Clinical Trials

Curcumin is supported by an extensive research landscape comprising numerous clinical trials across Early Phase 1 through Phase 4. Sponsored by academic institutions such as Washington State University and corporate entities like Immunoflex Therapeutics Inc., these studies evaluate indications including ulcerative colitis, cervical cancer, pancreatic neoplasms, chemotherapy-induced peripheral neuropathy, and pharmacokinetic profiles. These trials encompass varied recruitment statuses, including completed, active recruiting, and uninitiated protocols.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03769766 RECRUITING
Prostate Cancer
University of Texas Southwestern Medical Center
 2019-03-11 PHASE3
NCT07248020 NOT_YET_RECRUITING
Rectal Cancer; Locally Advanced Rectal Cancer; Radiation-Induced Enteritis; Radiation Proctitis; Chemoradiotherapy-Related Toxicity
Chang Gung Memorial Hospital
 2026-01-01 PHASE2
NCT04266275 NOT_YET_RECRUITING
Neoplasm Cervix
Lisa Flowers
 2027-04 PHASE2
NCT02064673 RECRUITING
Prostate Cancer
yair lotan
 2014-05 PHASE3
NCT07456605 RECRUITING
Multiple Myeloma Refractory; Multiple Myeloma in Relapse
University Health Network, Toronto
 2026-02-27 PHASE1
NCT06470061 NOT_YET_RECRUITING
Alzheimer Disease; Mild Cognitive Impairment; Cognitive Decline
Zaparackas and Knepper LTD
 2024-07 PHASE2
NCT07665294 NOT_YET_RECRUITING
Ulcerative Colitis
Ryan C Ungaro
 2026-10-01 PHASE4
NCT07753018 NOT_YET_RECRUITING
Fibromyalgia (FM)
Ain Shams University
 2026-08-01 PHASE2
NCT07436130 NOT_YET_RECRUITING
Sepsis
Hospital Civil de Guadalajara
 2026-03-01
NCT05774704 RECRUITING
Bioavailability; Gut Microbiome; Safety
Texas Tech University Health Sciences Center
 2023-08-21 PHASE1; PHASE2
NCT06063486 RECRUITING
Clonal Cytopenia of Undetermined Significance; Essential Thrombocythemia; Myelodysplastic Syndrome; Myelofibrosis; Polycythemia Vera
University of Southern California
 2024-03-01 PHASE2
NCT06626230 RECRUITING
Anal High Grade Squamous Intraepithelial Lesion
Lisa Flowers
 2025-03-17 PHASE1
NCT05640843 RECRUITING
Monoclonal Gammopathy of Undetermined Significance; Smoldering Multiple Myeloma
Memorial Sloan Kettering Cancer Center
 2022-11-29
NCT07699575 NOT_YET_RECRUITING
Joint Pains
Centre Hospitalier Universitaire de la Réunion
 2026-09-14
NCT07766720 RECRUITING
Exercise-induced Muscle Soreness; Exercise-induced Joint Pain; Exercise-induced Joint Stiffness; Exercise-induced Cartilage Turnover
ESM Technologies, LLC
 2026-02-01
NCT07063056 RECRUITING
Triglycerides
Medinutra LLC
 2025-07-18
NCT03865992 ACTIVE_NOT_RECRUITING
Breast Cancer; Joint Pain
City of Hope Medical Center
 2019-03-04
NCT06055894 RECRUITING
Multiple Myeloma, Smoldering; Multiple Myeloma; Monoclonal Gammopathy of Undetermined Significance
Memorial Sloan Kettering Cancer Center
 2023-09-20
NCT06053411 RECRUITING
Interaction
Washington State University
 2024-03-01 EARLY_PHASE1
NCT07196046 ACTIVE_NOT_RECRUITING
Joint Discomfort; Quality of Life (QOL)
Ultra Botanica LLC
 2025-12-10
NCT06478290 NOT_YET_RECRUITING
Healthy Participants
University of Manitoba
 2025-10-01
NCT06932848 RECRUITING
Oral Lichen Planus
Chulalongkorn University
 2025-06-01
NCT05377242 COMPLETED
Gulf War Illness
University of Alabama at Birmingham
 2023-05-31
NCT07785986 COMPLETED
Exercise-Induced Muscle Damage; Delayed Onset Muscle Soreness (DOMS); Sports Recovery; Exercise-Induced Oxidative Stress; Exercise-Induced Inflammation
University of Valladolid
 2026-01-31
NCT07251985 WITHDRAWN
Memory; Cognitive Function Decline
University of California, Los Angeles
 2026-04-01 PHASE2
NCT07331935 RECRUITING
Oral Leukoplakia
Alexandria University
 2025-11-25
NCT07184268 COMPLETED
Periodontitis, Adult
Cairo University
 2025-11-02
NCT06847984 NOT_YET_RECRUITING
Dental Caries; Dental Plaque Index; Oral Microbiome
Cairo University
 2025-03-01
NCT07379177 NOT_YET_RECRUITING
Healthy
Kingdomway (Inner Mongolia) Nutritional Food Co., Ltd.
 2026-01-28
NCT05947513 RECRUITING
Cervical Cancer
Addis Ababa University
 2025-04-10
NCT06359665 ENROLLING_BY_INVITATION
Arthritis of Carpometacarpal Joint of Left Thumb; Arthritis of Carpometacarpal Joint of Right Thumb
Brent DeGeorge
 2025-02-01 PHASE1
NCT05768919 RECRUITING
Glioblastoma
SignPath Pharma, Inc.
