CAS No. 866323-14-0
Batch:
Purity:99.74
Chemical Structure
Check the
Belinostat (PXD101)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 866323-14-0 | |
| Molecular Formula |
C15H14N2O4S |
|
| Molecular Weight (MW) | 318.35 | |
| SMILES | C1=CC=C(C=C1)NS(=O)(=O)C2=CC=CC(=C2)C=CC(=O)NO | |
| InChIKey | NCNRHFGMJRPRSK-MDZDMXLPSA-N |
Belinostat (PXD101) is a novel hydroxamate histone deacetylase inhibitor with an IC50 of 27 nM in HeLa cell extracts. It increases histone H3 and H4 acetylation, leading to cell cycle arrest, autophagy, and apoptosis in diverse human cancer cell lines. Additionally, treatment with belinostat significantly inhibits xenograft tumor growth in animal models without causing overt toxicity. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(201.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
63 mg/mL
(197.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 51 mg/mL |
| Water | Insoluble |
| DMSO |
64 mg/mL
(201.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 64 mg/mL |
| Water | Insoluble |
| DMSO |
64 mg/mL
(201.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
64 mg/mL
(201.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Belinostat (PXD101) Mechanism of Action: HDAC Inhibition in T-Cell Lymphocyte Research
- Belinostat (PXD101) Clinical Trials
- Belinostat (PXD101) Working Concentration | Cell Culture | Treatment
- Belinostat (PXD101) Solubility in DMSO
- Belinostat (PXD101) Stock Solution
- Belinostat (PXD101) Storage
- Belinostat (PXD101) Stability
- Belinostat (PXD101) Combination Database
- Belinostat (PXD101) Molecular Weight
- Belinostat (PXD101) SMILES
- Belinostat (PXD101) Chemical Structure (2D and 3D)
- Belinostat (PXD101) IC50 for Cell-based and Cell-free Assays
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- Belinostat (PXD101) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.