Clinical Trials

Numerous clinical trials evaluate the therapeutic profile of albendazole, primarily investigating intestinal diseases, soil-transmitted helminth infections, lymphatic filariasis, hookworm, trichuriasis, and ascariasis. These studies encompass Phase 1 through Phase 4 interventional protocols as well as observational designs, with recruitment statuses ranging from active and completed to not yet recruiting. Sponsored by diverse entities—including major pharmaceutical companies and academic institutions—this research reflects a broad clinical evaluation effort.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06565507 NOT_YET_RECRUITING
Brain Cysticercosis
Universidad Peruana Cayetano Heredia
 2026-12-01 PHASE2; PHASE3
NCT07707817 RECRUITING
Onchocerciasis (River Blindness); Schistosomiasis; Soil Transmitted Helminth (STH) Infections; Lymphatic Filariasis
Uwemedimo Friday Ekpo
 2026-07-01
NCT07159373 NOT_YET_RECRUITING
Lymphatic Filariasis; Scabies; Strongyloidiasis
Medicines Development for Global Health
 2026-03 PHASE3
NCT07661316 NOT_YET_RECRUITING
Trichuriasis; Strongyloidiasis; Ascariasis; Hookworm Infection; Soil-Transmitted Helminthiasis
Mundo Sano Foundation
 2026-11-01 PHASE3
NCT04713787 RECRUITING
Trichuriasis
Asociacion Benefica Prisma
 2024-09-07 PHASE2
NCT07258173 NOT_YET_RECRUITING
Trichuris Infection
Jennifer Keiser
 2026-11-15 PHASE2
NCT06613997 NOT_YET_RECRUITING
Loiasis With Positive Blood Microfilaremia; Loiasis
Programme National de Lutte contre l'Onchocercose, Republic of the Congo
 2025-01-15 PHASE3
NCT07074444 RECRUITING
Clonorchiasis
First Affiliated Hospital of Guangxi Medical University
 2025-07-22 PHASE4
NCT05949190 ACTIVE_NOT_RECRUITING
Malnutrition in Pregnancy; Preterm Birth; Child Development; Postpartum Depression; Antepartum Depression
Washington University School of Medicine
 2023-08-18
NCT06070116 ACTIVE_NOT_RECRUITING
Onchocercal Subcutaneous Nodule; Onchocerciasis; Onchocerciasis, Ocular; Onchocerca Infection; Tropical Disease
Washington University School of Medicine
 2024-04-05 PHASE2
NCT03435718 NOT_YET_RECRUITING
Trichuris Infection
Oxfendazole Development Group
 2024-07 PHASE2
NCT06282315 RECRUITING
Soil-Transmitted Helminths
Insud Pharma
 2025-09-01 PHASE3
NCT07045493 ENROLLING_BY_INVITATION
Soil Transmitted Helminth (STH) Infections
International Centre for Diarrhoeal Disease Research, Bangladesh
 2025-07-10 PHASE2
NCT06933862 NOT_YET_RECRUITING
Malnourished Children
Indonesia University
 2025-05-15
NCT06265870 RECRUITING
Eosinophilia
Prince of Songkla University
 2024-05-01
NCT06376396 NOT_YET_RECRUITING
Neurocysticercosis
R-Evolution Worldwide S.r.l. Impresa Sociale
 2024-06 PHASE4
NCT06483880 UNKNOWN
Pulmonary Hydatid Cyst
Ain Shams University
 2024-02-01
NCT06631612 ACTIVE_NOT_RECRUITING
Iron Deficiency Anemia Treatment
Ain Shams University
 2024-01-01 PHASE4
NCT03172975 COMPLETED
Hookworm Infections
Baylor College of Medicine
 2018-03-01 PHASE2
NCT04410406 COMPLETED
Lymphatic Filariasis
Washington University School of Medicine
 2020-08-20 PHASE3