 2023-03-03 PHASE1; PHASE2
NCT07523256 COMPLETED
Schizophrenia; Psychotic Disorders
Rinvil Renaldi
 2025-11-01
NCT07596927 ACTIVE_NOT_RECRUITING
Epidermolysis Bullosa (EB); Epidermolysis Bullosa Dystrophica; Epidermolysis Bullosa Acquisita
Universidade Ceuma
 2026-01-12 PHASE4
NCT04800107 UNKNOWN
Tinnitus, Subjective
Henry Ford Health System
 2021-01-06
NCT05688488 RECRUITING
Glottic Web of Larynx; Laryngeal Stenosis; Glottic Carcinoma; Laryngeal Leucoplakia; Laryngeal Polyp; Laryngeal Papilloma
Eye & ENT Hospital of Fudan University
 2023-05-05 PHASE1; PHASE2
NCT06312761 UNKNOWN
Hypogonadism, Male
University of Washington
 2024-06-01 PHASE1; PHASE2
NCT06886035 COMPLETED
Postoperative Care; Pain Management
Erzincan Military Hospital
 2025-03-21 PHASE4
NCT07052890 COMPLETED
Irritable Bowel Syndrome (IBS); Irritable Bowel Syndrome With Diarrhea (IBS-D)
Dr Anthony Hobson
 2024-09-19
NCT06080841 RECRUITING
Locally Advanced Cervical Cancer
National Institute of Cancerología
 2023-04-19
NCT05610878 RECRUITING
Romberg Disease; Craniofacial Microsomia; Burn Scar; Post-Traumatic Scar (Disorder)
University of the Punjab
 2020-11-20 PHASE1
NCT06974058 COMPLETED
Long COVID
Liaquat University of Medical & Health Sciences
 2025-07-22
NCT07141368 NOT_YET_RECRUITING
Healthy Volunteer
Vedic Lifesciences Pvt. Ltd.
 2025-09-01
NCT06829186 NOT_YET_RECRUITING
Hemodialysis
University of Guadalajara
 2025-03-15 PHASE2
NCT07183215 ENROLLING_BY_INVITATION
Osteoarthritis
Gadjah Mada University
 2025-06-01 PHASE2; PHASE3
NCT06595355 RECRUITING
Diabetic Macular Edema; Macular Edema; Retinal Neovascularization
Isfahan University of Medical Sciences
 2021-10-10 PHASE2; PHASE3
NCT06342830 COMPLETED
Periapical Disease
Ain Shams University
 2024-06-20 PHASE2
NCT05363267 ACTIVE_NOT_RECRUITING
Neurofibromatosis 1
Masonic Cancer Center, University of Minnesota
 2022-07-06 PHASE1
NCT06758739 NOT_YET_RECRUITING
Oral Submucous Fibrosis
Services Institute of Medical Sciences, Pakistan
 2025-04 PHASE3
NCT05856500 UNKNOWN
Stage IV Gastric Cancer; Stage IIIA Gastric Cancer; Stage IIIB Gastric Cancer; Stage III Esophageal Cancer; Stage IV Esophageal Cancer
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
 2023-06-01
NCT06777303 ACTIVE_NOT_RECRUITING
Periodontitis
Mansoura University
 2024-06-02
NCT07349264 COMPLETED
Joint; Joint Diseases
NXTVSION SDN. BHD.
 2025-04-01
NCT06269406 NOT_YET_RECRUITING
Dental Pain
S.LAB (SOLOWAYS)
 2025-07-28
NCT07278128 COMPLETED
Polycystic Ovary Syndrome (PCOS) With Concurrent Nonalcoholic Fatty Liver Disease (NAFLD)
Fateme Moshirenia
 2024-06-22 PHASE2; PHASE3
NCT06624241 UNKNOWN
Periodontal Diseases; Periodontal Pocket; Periodontal Attachment Loss
G. d'Annunzio University
 2024-06-12
NCT03598309 ACTIVE_NOT_RECRUITING
Lung Diseases; Lung Cancer, Protection Against
H. Lee Moffitt Cancer Center and Research Institute
 2019-06-05 PHASE2
NCT04896164 UNKNOWN
Oral Mucositis (Ulcerative)
Tata Memorial Centre
 2018-12-16 PHASE3
NCT06381076 COMPLETED
Chronic Kidney Disease 5D
University of Florida
 2025-02-03 PHASE3
NCT06531863 RECRUITING
Mood Disturbance
Auburn University
 2024-09-30 EARLY_PHASE1
NCT06752655 NOT_YET_RECRUITING
Periapical Diseases; Postoperative Dental Pain; Irrigation Solution; Photodynamic Therapy (PDT)
Ataturk University
 2025-01
NCT07149961 COMPLETED
ST Elevation Myocardial Infarction (STEMI); Malondialdehyde; Hs-CRP; Curcumin; Curcuma Xanthorrhiza; High-sensitivity C-reactive Protein
Universitas Diponegoro
 2025-02-05
NCT05975866 UNKNOWN
Thyroid Diseases; Hypothyroidism; Hashimoto Disease
National Nutrition and Food Technology Institute
 2023-09-23
NCT06653231 COMPLETED
Periodontitis
Cairo University
 2024-11-01 EARLY_PHASE1
NCT06413238 UNKNOWN
Women of Reproductive Age; Diabetes Mellitus
Fateme Moshirenia
 2024-06-10 PHASE1; PHASE2
NCT06581094 COMPLETED
Inflammation; Knee Pain Chronic
Taipei Medical University
 2024-08-20
NCT05062486 COMPLETED
Age-related Macular Degeneration
Paul A Knepper, MD PhD
 2021-10-04 PHASE2
