| E6917 |
PI3K/Akt/CREB activator 1 |
PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. It promotes neuronal proliferation, induces differentiation of Neuro-2a cells into a neuron-like morphology, and accelerates the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 exhibits the potential to be used in research of vascular dementia (VaD). |