NCT04311671 COMPLETED
Onchocerciasis
Medicines Development for Global Health
 2021-05-03 PHASE3
NCT06184399 COMPLETED
Trichuriasis; Ascariasis; Hookworm Infections
Jennifer Keiser
 2024-06-05 PHASE2
NCT06188715 COMPLETED
Trichuriasis; Ascariasis; Hookworm Infections
Jennifer Keiser
 2024-05-14 PHASE3
NCT03014167 COMPLETED
Helminthiasis; Filariasis
University of Washington
 2017-10-04 PHASE3
NCT04966702 COMPLETED
Malaria
Barcelona Institute for Global Health
 2022-03-17 PHASE3
NCT05208333 UNKNOWN
Toxocara Infection
Pham Ngoc Thach University of Medicine
 2022-05
NCT06037876 COMPLETED
Trichuriasis
Jennifer Keiser
 2023-10-09 PHASE3
NCT06201559 COMPLETED
Intestinal Diseases
GlaxoSmithKline
 2023-08-21 PHASE1
NCT04913610 TERMINATED
Onchocerciasis
AbbVie
 2021-05-22 PHASE2
NCT06201559 Completed
Intestinal Diseases
GlaxoSmithKline
 2023-08-21 Phase 1
NCT05538767 COMPLETED
Hookworm Infections
Jennifer Keiser
 2022-09-16 PHASE2
NCT03950037 WITHDRAWN
Subarachnoid Neurocysticercosis
Oregon Health and Science University
 2022-01-01 PHASE2
NCT05124691 TERMINATED
Helminthes; Infestation, Intestinal
Barcelona Institute for Global Health
 2022-01-20 PHASE2; PHASE3
NCT05354258 UNKNOWN
Malaria; Soil Transmitted Helminths; Schistosomiasis; Integrated Control; Seasonal Malaria Chemoprevention; Mass Drug Administration With Anthelminthic Drugs
London School of Hygiene and Tropical Medicine
 2022-06-16
NCT05453045 UNKNOWN
Pharmacological Action
Universidad Nacional de Salta
 2022-07-18
NCT05453045 Not yet recruiting
Pharmacological Action
Universidad Nacional de Salta|Fundacion Mundo Sano
 2022-07-18 Not Applicable
NCT05283954 WITHDRAWN
SARS-CoV2 Infection; COVID-19
Oriol Mitja
 2022-05-01 PHASE2; PHASE3
NCT02812615 UNKNOWN
Malnutrition; Infection
International Centre for Diarrhoeal Disease Research, Bangladesh
 2016-07-16
NCT04188301 COMPLETED
Onchocerciasis
Washington University School of Medicine
 2019-12-06 PHASE2
NCT03570814 COMPLETED
Trachoma; Lymphatic Filariases
London School of Hygiene and Tropical Medicine
 2021-12-01 PHASE4
NCT04726969 COMPLETED
Trichuriasis; Ascariasis; Hookworm Infections
Jennifer Keiser
 2021-06-15 PHASE3
NCT04700423 COMPLETED
Trichuriasis; Ascariasis; Hookworm Infections; Helminthes; Infestation, Intestinal
Jennifer Keiser
 2021-03-01 PHASE2; PHASE3
NCT04391998 UNKNOWN
Anemia of Pregnancy
Cairo University
 2020-05-13 PHASE4
NCT02876146 COMPLETED
Alveolar Echinococcosis
Centre Hospitalier Universitaire de Besancon
 2012-06
NCT07182305 COMPLETED
Alveolar Echinococcosis
Ministry of Health, Kyrgyzstan
 2017-05-01 PHASE2
NCT02947581 TERMINATED
Neurocysticercosis
Universidad Peruana Cayetano Heredia
 2016-11-14 PHASE3
NCT02636803 WITHDRAWN
Helminthiasis
Johns Hopkins Bloomberg School of Public Health
 2019-11 PHASE2
NCT03527732 COMPLETED
Trichuriasis
Jennifer Keiser
 2018-09-09 PHASE2; PHASE3
NCT04041453 COMPLETED
Trichuris Infection; Helminthiasis
Alejandro Krolewiecki
 2019-10-09 PHASE2
NCT03036059 COMPLETED
Lymphatic Filariasis; Helminth Infection
Noguchi Memorial Institute for Medical Research
