Clinical Trials

Numerous clinical trials spanning Early Phase 1 through Phase 4 evaluate 4-aminobutyric acid and related GABAergic interventions across completed, active, recruiting, and pending studies. Key research conditions include Fragile X Syndrome, temporal lobe epilepsy, insomnia, stress, post-thoracotomy pain, opioid dependence, overactive bladder, and diabetes mellitus. These trials are supported by a diverse array of sponsors, including academic medical centers, national research organizations, healthcare networks, and corporate pharmaceutical partners.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04062890 WITHDRAWN
Hyperinsulinism; Insulin Resistance; Insulin Sensitivity; Glucose Intolerance; Hypertension
University of Arizona
 2030-04-15 PHASE2
NCT03328455 NOT_YET_RECRUITING
Healthy Aging
University of Nevada, Reno
 2027-12-01
NCT07457736 RECRUITING
Healthy Adult Participants
Yale University
 2026-01-28 EARLY_PHASE1
NCT07549490 NOT_YET_RECRUITING
Acute Pain
National Center for Complementary and Integrative Health (NCCIH)
 2026-09-09
NCT06852469 RECRUITING
Stress Disorders, Post-Traumatic
VA Office of Research and Development
 2025-07-01 PHASE4
NCT04144439 RECRUITING
Epilepsy
Sherief Abd-Elsalam
 2018-07-01 PHASE4
NCT02219373 NOT_YET_RECRUITING
Pediatric Chronic Neuropathic Pain
Boston Children's Hospital
 2026-06 PHASE3
NCT07517757 NOT_YET_RECRUITING
Fibromyalgia (FM)
Universita degli Studi di Genova
 2026-04
NCT07752134 NOT_YET_RECRUITING
Bladder Pain Syndrome; Pregabalin; Educational Behavioral Intervention; Urinary Urgency
Beijing Tiantan Hospital
 2026-12-31 PHASE1
NCT07157852 RECRUITING
Fibromyalgia; Pregabalin; Mirogabalin; Pain
Beijing Tiantan Hospital
 2025-09-05
NCT07230171 RECRUITING
Fibromyalgia; Pregabalin; Esketamine
Beijing Tiantan Hospital
 2025-09-15
NCT07186751 RECRUITING
Fibromyalgia; Pregabalin; Venlafaxine; Pain
Beijing Tiantan Hospital
 2025-09-20
NCT04798274 RECRUITING
Autism Spectrum Disorder
National Institute of Mental Health (NIMH)
 2021-06-15
NCT07344467 RECRUITING
Oral; Melatonin; Pregabalin; Postoperative Pain; Anxiety; Spine Surgery
Tanta University
 2026-01-17
NCT07758920 RECRUITING
Postherpetic Neuralgia ( PHN )
Shanghai Yidian Pharmaceutical Technology Development Co., Ltd.
 2026-08 PHASE2
NCT06628908 RECRUITING
Diabetic Peripheral Neuropathic Pain
Vertex Pharmaceuticals Incorporated
 2024-10-01 PHASE3
NCT06150898 RECRUITING
Early-stage Breast Cancer; Estrogen-receptor-positive Breast Cancer
Jules Bordet Institute
 2025-05-12 PHASE2
NCT07451431 RECRUITING
Diabetic Peripheral Neuropathic Pain (DPNP)
Bangladesh Medical University
 2025-10-01 PHASE4
NCT07421427 RECRUITING
Amantadine; Duloxetine; Pregabalin; Mastectomy; Pain Syndrome
Cairo University
 2026-02-21
NCT04724252 RECRUITING
Pain, Postoperative
University of California, Davis
 2021-08-23 PHASE2; PHASE3
NCT04860141 RECRUITING
Dental Pain and Sensation Disorder; Pain, Postoperative
Loma Linda University
 2021-06-16 PHASE4
NCT06766916 RECRUITING
Neuropathic Pain
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2025-05-07 PHASE2
NCT07777965 RECRUITING
Healthy Non-dependent, Recreational Sedative Users
Viatris Inc.
 2026-06-18 PHASE4
NCT07750639 ENROLLING_BY_INVITATION
Opioid Abuse (Disorder); Opioid Analgesia; Opioid Analgesic Adverse Reaction; Opioid Consumption
AdventHealth
 2024-08-01 PHASE4
NCT07377721 RECRUITING
Diabetic Peripheral Neuropathic Pain
Shandong Suncadia Medicine Co., Ltd.
 2026-03-24 PHASE1
NCT05995535 RECRUITING
Opiate Withdrawal Syndrome; Opioid Use
University of Pennsylvania
 2024-01-01 PHASE2
NCT05302999 RECRUITING
Spinal Cord Injuries
MetroHealth Medical Center
 2022-03-14 PHASE4
NCT06328062 RECRUITING
Pain Postoperative; Osteoarthritis; Total Knee Arthroplasty
Thammasat University Hospital
 2024-04-01
NCT04267003 RECRUITING
Schizophrenia
University of California, Davis
 2020-01-09
NCT07593313 RECRUITING
Central Post-Stroke Pain
Nanchong Central Hospital
 2024-01-01
NCT07606638 ENROLLING_BY_INVITATION
Oral Cancer; Oral Cavity Cancer; Oral Squamous Cell Carcinoma (OSCC)
Mayo Hospital Lahore
 2026-02-01
NCT06790537 RECRUITING
Diabetic Pruritus; Efficacy of Pregabalin in Controlling Diabetic Pruritus Severity
Post Graduate Institute of Medical Education and Research, Chandigarh
 2025-04-17 PHASE4
NCT06997016 ENROLLING_BY_INVITATION
Postoperative Pain
Baylor Research Institute
 2025-05-05 PHASE4
NCT05640453 RECRUITING
Pregabalin; Delirium Treatment; Coronary Artery Bypass Grafting; Dexmedetomidine
Tanta University
 2022-12-15 PHASE4
NCT06464172 NOT_YET_RECRUITING
GABAergic System
Francois Corbin
 2025-05-05
NCT07382921 NOT_YET_RECRUITING
Fibromyalgia; Pregabalin; Pain
Beijing Tiantan Hospital
 2026-01-30
NCT04619862 UNKNOWN
Pain; Neuropathic Pain; Irritability
University of British Columbia
 2021-05-15 PHASE2
NCT06379425 RECRUITING
Pain, Postoperative; Postoperative Pain, Acute
Northwell Health
 2024-03-01 PHASE4
NCT06887998 NOT_YET_RECRUITING
Emergence Agitation
Cairo University
 2025-03 PHASE3
NCT05156060 RECRUITING
Head and Neck Cancer; Locally Advanced Head and Neck Carcinoma
Natalie Lockney
 2022-01-24 PHASE1; PHASE2
NCT05478382 UNKNOWN
Postoperative Pain; Pregabalin; Spine Surgery; Adverse Reaction to Pregabalin
Ajou University School of Medicine
 2022-10 PHASE4
NCT03498261 ACTIVE_NOT_RECRUITING
Pain, Postoperative; Opioid Use
Ohio State University
 2018-01-30 PHASE1
NCT04613024 WITHDRAWN
Weight Loss; Pain, Postoperative
Stanford University
 2025-07-01 EARLY_PHASE1
NCT06155916 RECRUITING
Neuropathic Pain; Insomnia; Sleep Disorder
Helsinki University Central Hospital
 2022-11-22
NCT06864520 RECRUITING
Climacteric Symptoms; Hot Flashes
Ospedale Policlinico San Martino
 2023-10-25
NCT07708948 COMPLETED
Fibromyalgia Syndrome
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
 2024-01-01 PHASE4
NCT05076110 COMPLETED
Hip Arthroscopy
Mayo Clinic
 2022-04-07 PHASE4
NCT07477288 COMPLETED
Skin Aging
Hasanuddin University
 2025-03-12 PHASE2
NCT07349680 COMPLETED
Postherpetic Neuralgia
Assiut University
 2023-03-15 PHASE3
NCT06893172 NOT_YET_RECRUITING
