Etanercept Clinical Trials

Size	Price	Qty
1mg	USD 397
5mg	USD 990

Clinical Trials

Etanercept has been evaluated in numerous clinical trials investigating a broad spectrum of autoimmune, inflammatory, and hematologic conditions, including rheumatoid arthritis, juvenile idiopathic arthritis, plaque psoriasis, graft versus host disease, and Alzheimer's disease. These investigations span Early Phase 1 through Phase 4 studies, such as a completed Phase 4 trial examining aggressive intervention in juvenile idiopathic arthritis (NCT00443430) and a recruiting Phase 1 trial exploring safety in Alzheimer's disease (NCT06585384). Sponsorship is distributed across academic medical centers, government health agencies like the National Institute of Allergy and Infectious Diseases, and major pharmaceutical corporations including Amgen and Pfizer. Trial recruitment statuses encompass completed, recruiting, active not recruiting, and terminated studies across diverse patient populations.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07352566	NOT_YET_RECRUITING	Psoriasis; Atopic Dermatitis	University of California, San Francisco	2026-08-01	PHASE4
NCT06011889	RECRUITING	SAPHO Syndrome	National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland	2024-09-04	PHASE2; PHASE3
NCT06585384	RECRUITING	Alzheimer Disease	Fondation Ophtalmologique Adolphe de Rothschild	2025-04-15	PHASE1
NCT03414502	RECRUITING	Rheumatoid Arthritis	University of Nebraska	2007-12-10	PHASE3
NCT07138898	RECRUITING	Rheumatic Disease	NYU Langone Health	2025-12-12	PHASE2
NCT03294954	RECRUITING	Neuroblastoma	Baylor College of Medicine	2018-01-18	PHASE1
NCT07184853	RECRUITING	Graft vs Host Disease	First Affiliated Hospital of Zhejiang University	2025-09-25
NCT06707194	RECRUITING	Spondyloarthritis (SpA); Ankylosing Spondylitis (AS)	Nanfang Hospital, Southern Medical University	2025-06-14	PHASE4
NCT04585711	WITHDRAWN	Juvenile Idiopathic Arthritis; Rheumatoid Arthritis; Obesity	Duke University	2026-07-01	PHASE1
NCT05950724	ENROLLING_BY_INVITATION	Lung Transplant; Complications	Northwestern University	2023-09-17	EARLY_PHASE1
NCT04066348	RECRUITING	Tinnitus, Noise Induced	Wayne State University	2022-07-01	PHASE2
NCT07386587	ENROLLING_BY_INVITATION	Juvenile Idiopathic Arthritis	University of Child Health Sciences and Children's Hospital, Lahore	2026-01-27	PHASE3
NCT02987257	COMPLETED	Stevens-Johnson Syndrome; Toxic Epidermal Necrolyses	Vanderbilt University Medical Center	2023-03-21	PHASE3
NCT06596772	RECRUITING	Rheumatoid Arthritis (RA)	mAbxience Research S.L.	2024-10-03	PHASE3
NCT04254627	COMPLETED	Gulf War Illness	Nova Southeastern University	2021-09-24	PHASE1
NCT06392074	COMPLETED	Healthy Volunteers	mAbxience Research S.L.	2024-03-07	PHASE1
NCT03997786	ACTIVE_NOT_RECRUITING	Moderate-to-severe Chronic Plaque Psoriasis	Sun Pharmaceutical Industries Limited	2020-01-15	PHASE2; PHASE3
NCT03976245	RECRUITING	Rheumatoid Arthritis	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	2020-03-01	PHASE4
NCT03728478	RECRUITING	Oligoarthritis, Juvenile; Polyarthritis, Juvenile, Rheumatoid Factor Negative	Istituto Giannina Gaslini	2019-05-29	PHASE3
NCT05164198	UNKNOWN	Ankylosing Spondylitis; Axial Spondyloarthritis	Hanyang University Seoul Hospital	2022-01-15	PHASE4
NCT04610476	UNKNOWN	Psoriatic Arthritis; Withdrawal; Reduction	University of Erlangen-Nürnberg Medical School	2020-10-19	PHASE3
NCT03182426	COMPLETED	Diabetes Mellitus, Type 1	University of Alberta	2017-08-15	PHASE1; PHASE2
NCT01793519	UNKNOWN	Rheumatoid Arthritis	Georgetown University	2013-01	PHASE4
NCT04485325	COMPLETED	Rheumatic Arthritis	Dr. Frank Behrens	2019-11-04	PHASE4
NCT05281614	COMPLETED	Type 1 Diabetes	Benaroya Research Institute	2022-09-21	EARLY_PHASE1
NCT02144857	UNKNOWN	Psoriasis	University of Athens	2014-05-30	PHASE4
NCT03451851	ACTIVE_NOT_RECRUITING	Psoriasis	Janssen Research & Development, LLC	2018-07-11	PHASE3
NCT02713997	COMPLETED	Pancreatitis, Chronic; Diabetes; Transplant	University of Minnesota	2016-12	PHASE4
NCT03792841	TERMINATED	Metastatic Castration-resistant Prostate Cancer; Prostate Cancer	Amgen	2019-02-05	PHASE1
NCT03813771	UNKNOWN	Rheumatoid Arthritis	University of Leeds	2019-03	PHASE4
NCT04082910	UNKNOWN	Solid Tumor; Hematological Malignancy	Chinese PLA General Hospital	2019-09-15	PHASE1; PHASE2
NCT02258282	UNKNOWN	Psoriasis	Chengdu PLA General Hospital	2014-05
NCT02464878	COMPLETED	Kidney Transplant; Type 1 Diabetes	Massachusetts General Hospital	2017-01	PHASE2
NCT05135312	UNKNOWN	Psoriasis; Psoriatic Arthritis; Psoriatic Nail	OptiSkin Medical	2021-08-09	PHASE4
NCT03649061	COMPLETED	Arthritis, Rheumatoid	P. Verschueren	2018-06-08	PHASE4
NCT04973566	COMPLETED	Healthy	Janssen Research & Development, LLC	2021-08-31	PHASE1
NCT01865630	WITHDRAWN	Subarachnoid Hemorrhage, Aneurysmal	Unity Health Toronto	2021-01	PHASE1
NCT04079374	UNKNOWN	Rheumatoid Arthritis	Joint Stock Company "Farmak"	2018-09-03	PHASE3
NCT03100253	TERMINATED	Rheumatoid Arthritis	Mario Negri Institute for Pharmacological Research	2018-03-01	PHASE4
NCT04077957	UNKNOWN	Ankylosing Spondylitis; Spondyloarthritis	Nanfang Hospital, Southern Medical University	2019-10-07	PHASE4
NCT03636373	TERMINATED	Gout Attack	Rutgers, The State University of New Jersey	2019-10-25	PHASE4
NCT02374021	COMPLETED	Arthritis, Rheumatoid	Brigham and Women's Hospital	2016-07	PHASE4
NCT01421069	COMPLETED	Juvenile Idiopahtic Arthritis	Pfizer	2011-10-10	PHASE3
NCT01602302	TERMINATED	Rheumatoid Arthritis	Medical University of Graz	2012-06	PHASE4
NCT02092467	COMPLETED	Arthritis, Rheumatoid	Pfizer	2014-03-14	PHASE4
NCT02373813	COMPLETED	Rheumatoid Arthritis	Amgen	2015-02-20	PHASE3
NCT02878161	UNKNOWN	Rheumatoid Arthritis	Fen Li	2016-01	PHASE4
NCT02821026	COMPLETED	Type 1 Diabetes	University of Alberta	2016-05	PHASE1; PHASE2
NCT02840175	COMPLETED	Juvenile Idiopathic Arthritis	Assistance Publique - Hôpitaux de Paris	2017-05-18	PHASE3
NCT03827876	RECRUITING	Psoriasis	Psoriasis Treatment Center of Central New Jersey	2019-01-16	PHASE4
NCT04255498	UNKNOWN	Gulf War Illness; Persian Gulf Syndrome; Occupational Diseases	South Florida Veterans Affairs Foundation for Research and Education	2017-10-30	PHASE1
NCT03504072	UNKNOWN	Spondyloarthritis	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	2018-01-16	PHASE4
NCT02509026	COMPLETED	Spondylitis, Ankylosing	Pfizer	2015-09-24	PHASE4
NCT02464033	COMPLETED	Diabetes Mellitus, Type 1	Johnny Ludvigsson	2015-05	PHASE2
NCT03073200	COMPLETED	Plaque Psoriasis	Eli Lilly and Company	2017-03-28	PHASE3
NCT02471144	COMPLETED	Chronic Severe Plaque-type Psoriasis	Novartis Pharmaceuticals	2015-09-29	PHASE3
NCT01610947	COMPLETED	Spondyloarthritis	University Hospital, Montpellier	2012-05-14
NCT03403140	UNKNOWN	Rheumatoid Arthritis	Gema Biotech S.A.	2016-10-06	PHASE3
NCT03160001	COMPLETED	Rheumatoid Arthritis (RA)	Faiq Gorial	2017-08-15	PHASE1; PHASE2
NCT02809781	UNKNOWN	Spondylitis; Spondylitis, Ankylosing; Ankylosis; Arthritis; Spondylarthritis; Spondylarthropathies; Spinal Diseases; Musculoskeletal Diseases; Bone Diseases	Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University	2016-06	PHASE2; PHASE3
NCT02313922	COMPLETED	Psoriasis	Zhejiang University	2014-11	PHASE4
NCT01936688	WITHDRAWN	Plaque-type Psoriasis	Sun Pharmaceutical Industries Limited	2013-09	PHASE3
NCT02376790	COMPLETED	Psoriatic Arthritis	Amgen	2015-03-03	PHASE3
NCT00841789	COMPLETED	Mucocutaneous Lymph Node Syndrome; Kawasaki Disease	Michael Portman	2009-03	PHASE2
NCT02656082	COMPLETED	Lupus Erythematosus, Discoid; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Chronic Cutaneous	University of Leeds	2016-02-01	PHASE2
NCT02999776	UNKNOWN	Psoriatic Plaque	Pantec Biosolutions AG	2016-11	PHASE1
NCT01971346	COMPLETED	Psoriasis	University of Michigan	2014-03-13	PHASE4
NCT02986139	COMPLETED	Arthritis, Rheumatoid; Arthritis, Psoriatic	Amgen	2016-11-29	PHASE3
NCT02749370	COMPLETED	Plaque Psoriasis	Amgen	2016-05-18	PHASE4
NCT03193203	COMPLETED	Healthy	Samsung Bioepis Co., Ltd.	2017-03-24	PHASE1
NCT03193957	COMPLETED	Rheumatoid Arthritis	Samsung Bioepis Co., Ltd.	2017-05-15	PHASE2
NCT02433184	COMPLETED	Rheumatoid Arthritis	University of Leeds	2011-07	PHASE4
