Research Area
Product Type
United States ( Change Country )
Vinorelbine (Navelbine) Chemical Structure
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Biological Activity
Vinorelbine (Navelbine) is the first 5´NOR semi-synthetic vinca alkaloid and exerts its activity through the MAPK (p38) pathway with median IC90 and IC50 of 15.5 and 2.3 μM. Vinorelbine (Navelbine) is obtained by semi-synthesis from alkaloids extracted from the rosy periwinkle, Catharanthus roseus. Vinorelbine (Navelbine) is an anti-mitotic chemotherapy agent that is given as a treatment for some types of cancer, including breast cancer and non-small cell lung cancer. In MCF-7 and MDA-MB-468, increased p38 activity was demonstrated following vinorelbine but not doxorubicin treatment, whether vinorelbine was given prior to or simultaneously with doxorubicin. Mitogen-activated protein kinase (MAPK) activity and p53 expression remained unchanged following vinorelbine treatment. [1][2][3]
References on Vinorelbine (Navelbine)
- [2] Cancer Res 2000;60:5045-5051
- [3] British Journal of Cancer 2003;88：1281 – 1284
Chemical Information
| Molecular Weight (WM): | 778.93 |
|---|---|
| Formula: | C45H54N4O8 |
| CAS No.: | 71486-22-1 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥156mg/mL |
| Water <1mg/mL | |
| Ethanol ≥156mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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