CAS No. 950769-58-1

Batch: Purity:99.04
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Quizartinib (AC220) Chemical Structure
Chemical Structure
Check the Quizartinib (AC220) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea
CAS Number 950769-58-1
Molecular Formula

C29H32N6O4S
Molecular Weight (MW) 560.67
SMILES CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
InChIKey CVWXJKQAOSCOAB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Quizartinib (AC220) is a receptor tyrosine kinase inhibitor targeting FLT3, inhibiting FLT3 autophosphorylation in MV4-11 cells with an IC50 of. By inhibiting wild-type and mutant FLT3 signaling, it blocks downstream STAT5, AKT, and ERK signaling pathways. This inhibition suppresses leukemic cell proliferation and selectively induces apoptosis in FLT3-driven acute myeloid leukemia cells, demonstrating low nanomolar potency and exceptional kinase selectivity. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (178.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.