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NSC-207895 (XI-006)

NSC-207895 suppresses MDMX with IC50 of 2.5 µM, leading to enhanced p53 stabilization/activation and DNA damage.

Catalog No.S2678
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NSC-207895 (XI-006) Chemical Structure
Molecular Weight: 279.25

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

NSC-207895 (XI-006) is available in the following compound libraries:

Inhibitor Library (96-well) Chemical Library (96-well)

Product Information

  • Compare Mdm2 Inhibitors & Chemicals
    Compare Mdm2 Inhibitors & Chemicals
  • Research Area
  • Combination Therapy
    Combination Therapy

Product Description

Biological Activity Protocol Chemical Information Tech Support & FAQs

Biological Activity

Description NSC-207895 suppresses MDMX with IC50 of 2.5 µM, leading to enhanced p53 stabilization/activation and DNA damage.
Targets

MDMX
IC50
In vitro NSC-207895 decreases both the MDMX mRNA and protein in MCF-7 cells. NSC-207895 induces expression of p53 as well as well-characterized p53-target gene, p21 and MDM2, in a dose-dependent manner in MCF-7 cells. NSC-207895 extends the half-life of p53 from 20 to 30 minutes to more than 3 hours as revealed by cycloheximide chase assays in MCF-7 cells. NSC-207895 also activates p53 and induces p21 and MDM2 expression in LNCaP prostate and A549 lung cancer cells. NSC-207895 increases the mRNA levels of proapoptotic genes including PUMA, BAX, and PIG3 in a dose-dependent manner in MCF-7 cells. NSC-207895 results in a significant increase in the numbers of sub-G0/G1 cells as well as G2 arrest. NSC-207895 also results in more than 40% of cells dying via apoptosis and decreases cell viability in A549 and LNCaP cells. [1] NSC-207895 inhibits biosynthesis of nucleic acids and proteins in L1210 cells. [2] NSC-207895 interacts with DNA repair to activate the DNA damage repair pathway in three species (S. cerevisiae, S. pombe and H. sapiens). [3] NSC-207895 acts as cytotoxic agent in the G/R-luc astrocytoma cell line with GI50 of 117 nM. [4]
In vivo
Clinical Trials
Features

Protocol(Only for Reference)

Cell Assay:

[1]

Cell lines MCF-7 cell
Concentrations 1-10 μM
Incubation Time 2 days
Method

MCF-7 cells treated with dimethyl sulfoxide (DMSO), nutlin-3a, or NSC-207895 are permeabilized with cold 70% ethanol overnight, and stained with a solution containing 50 μg/mL propidium iodide and 20 μg/mL RNase A at 37°C for 20 minutes. The cells are then subjected to flow cytometry analysis. The FlowJo software is used to calculate percentages of cells in each cell cycle phase. For terminal deoxynucleotidyl transferase–mediated dUTP nick end labeling (TUNEL) staining, MCF-7 cells treated with the NSC-207895 for 2 days are fixed with 4% paraformadelhyde for 1 hour, and then subjected to dUTP labeling using In Situ Cell Death Detection Kit TMR Red according to the manufacturer's protocol. For quantitation, at least 300 cells are randomly chosen and the numbers of TUNEL-positive cells are counted.
1

References

Chemical Information

Download NSC-207895 (XI-006) SDF
Molecular Weight (MW) 279.25
Formula

C11H13N5O4
CAS No. 58131-57-0
Synonyms N/A
Solubility (25°C)
  • DMSO 0.4 mg/mL
  • Water <1 mg/mL
  • Ethanol <1 mg/mL
Storage 2 years -20°CPowder
2 weeks4°Cin DMSO
6 months-80°Cin DMSO
Chemical Name 2,1,3-Benzoxadiazole, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide
Molarity Calculator Dilution Calculator Molecular Weight Calculator

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions
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