Postherpetic Neuralgia ( PHN )
University of Medicine and Pharmacy at Ho Chi Minh City
 2025-04-01
NCT06969417 RECRUITING
Herpes Zoster (HZ); Post Herpetic Neuralgia (PHN)
CMH Kharian Medical College
 2025-04-10
NCT04322305 SUSPENDED
Alcohol Use Disorder
New York State Psychiatric Institute
 2021-01-11 PHASE2
NCT06705101 NOT_YET_RECRUITING
Elective Surgical Patients; Blood Pressure
Liaquat National Hospital & Medical College
 2024-12-15 PHASE1; PHASE2
NCT05965492 WITHDRAWN
Spinal Disorder
University of Miami
 2024-06-01 PHASE3
NCT06833203 COMPLETED
Amantadine; Pregabalin; Post-thoracotomy Pain Syndrome
Cairo University
 2023-12-01
NCT05804591 UNKNOWN
Obesity; Postoperative Pain; Postoperative Nausea and Vomiting; Opioid Use
Medical University of Warsaw
 2023-04-24 PHASE4
NCT06781489 COMPLETED
Carpal Tunnel Syndrome
Universidad Europea de Madrid
 2025-02-19 PHASE4
NCT05935059 COMPLETED
Post-mastectomy Pain Syndrome
National Cancer Institute, Egypt
 2023-06-21
NCT04004416 COMPLETED
Schizophrenia; Bipolar Disorder; Healthy; Psychosis; Schizophreniform Disorders; Schizo Affective Disorder; Major Depression With Psychotic Features
University of Michigan
 2020-01-16 PHASE4
NCT06357260 UNKNOWN
Trigeminal Neuralgia
Postgraduate Institute of Dental Sciences Rohtak
 2024-04-01
NCT06794021 COMPLETED
Healthy; Menopause
Olly, PBC
 2025-01-21
NCT05658887 COMPLETED
Pelvic Organ Prolapse; Perioperative/Postoperative Complications
Joseph Kowalski
 2023-01-01 PHASE4
NCT05795478 UNKNOWN
Chronic Post Operative Pain; Oxycodone; Pregabalin; Postoperative Complications
Beijing Tiantan Hospital
 2023-10-24
NCT05488847 ACTIVE_NOT_RECRUITING
Shoulder Arthropathy; Shoulder Pain
Henry Ford Health System
 2022-06-25 PHASE4
NCT04865042 COMPLETED
Radiculopathy of Lumbosacral Spine Due to Disc Disorder
Lille Catholic University
 2022-02-02 PHASE4
NCT04429347 COMPLETED
Insomnia Due to Medical Condition; Chronic Pain
University of California, San Diego
 2020-07-29 PHASE2
NCT06755489 COMPLETED
Diarrhoea Predominant Irritable Bowel Syndrome
University of Pisa
 2023-04-17
NCT05829148 UNKNOWN
Endoscopic Sinus Surgery
Egymedicalpedia
 2023-05-01 EARLY_PHASE1
NCT06401499 UNKNOWN
Back Pain Lower Back Chronic
Muhammad Ilyas
 2024-06-01 PHASE4
NCT06600607 COMPLETED
Pain Detection; Pain Threshold
Latigo Biotherapeutics
 2024-10-07 EARLY_PHASE1
NCT05510856 COMPLETED
Oncology
Tanta University
 2022-09-01 PHASE4
NCT04705480 COMPLETED
Analgesics; Gabapentin; Injuries; Narcotics; Pain; Trauma
CAMC Health System
 2021-04-12 PHASE4
NCT06346522 COMPLETED
Catheter-related Bladder Discomfort (CRBD)
Ain Shams University
 2024-04-10 PHASE4
NCT06300346 UNKNOWN
Emetic Attacks During Caesarean Delivery With Spinal Anesthesia
Sohag University
 2024-03-01
NCT06271486 COMPLETED
Postdural Puncture Headache
Al-Azhar University
 2024-02-28 PHASE3
NCT04144933 UNKNOWN
Anesthesia; General Anesthesia; Analgesics, Opioid; Opioid Free Anesthesia; Postoperative Ileus; Colorectal Surgery; Laparoscopic Surgery; Analgesia; Dexmedetomidine; Lidocaine; Ketamine
University of Saskatchewan
 2021-05-15 PHASE3
NCT03689114 COMPLETED
Epilepsies, Partial
Mario Negri Institute for Pharmacological Research
 2021-05-10 PHASE4
NCT03216187 TERMINATED
Persistent Postoperative Pain
Benno Rehberg-Klug
 2018-01-09 PHASE3
NCT06077786 COMPLETED
Healthy Participants
H. Lundbeck A/S
 2023-10-13 PHASE1
NCT05389813 UNKNOWN
Anesthesia
An-Najah National University
 2021-08-15 PHASE2; PHASE3
NCT06261450 Not yet recruiting
Fragile X Syndrome
Université de Sherbrooke|Canadian Institutes of Health Research (CIHR)|Jazz Pharmaceuticals|Centre de recherche du Centre hospitalier universitaire de Sherbrooke
 2024-04-01 Phase 2
NCT06381479 Recruiting
Stress|Sleep Disorder
National Taiwan Sport University|Bened Biomedical Co. Ltd.
 2024-04-19 Not Applicable
NCT06361368 Not yet recruiting
Insomnia
National Yang Ming University|Bened Biomedical Co. Ltd.
 2024-04 Not Applicable
NCT05800847 UNKNOWN
Rotator Cuff Tears
Hughston Clinic
 2023-04 PHASE4
NCT06057233 Not yet recruiting
Epilepsy Temporal Lobe
University Hospital Grenoble|Université Grenoble-Alpes|Institut National de la Santé Et de la Recherche Médicale France
 2024-03 --
NCT05460871 TERMINATED
Osteo Arthritis Knee; Central Nervous System Sensitization
University of Iowa
 2023-02-21 PHASE4
NCT05248152 UNKNOWN
Postoperative Pain
University Medical Centre Ljubljana
 2022-01-13
NCT05160493 COMPLETED
Chronic Postsurgical Pain
Beijing Tiantan Hospital
 2021-12-20 PHASE2; PHASE3
NCT04855578 COMPLETED
Polypharmacy; Gabapentin; Pregabalin
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2021-05-28
NCT05699876 UNKNOWN
Anxiety, Preoperarative
All India Institute of Medical Sciences
 2023-01-15
NCT05933486 UNKNOWN
Fibromyalgia Syndrome
Quan Jiang
 2023-09 PHASE4
NCT06025474 UNKNOWN
Burning Mouth Syndrome
Federico II University
 2023-01-01 PHASE3
NCT02560766 UNKNOWN
RLS
XenoPort, Inc.
 2016-02 PHASE4
NCT05427474 UNKNOWN
Traumatic Brain Injury
Zagazig University
 2022-12-01 PHASE3
NCT05447364 COMPLETED
Knee Osteoarthritis
Thammasat University
 2021-07-01 PHASE4
NCT06112223 COMPLETED
Gabapentin; Tramadol; Postoperative Pain; Knee Arthroscopy; Spinal Anesthesia
Tanta University
 2023-04-01
NCT04218240 COMPLETED
Opioid Withdrawal
University of Pennsylvania
 2020-12-17 PHASE2
NCT04662125 COMPLETED
Analgesia
Zagazig University
 2020-12-10
NCT05494437 COMPLETED
Cannabis Withdrawal
PleoPharma, Inc.
 2022-10-27 PHASE2
NCT04122196 COMPLETED
Kidney Stone; Pain, Postoperative; Addiction; Opioid Use
University of Missouri-Columbia
 2020-06-01 PHASE2; PHASE3
NCT04772547 COMPLETED
Status Epilepticus, Electrographic; Coma
University of Florida
 2021-09-22 PHASE2
NCT05254652 UNKNOWN
Osteoarthritis
The Catholic University of Korea
 2022-05
NCT05322681 UNKNOWN
Osteoarthritis
The Catholic University of Korea
 2022-05
NCT05626998 COMPLETED
Anesthesia
Ain Shams University
 2022-11-01 PHASE4
NCT02849457 COMPLETED
Tuberous Sclerosis Complex
Martina Bebin
 2016-12 PHASE2
NCT05324059 COMPLETED
Neuropathic Pain
Laboratorios Silanes S.A. de C.V.