NCT01294072 UNKNOWN
Colon Cancer
University of Louisville
 2011-01
NCT06029023 COMPLETED
Traumatic Pulp Exposure in Children
Al-Azhar University
 2022-12-20 PHASE1
NCT06867939 COMPLETED
Inflamatory Bowel Disease
S.LAB (SOLOWAYS)
 2024-05-05
NCT04731844 COMPLETED
Prostate Cancer; Multiple Myeloma; Smoldering Multiple Myeloma (SMM); Monoclonal Gammopathy of Undetermined Significance
University of Rochester
 2021-12-14 PHASE2
NCT06458465 COMPLETED
Chronic Kidney Disease
Alexandria University
 2023-10-01
NCT05596214 UNKNOWN
Diverticulitis
Dr. Adi Lahat
 2022-08-14 PHASE2
NCT07585825 COMPLETED
Alcohol Hangover; Alcohol Misuse
OmniSolutions Laboratory Holdings Limited
 2024-06-20
NCT05613361 UNKNOWN
Acute Kidney Injury; Drug-Induced Nephropathy
October 6 University
 2023-01-01 PHASE3
NCT06177483 COMPLETED
Bioavailability
ESM Technologies, LLC
 2024-03-01
NCT04971382 UNKNOWN
Horizontal Alveolar Bone Loss
Ain Shams University
 2021-12-01 PHASE4
NCT05472753 COMPLETED
Colon Cancer
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
 2022-11-16
NCT06984640 COMPLETED
Over Age 60; Prediabetes or Overweight
Oklahoma State University
 2023-03-16
NCT05819632 UNKNOWN
Palate; Wound
Cairo University
 2022-11-01
NCT07078630 COMPLETED
Iron Supplementation and Gastrointestinal Health; Iron Deficiency
University of Westminster
 2023-10-05
NCT05753436 COMPLETED
Diabetes Mellitus, Type 2; Dyslipidemias; Hypertension
Ain Shams University
 2023-07-01 PHASE2
NCT06053411 Not yet recruiting
Interaction
Washington State University
 2024-01-01 Early Phase 1
NCT03935958 ACTIVE_NOT_RECRUITING
Disorder Related to Renal Transplantation
University of Illinois at Chicago
 2019-11-01
NCT06044142 COMPLETED
Oral Mucositis; Pediatric Cancer
Riyadh Elm University
 2023-03-15 PHASE1
NCT04687449 UNKNOWN
COPD
Danbury Hospital
 2022-01-01
NCT05966441 UNKNOWN
Chemotherapy-induced Peripheral Neuropathy
Ain Shams University
 2023-08-30 PHASE2
NCT04713631 UNKNOWN
Crohn's Disease
Sanjay Gandhi Postgraduate Institute of Medical Sciences
 2021-01-21 PHASE2
NCT06105840 UNKNOWN
Osteoarthritis, Knee
Gadjah Mada University
 2023-08-27 PHASE1; PHASE2
NCT06006663 UNKNOWN
Effective Intracanal Medicaments Against Enterococcus Faecalis
Tanta University
 2023-08-26 PHASE2; PHASE3
NCT04413266 COMPLETED
Chronic Kidney Diseases; Peritoneal Dialysis; Hemodialysis
Universidade Federal Fluminense
 2020-10-10
NCT05714670 COMPLETED
Lupus Nephritis; SLE Nephritis
Ain Shams University
 2023-04-01 PHASE2
NCT05947513 Not yet recruiting
Cervical Cancer
Addis Ababa University|Center for Innovative Drug Development and Therapeutic Trials for Africa Addis Ababa University|Akay Natural Ingredients Private Limited
 2023-10 Phase 1|Phase 2
NCT05414838 COMPLETED
Healthy Participants
University of Manitoba
 2022-07-11
NCT06281353 COMPLETED
Anogenital Wart
Indonesia University
 2022-08-16 PHASE2; PHASE3
NCT05147376 COMPLETED
Oral Ulcer; Orthodontic Appliances, Fixed
Chulalongkorn University
 2022-02-21 EARLY_PHASE1
NCT06605911 COMPLETED
Oral Lichen Planus
Shaymaa Hussein Rafat Kotb
 2023-06-01 PHASE3
NCT05966441 Not yet recruiting
Chemotherapy-induced Peripheral Neuropathy
Ain Shams University
 2023-08-30 Phase 2
NCT05774704 Recruiting
Bioavailability|Gut Microbiome|Safety
Texas Tech University Health Sciences Center
 2023-08-21 Phase 1|Phase 2
NCT04590196 COMPLETED
Age Related Macular Degeneration
University of Illinois at Chicago
 2020-11-01 EARLY_PHASE1
NCT05775237 COMPLETED
Healthy Children
NovoBliss Research Pvt Ltd
 2023-05-01
NCT04998617 COMPLETED
Halitosis
University of North Carolina, Chapel Hill
 2022-05-24
NCT05542394 COMPLETED
Plasma Levels of Different Curcuminoids Preparations
University of Jordan
 2022-09-20
NCT05982197 COMPLETED
Radiation-Induced Mucositis; Head and Neck Cancer
University of Baghdad
 2023-01-03
NCT05761327 COMPLETED
Ulcerative Colitis
Ardahan University
 2022-06-03
NCT05627843 UNKNOWN
Pediatric Patients Having Renal Failure and on Regular Hemodialysis
Ain Shams University