 2017-05-19 PHASE4
NCT04041427 COMPLETED
Helminthiasis
Universidad Nacional de Salta
 2019-07-17
NCT03079388 COMPLETED
Pregnancy; Malnutrition in Pregnancy; Nutrition Disorders; Stunting
Washington University School of Medicine
 2017-02-27
NCT03702530 COMPLETED
Necator Americanus Infection
Leiden University Medical Center
 2018-12-17
NCT03527745 COMPLETED
Trichuriasis; Hookworm Infections
Jennifer Keiser
 2018-10-23 PHASE2
NCT03474276 COMPLETED
Moderate Acute Malnutrition
Institut Pasteur
 2018-01-31 PHASE3
NCT03676140 COMPLETED
Trachoma; Yaws; Lymphatic Filariases; Scabies; Strongyloidiasis
Lihir Medical Centre
 2018-10-01 PHASE3
NCT03664063 COMPLETED
Lymphatic Filariasis; Yaws; Trauma
Lihir Medical Centre
 2018-09-01 PHASE2
NCT02974049 COMPLETED
Lymphatic Filariasis
University Hospitals Cleveland Medical Center
 2015-01
NCT03501251 COMPLETED
Trichuris Trichiura; Infection
Swiss Tropical & Public Health Institute
 2018-07-03 PHASE2
NCT02078024 COMPLETED
Onchocerciasis
University Hospitals Cleveland Medical Center
 2014-06 PHASE3
NCT03465488 COMPLETED
Soil-transmitted Helminth Infections
University Ghent
 2016-08-15
NCT01975441 COMPLETED
Lymphatic Filariasis
University Hospitals Cleveland Medical Center
 2014-05 PHASE2
NCT03177993 COMPLETED
Lymphatic Filariases; Scabies; Impetigo; Soil Transmitted Helminths
Washington University School of Medicine
 2017-07-13
NCT03278431 COMPLETED
Hookworm Infection
Swiss Tropical & Public Health Institute
 2017-09-27 PHASE4
NCT03155035 COMPLETED
Soil Transmitted Helminths
Dow University of Health Sciences
 2017-03-07
NCT02397772 COMPLETED
Helminthiasis; Nematode Infection; Disease Transmission, Infectious
London School of Hygiene and Tropical Medicine
 2015-03 PHASE4
NCT02899936 COMPLETED
Lymphatic Filariasis
Washington University School of Medicine
 2016-07
NCT03032042 WITHDRAWN
Helminth Infection
University of California, San Francisco
 2017-01 PHASE4
NCT03192449 COMPLETED
Soil Transmitted Helminthiasis; Neglected Tropical Diseases
Universidad Nacional de Salta
 2016-11-21 PHASE1
NCT02568098 COMPLETED
Drug Combination; Pharmacokinetics; Healthy
University of Oxford
 2015-10 PHASE1
NCT02845713 COMPLETED
Wuchereria Bancrofti Infection
University Hospitals Cleveland Medical Center
 2016-04-17 PHASE1
NCT02351687 COMPLETED
Malnutrition
Washington University School of Medicine
 2014-04
NCT02597556 WITHDRAWN
Intestinal Helminthiasis; Diarrhea
Oxford University Clinical Research Unit, Vietnam
 2016-02 PHASE4
NCT01825031 COMPLETED
Human Immunodeficiency Virus
Anna Griffiths, MRC
 2013-06 PHASE3
NCT01070277 UNKNOWN
Chronic Diarrhea; Abdominal Pain; Bloating
Sheba Medical Center
 2012-03
NCT02509481 COMPLETED
Malaria; Lymphatic Filariasis
Colorado State University
 2015-06 PHASE2; PHASE3
NCT02725255 COMPLETED
Helminthiasis; Tinea Capitis; Anemia
Kenya Medical Research Institute
 2015-05 PHASE2; PHASE3
NCT02243644 COMPLETED
Neurocysticercosis
All India Institute of Medical Sciences
 2014-03 PHASE3
NCT02102321 UNKNOWN
Hookworm Stool Burden; Anemia; Exercise Tolerance
Salmon, Margaret, M.D.