NCT02722772	UNKNOWN	Osteoarthritis of Knee	First Affiliated Hospital of Harbin Medical University	2016-02
NCT02722811	UNKNOWN	Osteoarthritis Of Knee	First Affiliated Hospital of Harbin Medical University	2016-02
NCT03033095	COMPLETED	Spondylitis, Ankylosing	University Hospital, Grenoble	2016-07
NCT03273088	COMPLETED	Phase 1; Bioequivalence	AryoGen Pharmed Co.	2016-12-04	PHASE1
NCT03332719	COMPLETED	Rheumatoid Arthritis	Gema Biotech S.A.	2016-02	PHASE3
NCT02030613	COMPLETED	Juvenile Idiopathic Arthritis	Assistance Publique - Hôpitaux de Paris	2013-10-01
NCT02638896	UNKNOWN	Ankylosing Spondylitis	Zhixiang Huang	2016-01	PHASE4
NCT02308163	COMPLETED	Rheumatoid Arthritis	Astellas Pharma Inc	2014-08-08	PHASE3
NCT02701205	UNKNOWN	Plaque Psoriasis; Psoriasis	Shanghai Celgen Bio-Pharmaceutical Co.,Ltd	2015-01	PHASE3
NCT02109289	TERMINATED	Rheumatoid Arthritis; Vascular Inflammation	Innovaderm Research Inc.	2014-04	PHASE4
NCT02031211	WITHDRAWN	CRPS; Chronic Regional Pain Syndrome	Stanford University	2014-06
NCT02960035	COMPLETED	Spondyloarthropathy	Sun Yat-sen University	2014-04	PHASE4
NCT02364479	COMPLETED	Spondyloarthritis	Sun Yat-sen University	2014-02-10	PHASE4
NCT02378506	COMPLETED	Arthritis, Rheumatoid	Pfizer	2015-04	PHASE3
NCT02116504	UNKNOWN	Rheumatoid Arthritis; Juvenile Idiopathic Arthritis	Assistance Publique - Hôpitaux de Paris	2014-04
NCT01331837	COMPLETED	Rheumatoid Arthritis	Hoffmann-La Roche	2011-08-02	PHASE4
NCT02346240	COMPLETED	Psoriasis; Plaque Psoriasis	UCB Biopharma S.P.R.L.	2015-02-11	PHASE3
NCT01294397	TERMINATED	Postmenopausal; Osteopenia; Rheumatoid Arthritis; Osteoporosis	Amgen	2011-03	PHASE1
NCT01894412	COMPLETED	Healthy	Hanwha Chemical	2013-07	PHASE1
NCT02489760	UNKNOWN	Ankylosing Spondylitis	Chung Shan Medical University	2008-07	PHASE4
NCT01295151	COMPLETED	Rheumatoid Arthritis	Julia Brown	2011-08	PHASE4
NCT02274792	COMPLETED	Plaque Psoriasis	Amgen	2015-01	PHASE4
NCT01716637	COMPLETED	Alzheimer's Disease	Life Extension Foundation Inc.	2010-02	PHASE1
NCT02115750	COMPLETED	Rheumatoid Arthritis	Coherus Oncology, Inc.	2014-05	PHASE3
NCT01729754	COMPLETED	Plaque Psoriasis	Sun Pharmaceutical Industries Limited	2013-02-05	PHASE3
NCT01934933	COMPLETED	Ankylosing Spondylitis	Sun Yat-sen University	2014-09-24	PHASE4
NCT00784966	WITHDRAWN	Type 1 Diabetes Mellitus	Virginia Commonwealth University	2011-08	PHASE1; PHASE2
NCT02134210	COMPLETED	Plaque Psoriasis	Coherus Oncology, Inc.	2014-06-16	PHASE3
NCT04345458	COMPLETED	Ankylosing Spondylitis	Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.	2014-03-06	PHASE3
NCT00468117	COMPLETED	Type 1 Diabetes Mellitus	National Institute of Allergy and Infectious Diseases (NIAID)	2007-01	PHASE3
NCT01927757	TERMINATED	Moderate to Severe Rheumatoid Arthritis	Amgen	2013-05-06	PHASE4
NCT01900782	WITHDRAWN	Psoriasis	Novartis Pharmaceuticals	2013-10	PHASE3
NCT01543204	TERMINATED	Psoriasis	Amgen	2012-02-01	PHASE4
NCT02164214	COMPLETED	Inflammatory Rheumatism; Psoriatic Arthritis; Rheumatoid Arthritis	Assistance Publique Hopitaux De Marseille	2011-09	PHASE3
NCT01578850	COMPLETED	Rheumatoid Arthritis	Pfizer	2012-07	PHASE4
NCT01764997	TERMINATED	Rheumatoid Arthritis	Sanofi	2013-04	PHASE3
NCT01021735	COMPLETED	Rheumatoid Arthritis	University of Glasgow	2010-04	PHASE4
NCT01730495	TERMINATED	Chronic Fatigue Syndrome; Myalgic Encephalomyelitis	Haukeland University Hospital	2012-10	PHASE2
NCT01783015	TERMINATED	Rheumatoid Arthritis	Pfizer	2013-09	PHASE4
NCT00888628	COMPLETED	Diabetes Mellitus, Type I	Massachusetts General Hospital	2009-05	PHASE1; PHASE2
NCT01690299	COMPLETED	Psoriasis; Psoriatic Arthritis	Amgen	2012-10-01	PHASE3
NCT01372930	UNKNOWN	Myocardial Infarction	Xijing Hospital	2010-04	PHASE4
NCT02132234	UNKNOWN	Rheumatoid Arthritis; Psoriatic Arthritis; Ankylosing Spondylitis; Hypertension	Jagiellonian University	2013-06	PHASE4
NCT00967538	COMPLETED	Psoriasis	Innovaderm Research Inc.	2009-09	PHASE4
NCT01891864	COMPLETED	Chronic Stable Plaque Psoriasis	Sandoz	2013-06	PHASE3
NCT01646177	COMPLETED	Psoriasis	Eli Lilly and Company	2012-07-28	PHASE3