 2022-07-11 PHASE3
NCT03928093 COMPLETED
Pain, Neuropathic; Itch; Epidermolysis Bullosa
The Hospital for Sick Children
 2019-08-07 PHASE3
NCT04015908 COMPLETED
Opioid Use
University of Utah
 2019-08-01 PHASE4
NCT05100160 WITHDRAWN
Thoracic; Pulmonary Disease
M.D. Anderson Cancer Center
 2021-09-15 PHASE3
NCT05432843 UNKNOWN
Globus Sensation
Universitaire Ziekenhuizen KU Leuven
 2010-03-12 PHASE4
NCT04847245 UNKNOWN
Chronic Visceral Pain; Major Depressive Disorder
Peking University
 2021-05-01
NCT05292066 UNKNOWN
Diabetic Peripheral Neuropathic Pain
Aga Khan University
 2022-10 EARLY_PHASE1
NCT02642484 UNKNOWN
Liver Cirrhosis
Tanta University
 2018-12 PHASE3
NCT03220776 COMPLETED
Alcohol Use Disorder; Bipolar Disorder
Medical University of South Carolina
 2017-08-07 PHASE2
NCT03794388 COMPLETED
Breast Cancer Patient
Institut Cancerologie de l'Ouest
 2019-03-19 PHASE3
NCT03423264 WITHDRAWN
Oropharyngeal Cancer; HPV-Related Squamous Cell Carcinoma
University of Chicago
 2018-01-22 PHASE2
NCT05539924 UNKNOWN
Opioid Use
Research Institute of Ophthalmology, Egypt
 2022-09-15 PHASE3
NCT04862572 COMPLETED
Tinnitus; Hearing Loss
University of Nottingham
 2021-08-09
NCT05442931 UNKNOWN
Functional Endoscopic Sinus Surgery
Minia University
 2022-05-01 PHASE1; PHASE2
NCT04939987 WITHDRAWN
Radical Prostatectomies
Wake Forest University Health Sciences
 2022-08 PHASE2; PHASE3
NCT04517110 TERMINATED
Opioid Use
Hamilton Health Sciences Corporation
 2021-04-09 PHASE3
NCT03867240 WITHDRAWN
Pain, Postoperative; Scoliosis Idiopathic
Emory University
 2019-06 PHASE3
NCT03589898 COMPLETED
Autism Spectrum Disorder
University of Massachusetts, Worcester
 2017-09-14 EARLY_PHASE1
NCT03747562 WITHDRAWN
Head Neck Cancer; Radiation Neuropathy; Pain, Neuropathic
University Hospital, Ghent
 2019-03-01 PHASE3
NCT05096468 COMPLETED
Esketamine; Pregabalin; Acute Postoperative Pain; Neurosurgical Procedures; Perioperative Complication; Spinal Cord Neoplasms
Beijing Tiantan Hospital
 2021-12-01 PHASE2; PHASE3
NCT04818450 COMPLETED
Sleep Deprivation; Critically Ill
Mahidol University
 2021-04-19
NCT04429022 COMPLETED
Pain, Postoperative
State University of New York at Buffalo
 2020-11-24 PHASE3
NCT05221151 COMPLETED
Anxiety
Menoufia University
 2022-01-30 PHASE4
NCT04802967 COMPLETED
No Condition
Dompé Farmaceutici S.p.A
 2021-02-08 PHASE1
NCT04660773 UNKNOWN
Refractory Uremic Pruritis
Alexandria University
 2021-08-01 PHASE2
NCT05172570 TERMINATED
Thoracotomy; Pain, Postoperative
Indiana University
 2021-04-06 PHASE3
NCT05413902 COMPLETED
Pain Management; Posterior Spinal Fusion
University of Puerto Rico
 2021-04-05 PHASE4
NCT02884908 COMPLETED
PTSD; Alcohol Use Disorder
University of Maryland, Baltimore
 2017-07-07 PHASE3
NCT04246619 TERMINATED
Painful Diabetic Peripheral Neuropathy
KRKA
 2019-11-12 PHASE4
NCT03806530 COMPLETED
End Stage Renal Disease; Restless Legs Syndrome
Population Health Research Institute
 2019-05-01 PHASE3
NCT01678586 COMPLETED
Pain
Massachusetts General Hospital
 2012-12
NCT03346668 COMPLETED
Scarring Alopecia; Frontal Fibrosing Alopecia; Lichen Planopilaris; Central Centrifugal Cicatricial Alopecia; Central Centrifugal Scarring Alopecia
University of Minnesota
 2016-01-28 EARLY_PHASE1
NCT04641273 TERMINATED
Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
Bayer
 2021-01-22 PHASE2
NCT04303468 COMPLETED
Prediabetes; Hypertension
Wageningen University
 2020-09-29
NCT05037994 COMPLETED
Pain, Shoulder
Zagazig University
 2021-04-01
NCT05071118 COMPLETED
Anesthesia
Ain Shams University
 2021-03-21 PHASE4
NCT04782310 UNKNOWN
Postoperative Pain
Cairo University
 2021-03-10 PHASE4
NCT03205423 COMPLETED
Opioid-use Disorder; Alcohol Use Disorder
New York State Psychiatric Institute
 2017-08-01 PHASE2
NCT03462641 COMPLETED
Parkinson Disease
University of Michigan
 2018-03-09 PHASE1; PHASE2
NCT04246697 COMPLETED
Head and Neck Cancer; Analgesia
University of Kansas Medical Center
 2019-11-01 PHASE4
NCT03347526 SUSPENDED
Infantile Spasm
University of Colorado, Denver
 2018-04-19 PHASE3
NCT05024825 TERMINATED
Pain, Postoperative
Albany Medical College
 2017-08-04 PHASE4
NCT04599894 COMPLETED
Pain, Postoperative; Arthroplasty, Replacement, Knee; Arthroplasty, Replacement, Hip
The First Hospital of Jilin University
 2020-11-01 PHASE4
NCT03574792 COMPLETED
Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8
Roswell Park Cancer Institute
 2018-05-03 PHASE2
NCT04329585 UNKNOWN
Moderate Sedation; Colonoscopy
National Taiwan University Hospital
 2020-03-25
NCT03012815 COMPLETED
Alcohol Withdrawal Syndrome
Mayo Clinic
 2017-02-01 PHASE4
NCT04622202 UNKNOWN
Anxiety State; Sedation
Zagazig University
 2020-11-15 PHASE1; PHASE2
NCT03084536 COMPLETED
Breast Cancer; Breast Cancer Female; Cancer of Breast
Washington University School of Medicine
 2017-06-07 PHASE2
NCT05455944 COMPLETED
Dacryocystitis
Sameh Fathy
 2020-01-01
NCT04148846 UNKNOWN
Headache, Post-Dural Puncture
University of Sao Paulo General Hospital
 2019-09-20
NCT04523935 COMPLETED
Cerebral Palsy; Excessive Crying; Pain
Sathbhavana Brain Clinic
 2005-12-07 PHASE4
NCT03123861 COMPLETED
Pelvic Organ Prolapse
University of North Carolina, Chapel Hill
 2017-06-01 PHASE4
NCT03820193 COMPLETED
Meniscus Disorder; Narcotic Use
Henry Ford Health System
 2019-01-22 EARLY_PHASE1
NCT03749642 COMPLETED
Painful Diabetic Neuropathy
Aziende Chimiche Riunite Angelini Francesco S.p.A
 2018-11-22 PHASE2
NCT07644065 COMPLETED
Impacted Third Molar; Postoperative Pain; Neuroinflammation; Anxiety
Plovdiv Medical University
 2019-09-30
NCT04653792 COMPLETED
Pain, Nerve; Prolapsed Intervertebral Disc
Ziauddin University
 2018-06-04 PHASE4
NCT02927405 WITHDRAWN
Postoperative Pain
State University of New York - Downstate Medical Center
 2020-03-04 PHASE4
NCT01511640 COMPLETED
Cannabis-use Disorders
Joshua A. Lile, Ph.D.
 2017-02-01 EARLY_PHASE1
NCT03418623 COMPLETED
Alcohol Use Disorder
Laboratorio Farmaceutico Ct S.r.l.
