Salinomycin

Catalog No.S2352 Synonyms: Procoxacin, AHR-3096

Salinomycin Chemical Structure

Molecular Weight(MW): 751.00

Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.

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  • Drug sensitivity of KPC tumor cell subpopulations. CD133, Aldefluor, and Sca-1-positive or -negative cells or unsorted KPC cells were cultured in the presence of increasing concentrations of salinomycin. After 72 hours, cell viability was assessed using CellTiter Glo reagent, and percent viability was normalized to vehicle-treated controls. Pair-wise multiple comparisons were performed with one-way ANOVA with Bonferroni adjustment. P values < 0.05 were considered statistically significant.

    Tumor and Stem Cell Biology, 2015, 75(21):4582-4592.. Salinomycin purchased from Selleck.

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Biological Activity

Description Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
In vitro

Salinomycin (Procoxacin) is an antibacterial and coccidiostat ionophore therapeutic agent. [1] Salinomycin (Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer compound (paclitaxel) in mice. [2] The mechanism of action by which salinomycin (Procoxacin) kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use.

In vivo LD50: Mice 18mg/kg (i.p.), 50mg/kg (i.g.). [3]

Protocol

Solubility (25°C)

In vitro Water 0.01 mg/mL (0.01 mM)
DMSO 0.005 mg/mL (0.0 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 751.00
Formula

C42H70O11

CAS No. 53003-10-4
Storage powder
Synonyms Procoxacin, AHR-3096

Bio Calculators

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID