Home Neuronal Signaling Others SB-334867 hydrochloride For research use only.

SB-334867 hydrochloride

Synonyms: SB 334867A

SB-334867 hydrochloride (SB 334867A) is an excellent,selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.

SB-334867 hydrochloride Chemical Structure

SB-334867 hydrochloride Chemical Structure

CAS No. 249889-64-3

Purity & Quality Control

SB-334867 hydrochloride Related Products

Biological Activity

Description SB-334867 hydrochloride (SB 334867A) is an excellent,selective and blood–brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo.

Chemical Information & Solubility

Molecular Weight 355.78 Formula
CAS No. 249889-64-3 SDF --
Storage (From the date of receipt) Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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