 2018-03-08 PHASE2
NCT04434430 COMPLETED
Non-obstetric Lower Abdominal Surgery
Indonesia University
 2019-11-11 PHASE1; PHASE2
NCT04181346 UNKNOWN
Nausea
Faculdade de Medicina do ABC
 2019-09-01 PHASE2
NCT00351611 COMPLETED
Epilepsies, Partial
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2006-07-26 PHASE4
NCT03825809 RECRUITING
Narcotic Use
Henry Ford Health System
 2019-01-22 PHASE2; PHASE3
NCT04068506 COMPLETED
Hand Injuries
Dow University of Health Sciences
 2019-09-01 PHASE4
NCT03229668 COMPLETED
Pregabalin on Catheter Related Bladder Discomfort
Saint Savvas Anticancer Hospital
 2017-07-28 PHASE2; PHASE3
NCT02737826 COMPLETED
Chronic Pain; Opioid Pain Medication
Medical University of South Carolina
 2016-05
NCT04086108 COMPLETED
GABA Plasmakinetics
Wageningen University
 2019-11-04
NCT02205879 COMPLETED
Alcoholism
St. Petersburg Bekhterev Research Psychoneurological Institute
 2013-01 PHASE4
NCT02160301 WITHDRAWN
Post Operative Pain Control
University of North Carolina, Chapel Hill
 2017-11 PHASE4
NCT04025203 COMPLETED
Carpal Tunnel Syndrome
Francisco Unda Solano
 2019-08-01 PHASE4
NCT03708237 TERMINATED
Restless Legs Syndrome; End Stage Renal Disease
University of Alberta
 2019-02-19 PHASE2
NCT03735368 COMPLETED
Conscious Sedation
Abd-Elazeem Abd-Elhameed Elbakry
 2018-12-10 PHASE2
NCT03927781 COMPLETED
Nephrolithiasis; Urolithiasis; Perioperative/Postoperative Complications; Pain, Postoperative; Pain, Acute; Anesthesia; Urologic Diseases; Anesthesia Morbidity
University of Missouri-Columbia
 2019-04-01 PHASE3
NCT03809702 COMPLETED
Herpes Zoster
B.P. Koirala Institute of Health Sciences
 2018-07-15 PHASE4
NCT02987985 COMPLETED
Anesthesia; General Anesthesia; Analgesics, Opioid; Postoperative Complications; Pathologic Processes; Physiologic Effects of Drugs; Narcotics; Analgesics; Sleep Disordered Breathing; Obstructive Sleep Apnea of Child; Tonsillectomy; Respiratory Depression; Dexmedetomidine; Ketamine; Lidocaine; Gabapentin; Pulse Oximetry
University of Saskatchewan
 2017-10-15 PHASE3
NCT03619785 UNKNOWN
Rib Fractures; Rib Fracture Multiple
Andrew A Herring
 2018-11-06 PHASE4
NCT01463306 COMPLETED
Epilepsy, Partial Seizures; Epilepsy, Primary Generalized Tonic-Clonic Seizures
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2012-02-21 PHASE3
NCT01846182 TERMINATED
Gulf War Illness
VA Office of Research and Development
 2015-06-24 PHASE2
NCT03472469 COMPLETED
Nonspecific Pain Post Traumatic Injury
The University of Texas Health Science Center, Houston
 2018-04-02 PHASE4
NCT03334721 COMPLETED
Bipolar I Disorder; Bipolar II Disorder; Cannabis Use Disorder; Substance Use Disorders
Medical University of South Carolina
 2017-10-01 PHASE2
NCT03496389 UNKNOWN
Muscle Weakness; Anterior Cruciate Ligament Rupture
Hospital Authority, Hong Kong
 2018-07-01 PHASE2; PHASE3
NCT03910088 COMPLETED
Post-Dural Puncture Headache
Cairo University
 2019-04-20 PHASE4
NCT03566394 UNKNOWN
Invasive Breast Cancer; Chemotherapeutic Toxicity; Myalgia; Arthralgia
British Columbia Cancer Agency
 2018-07-02 PHASE2; PHASE3
NCT03942796 COMPLETED
Chronic Post-thoracotomy Pain
Mansoura University
 2018-01-01
NCT02722603 TERMINATED
Chronic Pain
Pharmaceutical Research Management srl
 2018-09-12 PHASE3
NCT03256253 COMPLETED
Alcohol Use Disorder
New York State Psychiatric Institute
 2018-02-15 PHASE2
NCT03584074 UNKNOWN
Spinal Stenosis Lumbar
Seoul National University Bundang Hospital
 2018-07-01 PHASE4
NCT03635905 COMPLETED
Pain
Medstar Health Research Institute
 2017-05-26 PHASE4
NCT03521167 UNKNOWN
Cardiac Surgery
Shanghai Zhongshan Hospital
 2018-05-01
NCT03334903 COMPLETED
Knee Osteoarthritis; Knee Pain Chronic; Opioid Use; Opioid Dependence
Brigham and Women's Hospital
 2018-05-15 PHASE4
NCT02299115 WITHDRAWN
Infantile Spasms
The Hospital for Sick Children
 2017-09-05 PHASE3
NCT03473093 UNKNOWN
Fracture; Rib, Multiple
Assiut University
 2018-03 EARLY_PHASE1
NCT03211728 COMPLETED
Anterior Cruciate Ligament (ACL) Reconstruction
Yonsei University
 2017-07-19
NCT05389150 COMPLETED
Healthy
Laboratorios Silanes S.A. de C.V.
 2019-01-17 PHASE1
NCT01789216 COMPLETED
Orthopaedic Fractures
Major Extremity Trauma Research Consortium
 2013-07 PHASE3
NCT03232021 WITHDRAWN
Pregabalin on Catheter Related Bladder Discomfort
Saint Savvas Anticancer Hospital
 2017-08-16 PHASE2; PHASE3
NCT02924675 TERMINATED
Earache
University Hospital, Lille
 2015-06-05 PHASE2
NCT04308954 TERMINATED
Fragile X Syndrome (FXS); Idiopathic Intellectual Developmental Disorder (IDD)
Stanford University
 2016-11-01 PHASE1
NCT02701764 COMPLETED
Dry Eye
University of Miami
 2016-07-26 PHASE2; PHASE3
NCT03080493 COMPLETED
Abortion, Induced; Cervical Preparation; Pain
University of California, Davis
 2017-03-20 PHASE4
NCT01776671 UNKNOWN
Pain; Quality of Life
Chicago Anesthesia Pain Specialists
 2013-02 PHASE3
NCT00611572 COMPLETED
Cognitive Dysfunction
Yale University
 2007-01 PHASE1
NCT03712475 COMPLETED
Diabetic Peripheral Neuropathy; Fibromyalgia; Partial Seizure Disorder
Yung Shin Pharm. Ind. Co., Ltd.
 2018-01-19 PHASE4
NCT01967381 COMPLETED
Methamphetamine Abuse; Methamphetamine Dependence
University of Kentucky
 2013-10 EARLY_PHASE1
NCT02464813 COMPLETED
Scoliosis; Spondylolisthesis
Turku University Hospital
 2015-08-01 PHASE4
NCT03681574 COMPLETED
Pain, Postoperative; Agitation States as Acute Reaction to Exceptional Stress; Anesthesia; Vomiting
Hospital Infantil Albert Sabin
 2017-07-01 PHASE4
NCT02944656 COMPLETED
Pain
Emory University
 2016-12-08 PHASE4
NCT02531906 COMPLETED
Head and Neck Squamous Cell Carcinoma; Pain; Stomatitis
Roswell Park Cancer Institute
 2015-04-24 PHASE1
NCT03088306 COMPLETED
Lumbar Spinal Stenosis; Lumbar Spinal Instability; Lumbar Spine Degeneration
Johns Hopkins University
 2017-07-01 EARLY_PHASE1
NCT03047278 COMPLETED
Neuropathic Pain; Type 2 Diabetes Mellitus; Diabetic Neuropathy, Painful
Natalia Valadares de Moraes
 2015-11-01 PHASE4
NCT02985216 COMPLETED
Peripheral Neuropathic Pain
Yuhan Corporation
 2017-02-07 PHASE3
NCT02771925 TERMINATED
Alcohol Dependence
Dayanand Medical College and Hospital
 2016-06 PHASE4
NCT04292171 COMPLETED
Pain Control
University of Nevada, Las Vegas
 2017-05-01 EARLY_PHASE1
NCT02355886 COMPLETED
Bladder Carcinoma
University of Washington
 2015-04-22 PHASE2; PHASE3
NCT01271660 COMPLETED
Muscle Cramp; Liver Cirrhosis
Seoul National University Boramae Hospital
 2011-07 PHASE3
NCT01506453 COMPLETED
Acute Lymphoblastic Leukemia; Neuropathy; Neuropathic Pain
St. Jude Children's Research Hospital
 2012-01-24 PHASE2
NCT01940224 COMPLETED
Postoperative Pain
Larissa University Hospital
 2013-07
NCT02455726 UNKNOWN
Peripheral Arterial Disease
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
 2015-09
NCT01868425 COMPLETED
Pain
University of Wisconsin, Madison
 2013-04 PHASE4
NCT03603626 WITHDRAWN
Post-operative Analgesia; CSOM - Chronic Suppurative Otitis Media
Dhulikhel Hospital
 2015-09
NCT03347916 UNKNOWN
Emergence Agitation After Desflurane Anesthesia
Kuwait Specialized Eye Center
 2017-01-05
NCT03186443 UNKNOWN
Herpetic Neuralgia
Second Affiliated Hospital of Guangzhou Medical University
 2017-10-01 PHASE3
NCT02155257 COMPLETED
Osteoarthritis
Wake Forest University Health Sciences
 2014-07 PHASE4
NCT03302208 COMPLETED
Hysterectomy
Nesrine El-Refai
 2017-06-29 PHASE3
NCT02330094 COMPLETED
Aneurysmal Subarachnoid Hemorrhage
Mayo Clinic
 2014-12 PHASE4
NCT02999724 UNKNOWN
Pelvic Organ Prolapse
Mount Sinai Hospital, Canada
 2017-01 PHASE3
NCT00885586 COMPLETED
Herpes Zoster; Postherpetic Neuralgia; Pain
Dominik Irnich
 2008-11 PHASE4
NCT02703259 COMPLETED
Pain, Postoperative
Christiana Care Health Services
 2016-06 PHASE4
NCT02763930 COMPLETED
Hypertension
Laval University
 2016-02
NCT02374567 TERMINATED
Dementia; Depression; Schizophrenia; Psychosomatic Disorders; Anxiety Disorders
Hannover Medical School
 2015-01 PHASE3
NCT02926573 COMPLETED
Head and Neck Cancer; Acute Pain; Postoperative Pain
Washington University School of Medicine
 2016-06-24 PHASE4
NCT03407430 TERMINATED
Breast Cancer; Lymphoma; Pain
UNC Lineberger Comprehensive Cancer Center
 2016-01-27 PHASE2
NCT03151213 COMPLETED
Hepatocellular Cancer
Sherief Abd-Elsalam
 2017-01 PHASE4
NCT02605187 COMPLETED
Postoperative Pain
Stanford University
 2015-11
NCT02417935 COMPLETED
Diabetic Peripheral Neuropathic Pain
Eli Lilly and Company
 2015-04 PHASE4
NCT02402543 COMPLETED
Hemorrhoids; Fissure in Ano; Rectal Fistula; Anal Condyloma
University of Vermont
 2014-06
NCT02672202 TERMINATED
Post-operative Chronic Pain
Rambam Health Care Campus
 2016-02
NCT02954484 COMPLETED
Pain, Postoperative
National University Hospital, Singapore
 2015-04 PHASE3
NCT02076893 TERMINATED
Pain
Children's Hospitals and Clinics of Minnesota
 2014-03 PHASE4
NCT02187471 COMPLETED
Pain Associated With Fibromyalgia
Daiichi Sankyo
 2015-01-16 PHASE3
NCT03023501 COMPLETED
Postoperative Complications
King Saud University
 2014-03 PHASE2
NCT02639533 COMPLETED
Fibromyalgia
Hospital de Clinicas de Porto Alegre
 2014-12 PHASE2; PHASE3
NCT02794298 COMPLETED
Healthy Young Adults
Charite University, Berlin, Germany
 2016-04
NCT01496690 COMPLETED
Schizophrenia; Anxiety-comorbidity to Schizophrenia
University of Aarhus
 2012-01 PHASE4
NCT02600247 UNKNOWN
Osteoarthritis
The Catholic University of Korea
 2015-11
NCT02311777 WITHDRAWN
Phantom Pain
University of Texas Southwestern Medical Center
 2015-05-15 PHASE3
NCT02783183 COMPLETED
Peripheral Nueropathy Pain
Yuhan Corporation
 2016-06 PHASE1
NCT02617121 UNKNOWN
Postoperative Nausea and Vomiting
Hallym University Medical Center
 2015-11
NCT02187159 COMPLETED
Pain Associated With Fibromyalgia
Daiichi Sankyo
 2014-11 PHASE3
NCT02867176 COMPLETED
Pain
Instituto de Oftalmología Fundación Conde de Valenciana
 2016-01 PHASE4
NCT01067144 TERMINATED
Pain; Breast Cancer; Lung Cancer
Stanford University
 2010-05 PHASE3
NCT02530580 COMPLETED
Healthy
University College, London
 2016-02 PHASE1
NCT02557945 TERMINATED
Clinical High Risk for Psychosis
New York State Psychiatric Institute
 2015-08-01 PHASE1; PHASE2
NCT02372578 TERMINATED
Painful Diabetic Peripheral Neuropathy (PDPN)
Astellas Pharma Global Development, Inc.
 2015-05-27 PHASE2
NCT02690506 COMPLETED
Block
Kyungpook National University Hospital
 2016-02
NCT01893632 TERMINATED
Benzodiazepine Dependence
New York State Psychiatric Institute
 2013-07 PHASE2
NCT02783638 COMPLETED
Peripheral Neuropathy Pain
Yuhan Corporation
 2016-01 PHASE1
NCT01819675 TERMINATED
Stroke; Hemiplegia
Seoul National University Bundang Hospital
 2013-03
NCT02127853 UNKNOWN
Hyperalgesia
Seoul National University Hospital
 2014-07 PHASE4
NCT01701921 COMPLETED
Postoperative Pain
Larissa University Hospital
 2011-07 PHASE2; PHASE3
NCT01680549 COMPLETED
Postoperative Pain
Texas Tech University Health Sciences Center
 2012-09 PHASE4
NCT01821430 TERMINATED
Chronic Pain
Georgetown University
 2013-03 PHASE2
NCT02240199 COMPLETED
Post-mastectomy Pain Syndrome; Chronic Post-surgical Pain
McMaster University
 2014-11 PHASE3
NCT02466191 COMPLETED
Pendular Nystagmus; Oculopalatal Tremor
Hospices Civils de Lyon
 2015-06 PHASE4
NCT01801189 COMPLETED
Post-operative Pain
Legacy Health System
 2013-02 PHASE4
NCT03179345 COMPLETED
Healthy
Depomed
 2015-09-24 PHASE4
NCT02599701 TERMINATED
Sleep
Associação Fundo de Incentivo à Pesquisa
 2015-09 PHASE4
NCT02419443 UNKNOWN
Peripheral Nerve Disorder Associated With Repair of Hernia
United States Naval Medical Center, San Diego
 2011-08 PHASE4
NCT02135198 COMPLETED
Healthy
University College, London
 2014-09 PHASE1
NCT02215252 COMPLETED
Diabetic Neuropathy, Painful
Pfizer
 2014-11-10 PHASE2
NCT01966679 COMPLETED
Autism Spectrum Disorder
University of California, Los Angeles
 2013-10 PHASE2
NCT02099006 COMPLETED
Female Genital Diseases
University of Rochester
 2013-11 PHASE2; PHASE3
NCT01928381 COMPLETED
Diabetic Neuropathy, Painful; Diabetic Neuropathies
AstraZeneca
 2013-11 PHASE2
NCT02349607 COMPLETED
Healthy
Pfizer
 2015-01 PHASE1
NCT01585207 COMPLETED
Tourette's Disorder
Barbara J. Coffey
 2012-07 PHASE1; PHASE2
NCT01528540 COMPLETED
Chronic Pancreatitis
Asian Institute of Gastroenterology, India
 2012-04
NCT01781884 UNKNOWN
Type 1 Diabetes
Huashan Hospital
 2013-01
NCT01486706 COMPLETED
Urinary Urgency; Urinary Frequency; Nocturia; Incontinence; Detrusor Uninhibited Activity; Quality of Life
Michael E. Chua
 2010-10 PHASE2; PHASE3
NCT01450163 COMPLETED
Pain; Neuropathic Pain; Polyneuropathy
University of Sao Paulo
 2011-08 PHASE3
NCT02327000 COMPLETED
Healthy
GL Pharm Tech Corporation
 2014-10 PHASE1
NCT01563224 COMPLETED
No Condition; Brain GABA-B Function
Imperial College London
 2013-07
NCT01270828 COMPLETED
Post Herpetic Neuralgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2011-03 PHASE3
NCT02138500 COMPLETED
Healthy
Pfizer
 2014-05 PHASE1
NCT01904097 UNKNOWN
Fibromyalgia; Chronic Pain
Hospital de Clinicas de Porto Alegre
 2013-03 PHASE2
NCT01638273 COMPLETED
Healthy
GL Pharm Tech Corporation
 2014-02 PHASE1
NCT01441531 WITHDRAWN
Tourniquet-induced Pain; Tourniquet-induced Hypertension
Baylor College of Medicine
 2012-01 EARLY_PHASE1
NCT02233777 COMPLETED
Healthy
Dexa Medica Group
 2014-06
NCT01479556 UNKNOWN
Neuropathic Pain; Spinal Cord Injuries
Julian Taylor Green
 2011-12 PHASE4
NCT01489631 COMPLETED
Total Knee Arthroplasty
St. Antonius Hospital
 2013-03
NCT01332149 COMPLETED
Diabetic Neuropathy, Painful
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2011-07 PHASE3
NCT01397006 WITHDRAWN
Fibromyalgia
Newton-Wellesley Hospital
 2011-09 PHASE4
NCT01688947 COMPLETED
Postherpetic Neuralgia; Pain
Purdue Pharma LP
 2012-09 PHASE2
NCT01455428 COMPLETED
Postherpetic Neuralgia ( PHN )
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2011-12 PHASE4
NCT00221338 COMPLETED
Postoperative Delirium; Postoperative Pain; Opioid Use; Hospital Length of Stay
University of California, San Francisco
 2006-01 PHASE3
NCT01637077 COMPLETED
Pain; Peripheral Neuropathy
Academic and Community Cancer Research United
 2012-01 PHASE2
NCT01668667 COMPLETED
Restless Legs Syndrome
XenoPort, Inc.
