| NCT07593612 | NOT_YET_RECRUITING | Acute Heart Failure (AHF) |
Lucrecia Maria Burgos |
2026-06-15 | PHASE4 |
| NCT07648251 | NOT_YET_RECRUITING | Severe Preeclampsia |
Universidad Nacional Autonoma de Honduras |
2026-06-15 | PHASE2 |
| NCT04170855 | ACTIVE_NOT_RECRUITING | Cardio-Renal Syndrome |
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
2020-10-20 | |
| NCT06921603 | RECRUITING | Heart Decompensation, Acute; Acute Kidney Injuries |
University of Pittsburgh |
2025-06-29 | |
| NCT07286409 | NOT_YET_RECRUITING | Respiratory Distress Syndrome; Mechanical Ventilation Complication |
Tanta University |
2026-01 | |
| NCT07008365 | RECRUITING | Acute Heart Failure; Congestive Heart Failure; Intraabdominal Hypertension; Cardio-Renal Syndrome |
Instituto de Investigación Sanitaria Aragón |
2025-03-10 | PHASE3 |
| NCT07417969 | RECRUITING | Urine Output Decreased |
Jose J Zaragoza, MD MSc |
2025-06-01 | |
| NCT03753204 | ACTIVE_NOT_RECRUITING | High Blood Pressure; Salt; Excess; Inflammation |
Vanderbilt University Medical Center |
2021-09-01 | PHASE1; PHASE2 |
| NCT03071536 | COMPLETED | Kidney Function; Kidney Transplant; Complications; Delayed Graft Function |
King Chulalongkorn Memorial Hospital |
2016-11-25 | |
| NCT07348510 | RECRUITING | Diuretic Effect; Aminophylline; Furosemide; Cardiac Surgical Procedures |
Cairo University |
2026-01-17 | |
| NCT07336485 | COMPLETED | Kidney Stones |
Ain Shams University |
2026-01-01 | |
| NCT07804654 | COMPLETED | Acute Heart Failure (AHF) |
Universiti Teknologi Mara |
2026-01-01 | |
| NCT07431866 | COMPLETED | Healthy |
Merck Sharp & Dohme LLC |
2026-03-18 | PHASE1 |
| NCT05916963 | RECRUITING | Kidney Stone |
University Hospital, Tours |
2024-01-04 | PHASE3 |
| NCT06765031 | COMPLETED | Akut Kidney Injury |
Gulhane Training and Research Hospital |
2024-11-01 | |
| NCT07269496 | COMPLETED | Healthy |
SQ Innovation, Inc. |
2026-02-09 | PHASE1 |
| NCT05419115 | COMPLETED | Heart Failure |
NHS Greater Glasgow and Clyde |
2022-11-17 | PHASE2 |
| NCT06899061 | ACTIVE_NOT_RECRUITING | Advanced Solid Malignancies |
AstraZeneca |
2025-03-25 | PHASE1 |
| NCT06442280 | UNKNOWN | Heart Failure Acute; Diabetes Type 2; Heart Failure With Reduced Ejection Fraction; Heart Failure With Preserved Ejection Fraction |
University of Palermo |
2024-06 | PHASE4 |
| NCT06218199 | RECRUITING | Heart Failure, Congestive |
Heart Center Research, LLC |
2021-07-08 | PHASE4 |
| NCT05171686 | COMPLETED | Chronic Kidney Disease; Hypertension |
VA Office of Research and Development |
2023-02-01 | PHASE4 |
| NCT06467825 | RECRUITING | Healthy |
National Aeronautics and Space Administration (NASA) |
2022-08-09 | |
| NCT06821594 | ENROLLING_BY_INVITATION | Cutaneous Warts |
Jinnah Postgraduate Medical Centre |
2025-04-01 | EARLY_PHASE1 |
| NCT07073157 | COMPLETED | Health Volunteer |
Jiangsu HengRui Medicine Co., Ltd. |
2025-07-15 | PHASE1 |
| NCT05898022 | COMPLETED | Bronchopulmonary Dysplasia |
Children's Hospital Medical Center, Cincinnati |
2023-08-17 | PHASE4 |
| NCT05255159 | ACTIVE_NOT_RECRUITING | Neuroendocrine Tumors |
University of Alberta |
2022-10-15 | PHASE2 |
| NCT06491550 | COMPLETED | Healthy Participants |
AstraZeneca |
2024-07-15 | PHASE1 |
| NCT06326112 | UNKNOWN | Fluid Overload; Critical Illness; Sepsis; ARDS; Trauma |
Unity Health Toronto |
2024-05-01 | PHASE2 |
| NCT07307131 | COMPLETED | Cutaneous Warts; Human Papilloma Virus (HPV) |
Benha University |
2024-09-01 | PHASE2 |
| NCT06203236 | UNKNOWN | Acute Heart Failure; Chronic Kidney Diseases |
Assiut University |
2024-01 | PHASE4 |
| NCT05915286 | TERMINATED | End Stage Renal Disease on Dialysis |
University of Alberta |
2023-05-29 | PHASE4 |
| NCT05480722 | COMPLETED | Salt Sensitivity of Blood Pressure |
University of Delaware |
2022-06-01 | |
| NCT05986773 | TERMINATED | Acute Heart Failure; Diuretic Resistance |
Stadtspital Zürich |
2023-10-10 | PHASE4 |
| NCT05741372 | COMPLETED | Liver Cirrhosis |
Boehringer Ingelheim |
2023-09-07 | |
| NCT07688733 | COMPLETED | Acute Kidney Injury; Hypoalbuminemia |
Maithe Caroline Inacio |
2022-06-04 | |
| NCT06252454 | UNKNOWN | Dyspnea |
University Hospital Hradec Kralove |
2024-02-27 | PHASE2; PHASE3 |
| NCT05769738 | UNKNOWN | Chronic Obstructive Pulmonary Disease Exacerbation; COPD Exacerbation |
American University of Beirut Medical Center |
2023-03 | PHASE3 |
| NCT04893629 | TERMINATED | Cardiomyopathy |
Damascus University |
2021-05-20 | |
| NCT06475105 | RECRUITING | Acute Decompensated Heart Failure |
Universitas Diponegoro |
2024-04-20 | PHASE4 |
| NCT06036914 | COMPLETED | Heart Failure; With Decompensation |
Mayo Clinic |
2023-11-27 | PHASE2 |
| NCT06504862 | COMPLETED | Healthy |
Boehringer Ingelheim |
2024-08-20 | PHASE1 |
| NCT06362668 | COMPLETED | Acute Decompensated Heart Failure |
Reprieve Cardiovascular, Inc |
2024-05-17 | |
| NCT07464249 | COMPLETED | Acute Decompensated Heart Failure (ADHF) |
Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey |
2024-04-03 | |
| NCT05939193 | COMPLETED | Cytoreductive Surgery; Hyperthermic Intraperitoneal Chemotherapy; Hydration; Diuresis; Acute Kidney Injury; Postoperative Complications |
Peking University First Hospital |
2023-07-24 | |
| NCT06167707 | COMPLETED | Heart Failure; Fluid Overload |
scPharmaceuticals, Inc. |
2024-04-19 | PHASE1 |
| NCT05962255 | COMPLETED | Acute Heart Failure; Congestion; Heart Failure |
Wroclaw Medical University |
2022-02-01 | PHASE3 |
| NCT05779943 | ACTIVE_NOT_RECRUITING | Prostate Adenocarcinoma; Recurrent Prostate Carcinoma |
Emory University |
2023-04-27 | PHASE2 |
| NCT06024889 | COMPLETED | Acute Heart Failure |
Johannes Grand |
2023-09-01 | PHASE1; PHASE2 |
| NCT06105255 | COMPLETED | Healthy Male |
InventisBio Co., Ltd |
2023-05-24 | PHASE1 |
| NCT06251778 | Recruiting | Amyloidosis|Amyloidosis Cardiac|ATTR Amyloidosis Wild Type |
Paolo Milani|IRCCS Policlinico S. Matteo |
2024-01-26 | -- |
| NCT05807152 | UNKNOWN | Acute Decompensated Heart Failure |
Centro Cardiologico Monzino |
2019-02-19 | |
| NCT05098366 | COMPLETED | Ovarian Torsion |
Connecticut Children's Medical Center |
2021-05-29 | EARLY_PHASE1 |
| NCT05939245 | COMPLETED | Acute Kidney Injury Due to Sepsis |
Indonesia University |
2023-07-24 | |
| NCT05933642 | UNKNOWN | Acute Kidney Injury |
University of Malaya |
2023-07-02 | PHASE2; PHASE3 |
| NCT04216784 | TERMINATED | Cirrhosis, Liver; Volume Overload; Fluid Overload |
Rush University Medical Center |
2019-12-19 | PHASE4 |
| NCT05652322 | WITHDRAWN | Heart Failure |
Jan Kochanowski University |
2022-12-07 | PHASE2; PHASE3 |
| NCT05599971 | UNKNOWN | Plantar Wart |
Zagazig University |
2023-02-22 | |
| NCT05105009 | COMPLETED | Chronic Kidney Failure |
Instituto Nacional de Cardiologia Ignacio Chavez |
2020-03-03 | PHASE1 |
| NCT05981365 | COMPLETED | Sickle Cell Disease |
Pfizer |
2023-04-17 | PHASE1 |
| NCT05904808 | COMPLETED | Chronic Heart Failure; Diuretics Drug Reactions; Congestive Heart Failure |
Rambam Health Care Campus |
2023-04-19 | PHASE4 |
| NCT05365451 | COMPLETED | Interaction; Endogenous Biomarkers |
Washington State University |
2022-04-11 | EARLY_PHASE1 |
| NCT05594823 | UNKNOWN | Heart Failure; Heart Diseases |
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
2023-01-03 | PHASE4 |
| NCT05093621 | COMPLETED | Heart Failure |
Yale University |
2021-02-08 | PHASE3 |
| NCT05768360 | COMPLETED | Healthy Male Subjects |
AstraZeneca |
2023-04-25 | PHASE1 |
| NCT05620784 | RECRUITING | BPH With Urinary Obstruction; BPH; Hematuria; Same Day Discharge |
Northwestern University |
2023-03-01 | PHASE3 |
| NCT03946891 | WITHDRAWN | Premature Birth; Premature Infant |
NYU Langone Health |
2016-06 | EARLY_PHASE1 |
| NCT04533997 | COMPLETED | Heart Failure |
Puerta de Hierro University Hospital |
2021-01-01 | PHASE3 |
| NCT06105255 | Active not recruiting | Healthy Male |
InventisBio Co. Ltd |
2023-05-24 | Phase 1 |
| NCT05915286 | Suspended | End Stage Renal Disease on Dialysis |
University of Alberta |
2023-05-29 | Phase 4 |
| NCT05881603 | Recruiting | Cardiogenic Acute Pulmonary Edema |
Centre Hospitalier Universitaire de la Réunion |
2023-05-20 | -- |
| NCT07568886 | COMPLETED | Ovarian Hyper Stimulation Syndrome (OHSS) |
Al-Nahrain University |
2019-04-29 | |
| NCT04496596 | UNKNOWN | Acute Kidney Injury |
Rediscovery Life Sciences |
2020-11-13 | PHASE2 |
| NCT04588792 | TERMINATED | Covid19; Respiratory Failure |
Dr. John Muscedere |
2021-04-16 | PHASE2; PHASE3 |
| NCT03892148 | COMPLETED | Heart Failure; Acute Heart Failure; Chronic Heart Failure |
University Hospital, Clermont-Ferrand |
2019-05-17 | PHASE4 |
| NCT03750136 | UNKNOWN | Nephrotic Syndrome |
Medical University of Bialystok |
2018-12-15 | |
| NCT05379257 | UNKNOWN | Congestive Heart Failure |
Hadassah Medical Organization |
2020-01-20 | |
| NCT05569655 | UNKNOWN | Pulmonary Arterial Hypertension; Randomized Controlled Trial |
Chinese Pulmonary Vascular Disease Research Group |
2021-04-06 | |
| NCT05079789 | TERMINATED | Nephrotic Syndrome; Edema; Sodium Retention |
University Hospital Tuebingen |
2020-06-08 | PHASE3 |
| NCT05520658 | UNKNOWN | Plantar Wart |
Sohag University |
2022-07-01 | |
| NCT04465123 | UNKNOWN | Acute Heart Failure; Acute Kidney Injury |
Chiang Mai University |
2020-08-13 | PHASE3 |
| NCT03296813 | COMPLETED | Heart Failure |
Duke University |
2018-07-11 | PHASE3 |
| NCT03509545 | TERMINATED | Body Weight Changes |
Sarfez Pharmaceuticals, Inc. |
2021-06-30 | PHASE1 |
| NCT04343235 | TERMINATED | Hypertension, Pregnancy-Induced |
Wright State University |
2020-05-01 | PHASE4 |
| NCT01275729 | COMPLETED | Acute Kidney Failure |
University of Chicago |
2010-12 | |
| NCT02450773 | WITHDRAWN | Hypertension |
Indiana University |
2015-08 | PHASE2 |
| NCT04615624 | COMPLETED | Pre-Eclampsia; Hypertension in Pregnancy; Pregnancy Complications; Hypertension, Pregnancy-Induced |
Melanie Maykin, MD |
2021-01-04 | PHASE3 |
| NCT05158153 | TERMINATED | Acute Kidney Injury; Dialysis Hypotension |
University of California, San Francisco |
2021-10-18 | PHASE4 |
| NCT04752475 | COMPLETED | Postpartum Pregnancy-Induced Hypertension; Postpartum Preeclampsia; Hypertension, Pregnancy-Induced; Hypertension |
Columbia University |
2021-10-20 | PHASE3 |
| NCT03362515 | TERMINATED | Nasal Polyps |
Thomas Jefferson University |
2017-12-01 | PHASE2 |
| NCT05270421 | UNKNOWN | Urolithiasis; Nephrolithiasis; Urinary Calculi; Ureterolithiasis |
Shiraz University of Medical Sciences |
2020-07-01 | PHASE3 |
| NCT04763226 | COMPLETED | Healthy Participants |
Bristol-Myers Squibb |
2021-04-14 | PHASE1 |
| NCT04919564 | COMPLETED | Chronic Kidney Disease; Cardiac Disease |
National Cardiovascular Center Harapan Kita Hospital Indonesia |
2021-05-27 | PHASE2 |
| NCT03259165 | TERMINATED | Heart Failure; Heart Failure Acute; Acute Cardiac Failure; Acute Cardiac Pulmonary Edema |
Indiana University |
2017-12-14 | PHASE2 |
| NCT02649998 | WITHDRAWN | Heart Decompensation |
Chinese University of Hong Kong |
2017-01 | |
| NCT04850638 | COMPLETED | Healthy Male Subjects |
Jiangsu HengRui Medicine Co., Ltd. |
2021-06-28 | PHASE1 |
| NCT04846816 | COMPLETED | Heart Failure |
SQ Innovation, Inc. |
2021-05-06 | PHASE1 |
| NCT04397991 | COMPLETED | Respiratory Morbidity |
Makassed General Hospital |
2020-01-02 | |
| NCT04384653 | COMPLETED | Heart Failure |
SQ Innovation, Inc. |
2020-10-17 | PHASE1; PHASE2 |
| NCT04622709 | COMPLETED | Chronic Kidney Disease Requiring Chronic Dialysis |
University of North Carolina, Chapel Hill |
2020-10-07 | PHASE2 |
| NCT04235062 | COMPLETED | Heart Failure |
Momentum Research, Inc. |
2020-04-01 | |
| NCT03901729 | COMPLETED | Heart Failure (HF) |
Bayer |
2019-05-29 | PHASE2 |
| NCT04836572 | COMPLETED | Healthy Volunteer Study |
SQ Innovation, Inc. |
2021-01-20 | |
| NCT04590937 | COMPLETED | Healthy |
Boehringer Ingelheim |
2020-10-20 | PHASE1 |
| NCT04385589 | COMPLETED | Heart Failure |
Assiut University |
2020-05-01 | PHASE4 |
| NCT03731117 | TERMINATED | Acute Kidney Injury |
Assistance Publique - Hôpitaux de Paris |
2019-07-15 | PHASE4 |
| NCT04156451 | COMPLETED | Septic Shock |
Indonesia University |
2019-11-14 | |
| NCT04130815 | UNKNOWN | Healthy Volunteers |
Oxford Brookes University |
2019-10-14 | PHASE1 |
| NCT04161482 | COMPLETED | Healthy |
scPharmaceuticals, Inc. |
2019-12-02 | PHASE1 |
| NCT02531581 | COMPLETED | Pulmonary Embolism |
Centre Hospitalier Universitaire de Nice |
2015-12-23 | PHASE4 |
| NCT04393493 | COMPLETED | Cardiorenal Syndrome |
Hospital Civil de Guadalajara |
2017-07-01 | PHASE2 |
| NCT03837470 | COMPLETED | Heart Failure With Preserved Ejection Fraction |
Adhish Agarwal |
2019-05-06 | EARLY_PHASE1 |
| NCT02546583 | COMPLETED | Heart Failure |
Yale University |
2015-08-31 | PHASE1 |
| NCT04982874 | COMPLETED | Drug Use |
PT. Kimia Farma (Persero) Tbk |
2019-12-13 | |
| NCT03746002 | TERMINATED | Fluid Overload; Heart Failure Acute |
University of Maryland, Baltimore |
2019-01-01 | PHASE4 |
| NCT03730961 | COMPLETED | Cardiac Failure; Myocardial Failure; Congestive Heart Failure; Heart Decompensation |
Bristol-Myers Squibb |
2019-01-17 | PHASE2 |
| NCT03556761 | COMPLETED | Hypertension, Pregnancy-Induced |
University of Pennsylvania |
2018-06-20 | PHASE2 |
| NCT02527798 | COMPLETED | Bronchopulmonary Dysplasia |
University of North Carolina, Chapel Hill |
2015-11-27 | PHASE2 |
| NCT03684772 | UNKNOWN | Actinic Keratosis |
Maruho Co., Ltd. |
2018-10-22 | PHASE2 |
| NCT04628325 | COMPLETED | Heart Failure，Congestive |
University of Palermo |
2017-03-01 | PHASE3 |
| NCT03093090 | WITHDRAWN | Medication Absorption |
Yale University |
2018-12-31 | PHASE1 |
| NCT02345681 | COMPLETED | Fluid Balance of ICU Patients; Fluid Overload |
Nantes University Hospital |
2015-05 | PHASE3 |
| NCT03359161 | TERMINATED | Heart Failure |
Steward St. Elizabeth's Medical Center of Boston, Inc. |
2018-04-05 | PHASE2; PHASE3 |
| NCT04481789 | COMPLETED | Healthy Adult Subjects |
Shionogi |
2018-10-17 | PHASE1 |
| NCT03772262 | COMPLETED | Interaction Drug Food |
Washington State University |
2018-04-05 | EARLY_PHASE1 |
| NCT02905760 | UNKNOWN | Acute Myocardial Infarction With Right Ventricular Extension |
Assistance Publique - Hôpitaux de Paris |
2016-12 | PHASE3 |
| NCT02575963 | COMPLETED | AML |
Actinium Pharmaceuticals |
2012-10 | PHASE1; PHASE2 |
| NCT03334240 | TERMINATED | HPV-Induced Genital Lesions |
Maruho Co., Ltd. |
2017-10-05 | PHASE2 |
| NCT03801759 | COMPLETED | Drug Interaction Potentiation |
Akebia Therapeutics |
2018-07-20 | PHASE1 |
| NCT03170219 | TERMINATED | Acute Heart Failure; Decompensated Heart Failure |
Adrian Hernandez |
2018-04-27 | PHASE2 |
| NCT07173738 | COMPLETED | Pulmonary Arterial Hypertension |
Bial - Portela C S.A. |
2018-06-11 | PHASE1 |
| NCT03082742 | UNKNOWN | Secondary Hyperparathyroidism; Chronic Kidney Disease |
University of Sao Paulo General Hospital |
2015-08-01 | |
| NCT03307252 | COMPLETED | Healthy |
Boehringer Ingelheim |
2017-10-25 | PHASE1 |
| NCT02767024 | WITHDRAWN | Acute Heart Failure |
Montefiore Medical Center |
2018-05-01 | PHASE4 |
| NCT02971891 | COMPLETED | Cutaneous Common Warts |
Maruho Co., Ltd. |
2017-01 | PHASE3 |
| NCT02268903 | UNKNOWN | Pulmonary Embolism With Right Ventricle Enlargement |
Assistance Publique - Hôpitaux de Paris |
2015-04-13 | PHASE3 |
| NCT02960412 | COMPLETED | Cystoscopy |
University of South Florida |
2017-05-01 | PHASE4 |
| NCT02800135 | TERMINATED | Critical Illness; Oliguria |
Centre Hospitalier Universitaire de Saint Etienne |
2016-04-11 | |
| NCT01508260 | WITHDRAWN | Leukemia |
M.D. Anderson Cancer Center |
2013-03 | |
| NCT02183792 | COMPLETED | Heart Failure |
University of Southern California |
2014-12 | PHASE4 |
| NCT03592836 | COMPLETED | Heart Failure NYHA Class III; Heart Failure NYHA Class IV |
University of Turin, Italy |
2013-05-01 | PHASE3 |
| NCT04691687 | COMPLETED | Heart Failure |
New York Presbyterian Brooklyn Methodist Hospital |
2012-05-01 | PHASE4 |
| NCT03364842 | COMPLETED | Pulmonary Complication |
Cairo University |
2017-11-22 | PHASE2 |
| NCT02068937 | COMPLETED | Heart Failure |
Hospital de Clinicas de Porto Alegre |
2013-05 | |
| NCT02832973 | COMPLETED | Hypertension Resistant to Conventional Therapy |
Sao Jose do Rio Preto Medical School |
2015-09 | PHASE4 |
| NCT01942109 | UNKNOWN | Heart Failure |
Medical University of Warsaw |
2013-09 | PHASE4 |
| NCT02501213 | TERMINATED | Cancer |
Centre Oscar Lambret |
2016-05-30 | PHASE2 |
| NCT02877095 | COMPLETED | Acute Heart Failure |
Adrian Hernandez |
2016-12-19 | PHASE1 |
| NCT02730117 | COMPLETED | Acute Kidney Injury |
Chulalongkorn University |
2016-03 | |
| NCT03103568 | COMPLETED | Drug Drug Interaction |
Swedish Orphan Biovitrum |
2017-03-28 | PHASE1 |
| NCT02458157 | TERMINATED | Acute Kidney Injury; Fluid Overload; Critical Illness |
Nordsjaellands Hospital |
2015-10 | PHASE4 |
| NCT03010475 | COMPLETED | Diabetes; Healthy |
Novo Nordisk A/S |
2017-01-05 | PHASE1 |
| NCT02579057 | COMPLETED | Congestive Heart Failure |
Johns Hopkins University |
2016-02 | PHASE2; PHASE3 |
| NCT01901809 | COMPLETED | Heart Failure, Diastolic |
Johns Hopkins University |
2013-08 | PHASE4 |
| NCT03208894 | COMPLETED | Transient Tachypnea of the Newborn |
Armed Forces Hospital, Pakistan |
2016-11-01 | PHASE3 |
| NCT02689180 | UNKNOWN | Heart Failure |
Hospital de Clinicas de Porto Alegre |
2015-05 | PHASE3 |
| NCT01851980 | UNKNOWN | Breathlessness |
McGill University |
2016-04 | PHASE1 |
| NCT02802696 | COMPLETED | Transfusion-associated Circulatory Overload |
Sunnybrook Health Sciences Centre |
2016-06 | EARLY_PHASE1 |
| NCT02721511 | WITHDRAWN | Acute Decompensated Heart Failure |
Todd M Koelling, MD |
2016-05 | PHASE1; PHASE2 |
| NCT01815892 | UNKNOWN | End Stage Renal Disease |
Unity Health Toronto |
2015-05 | PHASE4 |
| NCT02524054 | COMPLETED | Dyspnea |
Beth Israel Deaconess Medical Center |
2014-11-01 | PHASE1; PHASE2 |
| NCT02854527 | COMPLETED | Healthy |
Boehringer Ingelheim |
2016-08-22 | PHASE1 |
| NCT02804282 | COMPLETED | Heart Failure |
scPharmaceuticals, Inc. |
2016-07 | PHASE3 |
| NCT02312115 | WITHDRAWN | Delayed Graft Function |
Loma Linda University |
2016-09 | PHASE2 |
| NCT02055872 | COMPLETED | Edema; Hypoproteinemia |
Hamilton Health Sciences Corporation |
2014-09 | PHASE3 |
| NCT02804035 | COMPLETED | Heart Failure |
scPharmaceuticals, Inc. |
2016-07 | PHASE2 |
| NCT01441245 | COMPLETED | Acute Heart Failure |
University of Siena |
2010-04 | PHASE4 |
| NCT00904488 | TERMINATED | Acute Decompensated Heart Failure |
University of North Carolina, Chapel Hill |
2008-10 | PHASE4 |
| NCT03547895 | COMPLETED | Decompensated Cirrhosis |
Zagazig University |
2015-06-01 | |
| NCT01440764 | COMPLETED | Healthy; Dyspnea |
Beth Israel Deaconess Medical Center |
2011-09 | PHASE1; PHASE2 |
| NCT02469597 | COMPLETED | Bronchiolitis |
Northwell Health |
2013-10 | PHASE2 |
| NCT02351934 | COMPLETED | Colorectal Disorders |
Mayo Clinic |
2015-02 | PHASE4 |
| NCT02417883 | UNKNOWN | Chronic Kidney Disease |
Instituto Nacional de Cardiologia Ignacio Chavez |
2015-04 | PHASE3 |
| NCT02881866 | COMPLETED | Dyspnea |
Oxford Brookes University |
2015-10 | PHASE1 |
| NCT02047422 | WITHDRAWN | Congestive Heart Failure |
Yonsei University |
2014-01 | |
| NCT02574845 | COMPLETED | Healthy |
Boehringer Ingelheim |
2015-10-12 | PHASE1 |
| NCT02821377 | COMPLETED | Ascites; Cirrhosis |
University of Palermo |
2013-12 | PHASE2 |
| NCT02329834 | COMPLETED | Heart Failure |
scPharmaceuticals, Inc. |
2015-04 | PHASE2; PHASE3 |
| NCT05840536 | WITHDRAWN | Acute Decompensated Heart Failure |
Ochsner Health System |
2014-05 | PHASE4 |
| NCT02333643 | COMPLETED | Cutaneous Warts |
Maruho Co., Ltd. |
2015-01 | PHASE2 |
| NCT01407848 | COMPLETED | Transient Tachypnoea of the Newborn |
University of Cologne |
2012-01 | PHASE2 |
| NCT02372292 | COMPLETED | Cardiorenal Syndrome |
Ankara University |
2013-02 | |
| NCT02350725 | COMPLETED | Heart Failure |
scPharmaceuticals, Inc. |
2014-12 | PHASE1; PHASE2 |
| NCT01709227 | COMPLETED | Acute Kidney Injury |
Children's Hospital Medical Center, Cincinnati |
2011-10 | |
| NCT01817803 | WITHDRAWN | Congestive Heart Failure |
Yonsei University |
2013-03 | |
| NCT02427880 | COMPLETED | Nephrotic Syndrome; Edema |
Shiraz University of Medical Sciences |
2015-04 | PHASE4 |
| NCT02712476 | COMPLETED | Brain Tumors |
Istanbul University |
2013-07 | |
| NCT01977430 | UNKNOWN | Chronic Kidney Insufficiency; Hemodialysis Treatment; Diuresis Preserved |
Corporacion Parc Tauli |
2013-11 | PHASE4 |
| NCT02231931 | COMPLETED | Healthy |
Boehringer Ingelheim |
2014-09-01 | PHASE1 |
| NCT01558674 | TERMINATED | Renal Impairment; Heart Failure |
Merck Sharp & Dohme LLC |
2014-05-23 | PHASE1 |
| NCT02163655 | COMPLETED | Preeclampsia |
Instituto Materno Infantil Prof. Fernando Figueira |
2014-06-20 | PHASE4 |
| NCT00978354 | TERMINATED | Acute Renal Failure |
University of Alberta |
2009-09 | PHASE2; PHASE3 |
| NCT02570581 | COMPLETED | Healthy |
Centre Hospitalier Universitaire de Nice |
2014-06 | PHASE1 |
| NCT00982423 | COMPLETED | Heart Failure; Kidney Dysfunction |
Mayo Clinic |
2009-07 | PHASE1; PHASE2 |
| NCT01146288 | COMPLETED | Obesity-induced Hyperfiltration |
Rabin Medical Center |
2010-07 | |
| NCT00673244 | COMPLETED | Acute Kidney Failure |
George Washington University |
2008-04 | |
| NCT01060293 | TERMINATED | Acute Decompensated Heart Failure |
Larissa University Hospital |
2009-07 | PHASE4 |
| NCT02028689 | COMPLETED | Healthy |
Ardea Biosciences, Inc. |
2013-10 | PHASE1 |
| NCT01887379 | COMPLETED | Gastroretentive Drug Formulation of Furosemide; Oedema |
LTS Lohmann Therapie-Systeme AG |
2013-06 | PHASE1 |
| NCT01628731 | COMPLETED | Fluid Overload |
Bambino Gesù Hospital and Research Institute |
2012-10 | PHASE3 |
| NCT01617798 | WITHDRAWN | Respiratory Failure; Volume Overload; Hypernatremia |
Oregon Health and Science University |
2012-06 | |
| NCT01584518 | COMPLETED | Fluid Over-load |
Creighton University |
2012-07 | |
| NCT01705470 | WITHDRAWN | Anemia Treatment Among Patients Suffering From Left Ventricular Systolic Dysfunction |
Tel-Aviv Sourasky Medical Center |
2012-10 | |
| NCT01457053 | TERMINATED | Acute Decompensated Heart Failure |
University of Cincinnati |
2011-11 | |
| NCT01210365 | TERMINATED | Congestive Heart Failure |
Eurofarma Laboratorios S.A. |
2011-01-01 | PHASE3 |
| NCT01724788 | COMPLETED | Renal Failure |
Sanofi |
2012-11 | PHASE1 |
| NCT00372762 | WITHDRAWN | Heart Failure |
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
2011-01 | PHASE3 |
| NCT01549158 | TERMINATED | Compensated Heart Failure |
Ferrer Internacional S.A. |
2012-02 | PHASE4 |
| NCT01318967 | COMPLETED | Chronic Kidney Disease |
Wake Forest University |
2010-10 | |
| NCT01156220 | WITHDRAWN | Healthy Male and Female Volunteers |
Universitätsklinikum Hamburg-Eppendorf |
2012-01 | PHASE4 |
| NCT01054404 | TERMINATED | Brain Swelling; Brain Edema; Dehydration |
Northwestern University |
2010-02 | |
| NCT00535925 | COMPLETED | Diabetic Nephropathy |
University of Campania Luigi Vanvitelli |
2005-10 | PHASE4 |
| NCT00936923 | WITHDRAWN | Renal Function Disorder |
Sun Yat-sen University |
2008-06 | PHASE3 |
| NCT01072071 | UNKNOWN | Intra-Abdominal Hypertension |
Ziekenhuis Netwerk Antwerpen (ZNA) |
2010-02 | |
| NCT01611415 | COMPLETED | Healthy Subjects; Pharmacokinetics of Ipragliflozin |
Astellas Pharma Europe B.V. |
2011-07 | PHASE1 |
| NCT01438359 | COMPLETED | Healthy |
Vifor Pharma |
2011-07 | PHASE1 |
| NCT01419132 | COMPLETED | ADHF |
University of Palermo |
2011-08 | PHASE4 |
| NCT01125514 | COMPLETED | Heart Failure |
Novartis Pharmaceuticals |
2010-05 | PHASE2 |
| NCT01028170 | COMPLETED | Congestive Heart Failure; Renal Insufficiency |
Aspirus Heart and Vascular Institute-Research and Education |
2009-11 | PHASE3 |
| NCT01140399 | TERMINATED | Acute Decompensated Heart Failure |
Niguarda Hospital |
2011-02 | PHASE4 |
| NCT00611741 | COMPLETED | Schizophrenia |
Yale University |
2007-03 | PHASE1 |
| NCT01073189 | WITHDRAWN | Kidney Failures, Acute |
Southeast Renal Research Institute |
2010-04 | PHASE4 |
| NCT00624650 | COMPLETED | Acute Lung Injury |
Oregon Health and Science University |
2008-02 | PHASE2 |
| NCT00355667 | COMPLETED | Congestive Heart Failure |
Hyogo Medical University |
2006-06 | PHASE4 |
| NCT00962286 | TERMINATED | Obesity-induced Hyperfiltration |
Rabin Medical Center |
2009-09 | |
| NCT00806910 | WITHDRAWN | Heart Failure |
Albert Einstein Healthcare Network |
2008-10 | PHASE4 |
| NCT00577135 | COMPLETED | Heart Failure |
Duke University |
2008-02 | PHASE3 |
| NCT00937092 | UNKNOWN | Acute Heart Failure |
Larissa University Hospital |
2009-01 | PHASE4 |
| NCT00531908 | COMPLETED | Acromegaly |
Assistance Publique - Hôpitaux de Paris |
2007-09 | |
| NCT00924014 | UNKNOWN | Heart Failure |
Hennepin County Medical Center, Minneapolis |
2009-07 | |
| NCT00690521 | COMPLETED | Congestive Heart Failure |
University of New Mexico |
2004-10-26 | |
| NCT00702728 | UNKNOWN | Contrast Induced Nephropathy |
Centro Cardiologico Monzino |
2008-06 | PHASE3 |
| NCT00409942 | COMPLETED | Congestive Heart Failure |
Ferrer Internacional S.A. |
2007-03 | PHASE4 |
| NCT00909519 | COMPLETED | Renal Hemodynamics |
NicOx |
2009-01 | PHASE1 |
| NCT00618852 | UNKNOWN | Lung Disease |
The Hospital for Sick Children |
2007-01 | PHASE3 |
| NCT00741663 | COMPLETED | Cirrhosis; Ascites |
University of Padova |
2005-04 | PHASE4 |
| NCT00575484 | TERMINATED | Congestive Heart Failure; Renal Insufficiency |
Barnes-Jewish Hospital |
2007-11 | PHASE2 |
| NCT00478543 | COMPLETED | Chronic Kidney Disease |
University of Campania Luigi Vanvitelli |
2005-09 | PHASE4 |
| NCT00671424 | COMPLETED | Type 2 Diabetes Mellitus; Diabetes Mellitus, Type 2 |
GlaxoSmithKline |
2008-03 | PHASE1 |
| NCT00285805 | COMPLETED | Insulin Resistance |
Radboud University Medical Center |
2006-02 | |
| NCT00115726 | COMPLETED | Hypertension; Hypotension; Edema; Congestive Heart Failure |
University of Calgary |
2000-09 | PHASE4 |
| NCT00778180 | COMPLETED | Healthy |
Ranbaxy Laboratories Limited |
2005-10 | |
| NCT00652782 | COMPLETED | Congestive Heart Failure; Renal Impairment |
NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) |
2004-12 | PHASE2 |
| NCT00151827 | COMPLETED | Essential Hypertension; Renal Impairment |
Sankyo Pharma Gmbh |
2003-08 | PHASE3 |
| NCT00151619 | TERMINATED | Chronic Heart Failure |
Rennes University Hospital |
1999-02-10 | PHASE2 |
| NCT00175227 | COMPLETED | Contrast-induced Nephropathy; Acute Renal Failure; Chronic Renal Failure |
University of Alberta |
1996-05 | |
| NCT00652652 | COMPLETED | Congestive Heart Failure; Chronic Heart Failure |
Scios, Inc. |
2003-03 | PHASE4 |
| NCT00141596 | TERMINATED | Hypertension |
St George's, University of London |
2003-07 | |
| NCT00283361 | TERMINATED | Heart Failure, Congestive |
Zealand Pharma |
2006-01 | PHASE2 |
| NCT00663195 | COMPLETED | Chronic Stable Heart Failure |
Tottori University Hospital |
2004-01 | PHASE4 |
| NCT00512811 | COMPLETED | Bronchiolitis |
Baqiyatallah Medical Sciences University |
PHASE3 | |
| NCT00240019 | COMPLETED | Diabetic Nephropathy |
Stanford University |
2003-12 | |
| NCT00261937 | COMPLETED | Bronchiolitis |
Bnai Zion Medical Center |
2005-12 | PHASE1 |
| NCT00298454 | TERMINATED | Renal Failure; Critically Ill |
Frisius Medisch Centrum |
2005-12 | PHASE3 |
| NCT00159614 | COMPLETED | Heart Failure, Congestive; Renal Insufficiency |
NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) |
2005-09 | PHASE2 |
| NCT00664222 | COMPLETED | Chronic Stable Heart Failure |
Tottori University Hospital |
2004-01 | PHASE4 |
(data from https://clinicaltrials.gov, updated on 2026-06-16)
Check the
Furosemide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
Note: Technical data last updated: Sep 1, 2026.