CAS No. 458-37-7

Batch: Purity:99.94
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Curcumin (Diferuloylmethane) Chemical Structure
Chemical Structure
Check the Curcumin (Diferuloylmethane) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
CAS Number 458-37-7
Molecular Formula

C21H20O6
Molecular Weight (MW) 368.38
SMILES COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
InChIKey VFLDPWHFBUODDF-FCXRPNKRSA-N

Ordering Information

Biological Activity

Curcumin is a natural polyphenol that acts as an inhibitor of p300 histone acetyltransferase (IC and histone deacetylase (HDAC). It activates the Nrf2 pathway while suppressing NF-κB activation. Consequently, curcumin induces autophagy, mitophagy, apoptosis, and cell cycle arrest to exert antitumor activity, while decreasing ferroptosis-mediated cell death to mitigate renal damage. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 250 mg/mL (678.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.