Axitinib (AG-013736) is a potent, broad-spectrum VEGFR, PDGFR, and cKIT tyrosine kinase inhibitor. It blocks VEGF/VEGFR and cKIT signaling by inhibiting receptor autophosphorylation, effectively suppressing tumor angiogenesis, cell proliferation, and migration.
Axitinib (AG-013736) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Axitinib (AG-013736) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.