 2022-12-01 PHASE3
NCT04294836 WITHDRAWN
Cervical Cancer, Stage IIB
Instituto Nacional de Cancerologia, Columbia
 2021-12-01 PHASE2
NCT03223883 COMPLETED
Chronic Kidney Diseases; Cognitive Decline
Diana Jalal
 2018-06-01 PHASE2
NCT05045443 COMPLETED
Acute Lymphoblastic Leukemia, Pediatric
Ain Shams University
 2021-08-22 PHASE2
NCT04403568 WITHDRAWN
Prostate Cancer
The University of Texas Health Science Center at San Antonio
 2021-10 EARLY_PHASE1
NCT04654689 COMPLETED
Amyotrophic Lateral Sclerosis
Fundación Universidad Católica de Valencia San Vicente Mártir
 2021-11-20 PHASE2
NCT00745134 TERMINATED
Rectal Mucinous Adenocarcinoma; Rectal Signet Ring Cell Adenocarcinoma; Recurrent Rectal Carcinoma; Stage IIA Rectal Cancer AJCC v7; Stage IIB Rectal Cancer AJCC v7; Stage IIC Rectal Cancer AJCC v7; Stage IIIA Rectal Cancer AJCC v7; Stage IIIB Rectal Cancer AJCC v7; Stage IIIC Rectal Cancer AJCC v7
M.D. Anderson Cancer Center
 2008-08-11 PHASE2
NCT04205929 COMPLETED
Bleeding; Implants; Breakthrough Bleeding
Oregon Health and Science University
 2020-04-15 PHASE4
NCT01608139 WITHDRAWN
Advanced Cancers
M.D. Anderson Cancer Center
 2012-11 PHASE1
NCT03670875 COMPLETED
Obesity in Childhood
Coordinación de Investigación en Salud, Mexico
 2021-07-31
NCT04989166 UNKNOWN
Acute Pancreatitis
National Nutrition and Food Technology Institute
 2021-10-19
NCT05150782 UNKNOWN
Post-acute COVID-19 Syndrome
PhysioMetrics
 2022-01-17
NCT02782949 ACTIVE_NOT_RECRUITING
Chronic Atrophic Gastritis; Gastric Carcinoma
National Cancer Institute (NCI)
 2017-04-04 PHASE2
NCT05346211 UNKNOWN
Exercise Induced Muscle Damage
St Mary's University College
 2022-05-01
NCT02445651 COMPLETED
Parkinson Disease; Idiopathic Parkinson Disease
Thomas Jefferson University
 2014-03
NCT04879810 COMPLETED
Irritable Bowel Disease
University of Louisville
 2018-03-01
NCT05407467 UNKNOWN
Diabetes Mellitus, Type 2; Insulin Resistance; Inflammation; Body Weight
Universitas Sebelas Maret
 2022-06 PHASE1; PHASE2
NCT02277223 WITHDRAWN
Ulcerative Colitis
Schneider Children's Medical Center, Israel
 2020-03-01 PHASE3
NCT06300021 COMPLETED
Healthy
Givaudan France Naturals
 2021-09-14
NCT04912921 COMPLETED
Inflammation; COVID19
Arizona State University
 2020-10-20
NCT05349032 UNKNOWN
Inflammation
Epiceutical Labs
 2022-03-01
NCT03953261 TERMINATED
Systemic Lupus Erythematosus
Loma Linda University
 2019-09-01 PHASE2
NCT05334043 UNKNOWN
Healthy Adult Subjects
The Affiliated Hospital of Qingdao University
 2022-03-23 PHASE1
NCT03980509 COMPLETED
Breast Cancer
Medical University of South Carolina
 2020-01-29 PHASE1
NCT05430087 COMPLETED
Systemic Lupus Erythematosus
Saiful Anwar Hospital
 2020-03-01 PHASE2
NCT04603690 COMPLETED
Covid-19
Liaquat University of Medical & Health Sciences
 2021-08-16
NCT05130671 COMPLETED
COVID-19
King Edward Medical University
 2021-10-25
NCT03500653 UNKNOWN
Inflammatory Bowel Diseases
Henit Yanai
 2020-06-09
NCT04728386 UNKNOWN
Necrotic Pulp
Cairo University
 2021-01
NCT04528212 COMPLETED
Diabetes Mellitus, Type 2
Rehab Werida
 2020-11-01 PHASE4
NCT04353310 WITHDRAWN
Asthma
Loma Linda University
 2021-09 PHASE2
NCT06553144 COMPLETED
Apical Periodontitis
University of Gaziantep
 2021-02-01
NCT04132648 WITHDRAWN
Chronic Kidney Diseases; Blood Pressure; Hyperemia; Vasoconstriction
University of Iowa
 2020-11-15 PHASE2
NCT03016039 UNKNOWN
Curcumin Use for Gynecological Conditions
Meir Medical Center
 2017-01-07
NCT04744545 COMPLETED
Depression
Meru Health, Inc.
 2021-02-01
NCT03192059 COMPLETED
Cervical Cancer; Endometrial Cancer; Uterine Cancer
University Hospital, Ghent
 2017-07-01 PHASE2
NCT04315350 TERMINATED
Insulin Resistance; Non-Alcoholic Fatty Liver Disease
University Hospital, Gentofte, Copenhagen
 2019-12-01
NCT05667376 COMPLETED
Periodontitis
Reham abdelfatah
 2021-01-01
NCT04458116 WITHDRAWN
Coronary Artery Disease; Oxidative Stress; Inflammation
Universidade Federal Fluminense
 2021-05-10
NCT05242718 COMPLETED
Immunity Disorders
Immunoflex Therapeutics Inc.
