IDO/TDO Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S8557	IDO inhibitor 1	IDO inhibitor 1 is a potent inhibitor of IDO (indoleamine-(2,3)-dioxygenase) with IC50 of 3 nM.	J Immunol, 2023, 211(2):261-273 Eur Respir J, 2020, 2000443
S9137	Erianin	Erianin, a natural product derived from Dendrobium chrysotoxum, has been used as an analgesic in traditional Chinese medicine and is a potential anti-tumor agent. This compound can inhibit IDO-induced tumor angiogenesis.	J Cancer, 2024, 15(8):2380-2390
E0090	GNF-PF-3777	GNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2, 3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM.
S8919	LY-3381916	LY-3381916 (IDO1-IN-5) is a brain penetrated, potent and selective Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor. This compound exhibits anti-tumor activity.
S5249	Coptisine chloride	Coptisine (Q-100696, NSC-119754) is an isoquinoline alkaloid isolated from Coptidis Rhizoma with anti-diabetic, antimicrobial, antiviral, anti-hepatoma, and anti-leukemia effects. Coptisine chloride is an efficient uncompetitive IDO inhibitor with IC50 value of 6.3 μM and Ki value of 5.8 μM.
S6728	IDO-IN-1	IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.