 2012-06 PHASE4
NCT01116583 COMPLETED
Pain, Postoperative
University of Aarhus
 2011-05 PHASE3
NCT01904487 COMPLETED
Alcoholism
Rajesh Narendran
 2011-04-19 PHASE1
NCT00448916 COMPLETED
Epilepsies, Partial
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-05 PHASE3
NCT01413711 WITHDRAWN
Infantile Spasms
Lundbeck LLC
 2012-06 PHASE4
NCT05436886 COMPLETED
Healthy Volunteers; Bioequivalence Study
University of Karachi
 2013-06-28
NCT01770964 UNKNOWN
Diabetes Mellitus; Painful Distal Symmetric Sensorimotor Polyneuropathy
Analgesic Solutions
 2012-12 PHASE4
NCT01432236 COMPLETED
Fibromyalgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2011-10 PHASE3
NCT00537940 COMPLETED
Epilepsy; Partial Seizure Disorder; Epilepsies, Partial; Complex Partial Seizure Disorder
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2008-02 PHASE4
NCT01808300 COMPLETED
Healthy
Unimed Pharmaceuticals
 2013-02 PHASE1
NCT01612832 UNKNOWN
To Assess the Beneficial Preemptive and Preventive Effects of PGL on the Immediate and Late (1- and 3 Months) Postoperative Analgesia Requirements
Tel-Aviv Sourasky Medical Center
 2012-06
NCT01603394 TERMINATED
Postherpetic Neuralgia
Pfizer
 2012-10 PHASE4
NCT01504412 COMPLETED
Pain; Diabetic Peripheral Neuropathy
Daiichi Sankyo Co., Ltd.
 2012-01 PHASE2
NCT00403780 TERMINATED
Critical Limb Ischemia; Arterial Occlusive Disease; Pain; Ischemia
Karolinska Institutet
 2006-06 PHASE4
NCT01561508 WITHDRAWN
Diabetes Mellitus
University of Alabama at Birmingham
 2012-06 PHASE2
NCT01480765 COMPLETED
Pain; Hyperalgesia; Chronic Illness; Neuropathic Pain
Barts & The London NHS Trust
 2011-12-12 PHASE4
NCT01333956 COMPLETED
Primary Total Knee Arthroplasty
Hospital for Special Surgery, New York
 2011-05 PHASE1; PHASE2
NCT01047488 UNKNOWN
Polyneuropathy
Odense University Hospital
 2010-02 PHASE4
NCT01298466 WITHDRAWN
Low Back Pain; Neuralgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2012-02 PHASE4
NCT01266291 TERMINATED
Complex Partial Seizures
University of Pennsylvania
 2010-08 PHASE4
NCT01268631 UNKNOWN
Fibromyalgia
Tel-Aviv Sourasky Medical Center
 2011-01
NCT02103686 COMPLETED
Healthy
IlDong Pharmaceutical Co Ltd
 2012-11 PHASE1
NCT01116531 WITHDRAWN
Diabetic Polyneuropathy; Postherpetic Neuralgia
Turku University Hospital
 2010-04 PHASE4
NCT01309074 WITHDRAWN
Epilepsy; Anxiety
Rush University Medical Center
 2009-11 PHASE4
NCT01391858 COMPLETED
Post-operative Pain
University of Texas Southwestern Medical Center
 2006-12 PHASE3
NCT00437281 COMPLETED
Epilepsies, Partial
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-04 PHASE1; PHASE2
NCT01281202 COMPLETED
Cocaine Addiction; Cocaine Dependence
Catalyst Pharmaceuticals, Inc.