NCT00802815	COMPLETED	Inclusion Body Myositis	Washington University School of Medicine	2005-04	EARLY_PHASE1
NCT01895309	COMPLETED	Rheumatoid Arthritis	Samsung Bioepis Co., Ltd.	2013-06	PHASE3
NCT01597245	COMPLETED	Psoriasis	Eli Lilly and Company	2012-05-18	PHASE3
NCT01875991	COMPLETED	Rheumatoid Arthritis; Plaque Psoriasis	Amgen	2013-06-05	PHASE4
NCT01394913	WITHDRAWN	Rheumatoid Arthritis	EMS	2013-08	PHASE3
NCT01731457	COMPLETED	Transplanted Kidney Ischemia Reperfusion Injury	Medical University of Warsaw	2011-04	PHASE2
NCT01901185	COMPLETED	Rheumatoid Arthritis; Psoriatic Arthritis	Amgen	2013-06-11	PHASE3
NCT00477191	TERMINATED	Psoriasis; Metabolic Syndrome; Hyperlipidemia; Obesity; Hypertension	Massachusetts General Hospital	2007-05
NCT01068353	COMPLETED	Alzheimer's Disease	University of Southampton	2011-01	PHASE2
NCT00837434	COMPLETED	Rheumatoid Arthritis	National Institute of Allergy and Infectious Diseases (NIAID)	2009-03	PHASE4
NCT01170715	COMPLETED	Psoriasis	Rockefeller University	2010-07-13
NCT01989689	COMPLETED	PSORIASIS	Emory University	2010-08	PHASE2
NCT01000441	COMPLETED	Rheumatoid Arthritis	University Hospital, Strasbourg, France	2009-12-23	PHASE4
NCT01865552	COMPLETED	Healthy	Samsung Bioepis Co., Ltd.	2013-05	PHASE1
NCT01358578	COMPLETED	Chronic Plaque Psoriasis	Novartis Pharmaceuticals	2011-06	PHASE3
NCT00789308	COMPLETED	Diabetes Mellitus, Type I	National Institute of Allergy and Infectious Diseases (NIAID)	2008-07-11	PHASE2
NCT00726375	COMPLETED	Acute Graft Versus Host Disease	University of Michigan Rogel Cancer Center	2008-05	PHASE3
NCT00844142	UNKNOWN	Moderate to Severe Active Axial Spondyloarthritis	Charite University, Berlin, Germany	2005-11	PHASE2
NCT01004432	COMPLETED	Arthritis; Arthritis, Rheumatoid; Autoimmune Diseases	Janssen Biotech, Inc.	2009-12	PHASE3
NCT01657513	UNKNOWN	Psoriasis	University Hospital, Gentofte, Copenhagen	2012-06
NCT01725620	COMPLETED	Healthy	LG Life Sciences	2012-11	PHASE1
NCT00992394	COMPLETED	Psoriasis	Pfizer	2010-01	PHASE4
NCT00848354	COMPLETED	Rheumatoid Arthritis	Pfizer	2009-06	PHASE4
NCT01313208	COMPLETED	Rheumatoid Arthritis	Amgen	2011-03	PHASE4
NCT01241591	COMPLETED	Psoriasis	Pfizer	2010-11	PHASE3
NCT01298531	COMPLETED	Axial Spondyloarthritis	Pfizer	2011-05	PHASE4
NCT01313221	COMPLETED	Psoriasis	Amgen	2011-04	PHASE3
NCT00654368	COMPLETED	Rheumatoid Arthritis	Amgen	2008-06	PHASE4
NCT00808210	TERMINATED	Rheumatoid Arthritis	Genentech, Inc.	2009-03-05	PHASE2
NCT01258738	COMPLETED	Spondylitis, Ankylosing	Pfizer	2011-02	PHASE3
NCT00931957	UNKNOWN	Behcet Syndrome; Uveal Disease	Tehran University of Medical Sciences	2010-10
NCT00434811	COMPLETED	Type 1 Diabetes Mellitus	National Institute of Allergy and Infectious Diseases (NIAID)	2006-10	PHASE3
NCT01287715	UNKNOWN	Juvenile Idiopathic Arthritis	Erasmus Medical Center	2011-01	PHASE4
NCT01030120	WITHDRAWN	Chronic Idiopathic Urticaria	University of Utah	2010-12	PHASE2; PHASE3
NCT00913458	COMPLETED	Active Rheumatoid Arthritis; Arthritis, Rheumatoid; Rheumatoid Arthritis	Pfizer	2009-09	PHASE4
NCT00858780	COMPLETED	Rheumatoid Arthritis	Pfizer	2009-01	PHASE4
NCT01270997	COMPLETED	Rheumatoid Arthritis	Hanwha Chemical	2010-12	PHASE3
NCT00726804	TERMINATED	SPONDYLOARTHRITIS	Glostrup University Hospital, Copenhagen	2008-03	PHASE4
NCT01053819	COMPLETED	Psoriasis; Melanoma; Non-melanoma Skin Cancer	University of Alabama at Birmingham	2007-09	PHASE4
NCT01431404	COMPLETED	Healthy	Hanwha Chemical	2011-08	PHASE1
NCT01009879	WITHDRAWN	Rheumatoid Arthritis	University of Pittsburgh	2009-11	PHASE4
NCT00800982	COMPLETED	Psoriasis	University of California, San Francisco	2008-10
NCT00639717	COMPLETED	Graft Versus Host Disease	University of Michigan Rogel Cancer Center	2009-03	PHASE2
NCT00141921	COMPLETED	Pediatric Plaque Psoriasis	Amgen	2005-08-11	PHASE3
NCT01276847	COMPLETED	Psoriasis	Merck Sharp & Dohme LLC	2011-03	PHASE1
NCT00405275	COMPLETED	Rheumatoid Arthritis	US Department of Veterans Affairs	2007-07
NCT00825344	COMPLETED	Inguinal Hernia; Postoperative Pain	Johns Hopkins University	2009-01
NCT00910273	TERMINATED	Ankylosing Spondylitis	Pfizer	2009-07	PHASE4
NCT01235442	COMPLETED	Psoriasis	Amgen	2010-09	PHASE3
NCT00309907	COMPLETED	Accelerated Phase Chronic Myelogenous Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Chronic Myelogenous Leukemia; Childhood Myelodysplastic Syndromes; Chronic Phase Chronic Myelogenous Leukemia; de Novo Myelodysplastic Syndromes; Disseminated Neuroblastoma; Juvenile Myelomonocytic Leukemia; Previously Treated Childhood Rhabdomyosarcoma; Previously Treated Myelodysplastic Syndromes; Pulmonary Complications; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Neuroblastoma; Recurrent Wilms Tumor and Other Childhood Kidney Tumors; Recurrent/Refractory Childhood Hodgkin Lymphoma; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes	Children's Oncology Group	2006-04	PHASE2
NCT00434850	COMPLETED	Diabetes Mellitus, Type 1	National Institute of Allergy and Infectious Diseases (NIAID)	2006-10	PHASE2
NCT00789997	COMPLETED	COPD Exacerbation	Ottawa Hospital Research Institute	2008-11	PHASE2; PHASE3
NCT00141739	COMPLETED	Graft-Versus-Host Disease	University of Michigan Rogel Cancer Center	2004-08	PHASE2
NCT00962741	COMPLETED	Arthritis, Juvenile Idiopathic	Pfizer	2009-09	PHASE3
NCT00565409	COMPLETED	Arthritis, Rheumatoid	Pfizer	2008-03	PHASE4
NCT00797784	UNKNOWN	Discoid Lupus Erythematosus (DLE)	Florida Academic Dermatology Centers	2008-10	PHASE2
NCT00936065	COMPLETED	Moderate to Severe Psoriasis	Pfizer	2009-07	PHASE4
NCT00733096	COMPLETED	Lumbosacral Radiculopathy	Johns Hopkins University	2008-08	PHASE2; PHASE3
NCT01072058	UNKNOWN	Arthritis, Rheumatoid; Spondylitis, Ankylosing	University of Sao Paulo	2008-02	PHASE4
NCT00550030	COMPLETED	Psoriasis	Medical University of Graz	2006-08
NCT01132235	UNKNOWN	Psoriasis	Florida Academic Dermatology Centers	2010-04	PHASE4
NCT01001208	COMPLETED	Psoriasis	Amgen	2009-11	PHASE3
NCT01303874	COMPLETED	Rheumatoid Arthritis; Inflammatory Arthritis	University of Leeds	2006-09	PHASE4
NCT01237262	UNKNOWN	Moderate to Severe Psoriasis.; Absolute Number, Density of Immune Infiltrate and Dendritic Cells and Inflammatory Cytokines Expression Pattern.	University of Padova	2010-11	PHASE4
NCT00443430	COMPLETED	Juvenile Chronic Polyarthritis; Juvenile Idiopathic Arthritis; Juvenile Rheumatoid Arthritis	Seattle Children's Hospital	2007-05	PHASE4
NCT00796705	TERMINATED	Rheumatoid Arthritis	National Institute of Allergy and Infectious Diseases (NIAID)	2008-11	PHASE4
NCT00965666	COMPLETED	Fanconi Anemia	Children's Hospital Medical Center, Cincinnati	2005-10	EARLY_PHASE1
NCT02915354	COMPLETED	Spondylitis, Ankylosing; Recurrence	Sun Yat-sen University	2007-07	PHASE4
NCT00031551	TERMINATED	Stomatitis	National Institute of Nursing Research (NINR)	2002-03	PHASE2
NCT00445770	COMPLETED	Arthritis, Rheumatoid	Pfizer	2006-07	PHASE3
NCT00421174	COMPLETED	Pneumonia; Idiopathic Pneumonia Syndrome	National Heart, Lung, and Blood Institute (NHLBI)	2007-08	PHASE3
NCT00112385	COMPLETED	Dermatomyositis	Brigham and Women's Hospital	2006-03	PHASE1
NCT00783536	WITHDRAWN	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2008-11	PHASE4
NCT00768053	COMPLETED	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2008-10	PHASE4
NCT00832364	WITHDRAWN	Plaque Psoriasis	Stiefel, a GSK Company	2009-10	PHASE4
NCT00640393	COMPLETED	Psoriasis Vulgaris	Innovaderm Research Inc.	2008-04	PHASE4
NCT00833729	COMPLETED	Plaque Psoriasis	Dermatrials Research	2009-02	PHASE4
NCT00714493	COMPLETED	Rheumatoid Arthritis	Centocor Ortho Biotech Services, L.L.C.	2008-07	PHASE4
NCT00663052	COMPLETED	Plaque Psoriasis; Psoriasis	Pfizer	2008-06	PHASE4
NCT00791765	COMPLETED	Psoriasis	Amgen	2008-10	PHASE4
NCT00706797	TERMINATED	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2008-09	PHASE4
NCT00285779	TERMINATED	Lichen Planus	Stanford University	2006-08	PHASE2
NCT00581555	COMPLETED	Psoriasis	Pfizer	2007-10	PHASE4
NCT00686595	COMPLETED	Psoriasis	Merck Sharp & Dohme LLC	2007-10-01	PHASE4
NCT00413400	COMPLETED	Metabolic Syndrome	Massachusetts General Hospital	2006-12
NCT00581100	COMPLETED	Nail Psoriasis; Plaque Psoriasis	Wyeth is now a wholly owned subsidiary of Pfizer	2007-09	PHASE4
