FXR Antagonists

Featured Inhibitors
Inhibitors (2)
Modulator (1)
Agonists (14)
Activator (1)
Antagonists (2)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S3792	Guggulsterone E&Z	Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.	Journal of Natural Products, October 4, 2024, 2393-2397 Nature Communications, October 30, 2023, 6908 Gut Microbes, 2024, 16(1):2379566
E4873	Mebhydroline	Mebhydroline acts as a selective antagonist of farnesoid X receptor (FXR). Mebhydrolin improves blood glucose balance in in vivo mice models by inhibiting hepatic gluconeogenesis through the FXR/miR-22-3p/PI3K/AKT/FoxO1 pathway and enhancing glycogen synthesis. It also acts as a specific antagonist of histamine H1 receptor. It has potential for its use in the treatment of Type 2 diabetes mellitus (T2DM).

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S3792

Guggulsterone E&Z

Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.

Journal of Natural Products, October 4, 2024, 2393-2397

Nature Communications, October 30, 2023, 6908

Gut Microbes, 2024, 16(1):2379566

E4873

Mebhydroline

Mebhydroline acts as a selective antagonist of farnesoid X receptor (FXR). Mebhydrolin improves blood glucose balance in in vivo mice models by inhibiting hepatic gluconeogenesis through the FXR/miR-22-3p/PI3K/AKT/FoxO1 pathway and enhancing glycogen synthesis. It also acts as a specific antagonist of histamine H1 receptor. It has potential for its use in the treatment of Type 2 diabetes mellitus (T2DM).