Salinomycin

Catalog No.S2352

Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.

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Salinomycin Chemical Structure

Salinomycin Chemical Structure
Molecular Weight: 751.00

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Product Information

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Product Description

Biological Activity

Description Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
LD50
In vitro Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. [1] Salinomycin (Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer compound (paclitaxel) in mice. [2] The mechanism of action by which salinomycin (Procoxacin) kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use.
In vivo LD50: Mice 18mg/kg (i.p.), 50mg/kg (i.g.). [3]
Features

Protocol(Only for Reference)

1

References

[1] Miyazaki Y, et al. J Antibiot (Tokyo), 1974, 27(11), 814-821.

[2] Huczynski A, Chem Biol Drug Des, 2012, 79(3), 235-238.

Chemical Information

Molecular Weight (MW) 751.00
Formula

C42H70O11

CAS No. 53003-10-4
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms Procoxacin, AHR-3096
Solubility (25°C) * In vitro DMSO 2 mg/mL (2 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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