NCT00361634	COMPLETED	Rheumatoid Arthritis	Amgen	2006-09	PHASE1
NCT00332332	COMPLETED	Psoriasis	Amgen	2006-03	PHASE4
NCT00524381	COMPLETED	Polymyalgia Rheumatica	Bispebjerg Hospital	2007-08	PHASE3
NCT00259610	COMPLETED	Rheumatoid Arthritis	University of Alabama at Birmingham	2004-05	PHASE4
NCT00527072	COMPLETED	Psoriasis	Centocor Ortho Biotech Services, L.L.C.	2007-07	PHASE3
NCT00713544	COMPLETED	Rheumatoid Arthritis	AstraZeneca	2008-07	PHASE2
NCT00459706	COMPLETED	Rheumatoid Arthritis	Pfizer	2007-09	PHASE3
NCT00298272	TERMINATED	Rheumatoid Arthritis	Biogen	2006-05	PHASE2
NCT00482170	COMPLETED	Psoriasis	Pfizer	2007-09	PHASE3
NCT00710580	COMPLETED	Moderate to Severe Plaque Psoriasis	AbbVie (prior sponsor, Abbott)	2008-07	PHASE3
NCT00509600	TERMINATED	Leukemia	M.D. Anderson Cancer Center	2004-09	PHASE2
NCT00156247	COMPLETED	Psoriasis	University of Medicine and Dentistry of New Jersey	2005-09	PHASE2
NCT00432406	COMPLETED	Psoriatic Arthritis	Chinese University of Hong Kong	2006-05	PHASE4
NCT00691964	COMPLETED	Plaque Psoriasis	AbbVie (prior sponsor, Abbott)	2008-05	PHASE3
NCT00447265	TERMINATED	Lupus Nephritis	National Institute of Allergy and Infectious Diseases (NIAID)	2008-02	PHASE2
NCT00422227	COMPLETED	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2007-06	PHASE4
NCT00420238	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2007-01	PHASE4
NCT00224874	COMPLETED	Graft vs Host Disease; Immune System Disorders	National Heart, Lung, and Blood Institute (NHLBI)	2005-09	PHASE2
NCT00357903	COMPLETED	Rheumatoid Arthritis	Amgen	1997-04	PHASE3
NCT00356590	COMPLETED	Rheumatoid Arthritis	Amgen	1998-12	PHASE3
NCT00118287	COMPLETED	de Novo Myelodysplastic Syndromes; Previously Treated Myelodysplastic Syndromes; Secondary Myelodysplastic Syndromes	Fred Hutchinson Cancer Center	2005-04	PHASE1; PHASE2
NCT00688103	COMPLETED	Rheumatoid Arthritis	Japan Biological Agent Study Integrated Consortium	2005-06	PHASE4
NCT00410046	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2006-12	PHASE4
NCT00705042	COMPLETED	Healthy Subjects	Wyeth is now a wholly owned subsidiary of Pfizer	2008-07	PHASE1
NCT00927069	COMPLETED	Plaque Psoriasis	Innovaderm Research Inc.	2007-03	PHASE3
NCT00420303	COMPLETED	Spondylarthropathies, Enthesitis	Wyeth is now a wholly owned subsidiary of Pfizer	2007-01	PHASE4
NCT00107991	COMPLETED	Hidradenitis Suppurativa	University of Pennsylvania	2005-04	PHASE2
NCT00141726	COMPLETED	Lung Injury, Acute; Respiratory Distress Syndrome, Adult; Bronchiolitis Obliterans	University of Michigan Rogel Cancer Center	2003-10	PHASE2
NCT00873730	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2006-12	PHASE4
NCT00585650	COMPLETED	Psoriasis	University of California, Irvine	2007-05	PHASE1; PHASE2
NCT00245960	COMPLETED	Psoriatic Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2005-12-27	PHASE4
NCT00293202	TERMINATED	End Stage Renal Disease	Kaysen, George A., M.D., Ph.D.	2005-01	PHASE2
NCT00195494	COMPLETED	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2004-11	PHASE4
NCT00247962	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2005-12	PHASE4
NCT00454584	COMPLETED	Psoriasis	Centocor, Inc.	2007-03	PHASE3
NCT00418717	COMPLETED	Arthritis, Rheumatoid	Wyeth is now a wholly owned subsidiary of Pfizer	2007-02	PHASE3
NCT00364572	COMPLETED	Sciatica	Johns Hopkins University	2006-05	PHASE1; PHASE2
NCT00217386	COMPLETED	Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases	Fred Hutchinson Cancer Center	2004-03	PHASE2
NCT00678782	COMPLETED	Persistent Knee Joint Synovitis	University of Padova	2005-04	PHASE2
NCT00730392	COMPLETED	Type 1 Diabetes	State University of New York at Buffalo	2002-10	PHASE1; PHASE2
NCT00046904	COMPLETED	Anorexia; Cachexia; Unspecified Adult Solid Tumor, Protocol Specific	Mayo Clinic	2003-05	PHASE3
NCT00581165	COMPLETED	Psoriasis	Wyeth is now a wholly owned subsidiary of Pfizer	2006-02	PHASE4
NCT00413452	COMPLETED	Rheumatoid Arthritis	Amgen	2006-12	PHASE3
NCT00353119	COMPLETED	Palmoplantaris Pustulosis	Innovaderm Research Inc.	2006-04	PHASE3
NCT00162279	COMPLETED	Rheumatoid Arthritis	Bristol-Myers Squibb	2000-10	PHASE2
