Quizartinib (AC220) is a potent, highly selective type II FLT3 inhibitor. It blocks FLT3/STAT5/AKT signaling by binding to the receptor and inhibiting its autophosphorylation, effectively suppressing cell proliferation and inducing apoptosis in acute myeloid leukemia.
Quizartinib (AC220) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Quizartinib (AC220) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.