 2021-01-10
NCT03475017 COMPLETED
Chronic Kidney Diseases
Denise Mafra
 2018-02-22
NCT04972045 COMPLETED
Healthy Adult Subjects
The Affiliated Hospital of Qingdao University
 2021-04-09 PHASE1
NCT04208334 COMPLETED
Cancer Cachexia; Head and Neck Cancer; Head and Neck Neoplasms
Phramongkutklao College of Medicine and Hospital
 2020-02-13 PHASE2
NCT02494141 COMPLETED
Polycystic Kidney, Autosomal Dominant
University of Colorado, Denver
 2015-11-12 PHASE4
NCT03847623 UNKNOWN
Breast Cancer
University of Malaya
 2017-06-18
NCT03864783 COMPLETED
Non-Alcoholic Fatty Liver Disease; Insulin Resistance; Glucose Tolerance Impaired; Obesity, Abdominal
Steno Diabetes Center Copenhagen
 2019-03-05
NCT04837664 UNKNOWN
Candida Albicans Infection; Cigarette Smoking
King Saud University
 2018-07-03 PHASE3
NCT04421716 COMPLETED
Bioavailability of Phytonutrients
The University of Texas Health Science Center at San Antonio
 2020-10-20 EARLY_PHASE1
NCT03542240 COMPLETED
Obesity; High Blood Pressure; High Cholesterol; Type2 Diabetes; Heart Diseases
Virginia Commonwealth University
 2018-09-19
NCT04382014 UNKNOWN
Healthy
Université de Sherbrooke
 2020-06-01
NCT03790605 UNKNOWN
Periodontitis
KLE Society's Institute of Dental Sciences
 2019-09-04 PHASE3
NCT04012424 COMPLETED
Acute Pulpitis
Cairo University
 2019-08-01
NCT04355416 UNKNOWN
Chronic Periodontitis
University of Baghdad
 2020-04-20 EARLY_PHASE1
NCT03122613 TERMINATED
Ulcerative Colitis in Remission
Chinese University of Hong Kong
 2017-06-19
NCT03877679 UNKNOWN
Oral Lichen Planus
Cairo University
 2019-05-01 PHASE1
NCT04207021 UNKNOWN
Osteoarthritis; Knee Pain Chronic
KOS Care SRL - Istituto di Riabilitazione Santo Stefano
 2019-12-18
NCT04109742 WITHDRAWN
NAFLD - Nonalcoholic Fatty Liver Disease; NASH - Nonalcoholic Steatohepatitis
Columbia University
 2019-12-09 PHASE2
NCT04119752 COMPLETED
Cardiovascular Risk Factor
Universidade Federal do Rio de Janeiro
 2019-01-04
NCT04723849 COMPLETED
Childhood Obesity
Universita di Verona
 2019-02-01
NCT01811381 UNKNOWN
Mild Cognitive Impairment
VA Office of Research and Development
 2014-01-20 PHASE2
NCT03845322 WITHDRAWN
Hematoma, Subdural, Chronic
University of New Mexico
 2018-12-18 EARLY_PHASE1
NCT02724202 TERMINATED
Metastatic Colon Cancer
Baylor Research Institute
 2018-02-20 EARLY_PHASE1
NCT03568513 COMPLETED
Irritable Bowel Syndrome
Medical College of Wisconsin
 2018-08-01
NCT03917784 UNKNOWN
PreDiabetes
Hospital General de México Dr. Eduardo Liceaga
 2019-02-25 PHASE4
NCT04028739 COMPLETED
Bioavailability
Handok Inc.
 2019-07-31
NCT04465851 COMPLETED
Iron Deficiency (Without Anemia)
University of Westminster
 2018-07-18
NCT02369549 COMPLETED
Chronic Kidney Disease
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2015-09 PHASE3
NCT03085680 COMPLETED
Older Adults; Physical Function; Cognitive Function
University of Florida
 2017-08-11 PHASE2; PHASE3
NCT02909686 COMPLETED
Gulf War Illness
University of Alabama at Birmingham
 2016-07
NCT04107987 COMPLETED
Dysglycemia
University of Pavia
 2018-10-01 PHASE3
NCT03534024 UNKNOWN
Metabolic Syndrome
National Nutrition and Food Technology Institute
 2018-08-30
NCT03514667 UNKNOWN
Metabolic Syndrome
National Nutrition and Food Technology Institute
 2018-08-30
NCT03795792 COMPLETED
Metabolic Syndrome
Coordinación de Investigación en Salud, Mexico
 2018-05-06
NCT02439385 COMPLETED
Colorectal Cancer
Gachon University Gil Medical Center
 2015-08-24 PHASE2
NCT02848417 UNKNOWN
Gulf War Syndrome
South Florida Veterans Affairs Foundation for Research and Education
 2016-04 PHASE1; PHASE2
NCT04890704 COMPLETED
Acute Kidney Injury; Contrast Media Toxicity; Curcuminoid; Chronic Kidney Diseases
Bangkok Metropolitan Administration Medical College and Vajira Hospital
 2018-10-01 EARLY_PHASE1
NCT03746158 COMPLETED
Metabolites; Gut Microbiota
University of Massachusetts, Amherst
 2018-09-01
NCT03262363 UNKNOWN
Chronic Kidney Diseases; Diabetes Mellitus, Type 2; Polymorphism
Unidad de Investigacion Medica en Enfermedades Renales
 2018-08-01 PHASE2; PHASE3
NCT03769857 COMPLETED
Exercise-induced Joint Pain; Exercise-induced Joint Stiffness; Exercise-induced Joint Cartilage Turnover
ESM Technologies, LLC
 2019-01-13
NCT01948661 COMPLETED
Colorectal Adenoma; Risk Reduction
Ente Ospedaliero Ospedali Galliera
