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U 95666E(Sumanirole maleate) Chemical Structure
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Biological Activity
Sumanirole maleate is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. It has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function. In rats, sumanirole is a full agonist for elevation of striatal acetylcholine levels (ED50 = 12.1 μmol/kg i.p.). Sumanirole s.c. dose dependently decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta with an ED50 of 2.3 μmol/kg i.v. [1][2]
References on U 95666E(Sumanirole maleate)
- [1] http://en.wikipedia.org/wiki/Sumanirole ;
- [2] J Pharmacol Exp Ther. 2005 Sep;314(3):1248-56.
Chemical Information
| Molecular Weight (WM): | 319.31 |
|---|---|
| Formula: | C11H13N3O.C4H4O4 |
| CAS No.: | 179386-44-8 |
| Synonyms: |
Sumanirole maleate, PNU 95666, U95666E
|
| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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