NCT00116181	COMPLETED	Psoriasis	Rockefeller University	2004-10	PHASE3
NCT00249041	COMPLETED	Rheumatoid Arthritis	Amgen	2005-10	PHASE3
NCT00141713	COMPLETED	Graft-Versus-Host Disease	University of Michigan Rogel Cancer Center	2003-10	PHASE2
NCT00201838	COMPLETED	Pancreatic Neoplasms; Adenocarcinoma	Ohio State University Comprehensive Cancer Center	2001-07	PHASE1; PHASE2
NCT00201682	COMPLETED	Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma	John Byrd	2002-10	PHASE1; PHASE2
NCT00161655	COMPLETED	Psoriasis; Arthritis, Psoriatic	Wyeth is now a wholly owned subsidiary of Pfizer	2005-04	PHASE4
NCT00356356	COMPLETED	Ankylosing Spondylitis	Amgen	2002-04	PHASE3
NCT00141791	COMPLETED	Asthma	Wyeth is now a wholly owned subsidiary of Pfizer	2005-05	PHASE2
NCT00346294	COMPLETED	Rheumatoid Arthritis	Amgen	2006-01	PHASE4
NCT00078819	COMPLETED	Psoriasis	Amgen	2004-09-08	PHASE3
NCT00110981	COMPLETED	Psoriasis	Amgen	2005-03	PHASE4
NCT00005853	COMPLETED	Leukemia; Myelodysplastic Syndromes	Fred Hutchinson Cancer Center	1999-12	PHASE2
NCT00127842	COMPLETED	Psoriatic Arthritis	Amgen	2005-08	PHASE4
NCT00111436	COMPLETED	Psoriasis	Amgen	2003-04	PHASE3
NCT00111956	COMPLETED	Metabolic Syndrome X	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2004-04	PHASE2; PHASE3
NCT00409318	COMPLETED	Metabolic Syndrome	Massachusetts General Hospital	2004-04
NCT00063869	COMPLETED	Pulmonary Fibrosis	Wyeth is now a wholly owned subsidiary of Pfizer		PHASE2
NCT02588534	COMPLETED	Healthy Men and Women	Amgen	2004-08	PHASE1
NCT00285233	COMPLETED	Type 1 Diabetes; Hypoglycemia	University of Minnesota	2000-09	PHASE1; PHASE2
NCT00078806	TERMINATED	Juvenile Rheumatoid Arthritis	Amgen	2001-06-04	PHASE3
NCT00205231	COMPLETED	HIV Infections	University of Wisconsin, Madison	2002-05
NCT00244556	COMPLETED	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2003-03	PHASE4
NCT00132418	COMPLETED	Rheumatoid Arthritis	Amgen	2000-04	PHASE4
NCT00201812	COMPLETED	Tumors	Ohio State University Comprehensive Cancer Center	2000-11	PHASE1
NCT02799498	COMPLETED	Healthy Men and Women	Amgen	2003-10	PHASE1
NCT01289743	UNKNOWN	Ankylosing Spondylitis	Charite University, Berlin, Germany	2002-02	PHASE2
NCT01289730	UNKNOWN	Spondyloarthritis	Charite University, Berlin, Germany	2002-02	PHASE2
NCT00005007	COMPLETED	Wegener's Granulomatosis	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	2000-06	PHASE2; PHASE3
NCT00035958	TERMINATED	Dermatomyositis	Children's Hospital Medical Center, Cincinnati	2002-08	PHASE2; PHASE3
NCT03781375	TERMINATED	Juvenile Rheumatoid Arthritis	Amgen	2000-08-24	PHASE3
NCT00317499	COMPLETED	Psoriatic Arthritis; Psoriasis	Amgen	2000-04	PHASE3
NCT03780959	COMPLETED	Juvenile Rheumatoid Arthritis	Amgen	1997-05-01	PHASE2; PHASE3
NCT00203320	COMPLETED	Alzheimer's Disease	Tobinick, Edward Lewis, M.D.	2005-04	PHASE1
NCT00434044	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2007-02	PHASE3
NCT00484237	COMPLETED	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2007-04	PHASE3
NCT00029328	COMPLETED	Respiratory Distress Syndrome, Adult; Bronchiolitis Obliterans; Pneumonia	FDA Office of Orphan Products Development	2001-09	PHASE1; PHASE2
NCT00195507	COMPLETED	Psoriasis	Wyeth is now a wholly owned subsidiary of Pfizer	2004-12	PHASE4
NCT00093366	COMPLETED	Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases	Fred Hutchinson Cancer Center	2004-06	PHASE1; PHASE2
NCT00444340	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2004-04	PHASE4
NCT00135720	COMPLETED	Pemphigus Vulgaris	Massachusetts General Hospital	2004-06	PHASE2
NCT00443950	COMPLETED	Arthritis, Rheumatoid	Wyeth is now a wholly owned subsidiary of Pfizer	2006-06	PHASE3
NCT00333034	COMPLETED	Psoriasis	Wyeth is now a wholly owned subsidiary of Pfizer	2006-06	PHASE3
NCT00134368	COMPLETED	Vitiligo	University of Medicine and Dentistry of New Jersey	2003-11	PHASE2
NCT00099554	COMPLETED	Rheumatoid Arthritis	Amgen	2004-05	PHASE4
NCT00121615	COMPLETED	Inflammation; Psoriasis	Amgen	2004-10	PHASE3
NCT00546533	COMPLETED	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2003-01	PHASE4
NCT00418548	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2004-06	PHASE3
NCT00276029	COMPLETED	Asthma	University Hospitals, Leicester	2003-12
NCT00091741	COMPLETED	HIV Infection	Georgetown University		PHASE1
NCT00111449	COMPLETED	Psoriasis	Amgen	2003-06	PHASE3
NCT00006070	COMPLETED	Healthy; Inflammation	National Institute of Dental and Craniofacial Research (NIDCR)	2000-07	PHASE2
NCT00458185	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2006-08	PHASE4
NCT00110903	COMPLETED	Rheumatoid Arthritis	Amgen		PHASE3
NCT00523692	UNKNOWN	Rheumatoid Arthritis	University Hospital Birmingham	2007-09	PHASE4
NCT00134394	COMPLETED	Psoriasis	University of Medicine and Dentistry of New Jersey	2005-02	PHASE2
NCT00001954	COMPLETED	Sjogren's Syndrome	National Institute of Dental and Craniofacial Research (NIDCR)	1999-12	PHASE2
NCT00421915	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2002-03	PHASE3
NCT00520572	COMPLETED	Rheumatoid Arthritis	AstraZeneca	2007-08	PHASE2
NCT00522184	COMPLETED	Rheumatoid Arthritis	Centre Hospitalier Universitaire de Nice	2005-02	PHASE3
NCT00034060	COMPLETED	Rheumatoid Arthritis; Healthy	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	2002-04	PHASE2
NCT00329823	COMPLETED	Hidradenitis Suppurativa	University of Athens	2005-09	PHASE2
NCT00317538	COMPLETED	Rheumatoid Arthritis	Centocor Ortho Biotech Services, L.L.C.	2003-06	PHASE3
NCT00001901	COMPLETED	Vasculitis; Wegener's Granulomatosis	National Institute of Allergy and Infectious Diseases (NIAID)	1999-02	PHASE2
NCT00111111	COMPLETED	Psoriasis	Amgen		PHASE3
NCT00502879	COMPLETED	Healthy	Wyeth is now a wholly owned subsidiary of Pfizer	2007-07	PHASE1
NCT00001955	COMPLETED	Temporomandibular Joint Disorder	National Institute of Dental and Craniofacial Research (NIDCR)	1999-12	PHASE2
NCT00252668	COMPLETED	Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2004-06	PHASE4
NCT00421980	COMPLETED	Ankylosing Spondylitis	Wyeth is now a wholly owned subsidiary of Pfizer	2002-06	PHASE3
NCT00393471	COMPLETED	Active Rheumatoid Arthritis	Wyeth is now a wholly owned subsidiary of Pfizer	2000-10	PHASE3
NCT00115219	COMPLETED	Rheumatoid Arthritis	Amgen	2005-05	PHASE4
NCT00048373	COMPLETED	Histiocytosis, Langerhans-Cell	Baylor College of Medicine	2001-10	PHASE2
NCT00133315	COMPLETED	Spondylarthropathies; Ankylosing Spondylitis; Psoriatic Arthritis	Hvidovre University Hospital	2004-09	PHASE4
NCT00203359	COMPLETED	Alzheimer's Disease	Tobinick, Edward Lewis, M.D.	2004-09	PHASE1
NCT00094341	COMPLETED	Rheumatoid Arthritis	Amgen	2004-10	PHASE4

(data from https://clinicaltrials.gov, updated on 2026-06-03)

Check the Etanercept product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Etanercept is a dimeric fusion protein that specifically binds to tumor necrosis factor (TNF), competitively blocking its interaction with cell surface TNF receptors and inhibiting downstream pro-inflammatory signaling cascades. By neutralizing TNF biological activity, etanercept suppresses cell-mediated inflammatory responses, thereby mitigating tissue damage and providing therapeutic benefit in inflammatory disorders such as rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.

Appendix RUO and cGMP Quality Standards

Quality Dimension	RUO (Research Use Only)	cGMP (Current Good Manufacturing Practice)
Clinical Applicability	Prohibited in human clinical trials or medical diagnostics.	Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status	Non-regulated grade; exempt from drug manufacturing laws.	Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment	Unclassified analytical or research laboratories.	Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control	Basic purity and activity testing.	Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation	Basic equipment calibration; no process validation required.	Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance	Vendor self-declared without required formal QMS.	Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact	High risk of IND rejection if used as a critical raw material.	Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).