Belinostat (PXD101): Mechanism of Action

Belinostat (PXD101) MOA:Targeting HDAC/Epigenetic Regulation Pathway for Peripheral T-Cell Lymphoma and Hematological Malignancies

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Belinostat (PXD101) is a potent pan-HDAC inhibitor. It affects apoptotic and cell cycle signaling by inducing the accumulation of acetylated histones and altering gene transcription, effectively promoting apoptosis and inhibiting tumor cell proliferation.

Primary Applications and Mechanism of Action