 2011-01 PHASE2; PHASE3
NCT03031340 TERMINATED
Spinal Fusion
Montefiore Medical Center
 2012-05 PHASE3
NCT00954187 TERMINATED
Postoperative Pain
Loma Linda University
 2009-11
NCT01485185 COMPLETED
Pain, Neuropathic
GlaxoSmithKline
 2011-10-11 PHASE1
NCT01271933 COMPLETED
Fibromyalgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2011-03 PHASE3
NCT00291148 COMPLETED
Neuropathic Pain; Multiple Sclerosis
University of Manitoba
 2006-03 PHASE3
NCT00879021 TERMINATED
Spinal Cord Trauma; Pain
Nova Scotia Health Authority
 2009-09 PHASE3
NCT01359085 UNKNOWN
Pain
Tel-Aviv Sourasky Medical Center
 2011-06
NCT00629889 COMPLETED
Brain and Central Nervous System Tumors; Seizure
Dr Andrea Rossetti
 2008-02 PHASE2
NCT01726205 COMPLETED
Post-thoracotomy Pain
Attikon Hospital
 2008-10 PHASE4
NCT00537238 COMPLETED
Partial Seizures
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-10 PHASE3
NCT00967135 COMPLETED
Neuropathic Pain
Centre hospitalier de l'Université de Montréal (CHUM)
 2010-06
NCT00611767 COMPLETED
Alcoholism
Yale University
 2005-11
NCT00624780 COMPLETED
Generalized Anxiety Disorder
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2009-05 PHASE4
NCT01314222 COMPLETED
Diabetic Peripheral Neuropathic Pain
Bristol-Myers Squibb
 2011-03 PHASE2
NCT01202227 COMPLETED
Spinal Cord Diseases; Spinal Cord Injuries; Neuralgia; Pain
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2010-09 PHASE3
NCT01419405 COMPLETED
Pain
Oslo University Hospital
 2011-12 PHASE4
NCT01057693 COMPLETED
Diabetic Neuropathy, Painful
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2010-03-31 PHASE3
NCT01352741 COMPLETED
Low Back Pain; Neuropathic Pain
Grünenthal GmbH
 2011-03 PHASE4
NCT01183312 COMPLETED
Hypersomnia; Primary Hypersomnia; Idiopathic Hypersomnia; Narcolepsy Without Cataplexy
Lynn Marie Trotti
 2010-09 PHASE1; PHASE2
NCT00596466 COMPLETED
Epilepsy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2008-04 PHASE3
NCT01529190 COMPLETED
Pain
Federal University of São Paulo
 2011-03 PHASE2
NCT01262092 COMPLETED
Opioid Dependence; Opioid Withdrawal; Opioid Detoxification
University of Arkansas
 2010-10 PHASE2
NCT01450345 UNKNOWN
Inguinal Hernia; Postoperative Pain
University of Malaya
 2009-09 PHASE3
NCT00785382 COMPLETED
Postoperative Pain
IWK Health Centre
 2009-01 PHASE4
NCT01370915 UNKNOWN
Deviated Nasal Septum
Samsung Medical Center
 2010-09
NCT01089556 COMPLETED
Diabetic Neuropathy, Painful
Eli Lilly and Company
 2010-03 PHASE3
NCT02120703 COMPLETED
Intervertebral Disc Prolapse
Aga Khan University
 2011-02 PHASE3
NCT01014533 COMPLETED
Alcohol Dependence; Insomnia
Dr. Kirk Brower
 2007-05
NCT01095679 COMPLETED
CHEYNE Stokes Respiration
Assistance Publique - Hôpitaux de Paris
 2010-03 PHASE1
NCT01420913 COMPLETED
Healthy
Yuhan Corporation
 2011-08 PHASE1
NCT01092520 WITHDRAWN
Pruritus
The Hospital for Sick Children
 2009-07 PHASE1
NCT00729690 COMPLETED
PAIN
Asokumar Buvanendran
 2008-08 PHASE3
NCT00991276 COMPLETED
Restless Legs Syndrome
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2009-12 PHASE3
NCT00934193 WITHDRAWN
Post-thoracotomy Pain
University of Kansas Medical Center
 2009-07 PHASE3
NCT01321671 COMPLETED
Healthy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2011-04 PHASE1
NCT01291524 COMPLETED
Healthy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2011-02 PHASE1
NCT00806026 COMPLETED
Idiopathic Restless Legs Syndrome
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2008-12 PHASE3
NCT00967707 COMPLETED
Post-traumatic Neuropathic Pain
Uppsala University
 2009-08 PHASE2
NCT00524030 TERMINATED
Epilepsies, Partial
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-09 PHASE3
NCT00611741 COMPLETED
Schizophrenia
Yale University
 2007-03 PHASE1
NCT00623285 UNKNOWN
Postoperative Pain.
University of Manitoba
 2008-04 PHASE3
NCT01168531 COMPLETED
Pain
Yonsei University
 2009-12
NCT01257516 COMPLETED
Healthy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2011-02 PHASE1
NCT01094808 COMPLETED
Healthy
Mayo Clinic
 2010-03 PHASE4
NCT00889148 COMPLETED
Postoperative Pain; Total Hip Replacement
McMaster University
 2007-10
NCT00493428 WITHDRAWN
Hepatocellular Carcinoma
University of Manitoba
 2007-07 PHASE2
NCT01058642 TERMINATED
Postherpetic Neuralgia
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
 2010-01 PHASE2
NCT00870454 COMPLETED
Diabetic Neuropathies
SK Life Science, Inc.
 2009-05 PHASE2
NCT00637975 COMPLETED
Cancer; Pain
Associazione Progetto Oncologia UMAN.A
 2007-09 PHASE2
NCT01094925 COMPLETED
Pain
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2010-04
NCT01202422 COMPLETED
Healthy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2010-10 PHASE1
NCT00584376 COMPLETED
Essential Tremor
University of South Florida
 2007-12 PHASE4
NCT00852436 TERMINATED
Neuropathic Pain; Orofacial Pain
University of Toronto
 2009-02 PHASE2
NCT00381095 TERMINATED
Bone Neoplasms; Pain, Intractable; Cancer
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2006-12 PHASE4
NCT01177514 COMPLETED
Pain After Photorefractive Keratectomy
Codet Vision Institute
 2010-04 PHASE4
NCT00772291 COMPLETED
Chronic Pain
Erasmus Medical Center
 2007-05 PHASE3
NCT01573052 COMPLETED
Alcohol Withdrawal
VA Salt Lake City Health Care System
 2004-03 PHASE4
NCT00740571 UNKNOWN
Cancer; Neuralgia
Radboud University Medical Center
 2008-09 PHASE3
NCT00883740 COMPLETED
Fibromyalgia; Sleep Disorders
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2009-06 PHASE3
NCT00581685 COMPLETED
Osteoarthritis
Sunnybrook Health Sciences Centre
 2008-01 PHASE3
NCT00593463 COMPLETED
Drug Dependence
University of Arkansas
 2006-09 PHASE1
NCT00312260 COMPLETED
Pain
The Hospital for Sick Children
 2006-04 PHASE3
NCT00468845 COMPLETED
Pain, Postoperative
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-06 PHASE3
NCT01061697 COMPLETED
Cervical Spondylosis; Cervical Spondylotic Myelopathy; Cervical Spondylotic Radiculopathy
Singapore General Hospital
 2008-01 PHASE4
NCT00638443 COMPLETED
Lumbar Spinal Stenosis
University of Rochester
 2008-03 PHASE4
NCT00644137 COMPLETED
Nicotine Dependence
Yale University
 2007-08 EARLY_PHASE1
NCT00982800 COMPLETED
Prostate Cancer
Sunnybrook Health Sciences Centre
 2007-06 PHASE4
NCT00588159 COMPLETED
Pain
Michelle Kinney
 2007-06
NCT00891397 TERMINATED
Complex Regional Pain Syndromes
McMaster University
 2007-11
NCT00684112 COMPLETED
Scoliosis
The Hospital for Sick Children
 2008-05 PHASE3
NCT00603473 COMPLETED
Epilepsies, Partial
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2008-01 PHASE3
NCT01107574 COMPLETED
Fibromyalgia
Good Samaritan Regional Medical Center, Oregon
 2004-04 PHASE3
NCT01009541 COMPLETED
Healthy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2009-11 PHASE1
NCT00378547 TERMINATED
Pain, Postoperative
Glostrup University Hospital, Copenhagen
 2006-01 PHASE4
NCT00797797 COMPLETED
Fibromyalgia
Forest Laboratories
 2008-11 PHASE3
NCT00735124 TERMINATED
Pain; Analgesia; Hernia, Inguinal
University of Oklahoma
 2008-11-06 PHASE2; PHASE3
NCT00905580 COMPLETED
Pain, Postoperative
Severance Hospital
 2009-05 PHASE4
NCT00385671 COMPLETED
Diabetic Neuropathy, Painful
Eli Lilly and Company
 2006-09 PHASE4
NCT00583869 COMPLETED
Post-operative Pain
University of Alabama at Birmingham
 2007-05 EARLY_PHASE1
NCT00391716 COMPLETED
Alcoholism; Alcohol Dependence
The Scripps Research Institute
 2004-02 PHASE2
NCT00793910 COMPLETED
Postoperative Pain
Walter Reed Army Medical Center
 2008-07
NCT00791739 COMPLETED
Fibromyalgia
Universidad de Granada
 2008-04 PHASE4
NCT00855738 COMPLETED
Focal Epilepsy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-05 PHASE4
NCT00551135 COMPLETED
Pain, Postoperative; Hernia, Inguinal
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2008-01 PHASE3
NCT00611130 COMPLETED
Cocaine Dependence
Catalyst Pharmaceuticals, Inc.
