Chlorocresol
Catalog No.S4209
Molecular Weight(MW): 142.58
Chlorocresol is an activator of ryanodine receptor.
Purity & Quality Control
Choose Selective Calcium Channel Inhibitors
Biological Activity
| Description | Chlorocresol is an activator of ryanodine receptor. | |
|---|---|---|
| Targets |
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| In vitro |
Chlorocresol (1 mM) is capable of releasing Ca2+ from a ruthenium red/caffeine-sensitive Ca2+ release channel selectively localized in terminal cistemae (TC), whereas Chlorocresol has no effect on longitudinal sarcoplasmic reticulum (LSR), indicating that Chlorocresol is not acting by inhibiting the Ca2+-ATPase or damaging the vesicles. Chlorocresol is capable of releasing Ca2+ from heparmn-treated cerebellar microsomes. In PC12 cells, Chlorocresol releases Ca2+ from a caffeine/thapsigargin- sensitive intracellular store. The chloro and methyl groups in Chlorocresols are important for the activation of the ryanodine receptor Ca2+ release channel. [1] Chlorocresol causes muscle contracture in malignant hyperthermia-susceptible (MHS) muscles at a concentration of 25–50 mM and potentiates the caffeine contracture response in human MHS muscles. Sub-threshold (20 mM) concentrations of Chlorocresol increases both the Kd (6.0 vs. 10 mM) and the Vmax (2.2 vs. 1.55 mmol Ca2+/min/mg protein) of caffeine-induced Ca2+ release from isolated rabbit terminal cisternae. [2] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 29 mg/mL (203.39 mM) |
|---|---|---|
| Ethanol | 29 mg/mL (203.39 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 142.58 |
|---|---|
| Formula | C7H7ClO |
| CAS No. | 59-50-7 |
| Storage | powder |
| Synonyms | N/A |
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