 2014-03
NCT04385979 COMPLETED
Recurrent Aphthous Ulcer; Recurrent Aphthous Stomatitis
Shahid Beheshti University of Medical Sciences
 2018-07-15
NCT03511261 UNKNOWN
Oral Submucous Fibrosis
H.K.E.S's S.Nijalingappa Institute of Dental Science and Research
 2014-01 PHASE2
NCT03072992 COMPLETED
Advanced Breast Cancer; Metastatic Breast Cancer
National Center of Oncology, Armenia
 2017-03-20 PHASE2
NCT02978339 COMPLETED
Primary Sclerosing Cholangitis
John E. Eaton
 2017-06-09 PHASE1; PHASE2
NCT03493997 COMPLETED
Prostate Cancer
Study Group for Urogenital Diseases, Italy
 2017-04-04 PHASE2
NCT02944578 TERMINATED
Neoplasms
Lisa Flowers
 2017-11-20 PHASE2
NCT03621865 COMPLETED
Healthy
Givaudan France Naturals
 2018-07-26
NCT02300727 TERMINATED
Mucositis
Amy Beres
 2015-02 PHASE1; PHASE2
NCT03598205 COMPLETED
Diabetic Macular Edema
Fondazione G.B. Bietti, IRCCS
 2018-02-05
NCT02598726 COMPLETED
Bladder Spasm; Malignant Neoplasm; Pain; Urinary Urgency
Mayo Clinic
 2016-03-01 PHASE1
NCT03530436 COMPLETED
Safety After Oral Intake; Pharmacokinetics After Oral Intake
University of Hohenheim
 2018-06-07
NCT01740323 COMPLETED
Breast Cancer
Andrew H Miller
 2015-05 PHASE2
NCT04032132 COMPLETED
Periodontitis
Ain Shams University
 2016-08-20 PHASE4
NCT04044417 COMPLETED
Periodontitis
Ain Shams University
 2016-08-25 PHASE4
NCT04103788 COMPLETED
Bioavailability
ESM Technologies, LLC
 2018-03-27
NCT02100423 COMPLETED
Contiguous Stage II Small Lymphocytic Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Stage 0 Chronic Lymphocytic Leukemia; Stage I Chronic Lymphocytic Leukemia; Stage I Small Lymphocytic Lymphoma; Stage II Chronic Lymphocytic Leukemia
Paolo Caimi, MD
 2014-10-16 PHASE2
NCT02095717 TERMINATED
Prostate Cancer Metastatic Castration Resistant
Centre Jean Perrin
 2014-03 PHASE2
NCT03329781 COMPLETED
Overweight
University of Glasgow
 2015-02
NCT01167673 UNKNOWN
Irritable Bowel Syndrome
NAFTALI TIMNA
 2011-04 PHASE2
NCT02138955 COMPLETED
Patients w/Advanced Cancer That Failed Std of Care Therapy
SignPath Pharma, Inc.
 2014-03 PHASE1; PHASE2
NCT03289507 COMPLETED
Healthy
Clinical Nutrition Research Center, Illinois Institute of Technology
 2017-09-19
NCT03140657 COMPLETED
Ankylosing Spondylitis
Tabriz University of Medical Sciences
 2017-04-29 PHASE2
NCT00852332 TERMINATED
Breast Cancer
Centre Jean Perrin
 2009-08 PHASE2
NCT02255370 COMPLETED
Crohn's Disease
University Hospital, Clermont-Ferrand
 2014-12 PHASE3
NCT03141918 COMPLETED
HIV Infections
Universidade Federal do Rio Grande do Norte
 2017-09-08
NCT03066791 COMPLETED
Inflammation; Skin
University of California, Davis
 2016-11-30
NCT02476708 TERMINATED
Schizophrenia; Schizoaffective Disorder
Yale University
 2016-02-11
NCT02554344 WITHDRAWN
Cervical Intraepithelial Neoplasia
Baylor Research Institute
 2015-06-22 EARLY_PHASE1
NCT02908152 COMPLETED
Type 2 Diabetes; Nonalcoholic Fatty Liver
National Nutrition and Food Technology Institute
 2017-02-10 PHASE2; PHASE3
NCT02998918 COMPLETED
Inflammation; Atherosclerosis; Cardiovascular Disease
University of South Carolina
 2016-09
NCT01968564 UNKNOWN
Vascular Aging
University of Colorado, Boulder
 2013-06
NCT01490996 COMPLETED
Colonic Cancer; Metastasis
University of Leicester
 2012-02 PHASE1; PHASE2
NCT03019848 UNKNOWN
Proteinuria
Instituto Nacional de Cardiologia Ignacio Chavez
 2016-05 PHASE2
NCT02724618 UNKNOWN
Prostate Cancer
Shahid Beheshti University of Medical Sciences
 2016-03 PHASE2
NCT01383161 COMPLETED
Age-associated Cognitive Impairment; Mild Cognitive Impairment (MCI)
University of California, Los Angeles
 2012-03 PHASE2
NCT01928043 TERMINATED
Bipolar Disorder
Sunnybrook Health Sciences Centre
 2013-09 PHASE2
NCT02683733 UNKNOWN
Ulcerative Colitis
Asian Institute of Gastroenterology, India
 2016-02 PHASE3
NCT02683759 UNKNOWN
Ulcerative Colitis
Asian Institute of Gastroenterology, India
 2016-02 PHASE3
NCT02298985 COMPLETED
Chronic Schizophrenia
Beersheva Mental Health Center
 2015-01 PHASE4
NCT00927485 COMPLETED
Familial Adenomatous Polyposis
University of Puerto Rico
 2007-11
NCT00641147 COMPLETED
Familial Adenomatous Polyposis
National Cancer Institute (NCI)
 2010-10 PHASE2
NCT01859858 COMPLETED
Advanced Colorectal Cancer
UNC Lineberger Comprehensive Cancer Center
 2013-06 PHASE1
NCT02556632 COMPLETED
Breast Carcinoma; Pain; Radiation-Induced Dermatitis; Stage 0 Breast Cancer
Gary Morrow
 2015-10-13 PHASE2
NCT01975363 COMPLETED
Atypical Ductal Breast Hyperplasia; BRCA1 Gene Mutation; BRCA2 Gene Mutation; Ductal Breast Carcinoma in Situ; Lobular Breast Carcinoma in Situ
Ohio State University Comprehensive Cancer Center
 2013-06
NCT02532023 UNKNOWN
Migraine
Tehran University of Medical Sciences
 2015-09 PHASE4
NCT02815475 COMPLETED
Healthy Adults
Newcastle University
 2016-03
NCT02321293 UNKNOWN
Lung Cancer
Lady Davis Institute
 2015-08 PHASE1
NCT02104752 COMPLETED
Schizophrenia; Cognition; Psychosis
VA Greater Los Angeles Healthcare System
 2014-07 PHASE1; PHASE2
NCT02017353 COMPLETED
Endometrial Carcinoma
University Hospital, Gasthuisberg
 2013-10 PHASE2
NCT01514370 COMPLETED
Multiple Sclerosis
Merck KGaA, Darmstadt, Germany
 2012-04-30 PHASE2
NCT03144882 COMPLETED
Hemodialysis Complication; Hemodialysis-Induced Symptom
Shahid Beheshti University of Medical Sciences
 2015-02-02
NCT02645656 UNKNOWN
Oral Submucous Fibrosis
SVS Institute of Dental Sciences
 2013-12 PHASE2
NCT02529969 UNKNOWN
Non Insulin Dependent Diabetes
National Nutrition and Food Technology Institute
 2015-07 PHASE2; PHASE3
NCT02529982 COMPLETED
Non Insulin Dependent Diabetes
National Nutrition and Food Technology Institute
 2015-07
NCT01160302 COMPLETED
Head and Neck Cancer
Louisiana State University Health Sciences Center Shreveport
 2010-06 EARLY_PHASE1
NCT02018328 UNKNOWN
Positivity for Helicobacter Pylori
Gingold Belfer Rachel
 2014-01
NCT01269203 WITHDRAWN
Multiple Myeloma
M.D. Anderson Cancer Center
 2012-10 PHASE2
NCT03211104 COMPLETED
Prostate Cancer
Samsung Medical Center
 2007-08-30
NCT04870060 COMPLETED
Oral Mucositis (Ulcerative)
Tata Memorial Centre
 2010-10-06 PHASE2
NCT02474953 COMPLETED
Healthy
KGK Science Inc.
 2015-04 PHASE1
NCT02281981 WITHDRAWN
Vascular Stiffness
University of Prince Edward Island
 2014-01
NCT01246973 COMPLETED
Radiation-induced Dermatitis
University of Rochester
 2011-02 PHASE2; PHASE3
NCT00969085 WITHDRAWN
Cutaneous T-cell Lymphoma
M.D. Anderson Cancer Center
 2012-11 PHASE2
NCT01225094 COMPLETED
Acute Kidney Injury; Abdominal Aortic Aneurysm
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2011-11 PHASE2; PHASE3
NCT01320436 COMPLETED
Ulcerative Colitis
Sheba Medical Center
 2011-07 PHASE3
NCT02337192 COMPLETED
Dentist-Patient Relations
University of Sao Paulo
 2014-01 PHASE1
NCT00094445 COMPLETED
Pancreatic Neoplasms; Adenocarcinoma
M.D. Anderson Cancer Center
 2004-11 PHASE2
NCT01831193 COMPLETED
Proteinuria
Instituto Nacional de Cardiologia Ignacio Chavez
 2013-02 PHASE3
NCT01925547 COMPLETED
Metabolic Syndrome, Protection Against
University of Hohenheim
 2013-07 PHASE2
NCT01964846 COMPLETED
Effect of Resveratrol and Curcumin on Inflammation
Laval University
 2013-10
NCT01201694 COMPLETED
Advanced Cancers
M.D. Anderson Cancer Center
 2011-10 PHASE1
NCT02152475 COMPLETED
Healthy
University of Sao Paulo
 2013-05 PHASE1
NCT01917890 COMPLETED
Prostate Cancer; Radiation Therapy
Shahid Beheshti University of Medical Sciences
 2011-03
NCT01925287 COMPLETED
Pharmacokinetics of Novel Curcumin Formulations; Safety of Novel Curcumin Formulations
University of Hohenheim
 2011-10 EARLY_PHASE1
NCT00689195 UNKNOWN
Osteosarcoma
Tata Memorial Hospital
 2008-05 PHASE1; PHASE2
NCT01982734 COMPLETED
Pharmacokinetics of New Curcumin Formulations; Safety of New Curcumin Formulations
University of Hohenheim
 2012-11 EARLY_PHASE1
NCT01909037 COMPLETED
Knee Osteoarthritis
Tilman S.A.
 2012-03 EARLY_PHASE1
NCT01285375 UNKNOWN
End Stage Renal Failure With Renal Transplant
Helsinki University Central Hospital
 2011-01 PHASE1
NCT01403545 COMPLETED
Drug Safety
SignPath Pharma, Inc.
 2011-08 PHASE1
NCT01344291 UNKNOWN
Hyperprolactinoma
Mashhad University of Medical Sciences
 2011-07 PHASE1
NCT01543386 COMPLETED
Healthy Volunteers (Middle-aged Smokers)
University Hospital, Clermont-Ferrand
 2012-02 PHASE1; PHASE2
NCT01330810 COMPLETED
Comparative Multidose Pharmacokinetics
University of North Carolina, Chapel Hill
 2011-03 PHASE1
NCT01489592 COMPLETED
Healthy Volunteers
Institut National de la Santé Et de la Recherche Médicale, France
 2011-10 PHASE2
NCT01875822 COMPLETED
Schizophrenia; Schizoaffective Disorder; Depression
Woodbury, Michel, M.D.
 2009-06 PHASE1; PHASE2
NCT01333917 COMPLETED
Colorectal Cancer
University of North Carolina, Chapel Hill
 2010-11 PHASE1
NCT01750359 COMPLETED
Major Depression
Vladimir Lerner
 2010-08 PHASE4
NCT01035580 COMPLETED
Uterine Cervical Dysplasia
Emory University
 2010-01 PHASE1
NCT01288859 COMPLETED
Healthy
Federico II University
 2010-12
NCT00752154 COMPLETED
Rheumatoid Arthritis
University of California, Los Angeles
 2010-01 EARLY_PHASE1
NCT00475683 COMPLETED
Chemotherapy Induced Mucositis
Hadassah Medical Organization
 2009-01 PHASE3
NCT01042938 COMPLETED
Breast Cancer
University of Rochester
 2008-01 PHASE2
NCT00118989 TERMINATED
Adenomatous Polyps
University of Pennsylvania
 2005-07
NCT00889161 COMPLETED
Inflammatory Bowel Disease; Ulcerative Colitis; Crohn's Disease
Seattle Children's Hospital
 2009-05 PHASE1
NCT01001637 TERMINATED
Alzheimer Disease
Jaslok Hospital and Research Centre
 2009-10
NCT01052025 UNKNOWN
Type 2 Diabetes; Pre-diabetes; Insulin Resistance; Cardiovascular Risk
Srinakharinwirot University
 2009-08 PHASE4
NCT01052597 UNKNOWN
Type 2 Diabetes Mellitus; Cardiovascular Abnormalities
Srinakharinwirot University
 2009-07 PHASE4
NCT01022632 COMPLETED
Major Depressive Disorder
Government Medical College, Bhavnagar
 2009-03
NCT00973869 UNKNOWN
Colorectal Cancer
University of Leicester
 2009-07 PHASE1
NCT01179256 COMPLETED
Atopic Asthma
University of South Florida
 2009-03
NCT00113841 COMPLETED
Multiple Myeloma
M.D. Anderson Cancer Center
 2004-11
NCT00895167 COMPLETED
Healthy
Daniel Doberer
 2009-01 PHASE1
NCT00779493 COMPLETED
Irritable Bowel Syndrome
Kaiser Permanente
 2008-11 PHASE4
NCT00525421 COMPLETED
Oral Lichen Planus
Nita Chainani Wu
 2007-10 PHASE2
NCT00365209 COMPLETED
Healthy, no Evidence of Disease; Tobacco Use Disorder
National Cancer Institute (NCI)
 2006-10 PHASE2
NCT00768118 COMPLETED
Healthy, no Evidence of Disease
Barbara Ann Karmanos Cancer Institute
 2008-04
NCT00595582 TERMINATED
Mild Cognitive Impairment
Louisiana State University Health Sciences Center Shreveport
 2005-05
NCT00248053 WITHDRAWN
Familial Adenomatous Polyposis
Johns Hopkins University
 2005-11 PHASE2
NCT00099710 COMPLETED
Alzheimer's Disease
John Douglas French Foundation
 2003-07 PHASE2
NCT00192842 COMPLETED
Pancreatic Cancer
Rambam Health Care Campus
 2004-07 PHASE2
NCT00181662 COMPLETED
Healthy
Massachusetts General Hospital
 2005-08
NCT00176618 TERMINATED
Aberrant Crypt Foci
University of Medicine and Dentistry of New Jersey
 2004-04
NCT01514266 COMPLETED
Chronic Obstructive Pulmonary Disease
Baylor College of Medicine
 2005-04
NCT00003365 TERMINATED
Colorectal Cancer
University of Medicine and Dentistry of New Jersey
 1996-08
NCT00164749 COMPLETED
Alzheimer's Disease
Chinese University of Hong Kong
 2004-10 PHASE1; PHASE2
NCT00027495 COMPLETED
Colorectal Cancer
University of Michigan Rogel Cancer Center
 2001-12 PHASE1
NCT00247026 WITHDRAWN
Myelodysplastic Syndrome
Hadassah Medical Organization
 2007-04 PHASE1; PHASE2
NCT00542711 WITHDRAWN
Healthy
Hadassah Medical Organization
 PHASE1
NCT00486460 UNKNOWN
Pancreatic Cancer
Tel-Aviv Sourasky Medical Center
 2005-06 PHASE3
NCT01048983 WITHDRAWN
Non Small Cell Lung Cancer
M.D. Anderson Cancer Center
 PHASE1; PHASE2
NCT00528151 COMPLETED
Optic Atrophy, Hereditary, Leber
Mahidol University
 2005-05 PHASE3
NCT00295035 UNKNOWN
Colon Neoplasm
Tel-Aviv Sourasky Medical Center
 2006-03 PHASE3
NCT00219882 COMPLETED
Cystic Fibrosis
Ramsey, Bonnie, MD
 2005-04 PHASE1
NCT00235625 COMPLETED
Psoriasis
University of Pennsylvania
 2005-10 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-06-15)

Check the Curcumin (Diferuloylmethane) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Curcumin directly inhibits p300 histone acetyltransferase and suppresses NF-κB signaling while activating the Nrf2 pathway, which triggers downstream cellular apoptosis, autophagy, and cell cycle arrest. This multi-target biochemical modulation leads to reduced cell proliferation and anti-inflammatory responses, providing the mechanistic basis for its clinical investigation in conditions such as cervical cancer and ulcerative colitis.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.