STAT Chemicals

Cat.No.	Product Name	Information	Product Use Citations
E6446^New	SD-2301	SD-2301 is a potent and selective PROTAC-based STAT3 degrader that targets the VHL–cullin 2 complex, enhancing dendritic cell function and anti-tumor immunity. It synergizes with anti-PD-L1 therapy to robustly suppress tumor growth in vivo.	Cells, 2025, 14(19)1523 Aging (Albany NY), 2025, 17(8):2189-2211 Microorganisms, 2025, 13(7)1440
E3098	Fritillariae Cirrhosae Bulbus Extract	Fritillariae Cirrhosae Bulbus Extract is obtained from Fritillariae cirrhosae, mediates apoptosis through a STAT1 and STAT4-mediated co-regulatory network, which may be the key novel mechanism for its antitumor activity.
S8897^New	SD-36	SD-36 is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. This compound also exerts anti-tumor activity. This chemical is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. It also exerts anti-tumor activity.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

E6446^New

SD-2301

SD-2301 is a potent and selective PROTAC-based STAT3 degrader that targets the VHL–cullin 2 complex, enhancing dendritic cell function and anti-tumor immunity. It synergizes with anti-PD-L1 therapy to robustly suppress tumor growth in vivo.

Cells, 2025, 14(19)1523

Aging (Albany NY), 2025, 17(8):2189-2211

Microorganisms, 2025, 13(7)1440

E3098

Fritillariae Cirrhosae Bulbus Extract

Fritillariae Cirrhosae Bulbus Extract is obtained from Fritillariae cirrhosae, mediates apoptosis through a STAT1 and STAT4-mediated co-regulatory network, which may be the key novel mechanism for its antitumor activity.

S8897^New

SD-36

SD-36 is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. This compound also exerts anti-tumor activity. This chemical is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. It also exerts anti-tumor activity.