Naltrexone HCl

Catalog No.S2103

Naltrexone HCl Chemical Structure

Molecular Weight(MW): 377.86

Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
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2 Customer Reviews

  • (b) plasma IL-6 and (c) plasma tumornecrosis factor (TNF)-a concentrations in the colon carcinomamodel. The values represent the mean±SD derived from sixanimals. *P < 0.05

    Photodermatol Photoimmunol Photomed, 2017, 33(2):84-91. Naltrexone HCl purchased from Selleck.

    The sex difference in epidermal melanocytes after tranexamic acid treatment following naltrexone treatment. Naltrexone was injected intraperitoneally into the mice throughout the experimental period. Five days after the final UVB irradiation of the eye, the number of Dopa-positive melanocytes in the epidermal sheets prepared from the ear was determined. The values are presented as the means±SD derived from six animals (biological replicates; *P < 0.05).

    Photodermatol Photoimmunol Photomed, 2016, 32(3):136-45.. Naltrexone HCl purchased from Selleck.

Purity & Quality Control

Choose Selective Opioid Receptor Inhibitors

Biological Activity

Description Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence.
Targets
opioid receptor [1]
8 nM
In vivo Naltrexone (0.32 mg/kg) reduces ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%) in rhesus monkeys. Naltrexone (0.1 mg/kg) reduces ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. [1] Naltrexone (1-3 mg/kg) potently and dose-dependently inhibits reinstatement of ethanol-seeking produced by non-contingent deliveries of the liquid dipper filled with 8% ethanol. [2] Naltrexone elicits optimal enhancement of morphine's antinociceptive potency in mice when co-administered (i.p.) at about 100 ng/kg together with morphine (3 mg/kg). [3] Naltrexone (10 ng/kg i.p.) augments the antinociception produced by an acute submaximal dose of intrathecal (5 mg) or systemic (7.5 mg/kg i.p.) morphine in the tail-flick test in rats. Naltrexone combined with Morphine inhibits the decline in morphine antinociception and prevented the loss of morphine potency in rats. [4] Naltrexone significantly suppresses ethanol self-administration and prevents ethanol-induced increases in dialysate dopamine levels. [5] Naltrexone completely prevents the reduction in anogenital distance in prenatally stressed (PS) males and restores the growth rate of both sexes. Naltrexone also decreases the anxiety of PS rats in the plus-maze, increases the opioid component of exploration to control levels, but increases anxiety in control males. [6]

Protocol

Solubility (25°C)

In vitro DMSO 14 mg/mL (37.05 mM)
Water 14 mg/mL (37.05 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 377.86
Formula

C20H23NO4.HCl

CAS No. 16676-29-2
Storage powder
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00667771 Completed Alcohol Dependence|Alcoholism National Institute on Alcohol Abuse and Alcoholism (NIAAA)|National Institutes of Health Clinical Center (CC) April 22, 2008 Early Phase 1
NCT03047005 Enrolling by invitation Binge-Eating Disorder|Obesity Yale University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) June 2017 Phase 2|Phase 3
NCT02978417 Not yet recruiting Opioid-Related Disorders Duke University|Laura and John Arnold Foundation|Alkermes, Inc.|FHR (Fellowship Health Resources, Inc.)|Drug Treatment Court (Wake County, NC) March 2017 Phase 4
NCT03008590 Not yet recruiting Osteoarthritis|Arthritis, Rheumatoid|Arthritis, Psoriatic VA Office of Research and Development February 2017 Phase 2
NCT02942550 Recruiting STEMI|Morphine|Ticagrelor|Methylnaltrexone Karolinska University Hospital November 2016 Phase 4
NCT02977286 Recruiting Constipation Tufts Medical Center November 2016 Phase 4

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Handling Instructions

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Opioid Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID