Home Biosimilar Antibodies Immunology & Inflammation Interleukins Lebrikizumab (Anti-IL-13)
For research use only. Not for use in humans.

Lebrikizumab (Anti-IL-13)

Synonyms: null

Lebrikizumab (anti-IL-13) is an humanized IgG4 monoclonal antibody against interleukin 13 (IL-13) with immunosuppressive and anti-asthmatic activities. MW: 145.8 KD.

Lebrikizumab (Anti-IL-13)

Quality Control

Batch: A295401 Purity: 99% Protein concentration: 5.127mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation IL-6 IL-1 IL-8 IL-12 IL-10 IL-13 IL-2 Others
SKF-86002 1
JTE-607 Dihydrochloride 2 TNF-alpha
A-740003 2 rat P2X7 receptor,human P2X7 receptor
Apilimod mesylate 6 PIKfyve
MD2-TLR4-IN-1 2 TLR4,TNF-α
Danirixin (GSK1325756) 2 CXCR2
Resatorvid (TAK-242) 65 TLR4,NO,TNF-α
Apilimod (STA-5326) 19 PIKfyve
LMT-28 1
Atractylodin 0 NAAA
Triolein 0 ROS,MMP-1
Ac-YVAD-cmk 5
Diethyl phosphate 1
RCM-1 5 STAT6,FOXM1,β-catenin
Stylopine 0 COX-2,TNF-α,NO
Myrislignan 1 NF-κB,COX-2,iNOS
NE 52-QQ57 2 iNOS,TNF-α,PGE2
PKR-IN-C16 9 PKR
(3R,8S)-Falcarindiol 3 STAT,ERK,JNK
Gardenoside 1 P2X7 Receptor,P2X3 receptor,NF-κB
T-5224 23 c-Jun,c-Fos/AP-1,Adamts-5
IQ 3 1 TNF-α,JNK3,JNK1
Isuzinaxib (APX-115 free base) 2 TNFα,MCP-1/CCL2,NOX2
AUDA 1 p38,Smad3,TGF-β
SAR-20347 1 IFN-α,TYK2,JAK1
SU 5201 0
Madecassic acid 3 TNF-α,COX-2,iNOS
Homoplantaginin 1 NF-κB,IKKβ,TNF-α
2',5'-Dihydroxyacetophenone 1 NF-κB,ERK1/2,iNOS
Forsythoside B 0 NF-κB,TNF-alpha,IκB
Mulberroside A 0 NF-κB,Caspase-1,NALP3
Chelidonic acid 0 glutamate decarboxylase,Caspase-1,NF-κB
4-Methylesculetin 2 MPO
Muscone 4 TNF-α,NLRP3 inflammasome,NF-κB
Ossirene (AS101) 16
Methylthiouracil 1 ERK1/2,NF-κB,TNF-α
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Lebrikizumab (anti-IL-13) is an humanized IgG4 monoclonal antibody against interleukin 13 (IL-13) with immunosuppressive and anti-asthmatic activities. MW: 145.8 KD.
References

Product Details

CAS No. 953400-68-5
Molecular Weight 145.28
Isotype Human IgG4SP
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT07352566 NOT_YET_RECRUITING Drug: Triamcinolone|Drug: 5-Fluorouracil|Drug: Calcipotriene Psoriasis; Atopic Dermatitis University of California, San Francisco 2026-08-01 PHASE4
NCT07542483 RECRUITING Drug: Lebrikizumab Nummular Eczema Almirall, S.A. 2026-04-24 PHASE3
NCT05735483 ENROLLING_BY_INVITATION Drug: Lebrikizumab|Drug: Placebo Atopic Dermatitis; Eczema Eli Lilly and Company 2023-03-09 PHASE3
NCT07620561 NOT_YET_RECRUITING Drug: Lebrikizumab Prurigo Nodularis (PN) University of Maryland, Baltimore 2026-09 PHASE2
NCT06906497 RECRUITING Drug: lebrikizumab Atopic Dermatitis Johann E Gudjonsson MD PhD 2025-07-02 PHASE4
NCT07471932 RECRUITING Drug: LAD106|Drug: Lebrikizumab Healthy Volunteers Almirall, S.A. 2026-02-17 PHASE1

(data from https://clinicaltrials.gov, updated on 2026-06-03)

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