 2014-03
NCT00755560 UNKNOWN
Toxocariasis
Hospital de Niños R. Gutierrez de Buenos Aires
 2008-09 PHASE3
NCT02641210 COMPLETED
Chronic Periodontitis
Federal University of Maranhao
 2015-01 PHASE4
NCT03238131 COMPLETED
Onchocerciasis
University Hospitals Cleveland Medical Center
 2012-04 PHASE3
NCT02253095 COMPLETED
Environmental Enteropathy
Washington University School of Medicine
 2014-10
NCT01748929 COMPLETED
Intestinal Diseases, Parasitic
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2014-02-24 PHASE4
NCT01658774 COMPLETED
Intestinal Helminthiasis; Ascariasis; Hookworm; Malaria
London School of Hygiene and Tropical Medicine
 2013-01
NCT02420574 COMPLETED
Helminthiasis
University Ghent
 2014-02
NCT01903057 WITHDRAWN
Trachoma; Lymphatic Filariasis
Emory University
 2014-02 PHASE4
NCT00511004 COMPLETED
Lymphatic Filariasis
National Institute of Allergy and Infectious Diseases (NIAID)
 2007-07 PHASE2
NCT01395381 WITHDRAWN
Kwashiorkor; Marasmus
Washington University School of Medicine
 2013-01
NCT01722539 COMPLETED
Healthy
Universiteit Antwerpen
 2012-11 PHASE3
NCT00857116 COMPLETED
Tuberculosis
Linkoeping University
 2009-03
NCT01541631 UNKNOWN
Anemia; Intestinal Helminthiasis; Intestinal Schistosomiasis; Human Immunodeficiency Virus I Infection; Hematologic Diseases; Opportunistic Infections
Catholic University of Health and Allied Sciences
 2012-05
NCT00441285 COMPLETED
Neurocysticercosis; Epilepsy
Universidad Peruana Cayetano Heredia
 2010-01 PHASE2; PHASE3
NCT01192802 COMPLETED
Intestinal Diseases; Helminthiasis
Albert Schweitzer Hospital
 2010-08 PHASE4
NCT01755637 COMPLETED
Helminthiasis
GlaxoSmithKline
 2012-04 PHASE1
NCT01308268 UNKNOWN
Helminthiasis; Strongyloides Stercoralis Infection
Universidad Nacional de Salta
 2010-12
NCT01213576 TERMINATED
Lymphatic Filariasis
London School of Hygiene and Tropical Medicine
 2009-01
NCT01440608 COMPLETED
Enteropathy
Washington University School of Medicine
 2011-10
NCT01459146 UNKNOWN
Malaria; Schistosomiasis; Helminthiasis; Anemia; Change in Sustained Attention
Navrongo Health Research Centre, Ghana
 2010-12 PHASE4
NCT02005653 COMPLETED
Filarial; Infestation
Indian Council of Medical Research
 2009-02 PHASE4
NCT00507221 COMPLETED
HIV Infections; Helminthiasis
University of Washington
 2008-02
NCT00375583 COMPLETED
Lymphatic Filariasis; Wuchereria Bancrofti Infection
National Institute of Allergy and Infectious Diseases (NIAID)
 2006-09-09 PHASE2
NCT00290823 COMPLETED
Neurocysticercosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2006-04 PHASE3
NCT01327469 COMPLETED
Infection by Trichuris Trichiura
University Ghent
 2010-12 PHASE4
NCT00347113 COMPLETED
Anaemia; Malaria; Hepatosplenomegaly
DBL -Institute for Health Research and Development
 2006-07
NCT01019083 COMPLETED
Cholera; Typhoid
International Centre for Diarrhoeal Disease Research, Bangladesh
 2008-02 PHASE1; PHASE2
NCT01069198 COMPLETED
Visceral Leishmaniasis
International Centre for Diarrhoeal Disease Research, Bangladesh
 2009-10
NCT00817713 TERMINATED
HIV Infections; Helminthiasis
Swiss Tropical & Public Health Institute
 2009-01
NCT00765024 COMPLETED
Chronic Strongyloidiasis
Mahidol University
 2008-07 PHASE3
NCT01586169 COMPLETED
Parasitic Diseases; Bacterial Diseases
Centre d'Appui à la lutte contre la Maladie
 2010-02
NCT01087099 COMPLETED
Infections With Soil-Transmitted Helminths (STH)
University Ghent
 2009-01 PHASE4
NCT01050452 COMPLETED
Parasitic Diseases
DBL -Institute for Health Research and Development
 2007-10
NCT02784743 COMPLETED
Lymphatic Filariasis
Centre d'Appui à la lutte contre la Maladie
 2001-05 PHASE4
NCT01050374 COMPLETED
Parasitic Diseases
DBL -Institute for Health Research and Development
 2007-10
NCT00339417 COMPLETED
Lymphatic Filariasis
National Institute of Allergy and Infectious Diseases (NIAID)
 2006-02-22 PHASE2
NCT00367627 COMPLETED
Helminthiasis
International Centre for Diarrhoeal Disease Research, Bangladesh
 2006-12
NCT01050517 COMPLETED
Parasitic Diseases
DBL -Institute for Health Research and Development
 2007-10
NCT00659997 COMPLETED
Ascariasis; Trichuriasis
Natural History Museum, United Kingdom
 2006-06 PHASE4
NCT00283699 COMPLETED
Neurocysticercosis
Columbia University
 2001-02 PHASE3
NCT00607074 COMPLETED
Giardiasis
University of Cambridge
 2003-06
NCT00222547 COMPLETED
Village Children
University of Oxford
 1999-01 PHASE4
NCT00002191 COMPLETED
Protozoan Infections; HIV Infections
SmithKline Beecham
 PHASE3
NCT00004403 COMPLETED
Epilepsy; Cysticercosis
Johns Hopkins University
 2000-05
NCT00207753 COMPLETED
Ascariasis; Trichuriasis; Hookworm Infection; Strongyloidiasis; Pediculosis
Centers for Disease Control and Prevention
 2005-02
NCT00344669 COMPLETED
Low Weight for Age in Preschool Children
Makerere University
 2000-08
NCT00396500 COMPLETED
Malnutrition; Worm Infestation; Under-Fives
King George's Medical University
 1994-04 PHASE3
NCT00133458 WITHDRAWN
Subarachnoid Cysticercosis
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE3
NCT00130910 COMPLETED
HIV Infections; Helminthiasis
University of Washington
 2006-03
NCT00215280 COMPLETED
Mansonelliasis; Pruritus; Lymphoedema; Abdominal Pains
DBL -Institute for Health Research and Development
 2005-11

(data from https://clinicaltrials.gov, updated on 2026-05-01)

Check the Albendazole product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Albendazole selectively binds to the colchicine-sensitive site of parasite tubulin to inhibit microtubule assembly, leading to structural alteration of intestinal cells and impaired glucose uptake. This depletion of parasite glycogen stores ultimately leads to cellular death, underlying its therapeutic efficacy against trial-studied conditions such as intestinal helminthiases, hookworm infections, and lymphatic filariasis.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.