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Bulevirtide (Myrcludex B)

Cat.No.P1105

Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.

Amino-acid Sequence

Bulevirtide (Myrcludex B) Amino-acid Sequence

CAS No. 2012558-47-1

Selleck's Bulevirtide (Myrcludex B) Has Been Cited by 1 Publication

Quality Control

Batch: Purity: 99.89%
99.89

Chemical Information & Solubility

Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL (18.52 mM)；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 50 mg/mL


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Biological Activity

Description Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.
Targets/IC50/Ki
NTCP

In vitro
In vitro

Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt. transport.
Cell Research Cell lines U2OS cells
Concentrations 200 nM
Incubation Time 1 h
Method

Cells were treated with indicated concentration of drug for 1 h.

References
  • https://pubmed.ncbi.nlm.nih.gov/24768844/
  • https://pubmed.ncbi.nlm.nih.gov/32039379/

Product Information

Molecular Formula

C248H355N65O72
Molecular Weight 5398.86
CAS No. 2012558-47-1
Appearance White Powder
Peptide Content (by %N) ≥80%
Single Impurity (by HPLC) ≤1.0%
Assay (By Anhydrous, Acetic Acid-free) 95.0~105.0%
MS Consistent
Packing plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage
(From the date of receipt)		 3 years-20°C powder
Shipping Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)