Naloxone HCl Dihydrate
Catalog No.S4501
Molecular Weight(MW): 399.87
Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose.
Purity & Quality Control
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Biological Activity
| Description | Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose. | |
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| Targets |
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| In vitro |
The Ki values of (−)-naloxone for the MOR, KOR, and DOR are 0.559 nM, 4.91 nM, and 36.5 nM, respectively. Naloxone HCl Dihydrate binds to the MOR with approximately 9-fold greater affinity relative to the KOR and around 60-fold greater affinity relative to the DOR.[1] |
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| In vivo | The combination of Naloxone HCl Dihydrate (0.5 mg/kg, i.p.) with tramadol (22 mg/kg) decreases the antiallodynic effect of tramadol. [2] |
Protocol
| Animal Research:[2] |
+ Expand
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Solubility (25°C)
| In vitro | DMSO | 79 mg/mL (197.56 mM) |
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| Water | 20 mg/mL warmed (50.01 mM) | |
| Ethanol | Insoluble | |
| In vivo | Add solvents individually and in order: Saline |
30mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 399.87 |
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| Formula | C19H26ClNO6 |
| CAS No. | 51481-60-8 |
| Storage | powder |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03033732 | Not yet recruiting | Opioid Use Disorder | Didier Jutras Aswad|Canadian Institutes of Health Research (CIHR)|Canadian Research Initiative in Substance Misuse | March 30, 2017 | Phase 4 |
| NCT03026790 | Not yet recruiting | Chronic Pain | University of Minnesota - Clinical and Translational Science Institute|Patient-Centered Outcomes Research Institute | August 2017 | -- |
| NCT02922959 | Not yet recruiting | Drug Overdose|Opioid-Related Disorders|Drug Addiction|Drug Abuse|Substance Abuse | University of Cincinnati|National Institute on Drug Abuse (NIDA) | April 2017 | -- |
| NCT03048643 | Not yet recruiting | Endocardits, Bacterial|Opioid-use Disorder|Buprenorphine|Outpatient Parenteral Antibiotic Therapy | Laura Fanucchi|University of Kentucky | March 2017 | -- |
| NCT02976337 | Not yet recruiting | Healthy Subjects|Hyperalgesia|Inflammations, Endodontic|Pain, Acute|Sensitization, Central | mads u werner|University of Kentucky|University of Copenhagen | January 2017 | Phase 2 |
| NCT02811783 | Recruiting | Mycosis Fungoides|Lymphoma, T-Cell, Cutaneous | Elorac, Inc. | January 2017 | Phase 3 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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