CAS No. 56390-09-1

Batch: Purity:99.82
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Epirubicin HCl Chemical Structure
Chemical Structure
Check the Epirubicin HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (7S,9S)-7-[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride
CAS Number 56390-09-1
Molecular Formula

C27H29NO11.HCl
Molecular Weight (MW) 579.98
SMILES CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl
InChIKey MWWSFMDVAYGXBV-FGBSZODSSA-N

Biological Activity

Epirubicin HCl is an anthracycline antineoplastic agent that acts as a topoisomerase II inhibitor. It intercalates into DNA and inhibits topoisomerase II activity, leading to the inhibition of DNA synthesis and function. This inhibition disrupts cellular proliferation, triggers cell cycle arrest, and induces apoptosis in target cancer cells through mechanisms involving free radical production and DNA damage. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (172.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Minotti G, et al. Pharmacol Rev. 2004;56(2):185-229.

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Note: Technical data last updated: Sep 1, 2026.