Catalog No.S2352 Synonyms: Procoxacin, AHR-3096
Molecular Weight(MW): 751.00
Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
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Drug sensitivity of KPC tumor cell subpopulations. CD133, Aldefluor, and Sca-1-positive or -negative cells or unsorted KPC cells were cultured in the presence of increasing concentrations of salinomycin. After 72 hours, cell viability was assessed using CellTiter Glo reagent, and percent viability was normalized to vehicle-treated controls. Pair-wise multiple comparisons were performed with one-way ANOVA with Bonferroni adjustment. P values < 0.05 were considered statistically significant.
Tumor and Stem Cell Biology, 2015, 75(21):4582-4592.. Salinomycin purchased from Selleck.
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|Description||Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.|
Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent.  Salinomycin (Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer compound (paclitaxel) in mice.  The mechanism of action by which salinomycin (Procoxacin) kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use.
|In vivo||LD50: Mice 18mg/kg (i.p.), 50mg/kg (i.g.). |
|In vitro||Water||0.01 mg/mL (0.01 mM)|
|DMSO||0.005 mg/mL (0.0 mM)|
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