 2008-01 PHASE2
NCT00928954 COMPLETED
Nystagmus
Case Western Reserve University
 2005-02
NCT00654953 COMPLETED
Cocaine Dependence; Depressive Symptoms
University of Arkansas
 2006-01 PHASE2
NCT00353704 COMPLETED
Intervertebral Disk Displacement; Disk Prolapse
Asker & Baerum Hospital
 2005-11 PHASE4
NCT00370656 COMPLETED
Diabetes Mellitus; Peripheral Neuropathies
University of Surrey
 2007-02 PHASE2; PHASE3
NCT00676026 COMPLETED
Healthy
University of Pennsylvania
 2005-05
NCT00624455 COMPLETED
Post-operative Pain
University of British Columbia
 2007-07 PHASE3
NCT00663962 COMPLETED
Chronic Pain
Queen's University
 2008-04 PHASE4
NCT00573664 TERMINATED
Pain
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2007-11
NCT01119222 COMPLETED
Healthy
Pfizer
 2008-07 PHASE1
NCT01261260 COMPLETED
Healthy Male Subjects
Mclean Hospital
 2006-11 PHASE1
NCT00310765 TERMINATED
Abdominal Pain; Surgical Adhesions
Henry Ford Health System
 2006-03 PHASE4
NCT00407511 COMPLETED
Diabetic Peripheral Neuropathic Pain (DPN); Postherpetic Neuralgia (PHN); HIV-related Neuropathic Pain (HIV); Chemotherapy Induced Neuropathic Pain
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-01 PHASE4
NCT00681720 COMPLETED
Anxiety
AstraZeneca
 2008-02 PHASE1
NCT00626340 COMPLETED
Menopause; Depression
University of Pennsylvania
 1999-07 PHASE4
NCT00726999 COMPLETED
Postoperative Pain
Medical College of Wisconsin
 2006-06
NCT00395044 COMPLETED
Cannabis Dependence
The Scripps Research Institute
 2006-08 PHASE2
NCT00573261 COMPLETED
Diabetic Neuropathy
Duke University
 2006-03 PHASE4
NCT00555776 UNKNOWN
Subjective Tinnitus
Islamic Azad University of Mashhad
 2007-01 PHASE2
NCT00506935 COMPLETED
Methamphetamine Addiction
Baylor College of Medicine
 2006-07 PHASE1
NCT01210079 COMPLETED
Opioid-Induced Hyperalgesia
University of California, Los Angeles
 2002-09 PHASE2
NCT00380874 TERMINATED
Chemotherapy-Induced Peripheral Neuropathy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-01 PHASE4
NCT00346034 COMPLETED
Fibromyalgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2006-12 PHASE3
NCT00264875 COMPLETED
Peripheral Neuropathy; HIV Infections
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2006-02 PHASE3
NCT00219544 COMPLETED
Neuropathic Pain
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-11 PHASE3
NCT00262639 COMPLETED
Alcohol Dependence
Medical University of South Carolina
 2005-12 PHASE2; PHASE3
NCT00877019 COMPLETED
Toothbrushing
University of Erlangen-Nürnberg Medical School
 2007-08
NCT00288639 COMPLETED
Epilepsy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-12 PHASE4
NCT00584779 TERMINATED
PK Properties Of Gabapentin In Subjects With Impaired Renal Function
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2007-10 PHASE4
NCT00232141 COMPLETED
HIV Infections; Peripheral Neuropathy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-10 PHASE3
NCT00527683 COMPLETED
Cocaine Dependence
NYU Langone Health
 2007-04 PHASE2
NCT00027963 COMPLETED
Neurotoxicity; Pain
Alliance for Clinical Trials in Oncology
 2002-02 PHASE3
NCT00209495 COMPLETED
Pain, Postoperative
Glostrup University Hospital, Copenhagen
 2005-06 PHASE4
NCT01250561 COMPLETED
Herpes Zoster; Post-herpetic Neuralgia
Center for Clinical Studies, Texas
 2002-02
NCT00218374 COMPLETED
Hyperalgesia; Opioid-Related Disorders
National Institute on Drug Abuse (NIDA)
 2006-10
NCT00087399 COMPLETED
Breast Cancer; Hot Flashes
Alliance for Clinical Trials in Oncology
 2004-11 PHASE3
NCT00373581 TERMINATED
Cocaine Dependence
New York State Psychiatric Institute
 2006-04 PHASE2
NCT00352651 TERMINATED
Herpes Zoster; Postherpetic Neuralgia
University of California, San Francisco
 2006-06 PHASE2
NCT00142883 TERMINATED
Cocaine Abuse; Cocaine-Related Disorders
Yale University
 2004-09
NCT00755508 COMPLETED
Sleep Initiation and Maintenance Disorders
Takeda
 2005-11 PHASE2
NCT00778401 COMPLETED
Healthy
Ranbaxy Laboratories Limited
 2002-10
NCT00778271 COMPLETED
Healthy
Ranbaxy Laboratories Limited
 2002-09
NCT00229125 COMPLETED
Alcohol Withdrawal Syndrome(AWS)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
 2001-07 PHASE2
NCT00666796 COMPLETED
Insomnia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-04 PHASE4
NCT00159705 COMPLETED
Radiculopathy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-04 PHASE3
NCT00141427 COMPLETED
Seizures
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2004-11 PHASE4
NCT00629681 COMPLETED
Painful Diabetic Neuropathy and Post Herpetic Neuralgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2004-11 PHASE4
NCT00141336 COMPLETED
Seizure Disorder, Partial
Pfizer
 1999-11 PHASE3
NCT00150293 COMPLETED
Seizure Disorder, Partial
Pfizer
 2002-03 PHASE3
NCT00257270 COMPLETED
Tinnitus
Tinnitus Research Consortium
 2003-08 PHASE2
NCT00245609 COMPLETED
Dental Anxiety
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2006-01 PHASE2
NCT00643136 COMPLETED
Sleep Deprivation; Epilepsies, Partial
Pfizer
 2002-11 PHASE3
NCT00057278 COMPLETED
Fibromyalgia
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
 2003-03 PHASE2; PHASE3
NCT00666939 COMPLETED
Transient Insomnia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2004-10 PHASE3
NCT00150423 COMPLETED
Diabetic Neuropathy, Painful
Pfizer
 2001-01 PHASE3
NCT00141245 COMPLETED
Seizure Disorder, Partial
Pfizer
 1998-10 PHASE3
NCT00159666 COMPLETED
Post-Herpetic Neuralgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2004-10 PHASE4
NCT00159731 COMPLETED
Diabetic Peripheral Neuropathy
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-01 PHASE4
NCT00235261 COMPLETED
Pain; Postoperative
Glostrup University Hospital, Copenhagen
 2005-10 PHASE4
NCT00151489 COMPLETED
Fibromyalgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-04 PHASE3
NCT00112138 COMPLETED
Hot Flashes; Menopause
North Toronto Primary Care Research Network
 2004-03 PHASE3
NCT00310583 UNKNOWN
Tactile Hyperalgesia; Neuropathic Pain
Professional Associations Clinic Bergmannsheil
 2006-07 PHASE4
NCT00151528 COMPLETED
Fibromyalgia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-01 PHASE3
NCT00141414 COMPLETED
Epilepsy, Partial
Pfizer
 1997-11 PHASE2
NCT00150436 COMPLETED
Neuralgia
Pfizer
 2002-02 PHASE3
NCT00150449 COMPLETED
Anxiety Neuroses
Pfizer
 2001-01 PHASE3
NCT00018291 COMPLETED
Alzheimer's Disease; Dementia
US Department of Veterans Affairs
 2001-01
NCT00141401 COMPLETED
Diabetic Neuropathy, Painful
Pfizer
 1999-09 PHASE3
NCT00666575 COMPLETED
Transient Insomnia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2004-12 PHASE3
NCT00674752 COMPLETED
Transient Insomnia
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2006-03 PHASE3
NCT00143156 COMPLETED
Diabetic Neuropathies
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
 2005-03 PHASE3
NCT00209872 UNKNOWN
Planned Abdominal Hysterectomy
Hvidovre University Hospital
 2005-10 PHASE4
NCT00141375 COMPLETED
Neuropathic Pain
Pfizer
 2002-08 PHASE3
NCT00189072 TERMINATED
Chronic Neuropathic Pain
UMC Utrecht
 2003-04 PHASE4

(data from https://clinicaltrials.gov, updated on 2025-07-30)

Check the 4-Aminobutyric acid (GABA) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

4-Aminobutyric acid acts as the principal inhibitory neurotransmitter in the central nervous system by binding to ionotropic and metabotropic GABA receptors, which promotes chloride influx or potassium efflux to hyperpolarize the neuronal membrane and diminish action potential firing. This suppression of excessive synaptic excitation dampens central nervous system hyperactivation, providing the physiological basis for its therapeutic investigation in neurological and pain disorders such as temporal lobe epilepsy, insomnia, and post-thoracotomy pain.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.