Home Peptide Products GsMTx4

research use only

GsMTx4

Cat.No.P1205

GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.

Amino-acid Sequence

GsMTx4 Amino-acid Sequence

CAS No. 1209500-46-8

Selleck's GsMTx4 Has Been Cited by 11 Publications

Quality Control

Batch: Purity: 99.82%
99.82

Chemical Information & Solubility

Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

Water : 100 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description GsMTx4 (Grammostola spatulata mechanotoxin 4, M-theraphotoxin-Gr1a, M-TRTX-Gr1a) is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families.
Targets/IC50/Ki
MSCs

In vitro
In vitro

Pretreatment of GsMTx4 and BAPTA-AM suppress the Yoda1-induced accumulation of HIF-1alpha, NFATC1, and NFATC3 proteins and also suppress Yoda1-induced VEGF-A expression at the mRNA and protein levels.
Cell Research Cell lines BMDMs, RAW264.7 cells
Concentrations 5, 10 µM
Incubation Time 30 min
Method

To study the effect of mechanical stretching, BMDMs or RAW264.7 cells were treated with Yoda1, with or without pretreatment with inhibitors for 30 min. The inhibitors included cyclosporin A, FK506, echinomycin, GsMTx4, BAPTA-AM and RN-1734. In some experiments, BMDMs were treated with GSK1016790A.

(Data sourced from selleck products)

References
  • https://pubmed.ncbi.nlm.nih.gov/28076814/
  • https://pubmed.ncbi.nlm.nih.gov/35198061/
  • https://pubmed.ncbi.nlm.nih.gov/36455360/
  • https://pubmed.ncbi.nlm.nih.gov/35775626/

Product Information

Molecular Formula

C185H273N49O45S6
Molecular Weight 4095.86
CAS No. 1209500-46-8
Appearance White Powder
Peptide Content (by %N) ≥80%
Single Impurity (by HPLC) ≤1.0%
Assay (By Anhydrous, Acetic Acid-free) 95.0~105.0%
MS Consistent
Packing plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage
(From the date of receipt)		 3 years-20°C powder
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)